1FAQ,2ROW,1R79,2DB6,1Y8F,2ELI,2ENN,3CXL,4L9M,6RA0,3BJI,4B6D,2FNF,6NYB,1KBF,2E73


Conserved Protein Domain Family
C1

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cd00029: C1 
protein kinase C conserved region 1 (C1 domain) superfamily
The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains. It contains the motif HX12CX2CXnCX2CX4HX2CX7C, where C and H are cysteine and histidine, respectively; X represents other residues; and n is either 13 or 14. C1 has a globular fold with two separate Zn(2+)-binding sites. It was originally discovered as lipid-binding modules in protein kinase C (PKC) isoforms. C1 domains that bind and respond to phorbol esters (PE) and diacylglycerol (DAG) are referred to as typical, and those that do not respond to PE and DAG are deemed atypical. A C1 domain may also be referred to as PKC or non-PKC C1, based on the parent protein's activity. Most C1 domain-containing non-PKC proteins act as lipid kinases and scaffolds, except PKD which acts as a protein kinase. PKC C1 domains play roles in membrane translocation and activation of the enzyme.
Statistics
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PSSM-Id: 410341
Aligned: 280 rows
Threshold Bit Score: 26.3257
Created: 1-Nov-2000
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H [HC] CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Structure:2E73; Homo sapiens PKC-gamma binds two Zn2+ ions.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         #              #  #                 #  #    #    #           #
1FAQ_A          4 HNFARKTFlk--lAFCdiCQKFLLn--------GFRCQtCgYKFHe--hCSTKVpt----mC 49   human
2E73_A          8 HKFTARFFkq--pTFCshCTDFIWgig----kqGLQCQvCsFVVHr--rCHEFVtf----eC 57   human
PRP88757     1303 HAFVDASFts--pTFCqwCDGFIWgfvgnpkmlLIECAdCeYSIHr--rCLNSLpp---ggC 1357 Planoprotostelium fungivorum
XP_004347997  129 HTFVPQLFkt--pRTCsmCNGVLWr-------sAMFCKdCdYVCHt--kCEVKVltgsdavC 179  Capsaspora owczarzaki ATCC 30864
Q55DD4       1142 HSFVLKSFri--iSECnyCRQYIWgvrgivareAFECVgCkYKTHk--kCLKEAsek--tfC 1197 Dictyostelium discoideum
XP_011410289   65 HSWAPFSLpk--pHSCdaCNVIIWs-------sSYSCQgCsMAIHpdqkCQDQVtk----iC 113  Amphimedon queenslandica
EDV27100      301 HRFQPQAFtt--iKYCgqCNRVIWgig----knAYHCQaCgFNVHis-aCAKSLly----sC 351  Trichoplax adhaerens
ROL48062      470 HTFTETSSik--pSFCrhCSRLIWgfy----kqRCKCKvCgVSCHk--dCCSHLai----eC 519  Anabarilius grahami
XP_028838275  504 HSFKEMHAmr--pTLCehCSGFIWgfy----rqRYKCQaCgVSCHe--aCRSQLai----eC 553  denticle herring
KJE90819     1671 HRFAVNHNmlrggTSCeyCNQSIWav-----ekVYVCEdCkFTCHp--kCAVRVvl----pC 1721 Capsaspora owczarzaki ATCC 30864

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