1IGN,1BA5,1MBE,1MBG,1MBJ


Conserved Protein Domain Family
SANT

?
cd00167: SANT 
Click on image for an interactive view with Cn3D
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.
Statistics
?
Aligned: 170 rows
Threshold Bit Score: 29.0806
Threshold Setting Gi: 585795
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
?
Program:
Drawing:
Aligned Rows:
 
DNA binding
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:specifically binds telomeric DNA by recognizing typical repeat motif [C2-3 A (CA)1-6]
  • Citation:PMID 8620531
  • Structure:1IGNA binds DNA; helix inserts in major groove
    View structure with Cn3D
  • Structure:11GN_A: alternating basic and hydrophobic side chains contact phosphate groups and deoxyribose rings, respectively, of successive bases, resulting in sequence dependent binding
    View structure with Cn3D

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1      #                                         ## ## ### ### 
1IGN_A     10 SFTDEEDEFILDVVRKNptrrtthtLYDEISHYVPn-------HTGNSIRHRFRVYL 59  baker's yeast
465911    217 DWSQAEQKAFETALQKYpkg--tdeRWERISEEIGs-------KTKKQVMVRFKQLA 264 Caenorhabditis elegans
465911    142 TWTPDELASLVRLSTEKypag-tpnRWEQMGRVLN--------RSAEDVIAMAGKMK 189 Caenorhabditis elegans
2494160   494 AWTQSQQKLLELALQQYpkg--asdRWDKIAKCVPs-------KSKEDCIARYKLLV 541 house mouse
2494160   327 EWTEEDLSQLTRSMVKFpgg--tpgRWDKIAHELG--------RSVTDVTTKAKELK 373 house mouse
3115347   514 PWTTEEQKLLEQALKTYpvn--tpeRWEKIAEAVPg-------RTKKDCMKRYKELV 561 human
3115347   414 NWSEDDLQLLIKAVNLFpag--tnsRWEVIANYMNihsssgvkRTAKDVIGKAKSLQ 468 human
7446171    21 KWTAEENKKFENALAFYdkd--tpdRWSRVAAMLPg-------KTVGDVIKQYRELE 68  thale cress
7484928    26 RWTEEEHNRFIEALRLYg------rAWQKIEEHVAt-------KTAVQIRSHAQKFF 69  thale cress
7500760   535 VWSATEQKTLEDAIKKHkss--dpeRWEKISTEVGt-------KSKKACIRRFKYLV 582 Caenorhabditis elegans

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap