1BJT,1BGW,1AB4


Conserved Protein Domain Family
TOP4c

?
cd00187: TOP4c 
Click on image for an interactive view with Cn3D
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.
Statistics
?
PSSM-Id: 238111
View PSSM: cd00187
Aligned: 57 rows
Threshold Bit Score: 407.338
Threshold Setting Gi: 464906
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:Active site [active site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1BJT        280 NIRSIPNVLDGFKPGQRKVLYGCFKKNLk-SELKVAQLAPYVSECTa-YHHGEQSLAQTIIGLAQNFvgSNNIYLLLPNG 357
gi 730968   735 TERSIPNIMDGWKPGQRKVLYGCFKRNLr-NECKVAQLVGYIAEHSayHHHGESSLQQTIINMAQTFvgSNNINFLEPCG 813
gi 6175065  746 NERSIPCLVDGFKPGQRKVLFACFKRADk-REVKVAQLAGAVAEISa-YHHGEQSLMGTIVNLAQDYvgSNNINLLLPIG 823
gi 418123   732 NERSIPSLVDGFKPGQRKVLFTCFKRNDk-REVKVAQLAGSVAEMSa-YHHGEQALMMTIVNLAQNFvgSNNINLLQPIG 809
gi 1174740  700 LQRSIPSMVDGLKPGQRKILFVAFKKIAr-KEMKVAQLVGYVSLLSa-YHHGEQSLASAIIGMAQDYvgSNNINLLLPNG 777
gi 6094499  805 NLRSIPSLIDGLKPGQRKILFASFKRRLt-NEIKVSQLSGYVAEQTs-YHHGEQSLNSTIVKMAHNFvgSNNLPLLTPSG 882
gi 464906   732 RIQSIPSLIDGLKPSQRKILWTLLNNMDesTEIKVSQLAGAVAHRQs-YHHGEESLVRTIIRMGQTFcgSSNLPLLQPIG 810
gi 9632132  649 LERSIPSVVDGFKPSQRKVLYCAFKRNLt-SDVKVAQFSGYVAEHSa-YHHGEVSLQGTIVNLAQDYvgSNNINWLLPEG 726
gi 6094495  681 NERGIPHCFDGLKPWQRKILWAMLKRSSs-EAAKVAHLSGYISEASa-FHHGEASMQETMIKMAQNFtgGNNINLLVPEG 758
gi 135994   681 NARAIPHCVDGLKPSQRKILWAMLKRHSs-EAAKVAQLSGYISEVSs-FHHGEASLQETIVKMAQNFtgGNNINLLVPEG 758
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                       #                                                               
1BJT        358 AFGTratGGKDAAAARYIYTELNKLTrKIFHPADDPLYKYIQEDEKTVEPeWYLPILPMILVNGAEGIGTGWSTYIPPFN 437
gi 730968   814 QFGSrkeGGKDASAARYIFTKLASSTrSIFNEYDDPILKYLNEEGQKIEPqYYIPVIPTILVNGCEGIGTGYSSFIPNYN 893
gi 6175065  824 QFGTrlqGGKDSASARYIFTQLSPVTrTLFPAHDDNVLRFLYEENQRIEPeWYCPIIPMVLVNGAQGIGTGWSTNIPNYN 903
gi 418123   810 QFGTrlhGGKDAASPRYIFTMLSTLArLLFPAVDDNLLKFLYDDNQRVEPeWYIPIIPMVLINGAEGIGTGWACKLPNYD 889
gi 1174740  778 QFGTrtsGGKDSASARYIFTKLSPVTrILFPKDDDLLLDYLNEDGQRIEPtWYMPIIPTVLVNGAEGIGTGWSTFIPNYN 857
gi 6094499  883 QFGTrlqGGSDSASARYILQLEPVGT-LPFNELDDPLLNYLEEEGESIQPdYYIPIIPMLLVNGSEGIGVGMSTSIPLFS 961
gi 464906   811 QFGTrheGGNDAASARYIFTALAPTTrLLFPQADDDLLQKNVEEGMVVEP-TLCPIVPLILINGTEGIGTGWSTKIANRN 889
gi 9632132  727 QFGSrlqGGKDHASARYIFTKLNPKTrQVFVDTDDNLLKYLYDDGDKIEPeCYVPIIPSILVNGSSGIGTGSSTNIPSYN 806
gi 6094495  759 QFGSrqqLGNVPEAPRYIFTKLRKVArLLFCCEDDPVLDYIVDDGETVEPnQYVPILPLLLCNGRVGIGFGFPSKMPTFH 838
