Conserved Protein Domain Family
HTH_ARSR

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cd00090: HTH_ARSR 
Click on image for an interactive view with Cn3D
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.
Statistics
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PSSM-Id: 238042
View PSSM: cd00090
Aligned: 178 rows
Threshold Bit Score: 37.2782
Threshold Setting Gi: 464693
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:dimerization interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1       ## #   #  ##  ##  #                               #                            #
1SMT_B       40 FAVLa-dPNRLRLLSLLARSe-LCVGDLAQAIGv-SESAVSHQLRSLRNLRLVSYRKqg------rhVYYQLqd----hH 106
gi 7429352   49 CTGIs--QSRLELLTLLYHAdeISQSDLQKKVNi-DSAAVTRHLKQLESKGMVSRRRkped---nriTLVRLt-----dQ 117
gi 7469653   27 LSSSh--STKEDILCYLLKEgqGSAIAMAEELGi-SPQAMRKHLKDLENDGLIEHQQerqsm-grpqFLYQLskq-greQ 101
gi 15613204   6 ADLLl-hPVRMRIIQAIMSKkpMSPLELLEVLQdvPQATLYRQIKVLEDADILRVVSthkrr-galeKVYGId-----qE 78
gi 15614432  13 YEALa-sKVRLAIIQQLTRKs-MNIRELAEAVGl-SSAIMTMHIKKLEKAGIIRTEMvpgka-giqkLCILDt-----dH 83
gi 15806022  19 GSPPe--RTKTRLLELLKRHgpQTAQDLAARLRv-TSPAARRHLTDLQAQGLVQVQVekpggrgrpqHVFGLtehaeerT 95
gi 15901882  23 EKRLgisLTRYQILLFLLEHspCNQMAVQERLKi-DQAALTRHFKILETEGLVERHRnpen---qreVLVEAaky-akeQ 97
gi 16264789  17 VQALg-sATRIEILNLLRLKgpLNVNEIATHMGl-PQSTTATNLKSLERAGLIQTHTmkatk-gnqkICSSIy-----gE 88
gi 20089105  42 TQILs-nETSLKILELLGKKs-MSATNIAEELKl-PLTTVKYNLDSLVESDLIKVKQikws---qkgRQVKIyes--veK 113
gi 20092398  26 ARTLs-rPLPMQILKQLQKKq-MSASELASELGl-RLNTLTYNLEVLKKVGLIKVRKvkws---ckgREVKIyap--aeQ 97
                        90
                ....*....|
Feature 1       # ### ### 
1SMT_B      107 IVALYQNALD 116
gi 7429352  118 GRERIESSKK 127
gi 7469653  102 FPQRYGEFAL 111
gi 15613204  79 TLHIPDDELE 88
gi 15614432  84 IEINFPPKKE 93
gi 15806022  96 FPKTYASLCL 105
gi 15901882  98 LVVNPPLQHI 107
gi 16264789  89 ILIRFDDRTN 98
gi 20089105 114 LIVLVPSRSP 123
gi 20092398  98 PVLLVPRENR 107

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