4HYV,1A3W,1PKM,1PKY


Conserved Protein Domain Family
pyruv_kin

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TIGR01064: pyruv_kin 
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pyruvate kinase
This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Statistics
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PSSM-Id: 273424
Aligned: 22 rows
Threshold Bit Score: 540.716
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4HYV_A        20 RANRIVCTIGPSTQSVEALKNLMK--------------------SGMSVARMNFSHGSHEYHQTTINNVRAAAAELGLHI 79  Trypanosoma bru...
O51323         4 KLTKIVATISDLRCEPEHIKDLHD--------------------AGVNVIRLNTAHQSHEDTIKVIDNVRKIS----NKI 59  Borrelia burgdo...
O06134         3 RRGKIVCTLGPATQRDDLVRALVE--------------------AGMDVARMNFSHGDYDDHKVAYERVRVASDATGRAV 62  Mycobacterium t...
Q55863        16 HRTKIVATIGPASSSVEVIRQMVD--------------------AGMNVARLNFSHGSYEDHATMVRLLRSVEQEMDTPI 75  Synechocystis s...
Q57572         6 RKTKILVTLGPSLEN--KLDKAIN---------------------LIDGVRFNMSHATTDYCEKFLNILEK------NNI 56  Methanocaldococ...
Q9Z984         3 TRTKIICTIGPATNSPEMLAKLLD--------------------AGMNVARLNFSHGSHETHGQAIGFLKELREQKRVPL 62  Chlamydia pneum...
P94685         3 ARTKIICTIGPATNTPEMLEKLLD--------------------AGMNVARLNFSHGTHESHGRTIAILKELREKRQVPL 62  Chlamydia trach...
P47458         6 KRTKIIATCGPALTKSLVSLKMLDdneyaaikkvayanieaiikSGVSVIRLNFSHGTHEEQQVRIKIVRDVAKAMNIPV 85  Mycoplasma geni...
WP_001310901  53 RRTKIVTTLGPATDRDNNLEKVIA--------------------AGANVVRMNFSHGSPEDHKMRADKVREIAAKLGRHV 112 Escherichia
WP_005691285   6 RRTKIVCTMGPSTDRDNNLEKIIA--------------------AGANVVRMNFSHGTPDDHIGRAERVRSIAKKLGKTV 65  Haemophilus inf...
4HYV_A        80 GIALDTKGPEIRTGLFKDGEVSFAPGDIVCVTTDPayEKVGTKEKFYIDYPQ----LTNAVRPGGSIYVDDGVMTLRVVS 155 Trypanosoma bru...
O51323        60 ALMIDTKGPEVRTANIEN-PIIVKTGDKVIISTSP----INEPNNFQTNYDG----FVKEVPQGSKVLIDDGELEMTVVA 130 Borrelia burgdo...
O06134        63 GVLADLQGPKIRLGRFASgATHWAEGETVRIT--Vg-ACEGSHDRVSTTYKR----LAQDAVAGDRVLVDDGKVALVVDA 135 Mycobacterium t...
Q55863        76 TLLQDLQGPKIRIGQLPGgEKQLREGEKVSLVP-Ve-IGDRHPGAVGIDYPH----LATEAKVGERILLDDGLLEMKVVS 149 Synechocystis s...
Q57572        57 AKVMDLKGIKIRIKEVKLkNKILKMGEKVVIG-----------EDIKLNYN------IDTIEEGHFILINDGKIKLRVVE 119 Methanocaldococ...
Q9Z984        63 AIMLDTKGPEIRLGNIPQ-PISVSQGQKLRLVSSDidG---SAEGGVSLYPKg---IFPFVPEGADVLIDDGYIHAVVVS 135 Chlamydia pneum...
P94685        63 AIMLDTKGPEIRLGQVES-PIKVQPGDRLTLVSKEilG---SKESGVTLYPSc---VFPYVRERAPVLIDDGYIQAVVVN 135 Chlamydia trach...
P47458        86 SIMLDTNGPEIRIVETKKEGLKITKDSEVIINTMS--KMIASDNQFAVSDASgkynMVNDVNIGQKILVDDGKLTLVVTR 163 Mycoplasma geni...
WP_001310901 113 AILGDLQGPKIRVSTFKEGKVFLNIGDKFLLDANLg-KGEGDKEKVGIDYKG----LPADVVPGDILLLDDGRVQLKVLE 187 Escherichia
WP_005691285  66 AILGDLQGPKIRVSTFKDGKIFLNVGDKFILDAELp-KGEGTQESVGLDYKT----LPQDVVPGDILLLDDGRVQLKVLS 140 Haemophilus inf...
4HYV_A       156 KEDDRt-LKCHVNNHHRLTDRRGINLPGCEVDLPAVSEKDRKDLEFGVAQGVDMIFASFIRTAEQVREVRAALGEKG-KD 233 Trypanosoma bru...
O51323       131 KLPDR--LICEIKNDGQIKNKKSINTPGISLKLQSVTEKDKGFIELAAKYNVDFIAHSFVRHSKDVQDVQEILTASGnPD 208 Borrelia burgdo...
O06134       136 VEGDD--VVCTVVEGGPVSDNKGISLPGMNVTAPALSEKDIEDLTFALNLGVDMVALSFVRSPADVELVHEVMDRIGr-R 212 Mycobacterium t...
Q55863       150 IQDPE--VICEVVTGGILKSRKGVNLPGLVLTLPSMTTKDKQDLEFGLSQGIDWVSLSFVRKGEDIHTLKQFLAERGhPD 227 Synechocystis s...
Q57572       120 KT-DK--IIAVVEVGGEIKEGMGVNLPDTRIELPIIDETDLKNIKFAVEKDFEYIALSFVRNKEDVKELKDIISEYKg-D 195 Methanocaldococ...
Q9Z984       136 SEADS--LELEFMNSGLLKSHKSLSIRGVDVALPFMTEKDIADLKFGVEQNMDVVAASFVRYGEDIETMRKCLADLGnPK 213 Chlamydia pneum...
P94685       136 AQEHM--VEIEFQNSGEIKSNKSLSIKDIDVALPFMTEKDIADLKFGVEQELDLIAASFVRCNEDIDSMRKVLESFGrPN 213 Chlamydia trach...
P47458       164 VDKQHnqVICVAKNDHTVFTKKRLNLPNAQYSIPFLSEKDLKDIDFGLSQGIDYIAASFVNTVADIKQLRDYLKLKNaSG 243 Mycoplasma geni...
WP_001310901 188 VQGMK--VFTEVTVGGPLSNNKGINKLGGGLSAEALTEKDKADIKTAALIGVDYLAVSFPRCGEDLNYARRLARDAGc-D 264 Escherichia
WP_005691285 141 IDGAK--VFTEVTVGGPLSNNKGINKLGGGLSADALTEKDKADIITAARIGVDFLAVSFPRSSADLNYARELAQQAGl-N 217 Haemophilus inf...
4HYV_A       234 ILIISKIENHQGVQN---IDSIIEASNGIMVARGDLGVEIPAEKVCVAQMCIISKCNVVGKPVICATQMLESMTSNPRPT 310 Trypanosoma bru...
O51323       209 VKIISKIENQEGIDN---IEEIAKASYGIMVARGDMGVEIPAEDVPIAQLKITQTCIKYGIPVITATQMLHTMIENPRPT 285 Borrelia burgdo...
O06134       213 VPVIAKLEKPEAIDN---LEAIVLAFDAVMVARGDLGVELPLEEVPLVQKRAIQMARENAKPVIVATQMLDSMIENSRPT 289 Mycobacterium t...
Q55863       228 LPVIAKIEKPQAIDN---LEEIVAVSNGIMVARGDLGVEVNPEKVPRLQKEIIRRCNVRAIPVITATQMLDSMIQNSRPT 304 Synechocystis s...
Q57572       196 CEVISKIETKEGLKN---IKEIARESDGVMVARGDLGVEVPIENIPIEQKNILRIANRYGILSITATQILDSMINNPFPT 272 Methanocaldococ...
Q9Z984       214 MPIIAKIENRLGVEN---FSKIAKLADGIMIARGDLGIELSVVEVPNLQKMMAKVSRETGHFCVTATQMLESMIRNVLPT 290 Chlamydia pneum...
P94685       214 MPIIAKIENHLGVQN---FQEIARAADGIMIARGDLGIELSIVEVPGLQKFMARASRETGRFCITATQMLESMIRNPLPT 290 Chlamydia trach...
P47458       244 VKIIAKIESNHALNN---IDKIIKASDGIMVARGDLGLEIPYYQVPYWQRYMIKACRFFNKRSITATQMLDSLEKNIQPT 320 Mycoplasma geni...
WP_001310901 265 AKIVAKVERAEAVCSqdaMDDIILASDVVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPT 344 Escherichia
WP_005691285 218 AKIVAKVERAETVANdeaMDDIILASDVIMVARGDLGVEIGDPELVGVQKKLIRRSRQLNRAVITATQMMESMISNPMPT 297 Haemophilus inf...
4HYV_A       311 RAEVSDVANAVLNGADCVMLSGETAKGKYPNEVVQYMARICVEAQSATHDTVMFNSI-KNLQKIPMCPEEAVCSSAVASA 389 Trypanosoma bru...
O51323       286 RAEVSDIANAILNGTDAIMLSGETAYGKYPIEAVKMMTSIAKKVEKHR-KMTLYKDE-LF--YDKSITRNYIIKCAIDAT 361 Borrelia burgdo...
O06134       290 RAEASDVANAVLDGADALMLSGETSVGKYPLAAVRTMSRIICAVEEN---STAAPP---LT-HIPRTKRGVISYAARDIG 362 Mycobacterium t...
Q55863       305 RAEASDVANAILDGTDAVMLSGESAVGQYPVKSVQMLRKIAEETEVGLH-LVNNPP-------IENTETHALSEALVVID 376 Synechocystis s...
Q57572       273 RAEVTDIANAIYDGTDCLMLSNETTIGKYPIEAIKVLNKVAKVADEH---YEEFGD---RVCLEVESIDEGLVYAVYELY 346 Methanocaldococ...
Q9Z984       291 RAEVSDIANAIYDGSSAVMLSGETASGAHPVAAVKIMRSVILETEKNLSHDSFLKLDdSNSALQVSPYLSAIGLAGIQIA 370 Chlamydia pneum...
P94685       291 RAEVSDVANAIYDGTSAVMLSGETALGAHPVHAVKTMRSIIQETEKTFDYHAFFQLNdKNSALKVSPYLEAIGFSGIQIA 370 Chlamydia trach...
P47458       321 RAEVTDVYFAVDRGNDATMLSGETASGLYPLNAVAVMQKIDKQSETFFDYQYNVNYYlKNSTANKSRFWHNVVLPLTKKT 400 Mycoplasma geni...
WP_001310901 345 RAEVMDVANAVLDGTDAVMLSAETAAGQYPSETVAAMARVCLGAEKIPS-INVSKHR-L--DVQFDNVEEAIAMSAMYAA 420 Escherichia
WP_005691285 298 RAEVMDVANAVLDGTDAVMLSAETAAGQYPSETVAAMASVCLGAEKMPS-INVSRHR-M--DKEFETIEESVAMSAMYAA 373 Haemophilus inf...
4HYV_A       390 FE--------VQ-AKAMLVLSNTGRSARLISKYRPNCPIICVTTRLQTCRQLNVTRSVVSVFYDaaksGEDKDKEKRVKL 460 Trypanosoma bru...
O51323       362 KL--------MD-IKAIIVDSLKGKTARIMATYRASVPLFITTNSERLARELALSYGVYSNLVD----NNFKRTTEFVVT 428 Borrelia burgdo...
O06134       363 ERl---------dAKALVAFTQSGDTVRRLARLHTPLPLLAFTAWPEVRSQLAMTWGTETFIVP----KMQST-DGMIRQ 428 Mycobacterium t...
Q55863       377 GIl---------dLKYIVTFTTSGFTSLLASNQRPSVPVIAFTPSEKVYHSLNLVWGIIPFLIN----EEFDTFEDLIQQ 443 Synechocystis s...
Q57572       347 KKl---------nTKLVITPTYSGRTAKLISKLRINSKIIAPTPNIRTLKRLRLVWGVESCLME----EFDDM-----EK 408 Methanocaldococ...
Q9Z984       371 ER--------AD-AKALIVYTESGSSPMFLSKYRPKFPIIAVTPSTSVYYRLALEWGVYPMLT------QESDRAVWRHQ 435 Chlamydia pneum...
P94685       371 EK--------AS-AKAIIVYTQTGGSPMFLSKYRPYLPIIAVTPNRNVYYRLAVEWGVYPMLT------LESNRTVWRHQ 435 Chlamydia trach...
P47458       401 VPkrklvnsaFK-YDFIVYPTNNINRIYALSNARLAAAVIILTNNKRVYTGHGVDYGIFCYLID----KNPNQLTKAELI 475 Mycoplasma geni...
WP_001310901 421 NH--------LKgVTAIITMTESGRTALMTSRISSGLPIFAMSRHERTLNLTALYRGVTPVHFD----S-ANDGVAAASE 487 Escherichia
WP_005691285 374 NH--------MKgVAAIVTLSSTGRTPLLMSRISSGLPIFALSRNQETLNLCALYRGVTPIYHG----EE-SRTEAGAKA 440 Haemophilus inf...
4HYV_A       461 GLDFAKKEKYASTGDVVVVVHA--DHSvkgyPNQTRL 495 Trypanosoma brucei brucei
O51323       429 SLKMLKEQGVVNDKDTVIIISGnpNRNiekgTEFMEI 465 Borrelia burgdorferi B31
O06134       429 VDKSLLELARYKRGD-LVVIVAgaPPGtvgsTNLIHV 464 Mycobacterium tuberculosis
Q55863       444 AEVLLRDRKMVEKGD-QLLIMAgiPTKiprgTNFLKI 479 Synechocystis sp. PCC 6803 substr. Kazusa
Q57572       409 IINTCREMAKKEIGKGIYLITLghPIGqk-kTNTIKV 444 Methanocaldococcus jannaschii DSM 2661
Q9Z984       436 ACIYGIEQGILSNYDRILVLSRgac---meeTNNLTL 469 Chlamydia pneumoniae
P94685       436 ACVYGVEKGILSNYDKILVFSRgag---mqdTNNLTL 469 Chlamydia trachomatis
P47458       476 ELAWKAINHYQAYGDLEKLKQClaVYN----ETIINL 508 Mycoplasma genitalium G37
WP_001310901 488 AVNLLRDKGYLMSGDLVIVTQGd-VMStvgsTNTTRI 523 Escherichia
WP_005691285 441 ALQSLKEKGYLSTGDLVLVTQGgqg---atqTNVCRt 474 Haemophilus influenzae
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