Conserved Protein Domain Family
LYZ1

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cd00119: LYZ1 
Click on image for an interactive view with Cn3D
C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have primarily bacteriolytic function; hydrolysis of peptidoglycan of prokaryotic cell walls and transglycosylation. LA is a calcium-binding metalloprotein that is expressed exclusively in the mammary gland during lactation. LA is the regulatory subunit of the enzyme lactose synthase. The association of LA with the catalytic component of lactose synthase, galactosyltransferase, alters the acceptor substrate specificity of this glycosyltransferase, facilitating biosynthesis of lactose.
Statistics
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PSSM-Id: 238066
View PSSM: cd00119
Aligned: 50 rows
Threshold Bit Score: 139.316
Threshold Setting Gi: 2392355
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:lysozyme catalytic site [active site]
Evidence:
  • Comment:hydrolysis of 1,4-beta-linkage between N-acetyl-D-glucosamine and N-acetylmuramic acid in peptidoglycan of prokaryotic cell walls

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                         #                 #                           
1LMQ          1 KVYDRCELARALKasgmdgyagnSLPNWVCLSKWESSYNTQATNRNTd-GSTDYGIFQINSRYWCDDGrtpgakNVCGIR 79
1GHL_A        2 KVYGRCELAAAMKrmgldnyrgySLGNWVCAAKFESNFNTGATNRNTd-GSTDYGILQINSRWWCNDGrtpgskNLCHIP 80
2EQL          1 KVFSKCELAHKLKaqemdgfggySLANWVCMAEYESNFNTRAFNGKNanGSSDYGLFQLNNKWWCKDNkrs-ssNACNIM 79
gi 17489981  66 KIYTRCKLAKIFSragldnywgfSLGNWICMAYYESGYNTTAQTVLDd-GSIDYGIFQINSFAWCRRGklk-enNHCHVA 143
gi 12861149  22 KVYDRCSLARTLQslglagfqgiTLANWVCLAKWESNFNTNTTRFNPedQSTSYGIFQINSRFWCNDGktpgsrNFCRIS 101
gi 16506785  19 KVFGKCEFAELLKrdyy--lsndDIKNWVCIAEFESSFNTAAINRNRn-RSTDYGIFQINNKYWCGSDyg---kNVCKIP 92
gi 12839292  20 NIIHRCSLAKILYeedldgfegySLPDWLCLAFVESNFNISKVNENVd-GSFDYGIFQINSRYWCNDYqsh-seNFCHVD 97
gi 12839415  94 KVFSRCELAKEMHdfgldgyrgyNLADWVCLAYYTSGFNTNAVDHEAd-GSTNNGIFQISSRRWCRTLasn-gpNLCRIY 171
gi 17486739  22 KIYERCELAARLEraglngykgyGVGDWLCMAHYESGFDTAFVDHNPd-GSSEYGIFQLNSAWWCDNGitp-tkNLCHMD 99
gi 15149455  19 KTLGRCDVYKIFKnegldgfegfSIGNYVCTAYWESRFKTHRVRSAD--TGKDYGIFQINSFKWCDDGtpg-gkNLCKVA 95
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
Feature 1                                                              
1LMQ         80 CSQLLTDDLTVAIRCAKRVVLDp-------nGIGAWVAWRLhCQNqDLRSYVagC 127
1GHL_A       81 CSALLSSDITASVNCAKKIVSDg-------nGMNAWVAWRKhCKGtDVNVWIrgC 128
2EQL         80 CSKLLDENIDDDISCAKRVVRDp-------kGMSAWKAWVKhCKDkDLSEYLasC 127
gi 17489981 144 CSALVTDDLTDAIICAKKIVKEt-------qGMNYWQGWKKhCEGrDLSDWKkdC 191
gi 12861149 102 CKALLKSNIWSAVLCAKRIVKDp-------qGIYSWAGWIKhCKNkNLKEYIrgC 149
gi 16506785  93 CSDLMSDDITEALRCAETIRRDterfrgrgkGYSAWVAYNSkCKNrDLDQYMaeC 147
gi 12839292  98 CQELLSPNLISTIHCAKKIVSGp-------gGMKNWVEWKLhCLGrPLSYWMtgC 145
gi 12839415 172 CTDLLNNDLKDSIVCAMKIVQEp-------lGLGYWEAWRHhCQGrDLSDWVdgC 219
gi 17486739 100 CHDLLNRHILDDIRCAKQIVSSq-------nGLSAWTSWRLhCSGhDLSEWLkgC 147
gi 15149455  96 CSDLLNDDLKASVGCAKLIVKMd--------GLKSWETWDSyCNGrKMSRWVkgC 142

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