1FWK


Conserved Protein Domain Family
thrB

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TIGR00191: thrB 
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homoserine kinase
Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine kinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.P.aeruginosa homoserine kinase seems not to be homologous (see PROSITE:PDOC0054) [Amino acid biosynthesis, Aspartate family]
Statistics
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PSSM-Id: 129295
View PSSM: TIGR00191
Aligned: 7 rows
Threshold Bit Score: 342.844
Threshold Setting Gi: 12084384
Created: 7-Oct-2014
Updated: 23-Jan-2015
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1FWK_A     3 VRVKAPCTSANLGVGFDVFGLCLKEPYDVIEVE------AIDDK------EIIIEVDD-KNIPTDPDKNVAGIVAKKMID 69  Methanocaldococcus ...
P00547     2 VKVYAPASSANMSVGFDVLGAAVTPVDGALLGDvv--tvEAAETf-----SLNNLGRFaDKLPSEPRENIVYQCWERFCQ 74  Escherichia coli K-12
P73646     4 FTVSVPATTANIGPGFDCLGAALGLYNHVTVTDpt--dpEVDLL-------IEARGRDgEKISTT-KDNLLYQAIAYFYQ 73  Synechocystis sp. P...
P04948     8 FSVTVPGSTANLGPGFDSVGMALSRYLKLTVFE------SDKWS-------FEAETETvAGIPAG-TDNLIYQVAKRTAD 73  Bacillus subtilis s...
AAA35154   5 FKIKVPASSANIGPGYDVLGVGLSLFLELDVTIdssqaqETNDDpnncklSYTKESEGySTVPLRSDANLITRTALYVLR 84  baker's yeast
O25690     1 MVVSVPATSANLGPGFDCLGLSLNLRNRFFIEP------SSFHA-------VKLVGEG-EGIPKFLTNNIFTKVFYEILK 66  Helicobacter pylori...
P44504     2 LRIYAPASSANISVGFDTLGAAISPIDGSLLGDvv--qiESISTg----fELESAGYFvRKLPKEPQKNIVYQAYVLFSE 75  Haemophilus influen...
1FWK_A    70 DFNIG----KGVKITIKKGVKAGSGLGSSAASSAGTAYAINELFKLNLDKLKLVDYASYGELassgakHADNVAPAIFGG 145 Methanocaldococcus ...
P00547    75 ELGKQ----IPVAMTLEKNMPIGSGLGSSACSVVAALMAMNEHCGKPLNDTRLLALMGELEGrisgsiHYDNVAPCFLGG 150 Escherichia coli K-12
P73646    74 QTGQAi---PPLKLEIDLEIPLARGLGSSATAIVGGLLAANQAAGNPCTTSEILQMAIAMEG------HPDNVAPALLGG 144 Synechocystis sp. P...
P04948    74 LYGKEm---PPVHVKVWSDIPLARGLGSSAAAIVAAIELADELCGLKLSEADKLHLASLEEG------HPDNAGASLVGG 144 Bacillus subtilis s...
AAA35154  85 CNNIRnf-pSGTKVHVSNPIPLGRGLGSSGAAVVAGVILGNEVAQLGFSKQRMLDYCLMIER------HPDNITAAMMGG 157 baker's yeast
O25690    67 KHGND----GSFKFLLHNKVPITRGMGSSSAMIVGAVASAFAFLGFDFDRENIVNTALIYEN------HPDNITPAVFGG 136 Helicobacter pylori...
P44504    76 QLKLRganvKPLRLTLEKNMPIGSGLGSSACSIVAALVALNQFHNEPFSKMELLEMMGELEGrisgsiHYDNVAPCYLGG 155 Haemophilus influen...
1FWK_A   146 FTMVTNYEP------------LEVLHIPID------------------------FKLDILIAIPNISINTKEAREILPKA 189 Methanocaldococcus ...
P00547   151 MQLMIEEND------------IISQQVPGF------------------------DEWLWVLAYPGIKVSTAEARAILPAQ 194 Escherichia coli K-12
P73646   145 CQLAVKNGDhw---------qLVALDWP--------------------------SKFVPVLAIPNFELSTEAARAVLPHQ 189 Synechocystis sp. P...
P04948   145 LVIGLHEDDe-----------TQMIRVPN-------------------------ADIDVVVVIPFYEVLTRDARDVLPKE 188 Bacillus subtilis s...
AAA35154 158 FCGSFLRDLtpqeverreiplAEVLPEPSGgedtglvpplpptdigrhvkyqwnPAIKCIAIIPQFELSTADSRGVLPKA 237 baker's yeast
O25690   137 YNAAFVEKKkv---------iSLKTKIP--------------------------SFLKAVMVIPNRAISTKQSRHLLPKR 181 Helicobacter pylori...
P44504   156 VQFMVQSLG------------NICQKLPFF------------------------DNWYWVLAYPGIEVSTAEARAILPKS 199 Haemophilus influen...
1FWK_A   190 VGLKDLVNNVGKACGMVYALYNKd-KSLFGRYMMSDKVIEPVRGKLIPNYFKIK---EEVKDK-VYGITISGSGPSIIAF 264 Methanocaldococcus ...
P00547   195 YRRQDCIAHGRHLAGFIHACYSR--QPELAAKLMKDVIAEPYRERLLPGFRQAR---QAVAEIgAVASGISGSGPTLFAL 269 Escherichia coli K-12
P73646   190 YDRSAAIFNASHLALLVQAFSQG--RGDWLALALQDQIHQPYRQSLIPAYDQLH---QAALAAgAYNLVISGAGPTLLAI 264 Synechocystis sp. P...
P04948   189 FPYADAVKASAVSNILIAAIMSKd-WPLVGKIMKKDMFHQPYRAMLVPELSKVE---HVAEMKgAYGTALSGAGPTILVM 264 Bacillus subtilis s...
AAA35154 238 YPTQDLVFNLQRLAVLTTALTMDppNADLIYPAMQDRVHQPYRKTLIPGLTEILscvTPSTYPgLLGICLSGAGPTILAL 317 baker's yeast
O25690   182 YSVQESVFNLSHASLMTMAIVQG--KWDLLRCCSKDRMHQYKRMQTYPVLFAIQ---KIALENnALMSTLSGSGSSFFNM 256 Helicobacter pylori...
P44504   200 YTRQNVIAHGRHLGGFVHACHTH--QENLAAIMMKDVIAEPYRESLLPNFAEVK---QATRDLgALATGISGSGPTIFSI 274 Haemophilus influen...
1FWK_A   265 PKEEF------IDEVENILRDYYENTIRTEVG--KGVEVV 296 Methanocaldococcus jannaschii
P00547   270 CDKPEtaq-rvADWLGKNYLQNQEGFVHICRLdtAGARVL 308 Escherichia coli K-12
P73646   265 ADEVRapq-iaSTLVETWHDAGIEAESHCLPIdtKGATIT 303 Synechocystis sp. PCC 6803 substr. Kazusa
P04948   265 TEKGKgeelkeQLALHFPHCEVDALTVPKEGSiiERNPLY 304 Bacillus subtilis subsp. subtilis str. 168
AAA35154 318 ATENFee--isQEIINRFAKNGIKCSWKLLEPayDGASVE 355 baker's yeast
O25690   257 CYEEDa-----PKLKQVLSKKFPKFRVAVLDFdnDGVLIE 291 Helicobacter pylori 26695
P44504   275 APDLQtai-klSSYLESHYLQNNEGFVHVCKVdnEGTREI 313 Haemophilus influenzae Rd KW20
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