Conserved Protein Domain Family
BRCT

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cd00027: BRCT 
Click on image for an interactive view with Cn3D
Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions within DNA strand breaks.
Statistics
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PSSM-Id: 237994
View PSSM: cd00027
Aligned: 144 rows
Threshold Bit Score: 29.2119
Threshold Setting Gi: 7505176
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Dimer interfaceBRCT sequence
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:Dimer interface [polypeptide binding site]
Evidence:
  • Citation:PMID 9799248
  • Comment:Residues at the dimer interface include specific salt bridges

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                        #   #  #  #  #                                                 
1CDZ_A        8 GKHFFLYGefp--gdERRKLIRYVTAFNG-ELEDyms---drvQFVITaqewdpsf--------eealmdnpSLAFVRPR 73
gi 6015052    3 NLVLCFTGfrk--keELVKLVTLVHHMGG-VIRKecn---skvTHLVAnctqgek----------frvavslGTPIMKPE 66
gi 1665785  136 DVTISCTSle---keKREEVHKYVQMMGG-RVYRdln---vsvTHLIAgevgskk----------ylvaanlKKPILLPS 198
gi 7496322  706 QFEIIYYRrr----kLKSPFTEWLLPLLN-QLTKtnadalpttTHCIVktdpdgtletd---nidlliwifnGVIIVKES 777
gi 7500728  180 DVKISFTGln---ltKKQELYEKIGWMCG-VVGDaly---hetTHLVTekaeqtek---------ykaavnnSIKLMRIG 243
gi 7505178  951 KVWIHYNDmmaeageADTDVKEAFVKMFPkNMVTdar----eaTHIILptdekgvlsfdvrgdkemfpyifrETVLMKNS 1026
gi 7507992  121 DVTMKLAAev----pNKRELVDLVHYMGG-SVRKdtv----srTNVFIaakveak----------vqsislvGVPTMRAD 181
gi 7505176   69 KVWCYVNEldkdetsEYYISRTEFSKLYAgNVVRkve----daTHIVLpenen---------------gsvtKTVVMKSS 129
gi 7504429  753 TMSYRIRIda----qLTGITYESFIERYKgNVTDqms----gvTHFIVltdatglfesd---dfgyimciflPTLIMKQQ 821
gi 7504456  875 ALKMGSYIna----yNKHGNTALHVAVRK-AHTSdeqm--sttTHCVVktnengilete---sleiffwifnGTIIVKEQ 944

                ....*..
Feature 1              
1CDZ_A       74 WIYSCNE 80
gi 6015052   67 WIYKAWE 73
gi 1665785  199 WIKTLWE 205
gi 7496322  778 WMTDCLE 784
gi 7500728  244 WIDDLWE 250
gi 7505178 1027 WMTACLK 1033
gi 7507992  182 WVTECWK 188
gi 7505176  130 WLKASIK 136
gi 7504429  822 WMNDCLK 828
gi 7504456  945 WMSDCLQ 951

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