2X7I


Conserved Protein Domain Family
mevalon_kin

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TIGR00549: mevalon_kin 
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mevalonate kinase
This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]
Statistics
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PSSM-Id: 273130
View PSSM: TIGR00549
Aligned: 19 rows
Threshold Bit Score: 247.974
Threshold Setting Gi: 8928130
Created: 7-Oct-2014
Updated: 23-Jan-2015
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2X7I_A        11 STGKIILIGEHAVTFGEPAIAVPFNAGKIKVLIEal-------------------------eSGN-Y---SS---IKSDV 58  Staphylococcus ...
CAC51370       7 AHGKVIIIGEHSVVYGYDALAMPIKALHIKTTVE----------------------------NNP-E---MW---MDTAR 51  Lactobacillus h...
BAB07790      34 AHAKAILLGEHAVVYGAPALALPIPQLTVTASVG----------------------------WSS-EasdSAgglSYTMT 84  Streptomyces sp...
P46086         7 APGKIILAGEHAVVHGSTAVAAAIDLYTYVTLRFplpsaenndrltlqlkdislefswslarIKE-Ai--PY---DSSTL 80  thale cress
P07277         9 APGKVIIFGEHSAVYNKPAVAASVSALRTYLLISessapdtie-----------ldfpdisfNHK-WsinDFnaiTEDQV 76  Saccharomyces c...
WP_003131564  11 AHSKLILIGEHSVVYGQPAIALPVTILKTTVTIT----------------------------SSKyG---QY---IENNE 56  Lactococcus lactis
WP_011064626  17 AHSKLILIGEHAVVHGQPAIAIPFPLIGVETVIE----------------------------YVP-Gt--VK---VDSSF 62  Oceanobacillus ...
WP_002379181  11 ATGKIILMGEHAVVYGEPAIAFPFQATEITAVFT----------------------------LAK-T---MQ---IDCAY 55  Enterococcus fa...
WP_031899083   9 STGKIILIGEHAVTFGEPAIAVPFNAGKIKVLIEal-------------------------eSGN-Y---SS---IKSDV 56  Staphylococcus ...
WP_011017674  10 AHSKIILIGEHAVVYGYPAIALPLTDIEVVCHIF----------------------------PAD-K------------- 47  Streptococcus p...
2X7I_A        59 YDGMLYDAPDHLKSl---------------------------VNRFVELNNItepLAVTIQTNLPPSRGLGSSAAVAVAF 111 Staphylococcus ...
CAC51370      52 YHGSFFDTPSEYDGlkyv---------------------vktMQKKANNNEP---LKITYTGEIPMERGFGSSAAVALGT 107 Lactobacillus h...
BAB07790      85 GTPSRALVTQASDGlhrl--------------------taefMARMGVTNAPh--LDVILDGAIPHGRGLGSSAAGSRAI 142 Streptomyces sp...
P46086        81 CRSTPASCSEETLKsiavlveeqnlpk---ekmwlssgistfLWLYTRIIGFn-pATVVINSELPYGSGLGSSAALCVAL 156 thale cress
P07277        77 NSQKLAKAQQATDGlsqelvslldpllaqlsesfhyhaafcfLYMFVCLCPHaknIKFSLKSTLPIGAGLGSSASISVSL 156 Saccharomyces c...
WP_003131564  57 FRRRLDLMGDEFEGirql--------------------imrlLSKFHSSKMP---FSLEIDSNIPQGRGLGASASLATAI 113 Lactococcus lactis
WP_011064626  63 YHGPLHHAPDYLQGianc--------------------vdetLAYLEIPNEDl--L-IRINSSIPPGKGLGSSASVAISV 119 Oceanobacillus ...
WP_002379181  56 FTGLLEDVPQELANikev--------------------vqqtLHFLKEDTFK---GTLTLTSTIPAERGMGSSAATAVAI 112 Enterococcus fa...
WP_031899083  57 YDGMLYDAPDHLKSl---------------------------VNRFVELNNItepLAVTIQTNLPPSRGLGSSAAVAVAF 109 Staphylococcus ...
WP_011017674  48 --PLVFDFYDTLStai-----------------------yaaLDYLQRLQEP---IAYEIVSQVPQKRGMGSSAAVSIAA 99  Streptococcus p...
2X7I_A       112 VRASYDFLG------------KSLTKEELIEKANWAEQIAHGKPSGIDTQTIVSGKPVWFQKGHA-------ETLKTLSL 172 Staphylococcus ...
CAC51370     108 TKALNQFFS------------LNMSESEIMAVTNHAEMINHGKASGLDAATVNSDYLVFFNKKMG-------PKVLQAKL 168 Lactobacillus h...
BAB07790     143 ALALADLFG------------HELAEHTAYELVQTAENMAHGRASGVDAMTVGASRPLLFQQGR--------TERLAIGC 202 Streptomyces sp...
