1DM9,1FJF,1C06


Conserved Protein Domain Family
S4

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cd00165: S4 
Click on image for an interactive view with Cn3D
S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized functional similarity between these three protein classes.
Statistics
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PSSM-Id: 238095
View PSSM: cd00165
Aligned: 266 rows
Threshold Bit Score: 29.1398
Threshold Setting Gi: 2500490
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
RNA binding
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding surface [nucleic acid binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1      #           ## ## ##  ## #      ## ##### #                                     
1DM9_B      9 VRLDKWLWAarfYKTRALAREMIEGGKVHYNGQRS-KPSKIVELnATLTLrqg--------------------------n 61  Escherichia coli
1FJF_D     99 SRLDNVVYRlgfAVSRRQARQLVRHGHITVNGRRVdLPSYRVRPgDEIAVaeksrnlelirqnleamkgrkvgpwlsldv 178 Thermus thermophilus
7447266     1 MRLDKYLTDkgiVPSREKAQAVIMAGQVLVNGKVVdKPGYRLKGnEKVEVkelpkyvsrggekl----ewaikrfsldlk 76  Aquifex aeolicus
1708222     1 MRLDEYVHSegyTESRSKAQDIILAGCVFVNGVKVtSKAHKIKDtDNIEVvqnikyvsragekl----ekafvefgisve 76  Brachyspira hyodys...
NP_348695   6 ERLDVLLVEkgiFESREKARASIMAGEIYVDDLRIdKCGQKVKVsSKVEFrgekmpyvsrggykl---eraiksfglglk 82  Clostridium acetob...
NP_229376   5 KRLDQLVLErglVESREKAKVLILAGKVLVNGERVtKASKLVPEdANVELleepkyvsrggykl----esafesfkidvs 80  Thermotoga maritima
BAB01316   55 QRLDEACVErfnEYSRTLIQSWIMQGKVLVDGRRViKAGMPVSTtAAIKItaevpkfvcrgglkl---eaalekldvdvs 131 thale cress
7447264     1 MRLDYALFSqhlVNSREKAKALVLKNQVLVNKMVVsKPSFIVKEnDKIELiaeklfvsragekl----gaflethfvdfk 76  Helicobacter pylori
NP_441733   7 QRLDALLVAkglCESRALAQRLIRAGEVKVNQQLVdKPGTLVTMdVAVELaqrppyvsrggekl----akaltefaidvt 82  Synechocystis sp. ...
AAG15202    4 QRLDQVLVSrglAETRARAQALIMAGQVLVNGQVQtKAGTLIADdASVEVrtglpyvsrggfkl----ahaldqfaldpt 79  Chloroflexus auran...
Feature 1             
1DM9_B     62 deRTVIVK 69  Escherichia coli
1FJF_D    179 egMKGKFL 186 Thermus thermophilus
7447266    77 dkVVLDVG 84  Aquifex aeolicus
1708222    77 nkICLDIG 84  Brachyspira hyodysenteriae
NP_348695  83 dkVCFDIG 90  Clostridium acetobutylicum
NP_229376  81 gkVACDIG 88  Thermotoga maritima
BAB01316  132 ekVVLDAG 139 thale cress
7447264    77 gkVVLDVG 84  Helicobacter pylori
NP_441733  83 grICLDGG 90  Synechocystis sp. PCC 6803
AAG15202   80 glTALDVG 87  Chloroflexus aurantiacus

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