1BKE,1BKE,1BKE


Conserved Protein Domain Family
ALBUMIN

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cd00015: ALBUMIN 
Click on image for an interactive view with Cn3D
Albumin domain, contains five or six internal disulphide bonds; albuminoid superfamily includes alpha-fetoprotein which binds various cations, fatty acids and bilirubin; vitamin D-binding protein which binds to vitamin D, its metabolites, and fatty acids; alpha-albumin which binds water, cations (such as Ca2+, Na+ and K+), fatty acids, hormones, bilirubin and drugs; and afamin of which little is known; these belong to a multigene family with highly conserved intron/exon organization and encoded protein structures; evolutionary comparisons strongly support vitamin D-binding protein as the original gene in this group with subsequent local duplications generating the remaining genes in the cluster
Statistics
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PSSM-Id: 237982
View PSSM: cd00015
Aligned: 59 rows
Threshold Bit Score: 149.783
Threshold Setting Gi: 386111
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
binding sitebinding site
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:binding site
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1BKE        386 KQNCELFeqLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCkhpe-akrmPCAEdYLSVVLNQLCvlhekt 464
1BKE        194 RLKCASLqkFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECChgd----llECAD-DRADLAKYICenq--d 266
1BKE          2 SEVAHRFkdLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVade---saeNCDKsLHTLFGDKLCtvatlr 78
gi 113581   411 KKMCAAEaaVSDDSFEKSMMVYYTRIMPQASFDQLHMVSETVHDVLHACCkdeqghfvlPCAEeKLTDAIDATCddydps 490
gi 386111   619 HRLCLDAhqLGEEKLADRIMIGLAQRISVASFVNISSVALHFAQSVIKCCdad---hekTCFMeQEFALEDQVCsdseal 695
gi 2134234  417 KSNCDSYkeLGDYFFTNEFLVKYSRMMPQAPTSFLIELTEKVGKVAEKCCnlds-nhqvSCALeNTDKVMGSICkyhnkh 495
gi 2641142  146 AQLCSSLqaLGAQKFLGRMVLVFSQRAPNATFDQISKLSHRFHSYAQTCCgeg---wspGCFAeQRHLIHDEMChdmeal 222
gi 3023295   39 SRLCGGLngLGEDAYRSHCVVYYTKRMGVVSLDHVEELANHCLRIVKQCCaeg---aadDCLQtELAAVQEQVCtrmsea 115
gi 3023295  436 DWWCRMSdlLGTDRFNLLLIVTYSQRVPQATFEQVEEISHHFALITRKCCshr---kngSCFLeERYALHDAICrdeawl 512
gi 3023295  241 QNLCKALksLGKEKFEDRIIVRFTQRAPQAPFELIQKLAHRFEVLAEKCCelg---hsdRCLVeERYTVDDELCleqsfv 317
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                     #  ##  #          
1BKE        465 pvSDRVTKCCTESLVNRRPCFSALEvdetyvpke-----fnaetftfhADICTLSEKERQIKKQTALVELVKHKPKaTKE 539
1BKE        267 siSSKLKECCEKPLLEKSHCIAEVEndempadlp-----slaadfvesKDVCKNYAEAKDVFLGMFLYEYARRHPDySVV 341
1BKE         79 etYGEMADCCAKQEPERNECFLQHKddnpnlp---------rlvrpevDVMCTAFHDNEETFLKKYLYEIARRHPYfYAP 149
gi 113581   491 siNPHIAHCCNQSYSMRRHCILAIQpdteftppe-----ldassfhmgPELCTKDSKDLLLSGKKLLYGVVRHKTTiTED 565
gi 386111   696 shIPSVSRCCELHPFDRSVCFHSLRstqastlasthvavgkddslpghVEECQAFASGNHSLTDQVMFEFARRHPRaSVS 775
gi 2134234  496 fiNDQICHCCNSSFISRWECISNLGpdlsfvppt-----fnpktmdnpEKLCSTSEDTVQKSKKGLLSELVKSKPNiSEE 570
gi 2641142  223 srVPAMAKCCQISGSARAKCMETIPrgkpvldv--------alarfdgHKVCQMNAEAPQELLGRMLYEFGRRHTDaSVG 294
gi 3023295  116 kdVPLVGRCCALAGSERHDCFHHAGgvaegegawphalpvtsppeydsVTVCALHATANARLYDTLLWEFSRRYPSaSDS 195
gi 3023295  513 sgLAEVSRCCAMDGRARILCFDELSshlnasve--------erpelcsTSLCSKYHDLGFEFKQRVAYGFGQRFPKaAMG 584
gi 3023295  318 atCPRLSSCCSLSGSSRAQCLETVPvletsdkas------patptlpiSEQCTLWAGKPVEFHKRVVWQISHRYPTtGVA 391
                       170       180       190
                ....*....|....*....|....*....|....*
Feature 1            #  #                          
1BKE        540 QLKAVMDDFAAFVEKCCKA--DDKETCFAEEGKKL 572
1BKE        342 LLLRLAKTYETTLEKCCAA--ADPHECYAKVFDEF 374
1BKE        150 ELLFFAKRYKAAFTECCQA--ADKAACLLPKLDEL 182
gi 113581   566 HLKTISTKYHTMKEKCCAA--EDQAACFTEEAPKL 598
gi 386111   776 QVESLARLYSELARACCALtdADQESCLHTARSQA 810
gi 2134234  571 ELAATILTFREIQKLCCEA--ENKKECFDKKGQEM 603
gi 2641142  295 EAKKIITEWMDGVKDCCAGnhSEEQACLVSKKAAI 329
gi 3023295  196 HLIALANEFITGLTTCCLVe-EEHGACLATLREDF 229
gi 3023295  585 QMRDLISKYLAMVQRCCDA--MSDFKMDVEEVELR 617
gi 3023295  392 QVEALAHHYLEHLTICCAS--EDKDTCIATEVAEF 424

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