Conserved Protein Domain Family
CHROMO

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cd00024: CHROMO 
Click on image for an interactive view with Cn3D
Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence implicates the chromo domain in the binding activity of these proteins to methylated histone tails and maybe RNA. May occur as single instance, in a tandem arrangement or followd by a related "chromo shadow" domain.
Statistics
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PSSM-Id: 237991
View PSSM: cd00024
Aligned: 121 rows
Threshold Bit Score: 30.31
Threshold Setting Gi: 1709132
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
histone binding
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:histone binding site
Evidence:
  • Structure:1GUW binds the Lysine 9-Methyl Histone H3 N-terminal Peptide
    View structure with Cn3D
  • Structure:determinants of specificity for methylated Lys
    View structure with Cn3D
  • Comment:induced-fit mechanism: the flexible N-terminal tail moves closer in the peptide-bound state

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
Feature 1          #                                     # #  #   #   #   ##              
1AP0          12 EEYVVEKVLDRRVvk-------------------gkVEYLLKWKGFsdeDNTWEPEENLdcp--dlIAEFLQS 63
1GUW_A        12 EEYVVEKVLDRRVvk-------------------gkVEYLLKWKGFsdeDNTWEPEENLdcp--dlIAEFLQS 63
gi 3024755    24 DEWPLAEILSVKDis-------------------grKLFYVHYIDFnkrLDEWVTHERLdl----kKIQFPKK 73
gi 584704     60 NTLHAAEIIKTRKtke------------------naEEFYVHYVGLnrrQNEWVDKSRVlqakqikTEELNNT 114
gi 7492650    14 KSYEAKDIVYKSKvfafkdgeyrkaeilmiqkrtrgVVYYVHYNDYnkrLDEWITIDNIdl---skGIEYPPP 83
gi 19074675   22 EEVFKAEILGKRAgk-------------------sgLEFYVHYVELnrrLDEWIDGSMIdlgdpaqIEIPKKK 75
gi 21237805  183 GNLEEEEWVRPVMkr--------------------dKQVLLHWGYYpdsYDTWIPASEIea----sVEDAPTP 231
gi 1311667    33 GSQHDADIVKTRYnkq-----------------agrEEYYVHYVGLnrrQNEWVDKSRLvltkppkEVETNGT 88
gi 3023717    33 DEERLAEILSINTrk-------------------apPKFYVHYVNYnkrLDEWITTDRInl---dkEVLYPKL 83
gi 7508719    44 EEERWAEVISRCRaan------------------gsIKFYVHYIDCnrrLDEWVQSDRLnl----aSCELPKK 94

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