2C7Y,3GOA


Conserved Protein Domain Family
AcCoA-C-Actrans

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TIGR01930: AcCoA-C-Actrans 
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acetyl-CoA acetyltransferases
This model represents a large family of enzymes which catalyze the thiolysis of a linear fatty acid CoA (or acetoacetyl-CoA) using a second CoA molecule to produce acetyl-CoA and a CoA-ester product two carbons shorter (or, alternatively, the condensation of two molecules of acetyl-CoA to produce acetoacetyl-CoA and CoA). This enzyme is also known as "thiolase", "3-ketoacyl-CoA thiolase", "beta-ketothiolase" and "Fatty oxidation complex beta subunit". When catalyzing the degradative reaction on fatty acids the corresponding EC number is 2.3.1.16. The condensation reaction corresponds to 2.3.1.9. Note that the enzymes which catalyze the condensation are generally not involved in fatty acid biosynthesis, which is carried out by a decarboxylating condensation of acetyl and malonyl esters of acyl carrier proteins. Rather, this activity may produce acetoacetyl-CoA for pathways such as IPP biosynthesis in the absence of sufficient fatty acid oxidation. [Fatty acid and phospholipid metabolism, Other]
Statistics
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PSSM-Id: 273881
View PSSM: TIGR01930
Aligned: 29 rows
Threshold Bit Score: 356.923
Threshold Setting Gi: 499224448
Created: 8-Oct-2014
Updated: 23-Jan-2015
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2C7Y_A          17 IVAAHRTPLC--KsKrGNFKDTYPDDLLAPVLRALIEKTn-LNPs-EVGDIVVGTVLAPGSQrA-SECRMAAFYAGFPET 91  thale cress
CAB46281        52 ILSAVRTPTA--LfN-GSFSSVSAPQLGATAIKEAIKRSsiPQE--KISHVYMGNVISAAAG-Q-APARQAAIFAGLPSS 124 Zymoseptoria ...
P10551           7 IVSTARTPIG--SfQ-GSLSSKTAVELGAAALKGALAKVpeLDAskDFDEIIFGNVLSANLG-Q-APARQVALTAGLGNH 81  Saccharomyces...
P45855           6 IVSAARTPFG--KfG-GVLKEVKAAELGGIVMKEALQQAg-VSGd-DVEGNVMGMVVQAGSG-Q-IPSRQAARLAGMPWS 78  Bacillus subt...
WP_000390637     6 ILDGIRTPFG--NfG-GTLKDLSAVDLGVLVSKTILERTg-VSPe-AIGESIFGNVIPTGKE-AiYLARHIGLKTGLPLG 79  Leptospira
WP_000412014     6 IVGAKRSAIG--AfG-GSLKECSAGALAGQVIQAALEAAq-LKPe-AVDEVIVGNVVSAGQG-M-GVGRQAALAAGVPQS 78  Vibrio cholerae
WP_010889685     7 IIDGLRTPNF--KfG-GSFKGLNIIDESSKVVKALLERNk-LY---KVDEVIIGNVISAGLG-Q-NIARQIALKSDLGDT 77  Lyme disease ...
WP_010866799    15 IVDGVRTTIG--KfG-RSLKDFKAVDLAALTIRELLERAg-VDPn-YIELAVYGHVIRAGTH-M-NTAKQAALKAGLRSD 87  Aeropyrum pernix
WP_011027721     6 VVEAVRTPIGkgKpN-GALAHVHPVELLAHTLRTLVERSg-VDPa-LIDDVIGGTVDQVGEQaM-NTTRYALLSAGFPES 81  Streptomyces ...
TIGR:PF14_0484  11 IVGFARTPIG--AlG-GCISHIPVHKLACATILKALERS--QIEkeHIDCLIFGQSFSSGCG-P-VPLQKIAISTGMHIN 83  Plasmodium fa...
2C7Y_A          92 VAVRTVNRQCSSGLQAVADVAAAIKAGFyDIGIGAGLESMTTNPM----Aw-E-GSVNP---AVKKFAQA---------Q 153 thale cress
CAB46281       125 VEATTINKVCASGMKAVAIAAQQVELGQeEALVAGGMENMSRVPYytprG--P-QLPAF---GNLSMEDGlmkd-glwdV 197 Zymoseptoria ...
P10551          82 IVATTVNKVCASAMKAIILGAQSIKCGNaDVVVAGGCESMTNAPYympaA--R-GGAKF---GQTVLIDGverd-glndA 154 Saccharomyces...
P45855          79 VPSETLNKVCASGLRAVTLCDQMIRAQDaDILVAGGMESMSNIPYavpaG--R-WGARM---GDGELRDLmvyd-gltcA 151 Bacillus subt...
