Conserved Protein Domain Family
met_A_Alw26

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TIGR02987: met_A_Alw26 
type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family
Members of this family are the m6-adenine DNA methyltransferase protein, or domain of a fusion protein that also carries m5 cytosine methyltransferase activity, of type II restriction systems of the Alw26I/Eco31I/Esp3I family. A methyltransferase of this family is alway accompanied by a type II restriction endonuclease from the Alw26I/Eco31I/Esp3I family (TIGR02986) and by an adenine-specific modification methyltransferase. Members of this family are unusual in that regions of similarity to homologs outside this family are circularly permuted. [DNA metabolism, Restriction/modification]
Statistics
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PSSM-Id: 274377
View PSSM: TIGR02987
Aligned: 6 rows
Threshold Bit Score: 609.077
Threshold Setting Gi: 20068992
Created: 8-Oct-2014
Updated: 23-Jan-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAQ72364   43 KRTGSYFTALELTDVMMQELVSYILKSDKDi-TELKFLEPCVGTGNFVFSYLKEISKLQLHKEqietLINNIYVADINQT 121  Geobacillus stear...
AAM09644   32 QKYGIYWTNLDLAYEIVSNLVDTFDEDFLEniTNKKFLEPCVGMGSFIFAFLRKLYEKKISKEqinkVIKNIYFCDIDEN 111  Acinetobacter lwo...
AAM09640   27 KATGKYYTDPKIALLMIEKLLPLINSCDK---KSYNVADPFSGDGRLITLLIKQW-MINGFPD----VEWNVYLFDIENT 98   Escherichia coli
AAR96016   38 KSKGQFYTHNFIGEKLVTEIVENIKFNDDS--EVIKIIDPFCGDGRLICILLDKFNAINKFRN----TLLEIEFWDIDPE 111  Geobacillus stear...
AAS09913  121 KAYGYFFTPISLGTRMVKLALKDKPKNLKS------IVDPACGIGSLLALALIYNPEIENVVG----IELDSFTANISHK 190  Geobacillus stear...
AAM09642  121 KHYGTFFTPPDIAKAMIANFSNEHG--------KTTLIDPCLGSGVLIAASLLFNEGICYKKLi--gVELDADIANWAKM 190  Hafnia alvei
AAQ72364  122 ALLEYKKLLSKFAklyfDIDLSEEYFNSHIGSALLIDVAAEqpeyikitdvfpdevvkegFDIVVTNPPYKNLKAEKGQY 201  Geobacillus stear...
AAM09644  112 ILIYFFSCYQDFVknlfNLDIDNKLFKSNSAKGLIFNNYSDeyislek-----afgkevkFDILITNPPYKGLKIDAKNY 186  Acinetobacter lwo...
AAM09640   99 GLTYAKNALSELK----LAGANINITIKNSDVFYEFKKYVDy------------------FDCVITNPPWENIKPDSREL 156  Escherichia coli
AAR96016  112 AVEVAYTNIKEKAn---ALEFNVQLKGRVCDTFLFAQDYFGs------------------YDICITNPPWVIIKPDKKEK 170  Geobacillus stear...
AAS09913  191 LLVRISKDLGITP------KIKIINQNFLDYVLNYEEEHKEk------------------FDLLIMNPPYGRVRFLKNSL 246  Geobacillus stear...
AAM09642  191 LLKRTAMLVGYSG------EISVINDNGLEYILNNIESDLFl------------------TSNIIINPPYGRLRITKDRA 246  Hafnia alvei
AAQ72364  202 S--NDLEYEIDRARYAEIKKMVKRIFNYST------DGVLN-----LYKLFVEEIIDKYANPNGFVSLLIPSSILTDKTC 268  Geobacillus stear...
AAM09644  187 S--NPLEYESDKKFYSDLSNKLTKNFELSN------QGVPN-----LYKFFVEKIILEYTHEKSYISLLIPNTFLADKTA 253  Acinetobacter lwo...
AAM09640  157 DffEPSMKSMYIDSLREFDDYLSRVLPYSQpkr-kfAGWGT-----NLSRVGAELSLEICNKNGLVAIVMPASFFADEQS 230  Escherichia coli
AAR96016  171 ErlSKEEEIEYIEILKNFDDFLSRYYPTSLptk-kyGGWGT-----NLARCGTEVALRLISKVGICGIVSPASLLGDQVS 244  Geobacillus stear...
AAS09913  247 TnkETKSGLTEGISELEKKLREETILNAADlrk-kfASVGLgkgtpEYSKVFLAISTKIVKQNGYVIAITPSSWLGDESG 325  Geobacillus stear...
AAM09642  247 TniETALSEKNKDFNKSIHDLHSKVRDDADairerySDILGergilEYSRIFFRACAEAALRGSEVSIISPDSWMSGKEG 326  Hafnia alvei
AAQ72364  269 TKLRTHMLVDSNILSIKMINEGSGYID-AQQALSAILIQ-------KGKRTESIKVTKDYSNNpnqiTDINMEDILNEN- 339  Geobacillus stear...
AAM09644  254 FNLRKYIIENTKINRIDYFEEKSGLFKgVTQALTNIYLR-------KFKVNNYSIVFSENSKK----TTVSIDIIKSFD- 321  Acinetobacter lwo...
AAM09640  231 YILREKFFNSGRIDCINYYPAEAKLFGgADVSSCSFIFNkg---esLNDNIQLSVYDKNLNIKslgfFDLSS--IDSQY- 304  Escherichia coli
AAR96016  245 DNLRVWMFNNYEVYSISYFVAEAKLFGkVDQAVITLTLSpkcddssGDIIPHLFYYDRELFEKryymDEYDWRIIKSLN- 323  Geobacillus stear...
