1CR8,1AJJ,1D2J,1D2L,1F5Y,1LDL


Conserved Protein Domain Family
LDLa

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cd00112: LDLa 
Click on image for an interactive view with Cn3D
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure
Statistics
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PSSM-Id: 238060
View PSSM: cd00112
Aligned: 565 rows
Threshold Bit Score: 31.023
Threshold Setting Gi: 7512094
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:calcium-binding site [ion binding site]
Evidence:
  • Comment:required for in vitro formation of the native disulfide isomer
  • Comment:necessary in establishing and maintaining the modular structure
  • Structure:binds Ca2+
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30
                 ....*....|....*....|....*....|....*..
Feature 1                          #  #   #     ##    
1CR8_A         4 ChtdEFQCRldGLCIPLRWRCDGDTDCMDSSDEk-sC 39
gi 1708864  2599 CaatEFRCRd-GSCIGNSSRCNQFIDCEDASDEm-nC 2633
gi 1708864    74 CqpnEHNCLgtELCIHMSKLCNGLHDCFDGSDEgphC 110
gi 4758688   299 CrgdEFQCGd-GTCVLAIKHCNQEQDCPDGSDEa-gC 333
gi 7511796    45 CaenEYRCDn-GACIPDVNHCNGAKDCTDGSDEv-gC 79
gi 7512093   301 CganEFQCDt-GTCIPDIQRCNNQIDCDDGSDEa-sC 335
gi 7512094   429 CaqdEFSCGn-SICIAESRHCNGYNDCYDGIDEk-nC 463
gi 15825096   73 CppnEHSCLgtELCVPMSRLCNGIQDCMDGSDEgahC 109
gi 16519539 2591 CstvEFRCAd-GTCIPRSARCNQNMDCSDASDEk-gC 2625
gi 17509113   51 CnenEFRCQs-GACIPSKARCNHMQDCNDASDEi-gC 85

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