Conserved Protein Domain Family
TIGR03491

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TIGR03491: TIGR03491 
RecB family nuclease, putative, TM0106 family
Members of this uncharacterized protein family are found broadly but sporadically among bacteria. The N-terminal region is homologous to the Cas4 protein of CRISPR systems, although this protein family shows no signs of association with CRISPR repeats.
Statistics
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PSSM-Id: 274603
View PSSM: TIGR03491
Aligned: 13 rows
Threshold Bit Score: 447.93
Threshold Setting Gi: 490184058
Created: 8-Oct-2014
Updated: 11-Oct-2014
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499929340   3 ITDSQLLSYQRCSRKVFLDVYG--DFRQQESPSDFRLKLIK-------D----S-SAFRSSIvgnynyqkpdypQGNF-- 66
gi 499173824   3 VTDSLLLDYKRCQRRAYLNTHG--SSEERRPERDFLLKLRQ-------E----S-QRHIQEV------------LEEQfp 56
gi 499695108   1 MNTLYLKSFIRCKRKAWLDFKG--NKSCEIWSPHKAIDKIN-------Q----Y-HIFSEFC------------NGDI-- 52
gi 499306585   3 INAEHLLQYQRCKRRPILDIHA--DRSQRDAPSELLLKLQQ-------D----K-YAHQHSI------------LAKF-- 54
gi 499444450   5 LNNLYLKSFIRCKRKAWLDYQG--NKSQRIWSPHQSIEIIK-------R----Y-KTFYKLS------------DGD--- 55
gi 499563569   3 LGDADLLDYLRCARRLYLNRWG--DRQQAEAPNAYLQRLRRlalerrrD----V-AAEWQAI------------AVDP-- 61
gi 499613542   9 INDHLLRSWIRCRRKAWLDIYG--DKQKKLWTAHSTLQLNH-------Q----I-DCFHNLS------------QKSY-- 60
gi 499437000  11 ITDRLLISWIRCRRKAWLDLYE--ENKHKDWSAHRALQLDH-------Q----Y-KSFSALL------------SEAP-- 62
gi 499443773  11 LTDRLLRSWLRCRRRAWLDLYG--DGEQRLWTAHRTLQLDD-------Q----Q-RNFVALL------------PRKP-- 62
gi 633374024  10 YAASDLVGFLACEHLTQLDLRAldAGQAPAAADDEQMALVQ-------A----KgQAHEQAW------------LERL-- 64
gi 499915787  20 GTVIDASALTRCRHRVHLDAAF--PEQLAAAPEDPGVRQRQ-------DaaaaK-REDVRRI------------LTGH-- 75
gi 490184058   3 ISYEDVENFLVCPRRYYLS-----KKISKEVSPNFSEELM---------------------------------------- 37
gi 499750380   1 --------------MPYLDRFG--PQEAKLPPDNLLEQWRR-------D----R-QALAAAV------------FERFpg 40
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499929340  67 ------------I------------A--------------GAKATKLLMASG-----------------VDVIYQGVL-- 89
gi 499173824  57 hyrepetptylgQ------------E--------------RAQETKTLMAQG-----------------VDCIYRGCL-- 91
gi 499695108  53 ------------------------------------------YTGLKACKKG-----------------SQGVIGLKI-- 71
gi 499306585  55 ------------AyhqpeypkrnweA--------------GQAATIELMQRG-----------------VEYIYQGVLla 91
gi 499444450  56 -----------------------------------------LYSGEKACKRG-----------------SSGVIGLKA-- 75
gi 499563569  62 ------------S------------D--------------RAASTLDLMAQG-----------------VDCIEGGRL-- 84
