1BQU,1EBA,1TTF,1FNH,1QG3,2FNB,1BPV,1MFN,1FNF,1IAR,1QR4,1C8P,1TEN,1CFB,1F6F,1EIB


Conserved Protein Domain Family
FN3

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cd00063: FN3 
Click on image for an interactive view with Cn3D
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Statistics
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PSSM-Id: 238020
View PSSM: cd00063
Aligned: 741 rows
Threshold Bit Score: 29.7719
Threshold Setting Gi: 9256880
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
InterdomainCytokine
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:Interdomain contacts
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1       #                                                                               
1BQU_B      104 PNPPHnL-SVINsee-lssILKLTWTNPsiks---viiLKYNIQYRtkd---astWSQIppedt---------------- 159
gi 6434249  393 PPPPVnI-VVSSvt---seSVVITWKPPkyn----eaiNKYVVNYRl-------kYSEGrssrgk--------------- 442
gi 585319   140 VGPPEnI-EVTPge----gSLIIRFSSPfdiadtstafFCYYVHYWek-----ggIQQVkgp------------------ 191
gi 6680373  135 VGPPKnI-SVTPgk----gSLVIHFSPPfdvf--hgatFQYLVHYWeks---etqQEQVegp------------------ 186
gi 7504409  368 PPKEEdV-RVLNsgs--alSCEVEWKSPaepn---griTKYFVSVRgamrksdgsLTPDdlpaavevdkrcanwdgdent 441
gi 6434249  909 PEAPE-IvSVSLdrdeppvVARIEWKMPkmkpn-etpiEKYNLWLRaqg----ypDSYVkaktv---------------- 966
gi 5921193 2986 PVVKM-LrEVQVfei-tenSAKLHWERPep-------pGPYFYDLTvts---ahdQSLVlkqn----------------- 3036
gi 126469   113 PARFG-V-SKEKtt---stGLHVWWTPSsg------kvTSYEVQLFde------nNQKIqgvqiq--------------- 160
gi 4758594  113 PARPV-V-SCQAad---yeNFSCTWSPSqis----glpTRYLTSYRkk------tVLGAdsqrrspstgp---------- 167
gi 2497557  588 PTHPQdV-VVYSns---snTLIITWKPPnrpn---gnvTHYIVKYKr-------qQEDVaem------------------ 635
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
Feature 1                               #                       #              
1BQU_B      160 -----------astrSSFTVQdLKPf---TEYVFRIRCMked---gkgYWS-DWSe-eASGIT 203
gi 6434249  443 ---------tmetleNSLVIDgLVAf---QTYEFTVRSAgp------vGVG-LESl-pVEAQT 485
gi 585319   192 ------------frsNSISLDnLKPs---RVYCLQVQAQll------wNKS-NIFr-vGHLSN 231
gi 6680373  187 ------------fksNSIVLGnLKPy---RVYCLQTEAQlilknkkirPHG-LLSn--VSCHE 231
gi 7504409  442 skhnginpidfanefYSCKFGpLKPn---RNYTVTVWAEns------aGRS-LPAvfhKNCVT 494
gi 6434249  967 -----------dgtdLSTTISgLWMg---VVYDVLLAAEnr------eGRS-QNAt--ETIAT 1006
gi 5921193 3037 -----------ltvtDRVIGG-LLAg---QTYHVAVVCY---------LRSqVRAtyhGSFST 3075
gi 126469   161 ----------estswNEYTFFnLTAg---SKYNIAITAVsg------gKRS-FSVy--TNGST 201
gi 4758594  168 -----wpcpqdplgaARCVVHgAEFw---SQYRINVTEVnp------lGAS-TRLl-dVSLQS 214
gi 2497557  636 ------------eqrEYCKGG-LKPhrptQGLEDIVNNEee------pNNS-TIGd--GTCCE 676

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