1E17,1D5V,2HDC,1KQ8


Conserved Protein Domain Family
FH

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cd00059: FH 
Click on image for an interactive view with Cn3D
Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as monomers, are also found in the Hepatocyte nuclear factor (HNF) proteins, which provide tissue-specific gene regulation. The structure contains 2 flexible loops or "wings" in the C-terminal region, hence the term winged helix.
Statistics
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Aligned: 48 rows
Threshold Bit Score: 113.803
Threshold Setting Gi: 20151753
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
DNA binding
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                         ##             #  ##                    #   
1E17_A     40 WGNQSYAELISQAIEsapekRLTLAQIYEWMVRTVPYFKdkgdsnssaGWKNSIRHNLSLHskFIKVhne---atgKSSW 116 human
2HDC_A      2 KPPYSYIALITMAILqspqkKLTLSGICEFISNRFPYYRek-----fpAWQNSIRHNLSLNdcFVKIprep-gnpgKGNY 75  Norway rat
Q08050    236 RPPYSYMAMIQFAINsterkRMTLKDIYTWIEDHFPYFKhia----kpGWKNSIRHNLSLHdmFVREtsa----ngKVSF 307 human
8134361   114 KPPYSFSCLIFMAIEdsptkRLPVKDIYNWILEHFPYFAna-----ptGWKNSVRHNLSLNkcFKKVdkersqsigKGSL 188 human
2506415    22 KPPYSFSLLIYMAIEhspnkCLPVKEIYSWILDHFPYFAta-----ptGWKNSVRHNLSLNkcFQKVershgkvngKGSL 96  human
2597917   156 WGKPVYSDLITRAIEsspdkRLTLSQIYEWMVRCVPYFKdkgdsnssaGWKNSIRHNLSLHsrFMRVqne---gtgKSSW 232 human
542483     93 RPKYSYNALIAMAIQsspfkSLRVSEIYKYISSNFSYYKnqk----plQWQNSVRHNLSLHkeFRKVrtl----dgKGSY 164 Caenorhabditis ele...
O15409    504 RPPFTYATLIRQAIMessdrQLTLNEIYSWFTRTFAYFRrn-----aaTWKNAVRHNLSLHkcFVRVen------vKGAV 572 human
NP_586657  41 RPGISYADLITEAIEssaegMLTLKEIYSYISSKHPYFSlk-----ktGWQNSIRHNLSLNksFYKVprts-vnpgKGSF 114 Encephalitozoon cu...
7506727   164 WGEESYSDIIAKALEsapdgRLKLNEIYQWFSDNIPYFGersspeeaaGWKNSIRHNLSLHsrFMRIqne---gagKSSW 240 Caenorhabditis ele...
Feature 1         
1E17_A    117 WMLN 120 human
2HDC_A     76 WTLD 79  Norway rat
Q08050    308 WTIH 311 human
8134361   189 WCID 192 human
2506415    97 WCVD 100 human
2597917   233 WIIN 236 human
542483    165 WAMT 168 Caenorhabditis elegans
O15409    573 WTVD 576 human
NP_586657 115 WKIN 118 Encephalitozoon cuniculi
7506727   241 WVIN 244 Caenorhabditis elegans

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