Conserved Protein Domain Family
CUB

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cd00041: CUB 
Click on image for an interactive view with Cn3D
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
Statistics
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PSSM-Id: 238001
View PSSM: cd00041
Aligned: 294 rows
Threshold Bit Score: 47.4071
Threshold Setting Gi: 7294668
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
Hierarchy
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heterodimeriz..
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimerization interface [polypeptide binding site]
Evidence:
  • Structure:1SPP
    View structure with Cn3D
  • Citation:PMID 9417941
  • Comment:annotation includes both PSPI/PSPII interaction residues highlighted

cd00041 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd00041 is a member of the superfamily cl00049.
cd00041:CUB7512178175080291794478975105897512178751217615277254544130813431311249761110728654249985813523681434928771887807188780718878015277254751217613358442751217812667806729466872910684557503167580407291068729575816758040167580401794478917508029929699924986777300456749602817510767175107677300455266146413591273011977511720750081226959791345609120901428521231751076772996122828509116854197577021312457513522026407552640753173878591152051152042055303205530575002281378613613774334751058972910681675804016758310730552575121787506598729106848264631168684135220264075386407545642905573878596407552115204115676640753111177022205530320553051750809172910681SPP B25008591140821140831SFP  1SPP A12585540174574541675892245575031675804072946686492289455750316758040751058972946687294668729106872946682146870749731075096037498849175662161750792974979017508603175077297507140749489217536123175528727498683749922175007737498681729720675036661266780672972067503664134596472910687499221729106872946687294668150792771360339821373481019074872946681751076775036887510589111807017505723183143427496220750835575030477504586455750316758040135110111686844557503175080917300456175107671675804075105891675804072910687294668750081272910687291068730050141385307291068169437091694370116943709169437031694370516943707138988417291068169436931694369116943695729466816551825130976301671645716716457167164571671645716716457167164571671645716716457136033981139548150792771671645716716457167164571671645716716457175650007297206135236824998581671645775105891139548136033981507927775105891675804072910687294668135912730119775117201312468870194836919941273607216758040751058972946682498677929699916758040455750316758040167580404557503455750316758040751058966810271471523166249207545323119939411675804016549794751058913124688134561575117201359127301197140428147301197135912131246881345615751172016758040729106872946684557503167580401351315165497944557503167580407291068167580404557503135912730119718202070134560975117204557503167580407510589701948327360726919941729466872910682828509169024351338516275105897512178751217615277254167580407294668729106816758040455750316758040167580407291068167580407512178175080291794478975105897512178751217615277254544130813431311249761110728654249985813523681434928771887807188780718878015277254751217613358442751217812667806729466872910684557503167580407291068729575816758040167580401794478917508029929699924986777300456749602817510767175107677300455266146413591273011977511720750081226959791345609120901428521231751076772996122828509116854197577021312457513522026407552640753173878591152051152042055303205530575002281378613613774334751058972910681675804016758310730552575121787506598729106848264631168684135220264075386407545642905573878596407552115204115676640753111177022205530320553051750809172910681SPP B25008591140821140831SFP  1SPP