gi 499613542  61 ------------------------------------------GIGIRACEEG-----------------KNIAYGVRI-- 79
gi 499437000  63 ------------------------------------------NRGIEALKRG-----------------SNGVVGLRL-- 81
gi 499443773  63 ------------------------------------------CRGLDGCSQG-----------------CPGVVGLRL-- 81
gi 633374024  65 ------------R------------A--------------RHPDLADVTRAGpdlaarlaatraamaagAPVIYQAAL-- 104
gi 499915787  76 ------------A------------PerwvqidteqslrlRAEDTLAACEAG-----------------ADRIWGAVL-- 112
gi 490184058  38 ------------------------------------------EAGFPLENPV-----------------IVCEFEG---- 54
gi 499750380  41 er-----------------------------------vapGNEALLAAMADG-----------------AERIYGGRI-- 66
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499929340  90 -MiqksaiesslenqvqT-----DNFLS------------T-----------NFVSYP---------------------- 118
gi 499173824  92 -Y---------------H-----SLPVN------------LhtdnnghlpmlELLGHP---------------------- 116
gi 499695108  72 -K---------------K-----NLFQN------------L-----------NVEIQP---------------------- 85
gi 499306585  92 nY---------------N-----ELIDTdd--------trY-----------TCLSRP---------------------- 110
gi 499444450  76 -R---------------S-----KVINN------------I-----------NTEMQP---------------------- 89
gi 499563569  85 --------------------------QV------------E-----------PHWADP---------------------- 93
gi 499613542  80 -K---------------Y-----PLIKN------------R-----------LIKANL---------------------- 93
gi 499437000  82 -K---------------G-----IGPQG------------L-----------KIEAHP---------------------- 95
gi 499443773  82 -K---------------G-----VGPAG------------Q-----------LLEAHP---------------------- 95
gi 633374024 105 -C---------------H----------------------G-----------PYVGHA---------------------- 113
gi 499915787 113 -P---------------L-----DRDAGrrarce-ilirdE-----------DHGGYI---------------------- 137
gi 490184058  55 ----------------------------------------H-----------ELVSNP---------------------- 61
gi 499750380  67 -Aae------------lFwqpqeDLNCTaeaellqlasepV-----------PHSSSPrdpipapedcemvpalalppea 122
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499929340 119 -------------DLLI-----KYP---GSSSFG----NW-IYIPTDIKLSKRPKLEYQIVTTFHAQILASIQKTWPEFA 172
gi 499173824 117 -------------HLLV-----KVP---GESRWG----PW-QYRPVSIQLGRRPKPEYKILAAFYAQLLAVHQGPLPRWV 170
gi 499695108  86 -------------QLLV-----KTN---GRSKWG----TY-KYLPAVYKLGHKTTKEHLFDLAFSSIILETFQESKIEKG 139
gi 499306585 111 -------------DLLI-----KQP---GQSKFG----DW-VYEPVDIELGKRPKQEYQVVTAFHTQILAKVQEVQPKNA 164
gi 499444450  90 -------------QLLK-----KVG---GHSKWG----EY-KYIPVVYKLGHRTTKEHLFDLAFSSMLLEPFQEAKIEKG 143
gi 499563569  94 -------------DLLV-----RQP---GQSIWG----DW-IYQPVAVKLAKKPKTEYLLQLAFQAELLTSIQGVWPEQG 147
