3PCO


Conserved Protein Domain Family
pheS

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TIGR00468: pheS 
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phenylalanyl-tRNA synthetase, alpha subunit
Most phenylalanyl-tRNA synthetases are heterodimeric, with 2 alpha (pheS) and 2 beta (pheT) subunits. This model describes the alpha subunit, which shows some similarity to class II aminoacyl-tRNA ligases. Mitochondrial phenylalanyl-tRNA synthetase is a single polypeptide chain, active as a monomer, and similar to this chain rather than to the beta chain, but excluded from this model. An interesting feature of the alignment of all sequences captured by this model is a deep split between non-spirochete bacterial examples and all other examples; supporting this split is a relative deletion of about 50 residues in the former set between two motifs well conserved throughout the alignment. [Protein synthesis, tRNA aminoacylation]
Statistics
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PSSM-Id: 273095
View PSSM: TIGR00468
Aligned: 13 rows
Threshold Bit Score: 372.03
Threshold Setting Gi: 552544931
Created: 7-Oct-2014
Updated: 23-Jan-2015
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3PCO_A        37 HLTLQMTTLRELPPEE--RPAAGAVINEAK------EQVQQALNARKAELE----SAALNARLAAETIDVSLPGRRIENG 104
gi 2500990   151 KIIDILKKRGYVDFDEe-KEIKIKLTEKGKefiknpIEIEEEITQLTRDII----ISGKWKKAYIRPYDVKVPTKPIYPA 225
gi 12229963  146 TLKTLMKRK-LVTKSEt-KQVYIEVMKKPE------IELEDIITDLTPEML----LEGTWRGKQFLKYDITIPAKEIYGG 213
gi 12229961  171 ALKDLKGRKGIVDIRKi-KRHTIELTTEGRkllergIEIVEEATQVTHEHL----KSGAWRKLHYRGYNIDAEYPLVYPG 245
gi 135111     37 HLTLQMTTLRELPPEE--RPAAGAVINEAK------EQVQQALNARKAELE----SAALNARLAAETIDVSLPGRRIENG 104
gi 1174507    39 HFTQLMQELRNVSAEE--RPAMGAKINEAK------QAALEFLNAKKTEWE----QAELNSKLEKERVDVSLPGRKVETG 106
gi 2500985    42 ELSLILKGMGKLSAEE--RPKFGAIANEVK------EALQHDLESRKANLQ----NAAIEAQLAAETLDVTMAGSYRPQG 109
gi 2507429    38 PITEVLRGMGKLSAEE--RPKMGALANEVR------ERIANAIADKNEKLE----EEEMKQKLAGQTIDVTLPGNPVAVG 105
gi 2500983    30 VFADKFNQLKHLNGEE--KNAFAKEIHHYK------QAFEKAFEWKKKAII----ELELEERLKKEKIDVSLFN-AIKTS 96
gi 1351151    35 DLKPLLQKIKTATKLSe-KSSLGKLYQSLD------IQLTDLLTSYKKTFE----INNQVSQKP--SLDVMLPATEFTNG 101
gi 2500984    35 DLKPLLSQIKETTDIEt-KRHLGQLYKQLE------STLQTLHDTQLQVFT----QAQSSSVLT--HGDVMLLATSFAPG 101
gi 552544931 183 KKKGADSVFFKIIEKLdlKFRLSSFGLEVKnflmksKLTGDELTKLTPEIL----KNKTYENKKFRAYNIHIPSAKTFIG 258
gi 836732    151 LDSIDAKILNDLKKRKliAQGKITDFNVTKg-----PEFSTDLTKLETDLTsdmvSTNAYKDLKFKPYNFNSQGVQISSG 225
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3PCO_A       105 GLHPVTRTIDRIESFFGELGFTVATGPE-IEDDYHNFDALNIPGHHPARADHDTFWFDT--------------------- 162
gi 2500990   226 KVHPLTRIIREVKEILLAMGFKEVKSPI-VETEFWNFDMLFEPQDHPAREMQDTFFLKYpnegdipedllskvke----- 299
gi 12229963  214 KIHPYERIIEECRKVFLEMGFTEIKGHY-VQPAFWNFDALFQPQDHPARDMQDTFYLDRyidlegeivervkatheng-- 290
gi 12229961  246 KMHPLRRIIDEIRSIFLKLGFTESRGPI-VESAFWNFDCLFQPQDHAAREMQDTFYVKNpavtdlpcedlvravqdahet 324
gi 135111    105 GLHPVTRTIDRIESFFGELGFTVATGPE-IEDDYHNFDALNIPGHHPARADHDTFWFDT--------------------- 162
gi 1174507   107 GLHPVTMTINRVTKFFSELGFSVENGPE-IESDYYNFDALNIPKHHPARADHDTFWFNP--------------------- 164
gi 2500985   110 RRHPLNSTVDRVLDIFVGLGYTVATGPQ-VETDYYNFEALNIPADHPARDMQDTFFLKD--------------------- 167
gi 2507429   106 GRHPLTVVIEEIEDLFIGMGYTVEEGPE-VETDYYNFESLNLPKEHPARDMQDSFYITE--------------------- 163
gi 2500983    97 SSHPLNYTKNKIIEFFTPLGYKLEIGSL-VEDDFHNFSALNLPPYHPARDMQDTFYFKD--------------------- 154
gi 1351151   102 SNNALYQVIDNLVEYFKSFLFTINFDSE-LTSISDCFDLLNIPKDHSSRNESDSFYIDK--------------------- 159
gi 2500984   102 SSNIIYQVIDELVNYFKKFLFTVNYDSE-LTTIADCFDLLNIPKDHPSRNLTDTFYLDK--------------------- 159
gi 552544931 259 RANSYLDYISKIKDKLVGLGFQEFDGPL-VETEFFNNDALFMPQFHPSRDIKDVYYISDpsmqeslpepyfsnvklahet 337
gi 836732    226 ALHPLNKVREEFRQIFFSMGFTEMPSNQyVETGFWNFDALYVPQQHPARDLQDTFYIKDpltadlpddktymdnikavhe 305
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3PCO_A       163 -------------------TRLLRTQTSG---VQIRTMKAQQ----PPIRIIAPGRVYRND-YDQTHTPMFHQMEGLIVD 215
gi 2500990   300 ---vhercwkykfdenvsrRLILRTHTTAssiRYLASLSDEEk--nKPHKVFCIDRVFRNEaIDYKHLPEFYQCEGIIMD 374
gi 12229963  291 -witgstgwggewslekarQLVLRTHTTA---ITIHYLAENPe---PPQKAFCIDRVYRREtIDATHLPEFDQLEGVVLD 363
gi 12229961  325 ggstgsegwqyewdrdvarQSVLRTHTTC---VSARFLSENe----PPLKMFSVGRVFRREtITYKHLPEFHQVEGIVAG 397
gi 135111    163 -------------------TRLLRTQTSG---VQIRTMKAQQ----PPIRIIAPGRVYRND-YDQTHTPMFHQMEGLIVD 215
gi 1174507   165 -------------------ELLLRTQTSG---VQIRTMEKMQ----PPIRIMAPGRVYRND-YDQTHTPMFHQIELLYVD 217
gi 2500985   168 -------------------GRLLRTHTSP---VQIRYMEKHD----PPIRIVAPGRVYRRDtVDATHSAVFHQVELLAID 221
gi 2507429   164 -------------------ETLMRTQTSP---VQTRTMEKHEg--kGPVKIICPGKVYRRDnDDATHSHQFMQIEGLVVD 219
gi 2500983   155 -------------------HKLLRTHTSP---VQIHTMQEQT----PPIKMICLGETFRRD-YDLTHTPMFHQIEGLVVD 207
gi 1351151   160 -------------------TSLLRTHCTA---TTLKAVRTSKktnnPDIRVVSLGAVFRNDsDDATHSHQFTQLDFMWIK 217
gi 2500984   160 -------------------NRLLRTHCTA---ATLRAVKETKksnnPDIRIASFGAVFRKDdDDATHSHQFNQLDFMWIK 217
gi 552544931 338 gyatgsrgwrysfsedlskRLVLRTHGTV-----LSAKQLINak-nP-SRYFGVIRCFRYDqVDATHGVDFYQTEGIVIE 410
gi 836732    306 qgrfgsigyrynwkpeecqKLVLRTHSTAisaRMLHDLAKDP----KPTRLFSIDRVFRNEaVDATHLAEFHQVEGVLAD 381
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3PCO_A       216 T--NISFTNLKGTLHDFLRNFFEedlQIRFRPSYFPFTEPSAEVDVMGkN--GK---------WLEVLGCGMVHPNVLRN 282
gi 2500990   375 D--NVNFNNLIGVLKEFLNRLGFe--KVRFRPAYFPFTEPSLEAEVYL-E--GKg--------WLEILGAGIFRPEVLEP 439
gi 12229963  364 R--DVGFKHLLGLLKEFFTKMGFe--DVRFRPGYFPYTEPSVEPEVYV-E--GLg--------WVELGGAGVFRKEVTEP 428
gi 12229961  398 D--EVNFRNLLGILREFYRKLGFe---VRFRPAYFPYTYLSTECEIYLpE--KKs--------WIELGGAGMFRPEVLEP 462
gi 135111    216 T--NISFTNLKGTLHDFLRNFFEedlQIRFRPSYFPFTEPSAEVDVMGkN--GK---------WLEVLGCGMVHPNVLRN 282
gi 1174507   218 K--KANFTELKGLLHDFLRAFFEedlQVRFRPSYFPFTEPSAEVDVMGkN--GK---------WLEVLGCGMVHPNVLRN 284
gi 2500985   222 K--GLAFTHLKGTIQAFIKQMFGealPIRFRASYFPFTEPSAEVDVQW-Q--GK---------WLEVMGCGMVDPNVMEA 287
gi 2507429   220 K--NISMSDLKGTLELVAKKMFGqdrEIRLRPSFFPFTEPSVEVDVTCfKcgGNgcsvckgtgWIEILGAGMVHPNVLKM 297
gi 2500983   208 QkgNIRFTHLKGVIEDFLHYFFGg-vKLRWRSSFFPFTEPSAEVDISCvFckQEgcrvcshtgWLEVLGCGMVNNAVFEA 286
gi 1351151   218 K--GLSLANLKWFINNMITHFFGentFTRFRLSHFPFTEPSFEIDIRCwLc-QNgcsickqtkWIEILGAGIIHPQVMNN 294
gi 2500984   218 K--DFSLTNLKWFMQNMINHIFGentSARFRLSHFPFTEPSFEIDIRCwLc-QNgcgvckktrWIEVLGAGILHPQVMAN 294
gi 552544931 411 D--GVSIKTLLGLLEIFAKELAGa-tEIKYVPAYFPFTEPSIEIHVKHp---VLg--------WFELGGSGIFRPEVTKP 476
gi 836732    382 Y--NITLGDLIKFMEEFFERMGVt--GLRFKPTYNPYTEPSMEIFSWH-E--GLq-------kWVEIGNSGMFRPEMLES 447
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
3PCO_A       283 VGIDPev-ySGFAFGMGMERLTMLRYGVTDLRSFFENDLR--FLKQF 326
gi 2500990   440 IGIEK----PVLAWGIGFSRLAMLRYGLTDIRDLHKNDLD--WLKRV 480
gi 12229963  429 LGIRG----KVLAWGLGIGRLAMLKIGLKDLRRLYLPDLG--WLRSM 469
gi 12229961  463 LGVET----PVAAFGLGIERLAMIRFDIKDIRMLYQSDLG--WLRGL 503
gi 135111    283 VGIDPev-ySGFAFGMGMERLTMLRYGVTDLRSFFENDLR--FLKQF 326
gi 1174507   285 VGIDPne-ySGFAVGMGVERLTMLRYNVTDLRSFFENDLR--FLKQF 328
gi 2500985   288 VGYDPev-yTGFAAGFGVERFAMVLHQIDDIRRLYNSDLR--FLRQF 331
gi 2507429   298 AGFDPke-yQGFAFGMGVERIAMLKYGIDDIRHFYTNDVR--FISQF 341
gi 2500983   287 IGYENv---SGFAFGMGIERLAMLTCQINDLRSFFETDLR--VLESF 328
gi 1351151   295 MGIGDteniTGIAAGIGIERLAMLKYGIDDIRDFYDNNFK--FLTQF 339
gi 2500984   295 MGFSDtdniRGIAAGIGIERLVMLKHGISDIRDLYDNNFK--FLAQF 339
gi 552544931 477 LGIDL----PVIAWGIGIDRMALMHLGLNDLRDLFTYDIGdvILRRG 519
gi 836732    448 MGLPKd--lRVLGWGLSLERPTMIKYKVQNIRELLGHKVSldFIETN 492
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