Conserved Protein Domain Family
ARM

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cd00020: ARM (this model, PSSM-Id:237987 is obsolete)
Click on image for an interactive view with Cn3D
Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, the junctional plaque protein plakoglobin, the adenomatous polyposis coli (APC) tumor suppressor protein, and a number of other proteins. ARM has been implicated in mediating protein-protein interactions, but no common features among the target proteins recognized by the ARM repeats have been identified; related to the HEAT domain; three consecutive copies of the repeat are represented by this alignment model.
Statistics
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PSSM-Id: 237987
View PSSM: cd00020
Aligned: 77 rows
Threshold Bit Score: 35.368
Threshold Setting Gi: 1707895
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
protein binding
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:protein binding surface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                      #   #   #                        
1IAL_A       70 DNIIRag-lIPKFVSFLGktd---------------------cspIQFESAWALTNIasgtseqTKAVVDg---GAIPAF 124
1BK6_A       36 DVVIQag-vVPRLVEFMRenq---------------------pemLQLEAAWALTNIasgtsaqTKVVVDa---DAVPLF 90
3BCT        291 NAVRLhy-gLPVVVKLLHpps---------------------hwpLIKATVGLIRNLalc-panHAPLREq---GAIPRL 344
1JPW_A       99 LAIFKsg-gIPALVKMLGspv----------------------dsVLFYAITTLHNLllhqegaKMAVRLa---GGLQKM 152
1JPW_A      395 APLREqg-aIPRLVQLLVrahqdtqrrtsmggtqqqfvegvrmeeIVEGCTGALHILard-vhnRIVIRGl---NTIPLF 469
gi 2133442  584 TPIRDqg-gLPKLVQLLMksyqdiqrrgpg---aqnmqdgvrmeeIVEGTVGALHILare-alnRSIIRDl---NCIPTF 655
gi 1709649  350 NSVRLny-gIPAIVKLLNqpn---------------------qwpLVKATIGLIRNLalc-panHAPLQEa---AVIPRL 403
gi 2133442  245 YAVMNntniVAALVGVTAtsn---------------------dgeTIRNVVGALHNMshh-rqgLMAIFKc---SGIPAL 299
gi 7301707  309 RLLDQiv-dYCSFLKTLLqsggeai--------------addsdrHPLAAISSLMKVsfd-eehRHAMCEl---GALHAI 369
gi 7494869  559 THFVQmg-gAQVLCGLLShgs----------------------trLLHELLKCLRRVs-----dLPAIQEqdmkESIHCI 610
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                     #   #  #   #                                      
1IAL_A      125 ISLLAs---------------------pHAHISEQAVWALGNIAGdgs-afRDLVIKhgaIDPLLALLavpdls------ 176
1BK6_A       91 IQLLYt---------------------gSVEVKEQAIWALGNVAGdst-dyRDYVLQcnaMEPILGLFnsn--------- 139
3BCT        345 VQLLVrahqdt------------qrgvrXEEIVEGCTGALHILARdv--hnRIVIRGlntIPLFVQLLysp--------- 401
1JPW_A      153 VALLNk---------------------tNVKFLAITTDCLQILAYgnq-esKLIILAsggPQALVNIMrtyt-------- 202
1JPW_A      470 VQLLYs---------------------pIENIQRVAAGVLCELAQdk--eaAEAIEAegaTAPLTELLhsr--------- 517
gi 2133442  656 VQLLYs---------------------eVENIVRVAAGVLCELAQdk--egADAIERegaTTILTELLhsr--------- 703
gi 1709649  404 VQLLVkahqdaqrhvaagtqqpytdgvrMEEIVEGCTGALHILARdp--mnRMEIFRlntIPLFVQLLyss--------- 472
gi 2133442  300 VKLLGh---------------------rIEAVVFYAITTLHNLLLhqe-gaKMAVRLalgLQKMVSLLqrp--------- 348
gi 7301707  370 PNLVHldhavhg---------pkpedqcCNSLRRYALMALTNLTFgdennkALLCGQkqfMEALVAQLdsa--------- 431
gi 7494869  611 VQLIGc---------------------sDVTIVELATGTLRNIGLhnk-mnKAFMVQdgvTSHAIAVLrtseqftyqpha 668
                       170       180
                ....*....|....*....|..
Feature 1                  #  #  ##  #
1IAL_A      177 ---tlacgYLRNLTWTLSNLCR 195
1BK6_A      140 -----kpsLIRTATWTLSNLCR 156
3BCT        402 -----ienIQRVAAGVLCELAQ 418
1JPW_A      203 -----yekLLWTTSRVLKVLSV 219
1JPW_A      518 -----negVATYAAAVLFRMSE 534
gi 2133442  704 -----ndgIAAYARAVLFRMSE 720
gi 1709649  473 -----venIQRVAAGVLCELAQ 489
gi 2133442  349 -----kvkFLAIVTDCLQILAY 365
gi 7301707  432 -----pddLLQVTASVLRNLSW 448
gi 7494869  669 nidlyrkqILSIYENCLSVLNN 690

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