Conserved Protein Domain Family
REC

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cd00156: REC 
Click on image for an interactive view with Cn3D
Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; contains a phosphoacceptor site that is phosphorylated by histidine kinase homologs; usually found N-terminal to a DNA binding effector domain; forms homodimers
Statistics
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PSSM-Id: 238088
View PSSM: cd00156
Aligned: 307 rows
Threshold Bit Score: 41.4073
Threshold Setting Gi: 7477508
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:acidic pocket
  • Structure:coordinates Mg2+ needed for phosphorylation
    View structure with Cn3D
  • Comment:Pro directs side chain of Lys towards the active site
  • Comment:Lys forms a salt-bridge with the putative phosphorylation site
  • Comment:Asn, Ser, Val implicated in the activation process
  • Citation:PMID 9878437

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##                                                         #         #       
1DCF_A      11 LVMDENg----vSRMVTKGLLVhl-------gCEV-TTVS--SNEECLRVVsh--eHKVVFMDVCMPg--VENYQIALRI 72
1DCK_B       7 HIVDDEe----pVRKSLAFMLTmn-------gFAV-KMHQ--SAEAFLAFApd-vrNGVLVTDLRMPd--MSGVELLRNL 69
gi 113635    4 LIVDDEp----lARERLARLVGqld-----gyRVLePSASn-GEEALTLIDsl--kPDIVLLDIRMPg--LDGLQVAARL 69
gi 113527    4 FICEDDp----kQRENMVTIIKnyimi-eekpMEI-ALATdnPYEVLEQAKnm-ndIGCYFLDIQLSt-dINGIKLGSEI 75
gi 2564260   8 FILEDDl----iQQQYLKKLLLeqksknnwkdIVI-LETAr-PNDIIEAVKsk-pnNNIYFLDIEIHnnfSSGFELAQEI 80
gi 1363369   6 ILCEDQi----tQLNQLETIIQnyilf-htelFNV-EIKTqsPMEVIEYLKkfnpkQGIYFLDIDLEs-sIDGIELAEQI 78
gi 1661199   5 FVLEDDf----lQQGRLETTIAaimkeknwsyKEL-TIFGk-PQQLIDAIPek-gsHQIFFLDIEIKkeeKKGLEVANQI 77
gi 1364139   5 YLLEDDlqqqaiYQQIIANTIMine-----faMTL-TCAAs-DTETLLAAIkd-qqRGLFFLDMEIEdnrQAGLEVATKI 76
gi 1617438   4 LVLEDTi----eHQVRIENVFEeisre-lnleIKA-KVTGk-IHEFKEYVEsd-evNQLYFLDIDIKgeeQKGLEMAQFI 75
gi 581307    5 YLLEDNe----aQRVEYISIIKniimikeydmQLV-VATGd-LQELMNNVMns--kEGLFFLDMEIGeqtQAGLNLADEI 76
                       90       100       110       120       130
               ....*....|....*....|....*....|....*....|....*....|....*..
Feature 1                       #                    #  ##              
1DCF_A      73 HekftkqrhqRPLLVALSGnt-dKSTKEKCms-fGLDGVLLKPVSlDNIRDVLSDLL 127
1DCK_B      70 Gdl-----kiNIPSIVITGhg-dVPMAVEAmk-aGAVDFIEKPFEdTVIIEAIERAS 119
gi 113635   70 Cer-----eaPPAVIFCTAh--dEFALEAFq--vSAVGYLVKPVRsEDLAEALKKAS 117
gi 113527   76 Rkh-----dpVGNIIFVTShselTYLTFVYk--vAAMDFIFKDDP-AELRTRIIDCL 124
gi 2564260  81 Rey-----dpFGWIVFVTTh--sEFLPITFkyklTALDFIDKSLPdQEFENRISECV 130
gi 1363369  79 Ran-----dvQAKIIFVTTh--dEMIPLTLqrrvEALGFVTKDQSlDDYRTEIVELL 128
gi 1661199  78 Rqh-----npSAVIVFVTTq--sEFMPLTFqyqvSALDFIDKSLNpEEFSHRIELAL 127
gi 1364139  77 Rqm-----mpFAQIVFITTh--eELTLLTLerkiAPLDYILKDQTmAEIKRQLIDDL 126
gi 1617438  76 Rqh-----npYAIIVFVTSh--sEFATLTFkykvSALDFIDKDINdNSFKKRVKDCI 125
gi 581307   77 Rqq-----lpCAQIVFITTh--eELSFLTLerriAPLDYILKEQGlDDIKQKIVKDI 126

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