2CPN,1DI2,1EKZ,1QU6,1T4L,1UHZ,2N3F,2YT4,2YT4,3C4T,3VYX,3VYY,4WFT,4WYQ,5CFF,5DV7,5DV7,5N8L,5N8L,2LRS,2L3J,2EZ6


Conserved Protein Domain Family
DSRM_SF

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cd00048: DSRM_SF 
Click on image for an interactive view with Cn3D
double-stranded RNA binding motif (DSRM) superfamily
DSRM (also known as dsRBM) is a 65-70 amino acid domain that adopts an alpha-beta-beta-beta-alpha fold. It is not sequence specific, but highly specific for double-stranded RNAs (dsRNAs) of various origin and structure. The DSRM domains are found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila Staufen protein, E. coli RNase III, RNase H1, and dsRNA dependent adenosine deaminases. They are involved in numerous cellular mechanisms ranging from localization and transport of messenger RNAs, through maturation and degradation of RNAs, to viral response and signal transduction. Some members harbor tandem DSRMs that act in small RNA biogenesis.
Statistics
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PSSM-Id: 380679
Aligned: 332 rows
Threshold Bit Score: 28.4048
Threshold Setting Gi: 940376709
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
RNA binding
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         ## #                             #                     ###  #        
2CPN_A         23 QELVVqkg---wrlPEYTVtqesgp---ahrkeFTMTCRVer----fIEIGSGt-SKKLAKRNAAAKML 80   human
2L3J_A         14 NEIKPg--------LQYMLlsqtgp---vhaplFVMSVEVng----qVFEGSGp-TKKKAKLHAAEKAL 66   Norway rat
ALD16269       67 QELCQhrl---wplPSYTFecsnvd--npskrqFTCTVKLqg----hTDRGVGr-SKQLAKRACAQAML 125  Macrostomum lignano
XP_013392191   29 QELAQkrl---lspPQYEItsvrgp---phdreFVCNVKLgr----iTKRGTGk-SKKKAKCNAAMKMM 86   Lingula anatina
AMN88359      106 QEFTQkrl---lkpPVYEFssdmgp---phareFSCSVKLgk----ySEKGTGr-SKKEAKRAAALAML 163  Mediterranean mussel
ELU17807      146 QEMTQkkl---wppPVYDYtseqgp---phareFICTVRLfq----iAEQGVGr-SKKLAKRNAAHAML 203  Capitella teleta
XP_002158541  452 YEMMVsiltrqyglLDFNEseidtrfasdidggFSCTLTVks----yKVTAAHq-DRKIAKNLAAQYIL 515  Hydra vulgaris
KII72141       91 NELAQrlk----vkLSFDFsvkld----gpskvFSCSATFge----iVAEATGh-KKQNCKSECAEFIL 146  Thelohanellus kitauei
9629651        32 ADYYQk-------eVKYDFdavesp---reapvFRCTCRFlg----yTIMTQGi-GKKNPKQEAARQML 85   Drosophila C virus
ARF08315      235 LEYVQknk---lapPSFDFeidn------ienkFYCRCSLeinqkiiTVTSDGftNKKDSKHNVCKKML 294  Catovirus CTV1

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