A1258554017457454167589224557503167580407294668649228945575031675804075105897294668729466872910687294668214687074973107509603749884917566216175079297497901750860317507729750714074948921753612317552872749868374992217500773749868172972067503666126678067297206750366413459647291068749922172910687294668729466815079277136033982137348101907487294668175107677503688751058911180701750572318314342749622075083557503047750458645575031675804013511011168684455750317508091730045617510767167580407510589167580407291068729466875008127291068729106873005014138530729106816943709169437011694370916943703169437051694370713898841729106816943693169436911694369572946681655182513097630167164571671645716716457167164571671645716716457167164571671645713603398113954815079277167164571671645716716457167164571671645717565000729720613523682499858167164577510589113954813603398150792777510589167580407291068729466813591273011977511720131246887019483691994127360721675804075105897294668249867792969991675804045575031675804016758040455750345575031675804075105896681027147152316624920754532311993941167580401654979475105891312468813456157511720135912730119714042814730119713591213124688134561575117201675804072910687294668455750316758040135131516549794455750316758040729106816758040455750313591273011971820207013456097511720455750316758040751058970194832736072691994172946687291068282850916902435133851627510589751217875121761527725416758040729466872910681675804045575031675804016758040729106816758040
cd00041 Sequence Cluster
cd00041 Sequence Cluster
Sub-family Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                      # # #                             #    #                          
1SPP_B         9 CGRVIKDt------SGSISNTDRQk-------nLCTWTILMKpd-qKVRMAIPYLNLa-----CgkEYVEVFDGlls--- 66
gi 13431311  132 CGGRFRLtg----sSGFVTDGPGNyky----ktKCTWLIEGQpn-rIMRLRFNHFATe-----CswDHLYVYDGd----- 192
gi 7512178   311 CSSKGRTit---gkNGTVRYPLSGnys---insVCRWMLAVQka-kTIEIRFLQLDIedh-atCtfDYLSFTVNe----- 377
gi 2499858   270 CDGRFLLtg----dSGVFQADRYPrpde--sgvVCRWIIRVNqg-lSIRMNFGSFIP------HytDVLDIYEGigp--- 333
gi 1352368   240 CDGRFLLtg----sSGSFEALHYPkpsn-ntsaVCRWIIRVNqg-lSIQLNFDYFNT------YyaDVLNIYEGmg---- 303
gi 7188780   193 CNSLHTIfg----sHGEFGTVGPAygn----feECSWKIEVPng-kRVRLHFKRFHLennnkyCpyDKLKIYDGssa--- 260
gi 7188780   309 CSVVNELtgp-sgtFGTTGSQYENn-------eVCSWKIEVAqn-kRVLLHIYRFNIeve-anCeyDSLTVYKGpnd--- 375
gi 2497611    94 CFGRIRIs-----dNASYISDGPLdys---psaKCTWLIEPEnsatPLKIRINSFFTe-----CgwDYLYIYDGd----- 155
gi 12667806  193 CNLTLEDf------YGVFSSPGYShlasvshpqSCLWLLDPHdg-rRLAVRFTALDLs-----Yg-DAVHVYDGagpp-- 257
gi 10728654 1285 CESRGILtnigksaIGSYQSYRSPwgas-levkECLWILQPKtlqaEKSLLQLEFQWqslamdCdeNAVYIYDSlpdltg 1363
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
Feature 1                                          #                         # # ##
1SPP_B        67 ----gpSYGKL----CAGAa-------------IVFLSTa-nTMTIKYNRIsgn-ssSPFLIYFYG 109
gi 13431311  193 -----sIYAPL----VAAFsglivperdgnetvPEVVATs-gYALLHFFSDaay-nlTGFNITYSF 247
gi 7512178   378 -----kMIRKV----CGSTi------------pSPLIVRs-nKVTVTFFSDgtf-tgRGFEIQFLA 420
gi 2499858   334 ---skiLRGSF----WETDp-------------GTIRIFs-nLVTVTFLIKsdeydyIGFNATYST 378
gi 1352368   304 ----ssKILRAs---LWSNnp-----------gIIRIFSn--QVTATFLIQsdesdyIGFKVTYTA 349
gi 7188780   261 ---sasLKGTL----CGKRr------------pKDIESTg-kTMFVTFSSDisl-tfPGFRIQYSV 305
gi 7188780   376 ---sapMLGKY----CGETi------------pTFMVSSg-nTMFIKFQTDgsa-rkPGFWIGYTT 420
gi 2497611   156 -----sVYGKQlaalCGEQp------------sQEFTAAs-gKALVHFFSDlai-nlNGFNVSYES 202
gi 12667806  258 --etprLLRSL----THFSng----------kaVTVETLs-gQAVVSYHTVaws-sgRGFNATYHV 305
gi 10728654 1364 atqqnqLLAVV----CAPYs------------sPRIIEArssHVTVHYKQGser-rhFGFNALYSV 1412

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