Conserved Protein Domain Family
ANK

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cd00204: ANK (this model, PSSM-Id:238125 is obsolete)
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ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other types of domains. The structural repeat unit contains two antiparallel helices and a beta-hairpin, repeats are stacked in a superhelical arrangement; this alignment contains 4 consecutive repeats.
Statistics
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PSSM-Id: 238125
View PSSM: cd00204
Aligned: 342 rows
Threshold Bit Score: 38.5187
Threshold Setting Gi: 137552
Created: 24-May-2001
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1IKN_D      39 NFQN--NLQQTPLHLAVITNQp----eIAEALLGAGCdp------------------eLRDF-RGNTPLHLACEQGCl-- 91
gi 137486  271 NARN--KFGTTPFYCGIIHGIs----lIKLYLESDTE---------------------LEID-NEHIVRHLIIFDAVe-- 320
gi 321379  322 DPLVt-VHGNSSLHYYMRRYMlc--ksVLDILLSTGVdi------------------nGINE-KFHTPLHTYVDKNSk-- 377
gi 321379  143 DVKD--VYGHNLLHLYLKSPYpk--lsIIKLLLDHGVdi-----------------naKTRM-HRHTPLHIYLMNSHmd- 199
gi 321379  288 NQLT--YRGHTPLLVYITMGLf----iESDAITCMIDhg-----------------adPLVTvHGNSSLHYYMRRYMlc- 343
gi 465059  212 NALD--NCGNTPFHLYLSIEMcnnihmTKMLLTFNPNf-------------------eICNN-HGLTPILCYITSDYiq- 268
gi 3097044 222 NKVN--NIGNTPLHNYVSQYDis--prIIFTLLSLGAdl------------------tIQNN-DRLTPIMEYIKCEYi-- 276
gi 3097049 371 ATMDktTDNNYPLHDYFVNNNlvd-vnVVRFIVENNGhmavnhvsn---ngrlcmyglILSR-FNNCGYHCYETILId-- 443
gi 3097050 170 NCVD--EDGLTSLHYYCKHISt----fHESNYYKSSHtkmraekrfiytiidhganinAVTK-IGNTPLHTYLQQYTkhs 242
gi 9802990  75 QAVD--NIGCSALHLCAEHGHy----rMIKLLLQYMKvveqyetp-----efragdkyPQRE-NVDEPLRLAIKNGHy-- 140
                       90       100       110       120       130       140       150       160
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1IKN_D      92 -aSVGVLTQscttphlhsilKATN-YNGH---------TCLHLASIHGy---LGIVELLVslg----------------- 140
gi 137486  321 --SLDYLLSrgv-----idiNYRT-IYNE---------TSIYDAVSYNa---YNTLVYLLnrn----------------- 363
gi 321379  378 -gVAPSIIQymi-----drgVSTA-RLSTtiftesileTFLRRNRQYLnt-tIEVVDYLLtvy----------------- 432
gi 321379  200 kkVVEFLLRng--------aDINY-GNYE---------TPLGTLFSHCs--sFKLIKSITtkl----------------- 242
gi 321379  344 ksVLDILLStgv------diNGIN-EKFH---------TPLHTYVDKNs---KGVAPSIIqymi---------------- 388
gi 465059  269 hdILVMLIHhyet---nvgeMPIDeRRMIv--------FEFIKTYSTRp---LDSITYLMnrf----------------- 317
gi 3097044 277 -eYNTLLMLinwye--skyrKLEK-EEGQ---------HLLHLFIRHNdsngLNILSYLLkkf----------------- 326
gi 3097049 444 --VFDILSKymd------diDMID-NENK---------TLLYYAVDVNn---IQFAKRLLeyg----------------- 485
gi 3097050 243 prVVYALLSrga------dtRIRN-NLDC---------TPIMEYIKNDca-tGHILIMLLnwheqkygklqkeegqhlly 305
gi 9802990 141 -dCARLLLTng--------aNANA-IYFD---------GPEITQVSPLd---TNFLELLLefg----------------- 181
                      170       180       190       200       210       220
               ....*....|....*....|....*....|....*....|....*....|....*....|....*.
1IKN_D     141 ---------------------advNAQEp-CNGR---------TALHLAVdl----qnPDLVSLLL 171
gi 137486  364 ---------------------gdfETIT--TSGC---------TCISEAVan----nnKIIMEVLL 393
gi 321379  433 ----------------------plNEPD--EYGF---------TPLLSAVyavnlnffNHFVKLGA 465
gi 321379  243 ----------------------leYGADi-NFPA---------ASGHSAMmsy--linNPDATVHP 274
gi 321379  389 ---------------------drgVSTA--RLSTtiftesileTFLRRNRqyl--nttIEVVDYLL 429
gi 465059  318 ---------------------kniDIHTr-YEGK---------TLLHIACey----nnTHVIDYLI 348
gi 3097044 327 ---------------------dmkNDEY--YNDI---------TPLHNACia----cnIDIISYLV 356
gi 3097049 486 ---------------------anvNATSl-SIIN---------TAIQKSSyrr---enKTKLVDLL 517
gi 3097050 306 lfikhnqgygshtlnilrylldrfDIQKdeYYNTm--------TPLHTAFqn----cnNNVASYLV 359
gi 9802990 182 ---------------------adpNVFD--RKGL---------TPIMKACrlr--dkgIEAIRILL 213
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