Conserved Protein Domain Family
hrcV

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TIGR01399: hrcV 
type III secretion protein, HrcV family
Members of this family are closely homologous to the flagellar biosynthesis protein FlhA (TIGR01398) and should all participate in type III secretion systems. Examples include InvA (Salmonella enterica), LcrD (Yersinia enterocolitica), HrcV (Xanthomonas), etc. Type III secretion systems resemble flagellar biogenesis systems, and may share the property of translocating special classes of peptides through the membrane. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]
Statistics
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PSSM-Id: 273600
Aligned: 8 rows
Threshold Bit Score: 912.115
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAA27643      14 ERKDIMLAVLLLAVVFMMVLPLPPLVLDILIAVNMTISVVLLMIAIYINSPLQFSAFPAVLLVTTLFRLALSVSTTRMIL 93  Yersinia pestis
AAK26714      13 SYHDLILALFFFMAVMMMIIPLPTVVVDIIIAINISTALLLLMLSIYIKNPLELTSFPTILLITTLMRLSLSVSTTRLIL 92  Escherichia coli
P74856        20 GRQDMVLATVLLIAIVMMLLPLPTWMVDILITINLMFSVILLLIAIYLSDPLDLSVFPSLLLITTLYRLSLTISTSRLVL 99  Salmonella ente...
AAG60783      14 AHPDFMVALMLLLAIGMMIMPIPIIVIDMLIGFNLGFAILLLMVALYLSTPLDFSSLPGVILISTVFRLALTIATTRLIL 93  Bradyrhizobium ...
AAG33877      17 RRSEVVGAFFVIAIVFMMITPLPTGLVDVLIAVNICISCLLIMLAMHLPRPLAFSTFPAVLLLTTMFRLALSISTTRLIL 96  Pseudomonas syr...
BAB20913       9 AGGEIGIVALVVAIISLMILPLPPLLIDMLLGLNITISVTLLMITMYVPDISALSAFPSLLLFTTMFRLSLNIASTKSIL 88  Burkholderia gl...
WP_009871438  23 KSSDLILAMWMLGVVLMIILPLPPAMVDFMITINLAISVFLLMVALYIPSALQLSVFPSLLLITTMFRLGINISSSRQIL 102 Chlamydia trach...
AAA16867      11 LRPELLILVLMVMIISMFVIPLPTYLVDFLIALNIVLAILVFMGSFYIDRILSFSTFPAVLLITTLFRLALSISTSRLIL 90  Salmonella ente...
AAA27643      94 LQADAGQIVYTFGNFVVGGNLIVGIVIFLIITIVQFLVITKGSERVAEVSARFSLDAMPGKQMSIDGDMRAGVIDVNEAR 173 Yersinia pestis
AAK26714      93 LHHDAGDIIYSFGNFVVGGNIVVGLVIFTIITIVQFMVITKGAERVAEVSARFSLDGMPGKQMSIDGDMRAGVIDPLEAK 172 Escherichia coli
P74856       100 LQHNAGNIVDAFGKFVVGGNLTVGLVVFTIITIVQFIVITKGIERVAEVSARFSLDGMPGKQMSIDGDLRAGVIDADHAR 179 Salmonella ente...
AAG60783      94 AEGDAGSIIHTFGDFVISGNIAVGIVIFLIVTMVQFMVLAKGAERVAEVSARFTLDALPGKQMAIDAELRNSHIDQHEAR 173 Bradyrhizobium ...
AAG33877      97 LNQDAGHIVEAFGQFVVGGNLAVGLVIFLILTVVNFLVITKGSERVAEVGARFTLDAMPGKQMSIDSDLRANLISVYEAR 176 Pseudomonas syr...
BAB20913      89 LHAEAGNIIESFGKLVVGGNLVVGLVVFAIITTVQFIVIAKGSERVAEVGVCFTLDALPGKQMSIDADLRANLLTTEEAK 168 Burkholderia gl...
WP_009871438 103 LHAYAGHVIQAFGDFVVGGNYVVGFIIFLIITIIQFIVVTKGAERVAEVAARFRLDAMPGKQMAIDADLRAGMIDATQAR 182 Chlamydia trach...
AAA16867      91 IEADAGEIIATFGQFVIGDSLAVGFVVFSIVTVVQFIVITKGSERVAEVAARFSLDGMPGKQMSIDADLKAGIIDADAAR 170 Salmonella ente...