WP_000390637    80 VPALTLNRLCGSGMEAIIQAAKKIYLGDaDAVLAGGVESMSNAPYvv-rNa-R-WGVRY---GSAEFEDTleqg--ltdQ 151 Leptospira
WP_000412014    79 VPAYSINMVCGSGMKSVMDAVAHIKAGDaSVVVAAGVEVMSQIPFvtpaSl-R-DGQKM---GAFEVKDLlihd-gltdV 152 Vibrio cholerae
WP_010889685    78 VPAFSVNKVCGSGLKALELAFNSIALGDnDIVLAGGVEDLTNSPYllprKi-RfDGLKF---GNFGIEDSiqkd-alidS 152 Lyme disease ...
WP_010866799    88 LEGFNVDMVCASGMASVVKASLLIDAGMySLALAGGMESMSNAPFiappSi-R-WGVRLlyqGALEMKDAmvsd-glydP 164 Aeropyrum pernix
WP_011027721    82 VPATTVDRQCGSSQQAVHFAAQGVMAGAyDLVVACGVESMSRVPMwsnvPpgA-DPFGP---GVAARYP----------- 146 Streptomyces ...
TIGR:PF14_0484  84 TKTYLVNNLCCSGLDSITIGYDLIRGGK-DTCVVGSMECMSQSPYflknLr-T-EKYSL---GNNILRDSiihdgydfmV 157 Plasmodium fa...
2C7Y_A         154 NCLLPMGVTSE-NVAQRFGVSRQEQDQAAVDSHRKAAAATAAGKFKDEIIPvkTKlvdpktGDEk----pITVSVDDGIR 228 thale cress
CAB46281       198 YNNIHMGNCAE-STAKKYDISREEQDEYAVLSFKRAQEAWKNKLFDEEIVPvvVK------GKKg-----DTTISEDEGY 265 Zymoseptoria ...
P10551         155 YDGLAMGVHAE-KCARDWDITRDQQDSFAIESYQKSQQSQKEGKFDNEIVPvtIK------GFRgk---pDTQVTNDEEP 224 Saccharomyces...
P45855         152 FDEVHMAVHGN-TAAKEYAISRREQDEWALRSHARAAKAADEGKFQDEIVPvnWI------GRKgk---pNVVDKDEAIR 221 Bacillus subt...
WP_000390637   152 YVGLIMGQTAE-NLADQYKISRQEQDEWAAISQTRAEKATLEGRLKEEIFTvtIP------G-Kk----pVILEKDEFIK 219 Leptospira
WP_000412014   153 FNQYHMGVTAE-NIAKQYDIARQTQDEFALASQMKATAAIEAGHFKREIVPisVK------KRRe----tVVFDTDEYPK 221 Vibrio cholerae
WP_010889685   153 LNFISMGLTAE-NLSEKYRITREMQDEFAYNSHVKALKARELGYFEDEIYPltVF------DKKtn--ssVTISSDEEIR 223 Lyme disease ...
WP_010866799   165 LNQLVMGQEAD-ETAWEYGAQREELDWIAYESNMRAARAWERGHMQKYTIPvkAG------Ga-------VVLDYDEGIR 230 Aeropyrum pernix
WP_011027721   147 QGLVPQGISAE-LIAAKWSLSRERMDAFAVSSHQKAATAHAAGRFDAEIAPldGVs------------------HDECVR 207 Streptomyces ...
TIGR:PF14_0484 158 NNKELKTNNSMeLFCKKYNIPRVDLDEYVINSFKRTANAYSENLIQQELFPlvIQ------KNKnkmqvdKSVIDSDEIY 231 Plasmodium fa...
2C7Y_A         229 PTTTLASLGKLKPVFkk----------dgTTTAGNSSQVSDGAGAVLLMKRSVAMQKGLp--VLGVFRTFAAVGVDPAIM 296 thale cress
CAB46281       266 NRLKPEKVATLKPAFdrs--------gngTVTAANASSMNDGASALVITNKELAKKYGGgkrVLARIVSYADAAVDPIDF 337 Zymoseptoria ...
P10551         225 ARLHVEKLKSARTVFqre---------ngTVTAANASPINDGAAAIILVSERVLKEKNl--kPLAIVKGWGEAAHLPADF 293 Saccharomyces...
P45855         222 RDTSLDQLAKLAPIYasd----------gsITAGNAPGVNDGAGAFVLMSEEKAAELGKr--PLATILGFSTTGMPAHEL 289 Bacillus subt...
