Conserved Protein Domain Family
EGF_CA

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cd00054: EGF_CA 
Click on image for an interactive view with Cn3D
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Statistics
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PSSM-Id: 238011
View PSSM: cd00054
Aligned: 562 rows
Threshold Bit Score: 28.7566
Threshold Setting Gi: 685200
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Ca2+ binding
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:Ca2+ binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
Feature 1        #  #                     #                            
1AUT_L         5 DGDQClvlplehpcaslCcgHGTCIXGIGSFSCdCRSGWEG---------RFCQ 49
1EMN          43 DTDECsvg-------npCg-NGTCKNVIGGFECtCEEGFEPgp------mMTCE 82
gi 1345964   670 EIDECas--------spClnGGQCIDRVDSYECvCAAGYTA---------VRCQ 706
gi 1125776   163 DEDECke--------nfCqnGADCENLKGSYECkCLKGFSG---------KYCE 199
gi 1730110   374 NINEClvn------nggC--SHICRDLVIGYECdCPAGFELvd------rRTCG 413
gi 630684    620 AINECasn------lhnCdtHAICQDQPVGYSCrCPFGFIDssptalepgRKCV 667
gi 15789306 1772 DIDECalg------lhnCsaAAICIDKKIGYECqCQEGYEDgnps--qpgRICA 1817
gi 6678732   554 ETDECrln------qniCg-HGQCVPGPSDYSChCNAGYRShp-----qhRYCV 595
gi 466037   2612 DVDECalg------lnnCsgVAHCIDRAVGYTCkCPDGYIDgnpd--epgRVCG 2657
gi 15789306 1215 RFDECadpk-----dndCdkHALCIDTDDSYTCqCKEGFFDeisdpkkpgRVCI 1263

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