AAA27643     174 ERRATIEKESQMFGSMDGAMKFVKGDAIAGLIIIFVNILGGVTIGVTQKGLAAAEALQLYSILTVGDGMVSQVPALLIAI 253 Yersinia pestis
AAK26714     173 VLRSRVQKESQFYGSMDGAMKFVKGDAIAGIIIVLVNLFGGVLIGMWQFDMPFSEALSLFSVLSVGDALVAQIPALIISV 252 Escherichia coli
P74856       180 TLRQHVQQESRFLGAMDGAMKFVKGDTIAGIIVVLVNIIGGIIIAIVQYDMSMSEAVHTYSVLSIGDGLCGQIPSLLISL 259 Salmonella ente...
AAG60783     174 RRRAALEQESQLHGAMDGAMKFVKGDAIAGLIVICINMLGGISIGLLSKGMSLDEALHQYTLLTIGDALISQIPALLLSI 253 Bradyrhizobium ...
AAG33877     177 NRRSELNKESQLFGAMDGAMKFVNGDAIASLIIVAINMIGGISIGVVQHGMTAGDALQLYTVLTIGDGLIAQIPALLISV 256 Pseudomonas syr...
BAB20913     169 RKRATLAVESQLHGGMDGAMKFVKADAIAAVIITMINILAGIAVAVAYHGMSAGDAANRFSVLSVGDAMVSQIPSLLLSV 248 Burkholderia gl...
WP_009871438 183 DKRSQIQKESELYGAMDGAMKFIKGDVIAGIVISLINIVGGLVIGVTMKGMTMAQAAHIYTLITIGDGLVSQIPSLLISL 262 Chlamydia trach...
AAA16867     171 ERRSVLERESQLYGSFDGAMKFIKGDAIAGIIIIFVNFIGGISVGMTRHGMDLSSALSTYTMLTIGDGLVAQIPALLIAI 250 Salmonella ente...
AAA27643     254 TAGIIVTRVS--SED--SSDLGSDIGKQVVAQPKAMLIGGVLLLLFGLIPGFPTVTFLILALLVGCGGYMLSRk---QSR 326 Yersinia pestis
AAK26714     253 TAGVVVTRVP--GESekEENLAGDIVQQVSVNSRPFLISAALMIVMAIIPGFPTLVFLFLAVCLLGIAWKLQK----KRT 326 Escherichia coli
P74856       260 SAGIIVTRVP--GEk--RQNLATELSSQIARQPQSLILTAVVLMLLALIPGFPFITLAFFSALLALPIILIRR----KKS 331 Salmonella ente...
AAG60783     254 TAATIVTRVN--GPS--KLRLGADIVHQLTASTEALRLAACVLVFMGLVPGFPLPPFAVLAVLFAAASYVKVGp---KDD 326 Bradyrhizobium ...
AAG33877     257 TCGMIITRVPn-TEAgvEANIGREIAEQITSQPKAWIIAAVAMLGFAALPGMPTGVFITIAIICGAGGMLQLQr--aKPk 333 Pseudomonas syr...
BAB20913     249 AAGVMITRVAdeRQAk-QRSLGDEIGHQLGSSSRALFFAAVLLLAFAIVPGFPSLLFVLLAAALSFAGYRLSVrkpsSRD 327 Burkholderia gl...
WP_009871438 263 TAGIVTTRVS--SDK--DTNLGKEISSQLVKEPRALLLSAGATLGIGFFKGFPLWSFALMAVLFAVLGILLITk---KNS 335 Chlamydia trach...
AAA16867     251 SAGFIVTRVN--GD---TDNMGRNIMTQLLNNPFVLVVTAILTISMGTLPGFPLPVFVILSVVLSVLFYFKFRe--aKRS 323 Salmonella ente...
AAA27643     327 NDEA---NqdlQSILTSGSgapaartkaKTSGankgrlgeqeaFAMTVPLLIDVDSSQQEaLEANal------nDELVRV 397 Yersinia pestis
AAK26714     327 FGTG---Nn-kDAMGADLS---------NSQNi----------SPGAEPLILNLSSNIYS-SDIT---------QQIEVM 373 Escherichia coli
P74856       332 VVSA---N------GVEAP---------EKDSm----------VPGACPLILRLSPTLHS-ADLI---------RDIDAM 373 Salmonella ente...