WP_000390637   220 GASGVDKLGSLKAVFre----------ggTVTAGNASGLNDGAAVTIVASSSYAKKLGKk--PLAIIRGYGHAGCDPAKM 287 Leptospira
WP_000412014   222 PTTTLAALQGLRAAFda----------qgTVTAGNASGINDGASAVIIASESAVKKLGLt--PIAEIMSYAQTGLDPKVM 289 Vibrio cholerae
WP_010889685   224 DNLTLNKLASLNPVFke----------sgTVTAGNSSSLNDGACFLILASEERVKSLGLs--PLAYIGGFKSVGLDPLYM 291 Lyme disease ...
WP_010866799   231 PDTTVERLSKLPPVFtp----------kgPHTAGNSSQISDGAVSLLVAGEEAVREMGLk--PKARIVGWGYAGVDPRRF 298 Aeropyrum pernix
WP_011027721   208 PDSSVEVLAGLRPAYhdpafaerfpqigwnVTAGNASPVNDGASAVLITSGDTAARLGLr--PLARLHSFAVTGSDPLLM 285 Streptomyces ...
TIGR:PF14_0484 232 KNYNIDKICNLNSES--------------IITNYNIAPFADGACALVLMSEQKLKELDIn--PIAEIITYDNASVYPDEF 295 Plasmodium fa...
2C7Y_A         297 GIGPAVAIPAAVKAAGLEl-dDIDLFEINEAFASQFVYCRNKL--------GldPEKINVNGGAMAIGHPLGATGARCVA 367 thale cress
CAB46281       338 PVAPAKVVPIALERAGITa-dQVKVWEFNEAFAAVVKANAKIL--------NlgIDNVNPRGGAISLGHALGSSGARILV 408 Zymoseptoria ...
P10551         294 TWAPSLAVPKALKHAGIEdinSVDYFEFNEAFSVVGLVNTKIL--------KldPSKVNVYGGAVALGHPLGCSGARVVV 365 Saccharomyces...
P45855         290 AAAPGFAINKLLKKNGLTv-qDIDLFEVNEAFASVVLTCEKIV--------GfdLEKVNVNGGAIALGHPIGASGARILM 360 Bacillus subt...
WP_000390637   288 GIGPALAIPAALKKAGLKl-sDMSLVEVNEAFAAQYLAVQKEL--------GlnPEITNVNGGAVAIGHPLGASGARVTI 358 Leptospira
WP_000412014   290 GLGPVSAVTQALAKAELSi-tQVDLFELNEAFAAQALGVVYGLaeqhaiqpEaiLEKANVNGGAIALGHPLGASGNRILV 368 Vibrio cholerae
WP_010889685   292 GFGAYMAIEGIISKLSLNp-sEIDLIEVNEAFAAQALSIEKALfk----kyNitSDIINVNGGAIALGHPFAVSGSRILL 366 Lyme disease ...
WP_010866799   299 PVAPVHAVRALLKKLGWRv-eDVDYWENNEAFAVNSLIMNREL--------GvpYERLNVVGGSIAVGHPLGSTGARLIL 369 Aeropyrum pernix
WP_011027721   286 LTGVVPATEKVLRRASLSl-gDIDLFEVNEAFASVVLAWQRET--------GadLAKVNVHGGAIALGHPLGASGTRLTT 356 Streptomyces ...
TIGR:PF14_0484 296 PFSIPYSIEKCLKKINKS---FIDYYEINELSALSVIFAMKKL--------NidLSNININGGALSLGHPTAVSGSRIVM 364 Plasmodium fa...
2C7Y_A         368 TLLHEMKRrgKdcRFGVVSMCIGTGMGAAAVFE 400 thale cress
CAB46281       409 TLLHQLKK--G--EYGCAAICNGGGAASGMVIQ 437 Zymoseptoria tritici
P10551         366 TLLSILQQegG--KIGVAAICNGGGGASSVVIE 396 Saccharomyces monacensis CBS 1503
P45855         361 TLVYELKRrgG--GLGVAAICSGAAQGDAVLVQ 391 Bacillus subtilis subsp. subtilis str. 168
WP_000390637   359 TLAYELKRrkA--KYGIASLCIGGGQGIALVLE 389 Leptospira
WP_000412014   369 TLLHELQRrqK--HYGVASLCVGGGMGTAIVIK 399 Vibrio cholerae
WP_010889685   367 TLSRSMKMknK--TKGIASVCIGGGQGISSFLY 397 Lyme disease spirochete
WP_010866799   370 QLVYTLEEngA--RRGVASICHGLGGAAAVAIE 400 Aeropyrum pernix
WP_011027721   357 TLVHALHErgA--RYGLQTMCEAGGLANAMILE 387 Streptomyces coelicolor
TIGR:PF14_0484 365 SLITVLKNydM--KLGCASINNYLGSSTSIIVE 395 Plasmodium falciparum 3D7
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