Conserved Protein Domain Family
FH

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cd00059: FH 
Click on image for an interactive view with Cn3D
Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as monomers, are also found in the Hepatocyte nuclear factor (HNF) proteins, which provide tissue-specific gene regulation. The structure contains 2 flexible loops or "wings" in the C-terminal region, hence the term winged helix.
Statistics
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PSSM-Id: 238016
View PSSM: cd00059
Aligned: 48 rows
Threshold Bit Score: 113.803
Threshold Setting Gi: 20151753
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
DNA binding
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                           ##             #  ##                    #   
1E17_A       40 WGNQSYAELISQAIEsapekRLTLAQIYEWMVRTVPYFKdkgdsnssaGWKNSIRHNLSLHskFIKVhne---atgKSSW 116
2HDC_A        2 KPPYSYIALITMAILqspqkKLTLSGICEFISNRFPYYRek-----fpAWQNSIRHNLSLNdcFVKIprep-gnpgKGNY 75
gi 12644391 236 RPPYSYMAMIQFAINsterkRMTLKDIYTWIEDHFPYFKhia----kpGWKNSIRHNLSLHdmFVREtsa----ngKVSF 307
gi 8134361  114 KPPYSFSCLIFMAIEdsptkRLPVKDIYNWILEHFPYFAna-----ptGWKNSVRHNLSLNkcFKKVdkersqsigKGSL 188
gi 2506415   22 KPPYSFSLLIYMAIEhspnkCLPVKEIYSWILDHFPYFAta-----ptGWKNSVRHNLSLNkcFQKVershgkvngKGSL 96
gi 2597917  156 WGKPVYSDLITRAIEsspdkRLTLSQIYEWMVRCVPYFKdkgdsnssaGWKNSIRHNLSLHsrFMRVqne---gtgKSSW 232
gi 542483    93 RPKYSYNALIAMAIQsspfkSLRVSEIYKYISSNFSYYKnqk----plQWQNSVRHNLSLHkeFRKVrtl----dgKGSY 164
gi 17432967 504 RPPFTYATLIRQAIMessdrQLTLNEIYSWFTRTFAYFRrn-----aaTWKNAVRHNLSLHkcFVRVen------vKGAV 572
gi 19075056  41 RPGISYADLITEAIEssaegMLTLKEIYSYISSKHPYFSlk-----ktGWQNSIRHNLSLNksFYKVprts-vnpgKGSF 114
gi 7506727  164 WGEESYSDIIAKALEsapdgRLKLNEIYQWFSDNIPYFGersspeeaaGWKNSIRHNLSLHsrFMRIqne---gagKSSW 240

                ....
Feature 1           
1E17_A      117 WMLN 120
2HDC_A       76 WTLD 79
gi 12644391 308 WTIH 311
gi 8134361  189 WCID 192
gi 2506415   97 WCVD 100
gi 2597917  233 WIIN 236
gi 542483   165 WAMT 168
gi 17432967 573 WTVD 576
gi 19075056 115 WKIN 118
gi 7506727  241 WVIN 244

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