AAG60783     327 KPAAk------IGASAAASapvpaavqkQAAH------------AEALPIALFLAPNLTDsIDKDel------eESISRV 382 Bradyrhizobium ...
AAG33877     334 ----------aEEQGAVAVapgdewqgkTLRT-----------FSPSRQFVLQFHPG-QNsALVDal------vSEIRQR 385 Pseudomonas syr...
BAB20913     328 RAWR---Re-tLASMQRVGrktevppilPRAP------------QFACAVGVRISPDLAAnVAMPtl------dAAFEAE 385 Burkholderia gl...
WP_009871438 336 PGKK---Gg-aSSTTTVGAadgaaasgeNSDD-----------YALTLPVILELGKDLSKlIQQRtksgqsfvdDMIPKM 400 Chlamydia trach...
AAA16867     324 AAKPktsKg-eQPLSIEEKegsslgligDLDKv----------STETVPLILLVPKSRREdLEKA---------QLAERL 383 Salmonella ente...
AAA27643     398 RRALYLDLGVPFPGIHLRFN-EgMGEGEYIISLQEVPVARGELKAGYLLVRESVSQ-LELLGIPyekGEHlLPDQEAFWV 475 Yersinia pestis
AAK26714     374 RWNFFEESGIPLPKIIVNPV-K-NNDSAIEFLLYQESIYKDTLTDDTVYFEAGHAE-ISFEFVQ---EKL-SANSIVYKT 446 Escherichia coli
P74856       374 RWFLFEDTGVPLPEVNIEVL-P-EPTEKLTVLLYQEPVFSLSIPAQADYLLIGADA-SVVGDSQ---TLP-NGMGQICWL 446 Salmonella ente...
AAG60783     383 SRLVSADLGITIPRIPAQIG-DsLSSSQFRVDVDSVPVERDVINPGHLALNDDVAN-IELSGIPfqqD----PETNRVWI 456 Bradyrhizobium ...
AAG33877     386 RNRLVVQFGLTLPSFIIEYV-DhLQPDEFRFTVYDVPMLKATFTQTHVAVDVRQFN--GEDVPAaisGTTdRQEDQWVWL 462 Pseudomonas syr...
BAB20913     386 RAALQEALGLPFPGITMWVH-ApLPVATFEILIHDVPHLMVTMPPGKAMLPDLRLVpAEVAAASarsCWRwPRRRGRPPV 464 Burkholderia gl...
WP_009871438 401 RQALYQDIGIRYPGIHVRTDsPsLEGNDYMILLNEVPYVRGKIPPNHVLTNEVEEN-LSRYNLPfitYKNaAG-LPSTWV 478 Chlamydia trach...
AAA16867     384 RSQFFIDYGVRLPEVLLRDG-EgLDDNSIVLLINEIRVEQFTVYFDLMRVVNYSDE-VVSFGINp-tIHQ-QGSSQYFWV 459 Salmonella ente...
AAA27643     476 SVEYEERLEKSQLEFFSHS-----QVLTWHLSHVLREYAEDFIGIQETRYLLEQMEGGYGELIKEVQRIVPLQRMTEILQ 550 Yersinia pestis
AAK26714     447 NEANQQLAHVSGMDVYAKTn----DKITFLLKKLVLSNAKEFIGVQETRYLMDIMERKYNELVKELQRQLGLSKIVDILQ 522 Escherichia coli
P74856       447 TKDMAHKAQGFGLDVFAGS-----QRISALLKCVLLRHMGEFIGVQETRYLMNAMEKNYSELVKELQRQLPINKIAETLQ 521 Salmonella ente...
AAG60783     457 EERHAAALKAAGIGYHRLS-----EVLALRLHSTLTRFAQRLVGIQETRQLLARMEQEYPDLVKEVLRTATVPRIAEVLR 531 Bradyrhizobium ...
AAG33877     463 PAE-----QGGELATVSSM-----TLITERMERALQSCGPQFIGLQETKAILGWLESEQPELAQEMQRVLTLTRFSAVLQ 532 Pseudomonas syr...
