Conserved Protein Domain Family
TPR

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cd00189: TPR (this model, PSSM-Id:238112 is obsolete)
Click on image for an interactive view with Cn3D
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans in various subcellular locations; involved in a variety of functions including protein-protein interactions, but common features in the interaction partners have not been defined; involved in chaperone, cell-cycle, transciption, and protein transport complexes; the number of TPR motifs varies among proteins (1,3-11,13 15,16,19); 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accomodate an alpha-helix of a target protein; it has been proposed that TPR proteins preferably interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes; examples of TPR-proteins include, Cdc16p, Cdc23p and Cdc27p components of the cyclosome/APC, the Pex5p/Pas10p receptor for peroxisomal targeting signals, the Tom70p co-receptor for mitochondrial targeting signals, Ser/Thr phosphatase 5C and the p110 subunit of O-GlcNAc transferase; three copies of the repeat are present here
Statistics
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PSSM-Id: 238112
View PSSM: cd00189
Aligned: 137 rows
Threshold Bit Score: 35.4336
Threshold Setting Gi: 115908
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:TPR motif
Evidence:
  • Comment:[WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE]
  • Comment:remaining conserved residues responsible for specificity
  • Comment:3 instances of the repeat shown here
  • Structure:1A17
    View structure with Cn3D
  • Comment:plays a role in inter-helix packing

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #                   #   #  #                                  #           
1A17         14 EELKTQANDYfk--------aKDYENAIKFYSQAIELNPSna--------------------iYYGNRSLAYLRt----- 60
gi 7704949   90 SIIFNRAACYlk--------eGNCSGCIQDCNRALELHPFsm--------------------kPLLRRAMAYETl----- 136
gi 7470549   53 QQYFNQGLKHyqq-----gnlTDFQAAQSSWEEALALWRQennl----------------pqiAVTLNFLCLVQrq---- 107
gi 1854386  112 GKYYKEIAELye-------leQNFEQAIIYFEKAADIYQSeeatt--------------aanqCNAKVAQFAAQl----- 165
gi 7511370  740 AIAYQQIATVye-------qlGDHQKALQFGLLASHLDPKtppddwvhwgdeaekfgmieeaaVCYDRAIHLNN------ 806
gi 6831707  277 PNNIKTNAKLycnrgtvnsklRKLDDAIEDCTNAVKLDDTyi--------------------kAYLRRAQCYMDt----- 331
gi 134515    48 LSSLPASNNVss--------nRNLERATNHYVSAAKLVPDnl--------------------lAWKGLFLLFRTtevv-- 97
gi 115908   360 SLCFLRGKIYfa--------qNNFNKARDAFREAILVDIKnf-------------------eaFEMLLSKNLLTpqeewd 412
gi 6831570  209 VKVLLGLKLQk---------mNKEAEGEQFVEEALEKSPCqt--------------------dVLRSAAKFYRRk----- 254
gi 114987   128 AVLCLQGKLWqa--------hKEHNKAVECYAAALKLNPFmw--------------------dAFLNLCETGVDlr---- 175
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   #   #  #                                       #            #   #  #
1A17         61 -------ECYGYALGDATRAIELDKKYi-------------------------kGYYRRAASNMALGk-fRAALRDYETV 107
gi 7704949  137 -------EQYGKAYVDYKTVLQIDCGLqland------------------svnrLSRILMELDGPNWrekLSLIPAVPAS 191
gi 7470549  108 ------lAPPTKALACYQELLTTAQALkdt----------------------qtEANGLVAIAQLQLq-qGNYQEAFESL 158
gi 1854386  166 -------EQYQKAIQIYEDIGRPSLNNnl------------------------lKYGVKGHLLNAGIc--QLCKGDVVAI 212
gi 7511370  807 -------ENWKFYEKRIEMLDRLNLRPlamrtrlqaaqlinneilqvdfewfhdLIRKVAQYYITMNdeeKAIQSLEAFV 879
gi 6831707  332 -------EQYEEAVRDYEKVYQTEKTKehkqllknaq-------lelkkskrkdYYKILGVDKNASEd--EIKKAYRKRA 395
gi 134515    98 ----pdiLSYDEYFDLCGQYADALLKQeq------------------------sQVELINDIKLLKKt-hPDCQKAFYQH 148
gi 115908   413 lfdsldfKEFGEDKEIMKNLYKINLSKyinteditksnei--lakdykladnvdVVRSKVDICYTQCk-fNECLELCETV 489
gi 6831570  255 -------GDLDKAIELFQRVLESTPNN---------------------------GYLYHQIGCCYKAk-vRQMQNTGESE 299
gi 114987   176 -----vsNIYKMSPELYSMVSSAALEDve------------------------sQVLPPDGPLQTQVnpnPSLDPFTAGT 226

                ....*.
Feature 1             
1A17        108 VKVKPH 113
gi 7704949  192 VPLQAW 197
gi 7470549  159 EKSLPL 164
gi 1854386  213 TNALDR 218
gi 7511370  880 LRSKEF 885
gi 6831707  396 LMHHPD 401
gi 134515   149 LKPGSL 154
gi 115908   490 LENDEF 495
gi 6831570  300 ASGNKE 305
gi 114987   227 TRSDST 232

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