Conserved Protein Domain Family
vWFA

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cd00198: vWFA 
Click on image for an interactive view with Cn3D
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.
Links
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Statistics
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PSSM-Id: 238119
View PSSM: cd00198
Aligned: 165 rows
Threshold Bit Score: 32.5378
Threshold Setting Gi: 24158933
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
Hierarchy
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metal
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:metal ion-dependent adhesion site (MIDAS)
Evidence:
  • Comment:divalent cations are bound by the MIDAS motif
  • Structure:1DZI; integrin alpha2 binds Co2+ (cobalt ion) that engages collagen (Glu residue)
    View structure with Cn3D
  • Comment:1IDN_1 shows the metal free state
  • Structure:1BHQ_1 with Cd2+ (cadmium ion)
    View structure with Cn3D
  • Structure:1AOX_A with Mg2+
    View structure with Cn3D
  • Structure:1JLM with Mn2+
    View structure with Cn3D

cd00198 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd00198 is a member of the superfamily cl00057.
cd00198:vWFAcd01450:vWFA_subfamily_ECMcd01451:vWA_Magnesium_chelatasecd01452:VWA_26S_proteasome_subunitcd01453:vWA_transcription_factor_IIH_typecd01454:vWA_norD_typecd01455:vWA_F11C1-5a_typecd01456:vWA_ywmD_typecd01457:vWA_ORF176_typecd01458:vWA_kucd01459:vWA_copine_likecd01460:vWA_midasincd01461:vWA_interalpha_trypsin_inhibitorcd01462:VWA_YIEM_typecd01463:vWA_VGCC_likecd01464:vWA_subfamilycd01465:vWA_subgroupcd01466:vWA_C3HC4_typecd01467:vWA_BatA_typecd01468:trunk_domaincd01469:vWA_integrins_alpha_subunitcd01470:vWA_complement_factorscd01471:vWA_micronemal_proteincd01472:vWA_collagencd01473:vWA_CTRPcd01474:vWA_ATRcd01475:vWA_Matrilincd01476:VWA_integrin_invertebratescd01477:vWA_F09G8-8_typecd01478:Sec23-likecd01479:Sec24-likecd01480:vWA_collagen_alpha_1-VI-typecd01481:vWA_collagen_alpha3-VI-likecd01482:vWA_collagen_alphaI-XII-like88194139253993024995139155342122908944337752297660915924398300188091607899823098297231115062299342423183413473074161249252298723921401500298371282009391789285258928526218852992722859610957393230533432983712821221492142858521633157017229601163307441324264628920251298309471582811723821225230187632983353323018985242119724239674289184492885039120129887311989932421201725145616234910382924943429249371254534658777310152899122882949523426901548738210720365136261792957113328828708216729032310934846558321223183134760472934931824213397249578324961272305012623051360156015172851556212258451831306914601147289013102302922622976950175515943043652312031812464081523052029156036932310465021323788212245471DZI A1AOX B1AOX A1CK4 B12643894126436391JLM  1BHQ 11IDN 1126437171N3Y A1CQP A1MJN A2497428190331051903310539287872827508717366074173662822634606427668184285461171753870217558302175504881273884231204531115352391318928703819543913138789032091525017555634230234046017001192321732309147729413456503182940142800202382181320141279318293920141279206516731829405921193134565213456525921193592119313456525921193134565213456521345652134565259211932737043028546117738758226788036115556283743131454811628175657738790611555628374313145491631454811622096361125836991878027312052774226521131755429673875817387582267880361FE8 C12644030244311132170318629738806115352391318930584073297388067505452138789035439132870381939131892780864727716387175604262870381911531454391313878903175673551IJK A1OAK A1M10 A1757005922044982217519982089511720895117277214012854611759211931345652288290842304382217550160175542281753791517537955175557341753368517506641175336891753368746585717569417889731757077374963891754187828546117749638966809721361531575515158978554899644939422361224544939425139521234801515139521749439174943912348015174943915139521236129957494391234801511Q0P A116126119904283929911213404915208290391564239828972161610417773341295716210159702133785231365502167508524217116231372953878947156058597463253391534848381392421711521675084293463172313741727366613229769512437461321244101234663512828247175694172009363228210485229723212297216521221124212199692303950623039508158079912297045723018152282955823049070212285802008914569123101706571572976923028476646959922758317297888082080511728922010289199851522727726450631223276702304073023039505230420423178943114600832229625612122647723052028200916692348511611649962828245229894762297842222958663273784832298941722972165282104851JEY A1JEQ A324185846307973154495662255971200642415990777289241114008550134625931206539198636399929270289174491755593024984351JEY B463079987785241M2O A1M2V A1271840937026314176521201417941453060272711624567227224477243143881M2V B1730731573448513124510131245097303833250051581312452013124526387579613124508277352562294539373168860667214558550123285717315741820225611281550112760181135959139144761709796278826501738055825347041236129364178132640038818203119282788872135629928828471279239984056421236190951907410572879291072880621266421755048817555634175387021756847375054523026220223017538273656602890058515921064158979561589795315921062173802312301964019552282114990392313794430268323217523501520814321082361164096753236199221902458456031231805245844593092322275115391589376423043788152185013068622623237924263901812776488427716351289269812737608823027918243737501723190427367212302404813432192302405130240683031403733199302495629212323462306154413471293230218672302903722959873293498732122117524967922297239216123186172292742297294629828406231046441560368722967219994589831789438230200002009128517231895234660921830949923059749234754596752871774158523061880288984071102469424639942229965011580592922127458234677201612092623467719138788701723031423042709222985171612092323467721288718781148572132863722963480229689353913146229748463913221321293236225079622649721220339230195182008976121673259229715681754884615790540195532001608167914285923229928272937536788194139253993024995139155342122908944337752297660915924398300188091607899823098297231115062299342423183413473074161249252298723921401500298371282009391789285258928526218852992722859610957393230533432983712821221492142858521633157017229601163307441324264628920251298309471582811723821225230187632983353323018985242119724239674289184492885039120129887311989932421201725145616234910382924943429249371254534658777310152899122882949523426901548738210720365136261792957113328828708216729032310934846558321223183134760472934931824213397249578324961272305012623051360156015172851556212258451831306914601147289013102302922622976950175515943043652312031812464081523052029156036932310465021323788212245471DZI A1AOX B1AOX A1CK4 B12643894126436391JLM  1BHQ 11IDN 1126437171N3Y A1CQP A1MJN A2497428190331051903310539287872827508717366074173662822634606427668184285461171753870217558302175504881273884231204531115352391318928703819543913138789032091525017555634230234046017001192321732309147729413456503182940142800202382181320141279318293920141279206516731829405921193134565213456525921193592119313456525921193134565213456521345652134565259211932737043028546117738758226788036115556283743131454811628175657738790611555628374313145491631454811622096361125836991878027312052774226521131755429673875817387582267880361FE8 C12644030244311132170318629738806115352391318930584073297388067505452138789035439132870381939131892780864727716387175604262870381911531454391313878903175673551IJK A1OAK A1M10 A1757005922044982217519982089511720895117277214012854611759211931345652288290842304382217550160175542281753791517537955175557341753368517506641175336891753368746585717569417889731757077374963891754187828546117749638966809721361531575515158978554899644939422361224544939425139521234801515139521749439174943912348015174943915139521236129957494391234801511Q0P A116126119904283929911213404915208290391564239828972161610417773341295716210159702133785231365502167508524217116231372953878947156058597463253391534848381392421711521675084293463172313741727366613229769512437461321244101234663512828247175694172009363228210485229723212297216521221124212199692303950623039508158079912297045723018152282955823049070212285802008914569123101706571572976923028476646959922758317297888082080511728922010289199851522727726450631223276702304073023039505230420423178943114600832229625612122647723052028200916692348511611649962828245229894762297842222958663273784832298941722972165282104851JEY A1JEQ A324185846307973154495662255971200642415990777289241114008550134625931206539198636399929270289174491755593024984351JEY B463079987785241M2O A1M2V A1271840937026314176521201417941453060272711624567227224477243143881M2V B17307315734485131245101312450973038332500515813124520131245263875796131245082773525622945393731688606672145585501232857173157418202256112815501127601811359591391447617097962788265017380558253470412361293641781326400388182031192827888721356299288284712792399840564212361909519074105728792910728806212664217550488175556341753870217568473750545230262202230175382736566028900585159210641589795615897953159210621738023123019640195522821149903923137944302683232175235015208143210823611640967532361992219024584560312318052458445930923222751153915893764230437881521850130686226232379242639018127764884277163512892698127376088230279182437375017231904273672123024048134321923024051302406830314037331993024956292123234623061544134712932302186723029037229598732934987321221175249679222972392161231861722927422972946298284062310464415603687229672199945898317894382302000020091285172318952346609218309499230597492347545967528717741585230618802889840711024694246399422299650115805929221274582346772016120926234677191387887017230314230427092229851716120923234677212887187811485721328637229634802296893539131462297484639132213212932362250796226497212203392301951820089761216732592297156817548846157905401955320016081679142859232299282729375367
cd00198 Sequence Cluster
cd00198 Sequence Cluster
Sub-family Hierarchy
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                #                                                                        
1DZI_A          3 IDVVVVCDEsns-------iypWDAVKNFLEKFVQGldig-------ptktQVGLIQYAn-------NPRVVfnlnty-- 59
1M2O_A        122 PIFFFVVDLtse-------tenLDSLKESIITSLSLlpp----------naLIGLITYGn-------VVQLHdlssetid 177
1M2V_A        122 PIFFFVVDLtse-------tenLDSLKESIITSLSLlpp----------naLIGLITYGn-------VVQLHdlssetid 177
1M2V_B        304 ATYCFLIDVsqssi----ksglLATTINTLLQNLDSipnh-------dertRISILCVDn-------AIHYFkipldsen 365
gi 28829084  1647 LDLVFCIDStgsm------sgeIKEVKEKITSIVDRieka-------kvnvNVGLVFYNdhe--iiyLPTDKsp------ 1705
gi 22962561    31 VEVAFVLDTtgsmsg--liegaKRKIWSIATTILDDnpd---------adiRMGLVAYRdi-----gDDYVVrsvdlt-- 92
gi 2829558     97 AVVMLVIDVsqsmr---atdvePSRMVAAQEAAKQFadel-------tpgiNLGLIAYAg-------TATVLvsptt--- 156
gi 28901310    85 QNRMLVLDMsrsmyasdikpnrLAQTRYKALDLLPKwk-----------egATGLIVYAg-------DAYSLspltt--- 143
gi 23017538    48 VDIVLCIDAtgsm------spiIDRVKESALRFHEDlrkvmaaksknidslRVRVIAYRdyycdapeEAMVTseffsl-- 119
gi 7505452  12121 IDLLLVIDSsnni-----kvldYRVMKELIKNFLTEhfnlr------khqvRVGLVKYGd-------GAEIPvslgdy-- 12180
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
1DZI_A         60 ---------------------------------------------------ktkeeMIVATsqtsq-----------ygg 77
1M2O_A        178 rcnvfrgdreyqlealtemltgqkptgpggaashlpnamnkvtpfslnrfflpleqVEFKLnqllenlspdqwsvpaghr 257
1M2V_A        178 rcnvfrgdreyqlealtemltgqkptgpggaashlpnamnkvtpfslnrfflpleqVEFKLnqllenlspdqwsvpaghr 257
1M2V_B        366 neesadqinmmdi-----------------------adleepflprpnsmvvslkaCRQNIetlltkipq---ifqsnli 419
gi 28829084  1706 ------------------------------------------------------tiVYEFTddiplvkkni--gtikafg 1729
gi 22962561    93 ---------------------------------------------------tdiqdLYGQLlqlqar---------gggd 112
gi 2829558    157 ----------------------------------------------------nreaTKNALdklqfa---------drta 175
gi 28901310   144 ----------------------------------------------------dastLAGIIenlspe---------lmpf 162
gi 23017538   120 --------------------------------------------------pqqaaeFSRFVngiear---------gggd 140
gi 7505452  12181 ---------------------------------------------------dneddLVHRIsesrr------------lk 12197
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           #                                  #                                          
1DZI_A         78 dlTNTFGAIQYARKyaysaas--ggrrsatKVMVVVTDGeshdgs---------------------------mlkavIDQ 128
1M2O_A        258 plRATGSALNIASLllqgc------yknipARIILFASGpgtvapglivnselkdplrshhdidsdhaqhykkackfYNQ 331
1M2V_A        258 plRATGSALNIASLllqgc------yknipARIILFASGpgtvapglivnselkdplrshhdidsdhaqhykkackfYNQ 331
1M2V_B        420 tnFALGPALKSAYHlig----------gvgGKIIVVSGTlpnlgigklqrrnesgv----vntsketaqllscqdsfYKN 485
gi 28829084  1730 gnDHPEAVADGLYEvsklkf-----rsnasKICILITDApahgfdsklnetysed------yhpngcpcghdsielvRSL 1798
gi 22962561   113 wpESVNEALDTAINklhwrq-----ggdtrRIVFLVGDApphmdyaq-----------------------dtkypetLAV 164
gi 2829558    176 tgEAIFTALQAIATvgavigg---gdtpppARIVLFSDGketmptnpd---------------------npkgaytaART 231
gi 28901310   163 qgSNLPAAIELSLSqfsqa-------ganqGDIVVLADDlddse-----------------------------larsLDL 206
gi 23017538   141 epETGLEALALAMRsdwdtk-----srkrrQIIVVWTDAsvh---------------------------------plEKN 182
gi 7505452  12198 grAQLGAGLREALDelsisgvdgvpqivliVKNGKASDDys----------------------------------saVKS 12243
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
Feature 1                                                                              
1DZI_A        129 CNhd----nILRFGIAvlgylnrn------------aldtknlIKEIKAIasip---------teryFF 172
1M2O_A        332 IAqrvaangHTVDIFAgcy---------------------dqiGMSEMKQltds---------tggvLL 370
1M2V_A        332 IAqrvaangHTVDIFAgcy---------------------dqiGMSEMKQltds---------tggvLL 370
1M2V_B        486 FTidcskvqITVDLFLase---------------------dymDVASLSNlsrf---------tagqTH 524
gi 28829084  1799 VRr-----gITFYTVScrpt--------------------pnsSDYLNAIasis---------egkcVN 1833
gi 22962561   165 ARqk----dIIVNAVQagda--------------------rdtARVWHEIadggrgryipipqdggqIV 209
gi 2829558    232 AKdq----gVPISTISfg------------------------tPYGFVEIndqr----------qpvPV 262
gi 28901310   207 VKgk----nIRVSVLAigtangapialpdgsllkttqgstvvaKTHLKNLqtlan-------ktggmFV 264
gi 23017538   183 AGd-----kPDGYPQDip-----------------------edFDELTDMwe-------------gqEY 210
gi 7505452  12244 LKae---rnVTVFVVDagddesq--------------qqnselTEEDKTIvisq---------wrgaDS 12286

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