gi 499613542  94 -------------PILR-----KTS---GESIWG----NF-AYQPILARQGKKITREHKLTLALTGLLINNLQKFQVKKG 147
gi 499437000  96 -------------PLLK-----KIN---LGSPWG----DF-SYIPVVAQQGRRLTREHRLSLALWSYLLEQVQQIEVKYG 149
gi 499443773  96 -------------PLLQ-----RVE---GQSRWG----AF-AYRPVLARQGRRLTREHRLALALAGRLLAPLQSAPVPEG 149
gi 633374024 114 -------------DFLL-----RTE---CPSALG----DY-GYEALDTKLARSPRASFVLQLSFYAWLLEHAQGVAPRSM 167
gi 499915787 138 -------------PVIVvnhkvTDP---GRGALTsdmfEWqPREDATRKPRSQVRDQMRVAQVYRMLERHGFASPALVAG 201
gi 490184058  62 -------------DLIV-----KDR--------D----GW---RIILRKSAKRFKDKYILESAYHALVFSR-AGLEVSGV 107
gi 499750380 123 vperrsvwvssslDLLI-----RDPalvGRSRHA----ARsSYLPVHIRIGKRPKPEYELVLALQAELLGSLQGNVPKRG 193
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499929340 173 YLIL-R-NKGLYKVNLQQRIQAMQQAISELIFMLQNSLE----PEVFISR-QKCSLCAWYNTCHAVAKTEKHLSLLPGVT 245
gi 499173824 171 EIIL-R-RGNSYSVDLLEWLPRFHQTLADCVQTLIHQRE----PEVFISR-QRCNLCHWYDHCYAIAQEQQHLSLVPGVT 243
gi 499695108 140 LVIS-S-FGNKVSIEEIYLNKKLRKKVFNVLLNLNASLEgf-iPEITQDR-KKCTICSWQNFCNKEAKENGYLSDIDGIG 215
gi 499306585 165 WLML-RgKETPYAVDLFKWIPQMQGILQEFTQDLESETA----PEVFIAR-QKCNLCLWHSQCYAIAQSEQHLSLLPGVT 238
gi 499444450 144 LVIS-N-FSNRINIEKIDLNPRLRKKVIHTFLNLNEYLKrs-iPDITEDR-KKCTICSWQKFCDTEAKDNGYLTDIDGIG 219
gi 499563569 148 WLLL-R-DCHPKAYNLDLRRSQLQEHLAACAPILQNQQE----PELFISR-SRCDLCVWQTDCRDRARDQVHLSLLPGVS 220
gi 499613542 148 LILH-K-ENEVIKVEKIKLSDNINTDLIGSLLHLEKDIEsrtpPPITSNR-KKCTICSWRKECDAVAIKEGSLSEVSGIG 224
gi 499437000 150 LAVSiR-NAGSLDIQEIAITKKLTNELFDSLKRLYKDIRkdvsPGLIADR-KKCTLCSWKKLCDEKANEEEDLSEISGIG 227
gi 499443773 150 LALA-G-AGRSLHMERVSLLGGLQRQLDDVLVKLAADLElsepPPLVADR-RKCKLCSWRGVCNAVASVEGHLSEVSGIG 226
gi 633374024 168 HVVL-G-SGRELALRVADYAHYLRQVLRRFEAAIAAEPA----PPTYPEPcEHCPQCRWRVACEARRVADDHLSLVAGMS 241
gi 499915787 202 AIGY-G-SDVIFVHDLTTILDDYDERFADRLAVARG--E----SATVPSRiGECRSCPWWPGCEEQLTQTHDVSLVA--T 271
gi 490184058 108 EIVS---DSFSRKMENWKNLIPIVEDVLREMLTIDDDPH----PRV---G-RHCRYCDFLEDCEGKFFEEKSLLLVNGIG 176
gi 499750380 194 ILIL-K-DGKWHPVHLSRRRAQVRQLLQEYLHSLNQPEP----PQVFMAR-SRCHLCHWREHCRQLNAAAQPLSLLPGVT 266
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499929340 246 SNRYAVLKRLNLTTLESLSQTNPNDL----ESy----pEFADGVAIEVVQQAQSVRENKVIlrN----Ekftkqleipal 313
gi 499173824 244 PSRYESLQMVGVLTIDSLARLQTQQV----AE------LMGTAIAEQLQQQALALVEKRAM--A----K----------- 296
gi 499695108 216 SKTALLLKANGISNIQELSSYNEKEL----GDklskfkDQKYEKASKFIKQAQAYISGKPFciS----N----------- 276
gi 499306585 239 PIRYTQLQNLDITSVESLAHTSPNIL----ENl----vGFDTQVAAKLVVQAQSVVEGQPLllP----F----------- 295
gi 499444450 220 SKTALFLQKNGISNIKELAATKKIDL----GKklfqfkEQRFEKASKFIKQSKAYLSGIPIriL----E----------- 280