gi 135994   759 QFGSrqqLGNDHAAPRYIFTKLSRFArLLFPEDDDPLLDYIDEEGTMVEPnHYVPILPLLLCNGAVGIGFGFATNIPSFH 838
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1BJT        438 PLEIIKNIRHLMNDeel----eqmHPWFRGWtgTIEEie----pLRYRMYGRIEQIgd-------nVLEITELPARTWTS 502
gi 730968   894 YKDIIDNIKRYINKepl----ipmVPWYKDFkgRIESng----kTGYETIGIINKIdn-------dTLEITELPIKKWTQ 958
gi 6175065  904 PRELVKNIKRLIAGepq----kalAPWYKNFrgKIIQid----pSRFACYGEVAVLdd-------nTIEITELPIKQWTQ 968
gi 418123   890 AREIVNNVRRMLDGldp----hpmLPNYKNFkgTIQElg----qNQYAVSGEIFVVdr-------nTVEITELPVRTWTQ 954
gi 1174740  858 PREIVANVRRLLNGesm----vpmDPWYRGFkgTIEKtaskeggCTYTITGLYEEVde-------tTIRITELPIRRWND 926
gi 6094499  962 PIDIIDQLMLRLNNqval---kklIPWYRGFkgTISPd-----rHTYRTNGVIKLVg--------rNLEITELPIGRWTS 1025
gi 464906   890 PIDIIDMIRRKIDSiste---yeiPPFYEEFrgKLEVvt----pTKFISSGKIQLIrperknastfSIEIVELPIGIWTS 962
gi 9632132  807 PKDIVDNVKRLISGedl----vemKPWYKGFkgKIMEts----pGVYVTKGLYMPNg--------kTIVVSELPVGKWTH 870
gi 6094495  839 PLEVSAAVRAMISGerakqvvrllVPWAVGLqgSIRRgp----eCELIAVGKYTTAra-------gRMHVTELPWMTSIE 907
gi 135994   839 PLDVSAAVRAMINGesakqvvrnlVPWAVGFqgTVRRgp----eKEYIAVGKYTAHrn-------gRLHVSELPWMTSIE 907
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1BJT        503 TIKEYLLLGLsgndki-kpwikDMEEQHDd-nIKFIITlspeema---ktrkigFYERFKLISPISLmNMVAFDpHGKIK 577
gi 730968   959 DYKEFLEELLtdekh---qlilDYIDNSShedICFTIKmdpaklq---kaeeegLEKVFKLKSTLTTtNMTLFDpNLKLQ 1032
gi 6175065  969 DYKEKVLEGLmessdkkspvivDYKEYHTdttVKFVVKlspgklr--elergqdLHQVFKLQAVINTtCMVLFDaAGCLR 1046
gi 418123   955 VYKEQVLEPMlngtdktpalisDYKEYHTdttVKFVVKmteekla---qaeaagLHKVFKLQTTLTCnSMVLFDhMGCLK 1031
gi 1174740  927 DYKNFLQSLKtdnga---pffqDVKAYNDeksVDFDLIlseenml---aarqegFLKKFKLTTTIATsNMHLFDkKGVIK 1000
gi 6094499 1026 DYKEVLNDLIdkd------vikSFQESNTensVHFTILlnnnqleqmedlteneLIKLFKLSASLNF-HLTCFDeNSKIQ 1098
gi 464906   963 KYKEKLSKIVetl------pvlEFSERHTekrVHFRITldrkkssrflqksnsdLLNYFKLRTSLTE-NRVLFDrNGELK 1035
gi 9632132  871 DYKEHLDGLLekk------iisYFREKHSdtdVLFEIDfvg-----------npNIDILKLETTIRStNMHAFDpSGKIK 933
gi 6094495  908 AFRTHISSLAaidr-----lvkRIADYSGanqIDIEMIvsegsm-----rtwaeCETDLGLRHRIYI-NGTVFSpDGTLI 976
gi 135994   908 AFRSHISSLAssd------vvqRIADYSGanhIDIDLIvregsm-----ttwaeCETDLALSQRIYI-NGTVFSpDGTLS 975
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1BJT        578 KYn-SVNEILSEFYYVRLEYYQKRKDHMSERLqWEVEKYSFQVKFIKMIiekeltVTNKpRNAIIQEle---nlGFPRfn 653
gi 730968  1033 RYs-TELDILKEFCYQRLKAYENRKSYLISKLeKEKRIISNKTKFILAIvnneliVNKKkKKVLVEEly---rkGYDPyk 1108
