2WTE


Conserved Protein Domain Family
cas_HTH
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TIGR01884: cas_HTH 
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CRISPR locus-related DNA-binding protein
Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]
Links
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Statistics
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PSSM-Id: 273852
Aligned: 10 rows
Threshold Bit Score: 167.918
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2WTE_A        10 SYFVTXGFNETFLLRLLNE-TSAQKeDSLVIV-VPSPIV-SGTRAAIESLRAQISRLn--YPPPRIYEIEITD---F--- 78  Sulfolobus solf...
Q57824         6 RYIATFGYHTNHIFDKNGKiIGIDDeKISNMI-LIYSLDvDADENTVNSIKNTKNYIeskLKEYNIPYLFVEV---N--- 78  Methanocaldococ...
WP_010979638   6 TLVFGVGFTAEYIIRAITE-RGIKDvLDVAIFsVTSEEE-FRKRQAQETMDSILKYLsaiGISGHPKYISIKE---P--- 77  Sulfolobus toko...
WP_010879362   4 ALIATLGFDEKFCYRAILR-HGIKE-GDRVIL-ITTQMV-ERVAKAYEWIRKLLETSygdRVEVEVLQVELKS---V--- 73  Archaeoglobus f...
WP_010980725   3 SYIFTVGIHEDFAVRRLVS-TNVGRdDVIVVL-VKSPIT-GGNRRAINGLSAVMSKMg--LRDAVVKEIEVKD---I--- 71  Sulfolobus toko...
WP_010876156   2 IIMDTTLISTIYSIEPVMF-CITQFsPRKVVL-LK---E-DKAPREKEQVEQVLRDTlgnFVEITTFETSLYD---V--- 69  Methanothermoba...
WP_010866250  10 VILATVGFNYSRPWRAVAS-IGLEP-GSLVII-VNSEPRtREAVDAVEKLKNMIIDAygdL-HVETRDVWLDPsngI--- 82  Aeropyrum pernix
WP_010923410   3 SYFVTMGFNETFLLRLLNE-TSAQKeDSLVIV-VPSPIV-SGTRAAIESLRAQISRLn--YPPPRIYEIEITD---F--- 71  Sulfolobus solf...
WP_011007095   2 RLAVTVGFDARLVVRALAN-IPARE---VTLV-RGATGN-EGDAKSKEAVAEIIKALg----KGTEYVVNLRD---P--- 65  Pyrobaculum aer...
CAB49931       2 LAVFPVGFDEKFIIRALMR-NQTKE-GDRLLA-VVPNDY-KKEERTVNALRAIKDIAiplIGEGNFKIIELPT---Tsge 74  Pyrococcus abys...

2WTE_A        79 N-LALSKILDIILTLPEP---IISDLTXGXRX-INTLILLGIIVSRK---------RFTVYVRDEggg------srVISF 138 Sulfolobus solf...
Q57824        79 P-YEFNTNVKNFRKYIVPk--TIINLTGGKRIvGYALFYAAVLEKEN---------VEKVFYVSK-----------LGDI 135 Methanocaldococ...
WP_010979638  78 FdFIVYQISDLLWTRNN----LEFYIIGGMRIlNLALYFYAILAKTL---------GKRVKAYSYt---------eDMSY 135 Sulfolobus toko...
WP_010879362  74 E-KAIREVADKIKEVEGYd-lVVVNISGGMRVlVVIVLLACMLGLPE---------NLKVEIEKEdf-------sdIVEL 135 Archaeoglobus f...
WP_010980725  72 F-HVVDQVSEILKEVKDP---LIVDISGGESKtLAIGTILAVAVNKR---------VGRIYLEEDe----------EVSF 128 Sulfolobus toko...
WP_010876156  70 V-SIARDMVEIIDEERAHgrrVVVNISGGRKTqALGALFGCYARNHD---------VQRIVYVTEe------------DN 127 Methanothermoba...
WP_010866250  83 P-RGVAKMRRVVEEAAPAs--AYILASGGLRWlVVSALLTAMALQTVgvfrgikveMLRVDLESEaegidlnirpeMLQP 159 Aeropyrum pernix
WP_010923410  72 N-LALSKILDIILTLPEP---IISDLTMGMRm-INTLILLGIIVSRK---------RFTVYVRDEggg------srVISF 131 Sulfolobus solf...
WP_011007095  66 A-EGLRQFYSLQFDE--------IALAGGPRLlILLGFVVAALKKAR---------IFVVPEYSSe----------AIDV 117 Pyrobaculum aer...
CAB49931      75 E-MVLKLKSAIENNITEDr-rVITILSGGMRPlNVIILLTVITIENV---------RVKVESDFEn----------LSGF 133 Pyrococcus abys...

2WTE_A       139 NDNTIRALXRDYSREEXKLLNVLYEt-KGtGITELAKXLDKSEKTLINKIAELKKFGILTQKG---KDRKVELNE 209 Sulfolobus solfatari...
Q57824       136 IEFPLIPPDIKLTELEMKILNLLDKe-GEmSVSNIAHKLERSLSTISEYVSQLEKKGLVKKLS---KGRRKIVKK 206 Methanocaldococcus j...
WP_010979638 136 KYELPVMIPAKPSDAEYEILEYLGSkyGEvYMNDIAKILNKSLPTISKQIDFLENQGYVECKEt--KPKPCKITD 208 Sulfolobus tokodaii
WP_010879362 136 PVGVLKIVKSPLGDDKVEVLKAVMn--GLrDVRGLSKHLGKDESTIRRHLAALEKMGLIEVKKr--KPLIVSATE 206 Archaeoglobus fulgidus
WP_010980725 129 QIEDFRTAAEGLSSELLKVLSTVVAn-PGiRHEVIAEMTGKKLKTTMNVVGILKKKRLVYQKG---RGDGIYPTK 199 Sulfolobus tokodaii
WP_010876156 128 ELIDLPILSFGISKTKKQVLEELKA--GEkSVKNLAVKIGISRGMTYNHIRELRDMGFIDRE----KLEITSAGE 196 Methanothermobacter ...
WP_010866250 160 LQLESVPPLATIDYKELLVVETLAGl-GRaRVKSIARSLQVSRTLADRLLRKLESKKLISSEVr-gRGKLYSLTD 232 Aeropyrum pernix
WP_010923410 132 NDNTIRALMRDYSREEMKLLNVLYEt-KGtGITELAKMLDKSEKTLINKIAELKKFGILTQKG---KDRKVELNE 202 Sulfolobus solfataricus
WP_011007095 118 SGLAAVTKLFGLSRRKLEILAVLD---GEkDVDTIAREVGLDNSTVYRHLVTLEEEGLTKSVGk--RGKRYHTDK 187 Pyrobaculum aerophilum
CAB49931     134 ISLELGPFLAPKNVRWINILCRLKA--GK-SVRRIAEELGVSPATISRELKNLLKYSLVEEISgknRPLGYVVTK 205 Pyrococcus abyssi GE5
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