gi 499563569 221 PSRFAILRDLKLDQLEALATADPQSL----AIa----aDWELGLAQRLVQQAAVFLSQQP--------Q----------- 273
gi 499613542 225 AKREVLLNKIGINNIEELAKIKHYKL----QEkleifgTQHSDISKQIILQSQSQSTNRAIklN----P----------- 285
gi 499437000 228 AKRKIILQEIGIKNLSQLALIDKDDL----TNklspygESHKKIAGQLIRQAKVQKKLSPErlS----S----------- 288
gi 499443773 227 TRRRQMLQELGILGLQDLAAADPNEL----GSrlqhfgEQHGEVACELVAQARAQRDGRYErlD----S----------- 287
gi 633374024 242 RQQARRLNAQGVATLAQLGALPEHAQvagiEAg----tLQRLRAQAALQWRARVDGARHYEllAaqdeG----------- 306
gi 499915787 272 GSRADMLRDAGCHTIDDLAAWDREPL----ED-------WPHGAFEDAVVTAKAWLAGAPLv------R----------- 323
gi 490184058 177 EETYRVLYGMGIETLEDLAEADQRIL----EK------VFGKEKGKRFVMAARAFLENRVImiT----P----------- 231
gi 499750380 267 GSRYPLLQEAGIHSIEALANARLEML----QAi----pKLGAGVALQLQLQARATLSRKPLwlQs---P----------- 324
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499929340 314 sitDYKLTKL--V-N-APVELYFDIEAQP--EINLDYLHGVLVVNKRY------NT------E------KFYVHLAENP- 368
gi 499173824 297 ---EKKVYPL--P-R-SPVELYFDIEAEP--ERNLDYLLGVVVVDHGQ------KT------E------KFYGFMAKDP- 348
gi 499695108 277 ---NNNSYDLieK-T-SSGFYIFDIESNP--DVRHDFLYGFLKINNLS------TKke---vR------IYEPILNLKN- 333
gi 499306585 296 ---PPPKGNL--VvN-SPVEIYFDIEAQP--DLNLDYLLGVLVVNKQT------NT------E------QFYSFVAEKP- 348
gi 499444450 281 ---NKNLSYLlkN-K-DSGFFIFDIESNP--DDKHDFLYGFLKVNSLF------ENie---dD------FYDPILNLKN- 337
gi 499563569 274 ---PLQTYAF--P-D-SDVEFFFDIEAQP--DLDLCYLHGVLIRDRRQ------PE------S------QFRPLLAEQP- 325
gi 499613542 286 ---EIELNNL--K-K-AKGLYIYDIESDP--DIRHDFLHGFIRLPKNI------KN------EislektKYSPLLNIEK- 343
gi 499437000 289 ---SMALPEL--N-S-AEGVFIYDIESDP--DAHHDFLHGFVSLAKRK------DGtwllddV------KYQPILNLSN- 346
gi 499443773 288 ---ASALPEL--A-T-APGVLLYDIESDP--DARDDFLHGFVRLGRRPdgswdlEG------A------QYHPFLVLYE- 345
gi 633374024 307 ---PRGLARL--P-RpDPGDMFFDMEGDPleDGGLEYLFGLYVIDDGA------ER--------------FVPFWAHDR- 359
gi 499915787 324 ---RFPEIRV--T-R-ADVEVDVDMESY---QEHGAYLWGTLLNVDGV------SA--------------YRPFVSWDPv 373
gi 490184058 232 ---PEDLPEG--T--------IVDIEYHP--SEERDFLYGFLIGDE------------------------YRYFLEEDQ- 271
gi 499750380 325 ---PQALPTA-------PVELYFDIEADP--RHNVAYLLGLLVVEQAE------ENk----vV------NYYSCLAAEP- 375
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499929340 369 --LDEELIWHQFLDL----VWKYPIA--------PI-YHFCEYE-----IQTVKKLAKLYNTP-TYKWKPLLK--RFVDI 425
gi 499173824 349 --EEEGLIWQEFVQL----IQTYPNA--------PI-YHFSEYE-----RETIKRLGKLYGTP-PKVREKILE--QCFDL 405
gi 499695108 334 --NKEE-SHNQIIKM----LFSNKEW--------PV-LHYGETE-----KIAIINIAKKLNLR-IEEIEFLKS--RFIDL 389
gi 499306585 349 --SEEELIWRQFLDL----VWQYPEA--------PI-YHFCVYE-----LDTVKRLAKLYRTP-YTSVSPVLY--RFVDI 405
