1A17,1ELR,1ELW


Conserved Protein Domain Family
TPR

?
cd00189: TPR (this model, PSSM-Id:238112 is obsolete)
Click on image for an interactive view with Cn3D
Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans in various subcellular locations; involved in a variety of functions including protein-protein interactions, but common features in the interaction partners have not been defined; involved in chaperone, cell-cycle, transciption, and protein transport complexes; the number of TPR motifs varies among proteins (1,3-11,13 15,16,19); 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accomodate an alpha-helix of a target protein; it has been proposed that TPR proteins preferably interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes; examples of TPR-proteins include, Cdc16p, Cdc23p and Cdc27p components of the cyclosome/APC, the Pex5p/Pas10p receptor for peroxisomal targeting signals, the Tom70p co-receptor for mitochondrial targeting signals, Ser/Thr phosphatase 5C and the p110 subunit of O-GlcNAc transferase; three copies of the repeat are present here
Statistics
?
PSSM-Id: 238112
Aligned: 137 rows
Threshold Bit Score: 35.4336
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:TPR motif
Evidence:
  • Comment:[WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE]
  • Comment:remaining conserved residues responsible for specificity
  • Comment:3 instances of the repeat shown here
  • Structure:1A17
    View structure with Cn3D
  • Comment:plays a role in inter-helix packing

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1            #                   #   #  #                                  #           
1A17        14 EELKTQANDYfk--------aKDYENAIKFYSQAIELNPSna--------------------iYYGNRSLAYLRt----- 60   human
7704949     90 SIIFNRAACYlk--------eGNCSGCIQDCNRALELHPFsm--------------------kPLLRRAMAYETl----- 136  human
7470549     53 QQYFNQGLKHyqq-----gnlTDFQAAQSSWEEALALWRQennl----------------pqiAVTLNFLCLVQrq---- 107  Synechocystis sp.
1854386    112 GKYYKEIAELye-------leQNFEQAIIYFEKAADIYQSeeatt--------------aanqCNAKVAQFAAQl----- 165  Vitis vinifera
7511370    740 AIAYQQIATVye-------qlGDHQKALQFGLLASHLDPKtppddwvhwgdeaekfgmieeaaVCYDRAIHLNN------ 806  Caenorhabditis e...
6831707    277 PNNIKTNAKLycnrgtvnsklRKLDDAIEDCTNAVKLDDTyi--------------------kAYLRRAQCYMDt----- 331  human
134515      48 LSSLPASNNVss--------nRNLERATNHYVSAAKLVPDnl--------------------lAWKGLFLLFRTtevv-- 97   baker's yeast
115908     360 SLCFLRGKIYfa--------qNNFNKARDAFREAILVDIKnf-------------------eaFEMLLSKNLLTpqeewd 412  baker's yeast
6831570    209 VKVLLGLKLQk---------mNKEAEGEQFVEEALEKSPCqt--------------------dVLRSAAKFYRRk----- 254  human
114987     128 AVLCLQGKLWqa--------hKEHNKAVECYAAALKLNPFmw--------------------dAFLNLCETGVDlr---- 175  Emericella nidulans
Feature 1                  #   #  #                                       #            #   #  #
1A17        61 -------ECYGYALGDATRAIELDKKYi-------------------------kGYYRRAASNMALGk-fRAALRDYETV 107  human
7704949    137 -------EQYGKAYVDYKTVLQIDCGLqland------------------svnrLSRILMELDGPNWrekLSLIPAVPAS 191  human
7470549    108 ------lAPPTKALACYQELLTTAQALkdt----------------------qtEANGLVAIAQLQLq-qGNYQEAFESL 158  Synechocystis sp.
1854386    166 -------EQYQKAIQIYEDIGRPSLNNnl------------------------lKYGVKGHLLNAGIc--QLCKGDVVAI 212  Vitis vinifera
7511370    807 -------ENWKFYEKRIEMLDRLNLRPlamrtrlqaaqlinneilqvdfewfhdLIRKVAQYYITMNdeeKAIQSLEAFV 879  Caenorhabditis e...
6831707    332 -------EQYEEAVRDYEKVYQTEKTKehkqllknaq-------lelkkskrkdYYKILGVDKNASEd--EIKKAYRKRA 395  human
134515      98 ----pdiLSYDEYFDLCGQYADALLKQeq------------------------sQVELINDIKLLKKt-hPDCQKAFYQH 148  baker's yeast
115908     413 lfdsldfKEFGEDKEIMKNLYKINLSKyinteditksnei--lakdykladnvdVVRSKVDICYTQCk-fNECLELCETV 489  baker's yeast
6831570    255 -------GDLDKAIELFQRVLESTPNN---------------------------GYLYHQIGCCYKAk-vRQMQNTGESE 299  human
114987     176 -----vsNIYKMSPELYSMVSSAALEDve------------------------sQVLPPDGPLQTQVnpnPSLDPFTAGT 226  Emericella nidulans
Feature 1            
1A17       108 VKVKPH 113  human
7704949    192 VPLQAW 197  human
7470549    159 EKSLPL 164  Synechocystis sp.
1854386    213 TNALDR 218  Vitis vinifera
7511370    880 LRSKEF 885  Caenorhabditis elegans
6831707    396 LMHHPD 401  human
134515     149 LKPGSL 154  baker's yeast
115908     490 LENDEF 495  baker's yeast
6831570    300 ASGNKE 305  human
114987     227 TRSDST 232  Emericella nidulans

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap