1DCF,1B00,1DC7,1DC8,1FSP,1TMY,1DCK,3CHY,1A04,1A2O


Conserved Protein Domain Family
REC

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cd00156: REC 
Click on image for an interactive view with Cn3D
Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; contains a phosphoacceptor site that is phosphorylated by histidine kinase homologs; usually found N-terminal to a DNA binding effector domain; forms homodimers
Statistics
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PSSM-Id: 238088
View PSSM: cd00156
Aligned: 307 rows
Threshold Bit Score: 41.4073
Threshold Setting Gi: 7477508
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:acidic pocket
  • Structure:coordinates Mg2+ needed for phosphorylation
    View structure with Cn3D
  • Comment:Pro directs side chain of Lys towards the active site
  • Comment:Lys forms a salt-bridge with the putative phosphorylation site
  • Comment:Asn, Ser, Val implicated in the activation process
  • Citation:PMID 9878437

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        ##                                                         #         #       
1DCF_A     11 LVMDENg----vSRMVTKGLLVhl-------gCEV-TTVS--SNEECLRVVsh--eHKVVFMDVCMPg--VENYQIALRI 72  thale cress
1DCK_B      7 HIVDDEe----pVRKSLAFMLTmn-------gFAV-KMHQ--SAEAFLAFApd-vrNGVLVTDLRMPd--MSGVELLRNL 69  Sinorhizobium meli...
113635      4 LIVDDEp----lARERLARLVGqld-----gyRVLePSASn-GEEALTLIDsl--kPDIVLLDIRMPg--LDGLQVAARL 69  Pseudomonas aerugi...
113527      4 FICEDDp----kQRENMVTIIKnyimi-eekpMEI-ALATdnPYEVLEQAKnm-ndIGCYFLDIQLSt-dINGIKLGSEI 75  Staphylococcus aureus
2564260     8 FILEDDl----iQQQYLKKLLLeqksknnwkdIVI-LETAr-PNDIIEAVKsk-pnNNIYFLDIEIHnnfSSGFELAQEI 80  Lactobacillus plan...
1363369     6 ILCEDQi----tQLNQLETIIQnyilf-htelFNV-EIKTqsPMEVIEYLKkfnpkQGIYFLDIDLEs-sIDGIELAEQI 78  Lactobacillus sakei
1661199     5 FVLEDDf----lQQGRLETTIAaimkeknwsyKEL-TIFGk-PQQLIDAIPek-gsHQIFFLDIEIKkeeKKGLEVANQI 77  Streptococcus mutans
1364139     5 YLLEDDlqqqaiYQQIIANTIMine-----faMTL-TCAAs-DTETLLAAIkd-qqRGLFFLDMEIEdnrQAGLEVATKI 76  Lactobacillus sakei
1617438     4 LVLEDTi----eHQVRIENVFEeisre-lnleIKA-KVTGk-IHEFKEYVEsd-evNQLYFLDIDIKgeeQKGLEMAQFI 75  Streptococcus gord...
581307      5 YLLEDNe----aQRVEYISIIKniimikeydmQLV-VATGd-LQELMNNVMns--kEGLFFLDMEIGeqtQAGLNLADEI 76  Lactobacillus plan...
Feature 1                      #                    #  ##              
1DCF_A     73 HekftkqrhqRPLLVALSGnt-dKSTKEKCms-fGLDGVLLKPVSlDNIRDVLSDLL 127 thale cress
1DCK_B     70 Gdl-----kiNIPSIVITGhg-dVPMAVEAmk-aGAVDFIEKPFEdTVIIEAIERAS 119 Sinorhizobium meliloti
113635     70 Cer-----eaPPAVIFCTAh--dEFALEAFq--vSAVGYLVKPVRsEDLAEALKKAS 117 Pseudomonas aeruginosa
113527     76 Rkh-----dpVGNIIFVTShselTYLTFVYk--vAAMDFIFKDDP-AELRTRIIDCL 124 Staphylococcus aureus
2564260    81 Rey-----dpFGWIVFVTTh--sEFLPITFkyklTALDFIDKSLPdQEFENRISECV 130 Lactobacillus plantarum
1363369    79 Ran-----dvQAKIIFVTTh--dEMIPLTLqrrvEALGFVTKDQSlDDYRTEIVELL 128 Lactobacillus sakei
1661199    78 Rqh-----npSAVIVFVTTq--sEFMPLTFqyqvSALDFIDKSLNpEEFSHRIELAL 127 Streptococcus mutans
1364139    77 Rqm-----mpFAQIVFITTh--eELTLLTLerkiAPLDYILKDQTmAEIKRQLIDDL 126 Lactobacillus sakei
1617438    76 Rqh-----npYAIIVFVTSh--sEFATLTFkykvSALDFIDKDINdNSFKKRVKDCI 125 Streptococcus gordonii
581307     77 Rqq-----lpCAQIVFITTh--eELSFLTLerriAPLDYILKEQGlDDIKQKIVKDI 126 Lactobacillus plantarum

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