1UAX,1I39,1EKE


Conserved Protein Domain Family
TIGR00729
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TIGR00729: TIGR00729 
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ribonuclease H, mammalian HI/archaeal HII subfamily
This enzyme cleaves RNA from DNA-RNA hybrids. Archaeal members of this subfamily of RNase H are designated RNase HII and one has been shown to be active as a monomer. A member from Homo sapiens was characterized as RNase HI, large subunit. [DNA metabolism, DNA replication, recombination, and repair]
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Statistics
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PSSM-Id: 129812
Aligned: 9 rows
Threshold Bit Score: 267.024
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1UAX_A   3 VAGVDEAGRGPVIGPLVI-GVAVIDEkn-iERLRDIGVKDSKQLTPGQREKLFSKLId-----ILDDYYVLLVTPKEID- 74  Pyrococcus horikoshii...
O29634   2 KAGIDEAGKGCVIGPLVVaGVACSDE----DRLRKLGVKDSKKLSQGRREELAEEIR------KICRTEVLKVSPENLD- 70  Archaeoglobus fulgidu...
O27102   3 VLGIDEAGRGPVIGPLVVaGVMIPERk--fSILRKMGVKDSKKLTPERRRFLARKIR------RIARVFTVKISASDIDr 74  Methanothermobacter t...
O59351   3 VAGVDEAGRGPVIGPLVIg-VAVIDEkn-iERLRDIGVKDSKQLTPGQREKLFSKLId-----ILDDYYVLLVTPKEID- 74  Pyrococcus horikoshii...
Q57599   3 IIGIDEAGRGPVLGPMVVc-AFAIEKer-eEELKKLGVKDSKELTKNKRAYLKKLLEn------LGYVEKRILEAEEINq 74  Methanocaldococcus ja...
Q9YET5   4 VVGVDEAGRGSLVGDLVVa-GFAVEEar-lGELQSLGVRDSKQLSPAARVELYREISg------VGFFTVEAIRPWEIDg 75  Aeropyrum pernix K1
P53942  35 IMGIDEAGRGPVLGPMVYaVAYSTQKyqdeTIIPNYEFDDSKKLTDPIRRMLFSKIYqdneelTQIGYATTCITPLDISr 114 Saccharomyces cerevis...
1I39_A  22 KAGIDEAGKGCVIGPLVVaGVACSDE----DRLRKLGVKDSKKLSQGRREELAEEIR------KICRTEVLKVSPENLD- 90  Archaeoglobus fulgidus
1EKE_A   3 IIGIDEAGRGPVLGPXVVc-AFAIEKer-eEELKKLGVKDSKELTKNKRAYLKKLLEn------LGYVEKRILEAEEINq 74  Methanocaldococcus ja...

1UAX_A  75 -----E-R--HHSMNELEAEKFVVALNSLRIKP------QKIYVDSADVDPKrf------aSLIKA-GLKyeATVIAEHK 133 Pyrococcus horikoshii...
O29634  71 -----E-R--MAAKTINEILKECYAEIILRLKP------EIAYVDSPDVIPErl------sRELEE-ITG--LRVVAEHK 127 Archaeoglobus fulgidu...
O27102  75 -----M-R--ERGFNLNEIEKIAIKRIIPEAQP------DRVIIDSVDVKPErl------eEEIRS-HFGe-IEVTAEHG 132 Methanothermobacter t...
O59351  75 -----E-R--HHSMNELEAEKFVVALNSLRIKP------QKIYVDSADVDPKrf------aSLIKA-GLKyeATVIAEHK 133 Pyrococcus horikoshii...
Q57599  75 -----L-Mn-SINLNDIEINAFSKVAKNLIEKLnirddeIEIYIDACSTNTKkfedsfkdkIEDIIkERNlnIKIIAEHK 147 Methanocaldococcus ja...
Q9YET5  76 -----E-Ni-NILVTKAVEEIVSRIVSYLGVHP------SLVVVDKYGDVQGl--------RLALTrLGIepRSILVEEK 134 Aeropyrum pernix K1
P53942 115 gmskfP-PtrNYNLNEQAHDVTMALIDGVIKQNvk---lSHVYVDTVGPPAS---------YQKKLeQRFpgVKFTVAKK 181 Saccharomyces cerevis...
1I39_A  91 -----E-R--MAAKTINEILKECYAEIILRLKP------EIAYVDSPDVIPErl------sRELEE---ItgLRVVAEHK 147 Archaeoglobus fulgidus
1EKE_A  75 -----LxN--SINLNDIEINAFSKVAKNLIEKLnirddeIEIYIDACSTNTKkfedsfkdkIEDIIkERNlnIKIIAEHK 147 Methanocaldococcus ja...

1UAX_A 134 ADAKYEIVSAASIIAKVTRDREIEKLKQK---YGEFGSGYPSDPRTKEWLEEYYKQy-GDFPPIVRRTWETARKIEE 206 Pyrococcus horikoshii OT3
O29634 128 ADEKYPLVAAASIIAKVEREREIERLKEK---FGDFGSGYASDPRTREVLKEWIAS--GRIPSCVRMRWKTVSNLRQ 199 Archaeoglobus fulgidus D...
O27102 133 ADTRYYPVAAASIIAKVERDLEIESIQKKnrkLGDIGSGYPSDPRTREFLESFTYD---ELPDFVRRSWATVQKKKQ 206 Methanothermobacter ther...
O59351 134 ADAKYEIVSAASIIAKVTRDREIEKLKQK---YGEFGSGYPSDPRTKEWLEEYYKQy-GDFPPIVRRTWETARKIEE 206 Pyrococcus horikoshii OT3
Q57599 148 ADAKYPVVSAASIIAKAERDEIIDYYKKI---YGDIGSGYPSDPKTIKFLEDYFKKh-KKLPDIARTHWKTCKRILD 220 Methanocaldococcus janna...
Q9YET5 135 ADSRYPVVSAASIVAKVVRDARLQVLRRM---YGVRGSGYPSDPETREWVREVFAR--GEAPRVIRYTWSTVRKLGG 206 Aeropyrum pernix K1
P53942 182 ADSLYCMVSVASVVAKVTRDILVESLKRDp--DEILGSGYPSDPKTVAWLKRNQTSlmGWPANMVRFSWQTCQTLLD 256 Saccharomyces cerevisiae...
1I39_A 148 ADEKYPLVAAASIIAKVEREREIERLKEK---FGDFGSGYASDPRTREVLKEWIAS--GRIPSCVRMRWKTVSNLRQ 219 Archaeoglobus fulgidus
1EKE_A 148 ADAKYPVVSAASIIAKAERDEIIDYYKKI---YGDIGSGYPSDPKTIKFLEDYFKKh-KKLPDIARTHWKTCKRILD 220 Methanocaldococcus janna...
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