gi 6175065 1047 TYt-SPEAITQEFYDSRQEKYVQRKEYLLGVLqAQSKRLTNQARFILAKinneivLENKkKAAIVDVli---kmKFDAdp 1122
gi 418123  1032 KYe-TVQDILKEFFDLRLSYYGLRKEWLVGMLgAESTKLNNQARFILEKiqgkitIENRsKKDLIQMlv---qrGYESdp 1107
gi 1174740 1001 KYv-TPEQILEEFFDLRFEYYEKRKETVVKNMeIELLKLENKARFILAVlsgeiiVNKRkKADIVEDlr---qkGFTPfp 1076
gi 6094499 1099 KLe-SVEEIIDQFYKVRLQFYGKRREYLLKSLdNQIKRLTTTIQFLEVIasgklkIQGRsKQDLIKElesgeivGFENfg 1177
gi 464906  1036 EFg-NISEIAAEFFEVRRDLYEKRLKIQKEECeAKLIYVENQLNFIEMVtngtieIRSMgRNQLEEKlq---emGFRVdp 1111
gi 9632132  934 KYd-TPLDIIRDWFEVRKDLYVKRKAYLLEDLtHRTNIAQNKHRFITMVnndeiiINKKhESVISAEle---klNFYKvd 1009
gi 6094495  977 PIdgDLTPVLQWHYDRRLNLYKRRRRQIRLDE-IDLARRQSTRKFVKHFglghidLIRAtDETLIKAcv---kmGLVRvd 1052
gi 135994   976 PIdaDLSPVLQWHYDRRLDLYKRRRTRQIGLLeMDLARLQSTRKFVEHFrqghidFLAAtDDTLTKTcv---klGLVRvd 1052
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1BJT        654 kegkpyygspndeiaeqindvkgatsdeedeesshedtenvingpeelygTYEYLLGMRIWSLTKERYQKLLKQKQEKET 733
gi 730968  1109 dinkikkeeifeqelld---------------aadnpedneeiiagitvkDYDYLLSMPIFSLTLEKVEDLLTQLKEKER 1173
gi 6175065 1123 vkkwkeeqklkelresgeielded-dlaavaveedeaissaakavetklsDYDYLVGMALIKLSEEEKNKLIKESEEKMA 1201
gi 418123  1108 vkawkeaqekaaeede----------------tqnqhddsssdsgtpsgpDFNYILNMSLWSLTKEKVEELIKQRDAKGR 1171
gi 1174740 1077 rkaesveaaiagavdddaa-----------eepeeilvdpessssyipgsEYDYLLAMAIASLTIEKVEELLADRDKMII 1145
gi 6094499 1178 th---------------------------------------------ppeVYQHLFSLSILDITKERIDNLTNQLTKRKS 1212
gi 464906  1112 matiaknskkvn------------------------linyedfqylnfqaNYGYLLEMPVSRLTSDEMKRLEERKSRRRT 1167
gi 9632132 1010 -------------------------------------------------gKYDYLLNMRISSLTLERATELEREAVKLNK 1040
gi 6094495 1053 -------------------------------------------------dDYDYMLMNPITFYTKTSGEKLQMQIEKTEI 1083
gi 135994  1053 -------------------------------------------------dGYDYILKKPITFYTKTSTEKLQADIKKTQD 1083
                       490       500
                ....*....|....*....|.
Feature 1                            
1BJT        734 ELENLLKLsaKDIWNTDLKAF 754
gi 730968  1174 ELEILRNItvETMWLKDIEKV 1194
gi 6175065 1202 EVRVIEKKtwQDLWHEDLDNF 1222
gi 418123  1172 EVNDLKRKspSDLWKEDLAAF 1192
gi 1174740 1146 AVADMKKTtpKSLWLSDLESL 1166
gi 6094499 1213 EHQSISSSdpKSLWTADLQQL 1233
gi 464906  1168 ELEAAESAdwKSVWRSELDKL 1188
gi 9632132 1041 ELDDLSKTteTDMWNNDLQSL 1061
gi 6094495 1084 RMGVLKQTtpVKLWLRDLETI 1104
gi 135994  1084 SIAVLKQTtpVKMWLTDLDKF 1104

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap