Conserved Protein Domain Family
Tryp_SPc

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cd00190: Tryp_SPc 
Click on image for an interactive view with Cn3D
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.
Statistics
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PSSM-Id: 238113
View PSSM: cd00190
Aligned: 177 rows
Threshold Bit Score: 124.696
Threshold Setting Gi: 476147
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:catalytic triad for serine proteases
  • Citation:PMID 8140095

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                          #                           
1MKX_K      50 IVEGQDaev----glSPWQVMLFrks-----pqeLLCGASLISd-RWVLTAAHCLlyppwdknftvddLLVRIGKHSRtr 119
1BUI_A      21 VVGGCVahp----hsWPWQVSLRtrf------gmHFCGGTLISp-EWVLTAAHCLeksp-----rpssYKVILGAHQEvn 84
gi 1644281  27 IVGGEEaia----heFPYQISLQwnynndeqdpfHFCGGSLIAe-KFVLTAGHCVpsais----pdgfPEAVAGEHDFsq 97
gi 1336053  26 IVGGDEaea----heFPYQISLQwnfndgqtetmHFCGASVLNe-NFVLTAAHCKtays-----ntgfIEVVAAEHDVav 95
gi 117613    1 IVGGTDapr----gkYPYQVSLRap--------kHFCGGSISK--RYVLTAAHCLvgks------khqVTVHAGSVLLnk 60
gi 2765010  32 IIGGTEani----snFPWQVSVEsa-------gdHTCGGSLISp-DWVLTFSLCLdgfs-----gvfeHLLQFVSLRAgt 94
gi 2326314 335 INEDFRaey----geFPWMVALFqlp-----eqrYCCNGALIDp-KAILTTAHCVtncgg----raanIMVRFGEWNMss 400
gi 2833332  33 VVGGEVakn----gsAPYQVSLQvpg------wgHNCGGSLLNd-RWVLTAAHCLvgha------pgdLMVLVGTNSLke 95
gi 2833284  50 IVGGSVase----gqFPHQVALLrg-------naLTCGGSLIEs-RWVLTAAHCVyn---------gaLVVPASSIVVva 108
gi 476147   51 IVGGREvddydedtgVHFIAKLFlpd-----gngFYCSGSVISksGHVLTRAGCEpr---------vnDVVRLGGSRLyn 116
                       90       100       110       120       130       140       150       160
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                    #                                                 
1MKX_K     120 ye--rkveKISMLDKIYIHpRYnwkenldRDIALLKLkrPIELsdyiHPVCLPDkqtaaklLHagFKGRVTGWGNRretw 197
1BUI_A      85 le---phvQEIEVSRLFLEpTR-------KDIALLKLssPAVItdkvIPACLPSpn---yvVAdrTECFITGWGETqgt- 150
gi 1644281  98 yd---agvQRRRIAEMYVHeDYegs-vgpNDIAIFRVdkPFHLnrniQLVSLPEp-----nAIptGETTISGWGSTsfsf 168
gi 1336053  96 ae---gseQRRLVAEFIVHeDYqgg-vspDDIAVIRVdkPFELndkvKAVKLPKq-----lEQfdGDVTLSGWGSVsttv 166
gi 117613   61 ------eeAVYNAEELIVNkNYnsi-rliNDIGLIRVskDISYtqlvQPVKLPVsn----tIKagDPVVLTGWGRIyvn- 128
gi 2765010  95 stk-gsggVVLLAAEMYEHpLYipl-tvdYDVALIKVngSFALgpnvQAVSLPEqg---ydPPvgLPVTITGWGYNvtd- 168
gi 2326314 401 themaiprEDIGVKSVHQHpRYsps-allNNIAVLELahPVQYqatiQPVCLPSan---qpLRamENMIATGWGRVmeen 476
gi 2833332  96 ------ggELLKVDKLLYHsRYnlp-rfhNDIGLVRLeqPVQFselvQSVEYSEk-----aVPanATVRLTGWGRTsan- 162
gi 2833284 109 gsvslsngVRRAVARVITHeRYgn---fkNDVALLQLqlSLPSsayiRPIALRTs-----sVPagSEVVISGWGVCtkv- 179
gi 476147  117 -------gVVARVAKVSIHpKYdpa-gevADVAVLKLkgVSESrl-lRAGVVPVfln--rvWDnpHGMYFTGYGATdkaa 185
                      170       180       190       200       210       220       230       240
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                          #           
1MKX_K     198 ttsvaevqPSVLQVVNLPLVERpVCkastr------------iritdNMFCAGYkpgegkrGDACEGDSGGPFVMKspy- 264
1BUI_A     151 ------fgAGLLKEAQLPVIENkVCnryefl----------ngrvqsTELCAGHla---ggTDSCQGDSGGPLVCFek-- 209
gi 1644281 169 ----epsyPNILMKTTLPIMDLeVCrkiyft-----------etvadSNICAGTme---gtSSVCSGDSGGPLVQIdd-- 228
gi 1336053 167 ----fpdyPDKLRKVVLPLVDYeQCdtlwgn----------dsalakSNVCAGPid---gsKSACSADSGGPLVKQsg-- 227
gi 117613  129 -----gpiPNNLQQITLSIVNQqTCkfkhw-------------gltdSQICTFTkl----gEGACDGDSGGPLVAN---- 182
gi 2765010 169 -----gslSSVLQKVDVNIVDRaVCqatyvi-----------rnvtaRMVCAGEl-----lRGSCDGDFGXPLVSG---- 223
gi 2326314 477 -----appTQILKRLDLQRMEPsICrealrrvrr-----pypfildsSFVCSTTnhg--dqERPCDGDAGAPVVVElpgt 544
gi 2833332 163 -----gpsPTLLQSLNVVTLSNeDCnkkggd----------pgytdvGHLCTLTkt----gEGACNGDSGGPLVYE---- 219
gi 2833284 180 -----apyQTCFDTTVLPVVADqQCrdpt--------------gistGLICFTSpv----nNGACNGDSGGPAILN---- 232
gi 476147  186 ----qsagSLTLKRAYLPVAPWwNCrritdtvvvpglsrpglpispaAQVCLRGgr---gaGALCERDPGGPMYRVsthr 258
                      250       260       270       280
               ....*....|....*....|....*....|....*....|....*.
Feature 1                                                    
1MKX_K     265 -nnrWYQMGIVSWGEg------CdrdgKYGFYTh-VFRLKKWIQKV 302
1BUI_A     210 --dkYILQGVTSWGLg------CarpnKPGVYVr-VSRFVTWIEGV 246
gi 1644281 229 ---eIVQVGIVSWGGi-----pCggykNPGVFVr-VSYFIDWINDK 265
gi 1336053 228 --eeVIQVGVVSWGAv-----pCgsprRPTVFAg-VSHYVDWIEQQ 265
gi 117613  183 ----GVQIGIVSYGHp------Cav-gSPNVFTr-VYSFLDWIQKN 216
gi 2765010 224 ----STQVGVLSWTLf-----pCe--lGLDVYAn-VVSFRSWISEV 257
gi 2326314 545 -tnrYYLHGLVSWGYg------ChqkqIPYTVLtkVVHFREWIDRI 583
gi 2833332 220 ----GKLVGVVNFGVp------Cal-gYPDGFAr-VSYYHDWVRTT 253
gi 2833284 233 ----NQLVGRPNFIIn-----yCgs-aSPDGYAk-VSDFVTWIQTT 267
gi 476147  259 gvkiYTLYAVSSYWIglgadnrCpr-aMPNVGSk-VAFYYSWIQNQ 302

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