P46086       157 TAALLASSIsektrgngwsslDETNLELLNKWAFEGEKIIHGKPSGIDNTVSAYGNMIKFCSG---------EITRLQSN 227 thale cress
P07277       157 ALAMAYLGGligsn--dleklSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHngtintnNFKFLDDF 234 Saccharomyces c...
WP_003131564 114 IRAFYDFFD------------AELPQKDLLFYANFSENITHGKSSGIDVATVNSEHPLWFIKDST-------IEPFELNL 174 Lactococcus lactis
WP_011064626 120 IRSLFDYAD------------RSYTTEELLRLANVAETYAHGDPSGLDTLTITSNLPVWFEKDHP-------VDYIELGE 180 Oceanobacillus ...
WP_002379181 113 VRSLFDYFD------------YAYTYQELFELVSLSEKIAHGNPSGIDAAATSGADPLFFTRGFP-------PTHFSMNL 173 Enterococcus fa...
WP_031899083 110 VRASYDFLG------------KSLTKEELIEKANWAEQIAHGKPSGIDTQTIVSGKPVWFQKGHA-------ETLKTLSL 170 Staphylococcus ...
WP_011017674 100 IRAVFSYCQ------------EPLSDDLLEILVNKAEIIAHTNPSGLDAKTCLSDHAIKFIRNIG-------FETIEIAL 160 Streptococcus p...
2X7I_A       173 D-GYMVVIDTGVKGSTRQAVHDVHKLC-EDP--QYMSHVKHIGKLVLRASDVI--------EHHK--------FEALADI 232 Staphylococcus ...
CAC51370     169 G-ATLFIMDTGELGNTKKAVAQVSQLL-SESe-QAKANMKRLGELADLTKKAW--------INHD--------VKTVGNI 229 Lactobacillus h...
BAB07790     203 D-SLFIVADSGVPGSTKEAVEMLREGF-TRSagTQERFVGRATELTEAARQAL--------ADGR--------PEELGSQ 264 Streptomyces sp...
P46086       228 MpLRMLITNTRVGRNTKALVSGVSQRA-VRHpdAMKSVFNAVDSISKELAAII--------QSKDetsv-tekEERIKEL 297 thale cress
P07277       235 PaIPMILTYTRIPRSTKDLVARVRVLVtEKFpeVMKPILDAMGECALQGLEIMtklskckgTDDEavetnnelYEQLLEL 314 Saccharomyces c...
WP_003131564 175 H-GFIVIGDTGVHGFTSQAINIVREKL-VEEkeKTQDSINHLGQLATDSKDFL--------MTDK--------LKEFGHV 236 Lactococcus lactis
WP_011064626 181 D-LHFIVADSGRVGDTRTSVESVAQLL-RMApkRIHAKIERIGELTHHAKDAL--------EKAS--------KQFLGQL 242 Oceanobacillus ...
WP_002379181 174 SnAYLVVADTGIKGQTREAVKDIAQLA-QNNptAIAETMKQLGSFTKEAKQAI--------LQDD--------KQKLGQL 236 Enterococcus fa...
WP_031899083 171 D-GYMVVIDTGVKGSTRQAVEDVHKLC-EDP--QYMSHVKHIGKLVLRASDVI--------EHHN--------FEALADI 230 Staphylococcus ...
WP_011017674 161 N-GYLIIADTGIHGHTREAVNKVAQFE-EMNl----PYLAKLGALTQALERAI--------NQKN--------KVAIGQL 218 Streptococcus p...
2X7I_A       233 FNECHADLKALTVSHDKIEQLMKIGKENGaIAGKLTGAGRGGSMLLL 279 Staphylococcus aureus subsp. aureus MRSA252
CAC51370     230 FNEAQKILHSFNISTTKIDQLQKIALDNGaLGFKLSGGGLGGITIAL 276 Lactobacillus helveticus
BAB07790     265 LTYYHELLHEARLSTDGIDALVEAALKAGsLGAKITGGGLGGCMIAQ 311 Streptomyces sp. CL190
P46086       298 MEMNQGLLLSMGVSHSSIEAVILTTVKHk-LVSKLTGAGGGGCVLTL 343 thale cress
P07277       315 IRINHGLLVSIGVSHPGLELIKNLSDDLRiGSTKLTGAGGGGCSLTL 361 Saccharomyces cerevisiae S288c
WP_003131564 237 MNKAHERLSDLGVSHPRLDNLVETARKNGaLGAKLTGSGLGGVMVAL 283 Lactococcus lactis
WP_011064626 243 LNEAQKELEALGVSDAGLNKLIHLAREEGaLGAKLTGGGNGGCIIAL 289 Oceanobacillus iheyensis
WP_002379181 237 MTLAQEQLQQLSVSNDMLDRLVALSLEHGaLGAKLTGGGRGGCMIAL 283 Enterococcus faecalis
WP_031899083 231 FNECHADLKALTVSHDKIEQLMKIGKENGaIAGKLTGAGRGGSMLLL 277 Staphylococcus aureus
WP_011017674 219 MTQAHSALKAIGVSISKADQLVEAALRAGaLGAKMTGGGLGGCMIAL 265 Streptococcus pyogenes
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