AAS09913  326 RELRKYLVENHGISCIWNFKESAKLFSgVNQPTTVVKIKvn----sNESKIEIQGPLSSLEELgrdiQYLDTCNIKKYSp 401  Geobacillus stear...
AAM09642  327 ERLREFIIKNRLINKIQLIQEKSGTFStVNQATSITHLNs------KSKKAFSIFSSYSEHQQgdniEYVKLNKISRMG- 399  Hafnia alvei
AAQ72364  340 TGNAIFAINNHEYFILKQLRKFPVVKDLDFI---INLRGELDLTANKDSIVNIDTGYPLLRGRNIGYYEILDTCSG---- 412  Geobacillus stear...
AAM09644  322 KNLSLSKYDSKDINTLSELKKFPTVESLPFV---KNQRGELDLTMFKSYIKKEQTNFKLIKGNNIQKFFLKDLEDA---- 394  Acinetobacter lwo...
AAM09640  305 LSIPVSQGVHAVHLLRKLQEGYPTWGSLEKng-eIWAGREIDETGSSDWTQKSGGgLLFIKGKMIGRYNFHNEKS----- 378  Escherichia coli
AAR96016  324 YVIPIQFGLEIIKMN-RLFKSLPTLGDLENEkegIWLGRELDETGIKEKLANKGQ-YRFIKGKMVGRYNLIEESNQ---- 397  Geobacillus stear...
AAS09913  402 EWYRIPQCGNERAKILSKLHNHAPLSSHKKI---YNLRGELDLTSHKDLLSDNPNHWRLIRGDHVEKFNLKNPEESeklg 478  Geobacillus stear...
AAM09642  400 --TAIPRGSGHLLTVFERLSTLKKFSEVEWI---TNARGEIDQTAQKGLFSELSTAIPLVRGEHVERFAFNHSSTSekps 474  Hafnia alvei
AAQ72364  413 ---EFVSKDFIENSKKSRYIKEKRIVCQQVVNMKKERRVTFALVEENYVLGNSCNFISVMDNDYNID---LYAILGLFNT 486  Geobacillus stear...
AAM09644  395 ---LYISDEFITKTKKSIYINKKRIACPQISNQKSAVRIKFSLVNENLILGNSCNFISVEDNIFGYN---IYYFLALFNT 468  Acinetobacter lwo...
AAM09640  379 ---LRITKKIDKVLSNSNFVR---IAWRDISRPSQKRRMIATIIPPNSLAGNSLGVVYYKSGSQDS----LFSLLGIINS 448  Escherichia coli
AAR96016  398 ---YIDVRKIDKIPKSVEFYR---LVWRDVSRTTQKRRLISTIIPPKYITGNSLNVAYFKDNNLKK----LKALLAIMNS 467  Geobacillus stear...
AAS09913  479 fvdHQLFIKRMGKSNKLRHIKNWRITLPQCSYMNKKKRIEACIVEPNNIIANSCNYITLEDCNELVDn--LLLLCAIINS 556  Geobacillus stear...
AAM09642  475 flkEDEFAEFIENRPKRKHYAMERIVGRQCSYAQQSRRLIFCRVPALHAVGNSCNYISISGSLEIERkkrSYFLLGLLNS 554  Hafnia alvei
AAQ72364  487 SIINWLFKLTSSNNHVNNYEIDCFPVPIGSPYLNK---ISNLVKKYLSNKDSS-----LLEKIEEYAYIAYGIREAKEDN 558  Geobacillus stear...
AAM09644  469 EIINWFFKKFNSNNHIGNYEISQFPVHTDKEVIDR---ISILCEKYLKTQDNK-----ILDEINSISLKGFNLLVPSEDG 540  Acinetobacter lwo...
AAM09640  449 LCFEFQLRSFLATGHVSLSALRKTAIPSEKILLQHs-eLKQLVISCIEGCCDA-----ELKIEAYVAKNIYKLDLNEFNK 522  Escherichia coli
AAR96016  468 FVFEAQVRANLSTNHISLGIIRRAHIPKLEGRVVDe--LSQLVDNYVNEESEL-----LLEVK---VAKAYGLSFEDFSS 537  Geobacillus stear...
AAS09913  557 AVIEWRFRLFNSNNHVSNYEIDEFPIFKFDTETEMltmLKGFLHKPIEN----------WSKIEALIALMYGLNIEDMKV 626  Geobacillus stear...
AAM09642  555 AIFDWYFRIENSNNHVGNYEIDNFPVPPNEKWTNLiamLAYQLEVCAKDEGSKdkftwLMNLLEASVGVSYELAIDDEFS 634  Hafnia alvei
AAQ72364  559 ED---------------------KDDIANLKETNDIIKKYYSA 580  Geobacillus stearothermophilus
AAM09644  541 LHntikkvnlnefdekkffkqiiSHDLSQFENTALLAKRYKDL 583  Acinetobacter lwoffii
AAM09640  523 LLs--------------------SFDKIELAEKESLLRIFQHY 545  Escherichia coli
AAR96016  538 ILs--------------------LFDKIGKDEKEKILQVAKKY 560  Geobacillus stearothermophilus
AAS09913  627 ILn-----------------------DLEYEDKDKILKYMDIY 646  Geobacillus stearothermophilus
AAM09642  635 LIl----------------------QQVKGCDVESVLNYARHM 655  Hafnia alvei
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