BAB20913     465 DSAGTPRLDRRARGAGQDAvwrteQIIAHRLVAPCGATATLFLGIQEVQWILDQLSHDAPGLVAEVQKVLPPQRIADVLR 544 Burkholderia gl...
WP_009871438 479 STDALTILEKAAIKYWSPL-----EVIILHLSYFFHRNSQEFLGIQEVRSMIEFMERSFPDLVKEVTRLIPLQKLTEIFK 553 Chlamydia trach...
AAA16867     460 THEEGEKLRELGYVLRNAL-----DELYHCLAVTVARNVNEYFGIQETKHMLDQLEAKFPDLLKEVLRHATVQRISEVLQ 534 Salmonella ente...
AAA27643     551 RLVGEDISIRNMRSILEAMVEWGQKEKDVVQLTEYIRSSLKRYICYKYANGNNILPAYLFDQEVEEKIRSGVRQTSAGSY 630 Yersinia pestis
AAK26714     523 RLVEENISIRDLRTIFETLIFWSTKEKDVVILCEYVRIALRRHILGRYSVRGTLLNVWLIGSDIENELRESIRQTSSGSY 602 Escherichia coli
P74856       522 RLVSERVSIRDLRLIFGTLIDWAPREKDVLMLTEYVRIALRRHILRRLNPEGKPLPILRIGEGIENLVRESIRQTAMGTY 601 Salmonella ente...
AAG60783     532 RLLDEGIPIRNTRLLLEALAEWSEREQNAVLLTEYVRATLKRQICFRYANAHRVVVAFIIERESEEIIRGAVRETAVGPY 611 Bradyrhizobium ...
AAG33877     533 RLASECVPLRAIRVIAETLIEHCQHERDTNVLTDYVRIALKSQIYHQYCGADG-LQVWLLTPESEGLLRDGLRQTQTETF 611 Pseudomonas syr...
BAB20913     545 RLLEEQVSIRNVRSFMESLIAWGAKEKDMLMLTEYVRGDLSRFLAHRAAKGERQLSAVLFDMQAEQHIRAAIKQTPTGNF 624 Burkholderia gl...
WP_009871438 554 RLVQEQISIKDLRTILESLSEWAQTEKDTVLLTEYVRSSLKLYISFKFSQGQSAISVYLLDPEIEEMIRGAIKQTSAGSY 633 Chlamydia trach...
AAA16867     535 RLLSERVSVRNMKLIMEALALWAPREKDVINLVEHIRGAMARYICHKFANGGE-LRAVMVSAEVEDVIRKGIRQTSGSTF 613 Salmonella ente...
AAA27643     631 LALEPAVTESLLEQVRKTIGdlsqIQSKPVLIVSMDIRRYVRKLIESEYYGLPVLSYQELTQQINIQPLGRI 702 Yersinia pestis
AAK26714     603 LNISPERSEQIIGFLKNIVN----PTGNGVILTALDIRRYVKKMIEGSFPSVPVLSFQEVGNNIELKVLGTV 670 Escherichia coli
P74856       602 TALSSRHKTQILQLIEQALK----QSAKLFIVTSVDTRRFLRKITEATLFDVPILSWQELGEESLIQVVESI 669 Salmonella enterica sub...
AAG60783     612 LVLDEWQSEKLLAQFRQIHAtiaqSKSQPVVLGSMDIRRFVRGFLTRNGIDLPVLSYQDLAADFTVRPIGSV 683 Bradyrhizobium japonicum
AAG33877     612 FALSNDISQMLVQQLHIAFPl--rAPEQAVLLVAQDLRSPLRTLLREEFYHVPVLSFAEISNAAKVRVMGRF 681 Pseudomonas syringae pv...
BAB20913     625 LALPPNDAAFLIDRIQSFVGaaprE--GVVLVTSMDIRRYVRRMIESRLGWLSVYSYQELGEHVELKPVGRV 694 Burkholderia glumae
WP_009871438 634 LALDPDSVNLILKSMRMTITptppGGQPPVLLTAIDVRRYVRKLIETEFPDIAVISYQEVLPEIRIQPLGRI 705 Chlamydia trachomatis
AAA16867     614 LSLDPEASANLMDLITLKLDdlliAHKDLVLLTSVDVRRFIKKMIEGRFPDLEVLSFGEIADSKSVNVIKTI 685 Salmonella enterica sub...
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