gi 499444450 338 --NTKK-SNQEIIQK----LFSQKYW--------PV-LHYGETE-----KIAILNLARQSDLD-LKEIEILNS--RFIDL 393
gi 499563569 326 --DQEADTWQQLLQL----LDRHPQA--------PV-YHFCSFE-----VDSLRRLGQRYGCS-TRRLEALLT--RFIDI 382
gi 499613542 344 --NTESFLWKRITKK----LSINQDY--------PI-IHYGETE-----PISLLKLGIRQGAN-PHEIEELKN--RFIDI 400
gi 499437000 347 --HTEEIAWGNIKRK----LKSHPNW--------PV-LHYGETE-----SLSICRMAKRQGEE-DKEINIIRN--KFIDI 403
gi 499443773 346 --HGEARCWQRLQRM----LKSYPDW--------PV-MHYGETE-----SLALRRMAKRQGVD-AAELSALSK--RMIDV 402
gi 633374024 360 --RQEKQAFEAFMDFvaerLRRHPDA--------HI-YHYAPYE-----ATALKKLMSLHGTR-EAEVDHLLRagKLVDL 422
gi 499915787 374 ptQDEARSFAEFWTW----LMAEREAaalsgrtfAA-YCYSRSAedkwlLDSARRFAGAPGIPtEADIREFIDspQWVDI 448
gi 490184058 272 ---------GDLIAF----LNSLDDE--------SVfYHYHGPE-----KRKLISLIGRNKRM------------NFLDV 313
gi 499750380 376 --REEGQAWQQFLQL----VQRYPEA--------PI-YHFHSFE-----VQTCRRLGEQHQTD-PREVRQLLK--RFVDL 432
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499929340 426 HKIITQTITLPIESYALKNIARWLGFEWRNPEANGAQSVCWYDQWLA--T-G--DRS---L---LDAIIIYNEDDCYATY 494
gi 499173824 406 HHYVVNHVICPVESYSLKSLASWLGFQWRDAQASGDQSVCWYDNWLT--T-G--DRQ---F---LELILRYNEDDCRATW 474
gi 499695108 390 HTLIRKSWILPIKNYSLKTVSNWLGFEWEQKDVNGSKALYWWIQYQL--T-E--NEV---F---LKKIIKYNKDDCLATL 458
gi 499306585 406 YEHLTQSVALPIESYALKAIARWMGFEWRDKEASGAKCIYWYDQWLE--T-G--DRA---L---LEIIIRYNEDDCRATR 474
gi 499444450 394 HLIVRGSWILPIRNYSLKTVANWIGFKWEQENVSGSKALYWWIQYKS--T-L--NDI---F---LKKIIKYNRDDCLATL 462
gi 499563569 383 HAVLTRSVLLPTESYALKSIARWLGFDWRDTEANGSQAILWYDYWLE--T-G--DRT---W---LDRILLYNEDDCRATA 451
gi 499613542 401 HLLIREYWCLPVRNYGLKSIAEWIGFEWKQSNADGARALLWWRQWKK--S-RkiNKM---YsrnLNSIFEYNRDDCIATL 474
gi 499437000 404 HSRLKGSWVLPVNSYSLKEVAKWLKFEWSQKGSSGAKALLWWRQCQKaiS-Q--NNI---KpkqLELIMRYNQDDCIATW 477
gi 499443773 403 HDRVRRSWRLPLNSYGLKCVASWLGFCWRQVGVDGARALLWWRQWRG--S-GlqDRGssyS---LRWIFDYNHDDCLATW 476
gi 633374024 423 YRVVREGLRISEPSYSIKYVERFYLPRRAGEVTNAGASIVYYERWKA--T-G--EPR---L---LQDIADYNRDDVISTW 491
gi 499915787 449 YQAVSDQFICPGG-KGLKKIAPVAGFRWRDADASGEASMSWYREAVG--YdG--EPD---Lt-qRERLLQYNEDDVIATK 519
gi 490184058 314 FTILRNHFVFPVMSYSLKRIAKYLGYDWR-TSLNGYEILRLYEKWKK--T-R--NEE---L---LKQMLLYNEDDVRATK 381
gi 499750380 433 HIWVQRSVVLPIESYSLKNIARWLGFKWQLPEGSGAHSIYWYSQWLE--T-R--DRR---Y---LEQSLIYNEDDCRATY 501

                 ....*.
gi 499929340 495 YVKEWL 500
gi 499173824 475 ILKDWL 480
gi 499695108 459 HIAKFL 464
gi 499306585 475 KVKDWL 480
gi 499444450 463 QIAKWL 468
gi 499563569 452 IVKDWL 457
gi 499613542 475 MIAKWL 480
gi 499437000 478 KIAEWI 483
gi 499443773 477 AVAAWL 482
gi 633374024 492 RLRDWL 497
gi 499915787 520 VLREWM 525
gi 490184058 382 LVLDFM 387
gi 499750380 502 CLKNWL 507
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