1AKH,1B72,1FJL,1BW5,1B72,1NK2,1OCP,1CQT,2LFB


Conserved Protein Domain Family
homeodomain

?
cd00086: homeodomain 
Click on image for an interactive view with Cn3D
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
Statistics
?
Aligned: 317 rows
Threshold Bit Score: 31.4449
Threshold Setting Gi: 7510366
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
specific DNADNA binding
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:specific DNA base contacts [nucleic acid binding site]
Evidence:
  • Comment:sequence specific interactions with major and minor groove nucleotides
  • Comment:position of residues interacting with minor groove (helix1) are shifted in subgroups
  • Citation:PMID 9154919
  • Structure:1AKH; MATalpha1
    View structure with Cn3D
  • Citation:PMID 7569974

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1        #  #                                                  #  ##  #      
1AKH_B       3 PYRGHRFTKENVRILESWFAkni---enPYLDTKGLENLMKNTS-----LSRIQIKNWVSNRRRKEKTIT 64   baker's yeast
4138131    731 KRKRTIMNDEQVMLIERALLde----pdMQRNAASLQSWADKLSlhgsdVTPSQIKNWLNNRKARLARTA 796  Lotus japonicus
7510366    460 PKPKSQYSKFEDETMEKAYMrtvkmnpsSYESRDLLESISISLR-----MSLIKVHEWFNNRKFVDSVSI 524  Caenorhabditis elegans
NP_598305    3 AQTGSGPTEDQVEILEYNFNkv-----nKHPDPTTLCLIAAEAG-----LTEEQTQKWFKQRLAEWRRSE 62   Norway rat
AAC12733   240 EQKRSTFTPDQLEALEQAFNrg-----hYPTDPFNRDNMSNKVD-----LSQTRVQDVKPSISCSTTSVA 299  Florida lancelet
544148     582 LSPGQPPLKNLLSLLKAYYAl------nAQPSAEELSKIADSVN-----LPLDVVKKWFEKMQAGQISVQ 640  chicken
7503266    318 EKNWSSFSYDAIHFLEQEYRk------tKYISSTDCQKISEKIH-----LDEELIEKWFRARRATSKREA 376  Caenorhabditis elegans
O60315     645 MTSPINPYKDHMSVLKAYYAm------nMEPNSDELLKISIAVG-----LPQEFVKEWFEQRKVYQYSNS 703  human
7503437    464 ERKRTSNLDYASRILEQKFAn------rANLLPSDLVDLEKTIG-----WTLDEISEWFETREKLQERRE 522  Caenorhabditis elegans
NP_196688  283 WSAQKRVKKAHIETLEKVYRr------sKRPTNAVVSSIVQVTN-----LPRKRVLKWFEDKRAEDGVPD 341  thale cress

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap