Conserved Protein Domain Family
PRK05761

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PRK05761: PRK05761 
DNA polymerase I; Reviewed
Links
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Statistics
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PSSM-Id: 235594
View PSSM: PRK05761
Aligned: 44 rows
Threshold Bit Score: 578.566
Threshold Setting Gi: 16081572
Created: 9-Dec-2010
Updated: 17-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218884625  13 SYKVLSKphyLLGVYYDGRLGKAILEFLDEDGSKLVKIMDPvgHKPYFLTDLSIDEvksl----ndiARDKHVEGFEEVY 88
gi 55376565   27 ERDDYSP--------------------------------------RFYVASRAPDDeidltrlrsvyERHPDVVATDIVA 68
gi 16120259   27 ERDNYTP--------------------------------------RFYVAARDPDAdldlttlqsvyDQHPDVVATEMVA 68
gi 169237626  27 ERDNYTP--------------------------------------RFYVAARDPDAdldlttlqsvyDQHPDVVATEMVA 68
gi 169237743  26 ERRDYTP-------------------RFHVAARSPETDVDLsgLQAFY-------------------ERHPDVVATEYVD 67
gi 169237239  26 ERRDYTP-------------------RFHVAARSPETDVDLsgLQAFY-------------------ERHPDVVATEYVD 67
gi 292653630  28 ERDDYTP--------------------------------------RFYVAARDPETdldlttlqsvyDQHPDIVATEMVA 69
gi 13541876    1 --------------MYEYTGNNKIKKKRYRNSTWIFVSGDR-----YDLDNLARDL-------------DQSSLRYEWAE 48
gi 222476155  27 EHDDYTP--------------------------------------RFYVGPRSPDSdidltklrriyENHPDVVATEIVS 68
gi 300712715  31 RVTDYTP---TIYVTYDGRAEDGLSDLQERL------------------------------------ASSPTVASMAIEQ 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218884625  89 KTNPLTmkkirvtk-----iitrdplaVKKLRSKMPSN--A---SVWEAKIKYHNNYVYDNGLipgmkyiiendgskpri 158
gi 55376565   69 QRPGFRrddedvlavdvahidritslaRQARQLSEYPVgdL---ACFNVDLSREFRYCLENDV----------------- 128
gi 16120259   69 RRPGFRrdeeavlavdvahidrvtplaRQARQLSAYPVgdL---ACFNVDFSREFRYCLETGA----------------- 128
gi 169237626  69 RRPGFRrdeeavlavdvahidrvtplaRQARQLSAYPVgdL---ACFNVDFSREFRYCLETGA----------------- 128
gi 169237743  68 RHPGFRrdlervlavdvshidrvtalaRQTRQLSEYPIgdI---ACFNVDFSREFRYCLENNV----------------- 127
gi 169237239  68 RHPGFRrdlervlavdvshidrvtalaRQTRQLSEYPIgdI---ACFNVDFSREFRYCLENNV----------------- 127
gi 292653630  70 RRPGFRrdeepvlavdvahidrvtplaRQARQLSDYPIgdI---ACFNVDFSREFRYCLETGV----------------- 129
gi 13541876   49 MPDVYGyilglki-------ytrpssaYRLGNLIYAKLgyGrrfRVYNADIDPVLRFMASNGLef--------------- 106
gi 222476155  69 RRPGFRrdgeevlavdvthvnrvttlaPQARQLSEFPIgdL---ACFNVDFLREFRYCLENDI----------------- 128
gi 300712715  72 WRQGFRhehesilr-----idvrelaaVRPLASQIRKLgwPgeyKLYNVDFSREFRYCLERG------------------ 128
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218884625 159 tlvkpeipltliqslrelfknepeetiklaedyLLLFEEAPPKALRIAIDIEVYTPFkgrIPNprqgeypvisiglssnn 238
gi 55376565  129 --------------------------------------DPTPTCDLSTLRLDV--------PLtettgdayte------- 155
gi 16120259  129 --------------------------------------DPTPASELSTLRLSV--------PVtetsndiyee------- 155
gi 169237626 129 --------------------------------------DPTPASELSTLRLSV--------PVtetsndiyee------- 155
gi 169237743 128 --------------------------------------NPTPANELSTLHLSI--------PVtetnsktyte------- 154
gi 169237239 128 --------------------------------------NPTPANELSTLHLSI--------PVtetnsktyte------- 154
gi 292653630 130 --------------------------------------NPTPASELSSLRLSV--------PVtetsndvyge------- 156
gi 13541876  107 -------------------------------fqLRTFYDEDPDLNVIYVSCTSSSCK----------------------- 132
gi 222476155 129 --------------------------------------DPTPASELSTLRLSV--------PVtettgdayte------- 155
gi 300712715 129 -------------------------------------RDPTPTRVPSVLAIDAEPPA---LSNppltelqineetvtgsp 168
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218884625 239 gfrkvlllgrrfkerfdymsddypvdievevfDSEKALILEALKTISRYPVVLTYNGDnfdlmYIYTRAIRLGIPRHTIP 318
gi 55376565  156 -----------------------lavggetvtGPPEDILTTVQAALDNHDPDVLVCSTseivpTLYEMAASTGADNFSLS 212
gi 16120259  156 -----------------------lsvagdavtGSSTDILAAVQGALEAHDPDVLVCSTseivpTLHEMATDAGVDDFSLS 212
gi 169237626 156 -----------------------lsvagdavtGSSTDILAAVQGALEAHDPDVLVCSTseivpTLHEMATDAGVDDFSLS 212
gi 169237743 155 -----------------------lgvdgetvtGPPEELLAAVQDALDVRDPDVLVCSTseiipTLYAMARDAGVDGFTLS 211
gi 169237239 155 -----------------------lgvdgetvtGPPEELLAAVQDALDVRDPDVLVCSTseiipTLYAMARDAGVDGFTLS 211
gi 292653630 157 -----------------------lsvagdtvtGSPTEILTAVKAALEEHNPDVLVCSTseiipTLYEMTTDADVDDFSLS 213
gi 13541876  133 --------------------------------VNGKAVNDQALEDMLFDSHVVVYDGPe----YFYRKLSMIGVPARYYP 176
gi 222476155 156 -----------------------lsvdgetitGSTEDILTAVQAAVDERDPDILVCSTsqiipTLHEMATHAGVGNFSLS 212
gi 300712715 169 ea------------ilyaiqrrlrqvdpdvlvlSSGELIPTLSEMADQHDVDLQLGRRpg-------------------- 216
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218884625 319 FILGEdmvridtgihldlyKFFSNRAVKNYAFGGKYQ--EEKLDAVSSALLGISKigfeeaigdisashliaynmrdadi 396
gi 55376565  213 RTPKG--------------DFQQLASRSTYASYGRVGhsPARYNVPGRAIIDRSN------------------------- 253
gi 16120259  213 RWPDV--------------DYQQLASRSTYSSYGRVGhsPARYNVPGRAIIDESN------------------------- 253
gi 169237626 213 RWPDV--------------DYQQLASRSTYSSYGRVGhsPARYNVPGRAIIDESN------------------------- 253
gi 169237743 212 RWPNV--------------DYQQLAGRSTYSSYGRVGhsPARYNVPGRAIIDESN------------------------- 252
gi 169237239 212 RWPNV--------------DYQQLAGRSTYSSYGRVGhsPARYNVPGRAIIDESN------------------------- 252
gi 292653630 214 RWPDV--------------DYQQLASRSTYSSYGRVGhsPARYNVPGRAIIDESN------------------------- 254
gi 13541876  177 G--------------------------RSFTSYGQIYfrDAYIDIQDRIAIPAS-------------------------- 204
gi 222476155 213 RWPDV--------------DYQQLASQSTYSSYGRVGhsPARYNVPGRAIIDESN------------------------- 253
gi 300712715 217 --------------------weRLAGRSTYESYGSVGhsPARYNVPGRVIIDRSN------------------------- 251
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218884625 397 tlqlTIFSNELVWKLMILLARISKTSIEDVCRRQISNWIQNQFFWEHRRLGYLIPNSEDirryAGKAGTKATIEGKKYAG 476
gi 55376565  254 ----TFFFGETNIDGVLDLVSRSRKPIQEAAWASIGNILTAIQICEAHDRGVLVPWHSW----RHEKFKSTGVLHDADRG 325
gi 16120259  254 ----TFFYGETNLDGVLDLVSRSKNPVQELAWASIGNVLTAIQICEANDRGVLVPWNSW----RHEFYKPMGTLHDADRG 325
gi 169237626 254 ----TFFYGETNLDGVLDLVSRSKNPVQELAWASIGNVLTAIQICEANDRGVLVPWNSW----RHEFYKPMGTLHDADRG 325
gi 169237743 253 ----AFFFGETNLDGILDLVTRSKKPIQELAWASIGNVLTAIQICEAHKRGVLTPWNSW----RHEFYKPMTTLHDADRG 324
gi 169237239 253 ----AFFFGETNLDGILDLVTRSKKPIQELAWASIGNVLTAIQICEAHKRGVLTPWNSW----RHEFYKPMTTLHDADRG 324
gi 292653630 255 ----TFFYGETNLDGVLDLVSRSKKPVQELVWASIGNVLTAIQICEAHDRSVLVPWNSW----RHEFYKPMGTLHDADRG 326
gi 13541876  205 ----SFLYSESGLSGIFEVSRVSYLNPVSVSIVTPGTAVSSMEVALAVNRGLLVPMKKD----DHEGQKSPEELIKRDRG 276
gi 222476155 254 ----TFFYGETNLDGVLDLVSRSKKPVQELAWASIGNVLTAIQICEAHDRGILVPWNSW----RHEFYKPMGTLHDADRG 325
gi 300712715 252 ----TFFHSQSGLDGCLDMVRRSGKPLQELGWASIGNVLTAMQIREARDREVLVPWNSW----RHEFFKPLSTLHDADRG 323
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218884625 477 ALVIEPPRGIFFNVTVLDIASLYPSIIKKYNLSYETVDmpwckstidiidetgrklhvvcveKPGLTAQITGIL--RDFR 554
gi 55376565  326 GFIFAPEVGLHEDVHELDFSSLYPNIICTHNVSPDVIRcechrdredv----pglgysicddRGYLVDVLQPIIdaRDEI 401
gi 16120259  326 GFIFAPEVGLHENVHELDFSSLYPNIICTRNVSPDVIRcdchsdrddv----pglgysicddRGYLVDVLQPIIdaRDEI 401
gi 169237626 326 GFIFAPEVGLHENVHELDFSSLYPNIICTRNVSPDVIRcdchsdrddv----pglgysicddRGYLVDVLQPIIdaRDEI 401
gi 169237743 325 GFIFAPEVGLHEDVHELDFSSLYPNIICTRNVSPDVIRcdchsdrddv----pglgyaicddRGYLVDVLQPIIdaRDEI 400
gi 169237239 325 GFIFAPEVGLHEDVHELDFSSLYPNIICTRNVSPDVIRcdchsdrddv----pglgyaicddRGYLVDVLQPIIdaRDEI 400
gi 292653630 327 GFIFAPEVGLHENVHELDFSSLYPNIICTRNVSPDVIRcdchsgrddv----pglgysicddRGYLVDVLQPIIdaRDEI 402
gi 13541876  277 GLVFQPVPGIYRDVYEIDFSSMYPSIIVKYNLSPGNVK--------------------------FLPEALNGLLerRLFY 330
gi 222476155 326 GFIFAPEVGLHEDVHELDFSSLYPNIICTRNVSPDVIRcechrdrddv----pglgysicdeRGYLVDVLQPIIdaRDDI 401
gi 300712715 324 GYTFSPEAGFHENVHELDFSSLYPNIICQFNVSPETIRcdchadradv----pgleysicdeRGYLPDVLQPLIdaRDTM 399
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218884625 555 VGIYKKRAKDKTlpkdllawYDVVQRAIKVFINASYGVFGDERFSLFSPAVAESVTAMGRKSFLTIILKAAELGIKPLYG 634
gi 55376565  402 KAAIRREQERDDpdkerldeLEGRSGALKWILVACFGYQGFNNAKYGRIECHEAINAFAREILLTAKQRLEAAGWRVVHG 481
gi 16120259  402 KAAIRRETDRDDpdedrlaeLEGRSGALKWILVACFGYQGFSNAKFGRIECHEAINAFAREILLMAKQRLEAGGWRVVHG 481
gi 169237626 402 KAAIRRETDRDDpdedrlaeLEGRSGALKWILVACFGYQGFSNAKFGRIECHEAINAFAREILLMAKQRLEAGGWRVVHG 481
gi 169237743 401 KTAIRREEQRENpdqdcldeLEGRSAALKWILVACFGYQGFSNAKFGRIECHEAINAFAREILLIAKQRLEAGGWRVVHG 480
gi 169237239 401 KTAIRREEQRENpdqdcldeLEGRSAALKWILVACFGYQGFSNAKFGRIECHEAINAFAREILLIAKQRLEAGGWRVVHG 480
gi 292653630 403 KAAIRREKERNNpdedrlaeLEGRSGALKWILVACFGYQGFSNAKFGRIECHEAINAFAREILLTAKQRLEAGGWRVVHG 482
gi 13541876  331 KRISASSe-----------vYSNRNAALKWLLLTSFGYTGYKNAKFGKIEVHEDITEIGRKLLADAISIAHDHGFEMIHG 399
gi 222476155 402 KAAIRREQQRDEpdqarfaeLEGRSGALKWILVACFGYQGFSNAKFGRIECHEAINAFAREILLTAKQQLEASGWRVVHG 481
gi 300712715 400 KREIREIDdeer-----vavLKSRADAIKWILVSCFGYQGFSNAKFGRIECHEAINAYAREILLDTKETFEANGWHLLHG 474
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218884625 635 DTDSIFVWNpn------qSQLEMLQKWILENLGLEIELDkEFTYVVF-------TGLKKNYLGRM----KDG-GIEIKGL 696
gi 55376565  482 IVDSIWVTPnpdvddedrESLEALATEITEAVDIRLEYEsHYDWVAFvpqresdAGALTKYFGKVv---DED-EFKIRGI 557
gi 16120259  482 IVDSIWVTPdpdvdeedrEDLQTLATEITERVEIRLEHEaHYDWVAFvpqresdAGALTKYFGKVa---GDD-DFKVRGI 557
gi 169237626 482 IVDSIWVTPdpdvdeedrEDLQTLATEITERVEIRLEHEaHYDWVAFvpqresdAGALTKYFGKVa---GDD-DFKVRGI 557
gi 169237743 481 IVDSIWVTPdpdvsdderGSLETLAAEITDTVDIRLEYEaEYEWVAFvpqresdAGALTKYFGKV----AGKdEFKIRGI 556
gi 169237239 481 IVDSIWVTPdpdvsdderGSLETLAAEITDTVDIRLEYEaEYEWVAFvpqresdAGALTKYFGKVa---GKD-EFKIRGI 556
gi 292653630 483 IVDSIWVTPdpdiddddrEDLETLATEITERVEIRLEHEaHYDWVAFvpqresgAGALTKYFGKVa---GDD-EFKIRGI 558
gi 13541876  400 IVDSLWISGn--------GDIEEVIREIRERTMVDIVVSgHYRWIVFlpe-ndgSGSPSRYYGLD----YNG-SYKVRGI 465
gi 222476155 482 IVDSIWVTPdpdvddsqrEDLDVLAREITDRVEIRLEHEaHYDWVAFvpqrestAGALTKYFGKVa---GED-EFKLRGI 557
gi 300712715 475 IVDSLWVTAieg---qkqTPLTELATVISDRVGIRLEYEsAFEWLALvplrdrdEGALTKYFGKVasatGDEpEYKYRGI 551
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218884625 697 VAKKRNTPEFLKELFKEMLEKMKAIETPENFVVFVDWLREMLKEYYDGLKRKEIPldhlaiRVALTKPPSSYNKTKpPHV 776
gi 55376565  558 EARQRSTPPFIEDVQRECLDRLDATQSPE-------AVLSCLDRAVSKLHAGEVAverlveRNRVSKPLDGYTQNT-QNV 629
gi 16120259  558 EARQRSTPPFIEDVQRDCLDRLDATRSPD-------AVLGRLERAIDELQAGNVAverlveRNRVSKPLEGYSQNT-QNV 629
gi 169237626 558 EARQRSTPPFIEDVQRDCLDRLDATRSPD-------AVLGRLERAIDELQAGNVAverlveRNRVSKPLEGYSQNT-QNV 629
gi 169237743 557 EARQRSTPGFIEDVQRDCLEILGQTQSPD-------VVINRLERAISELHAGDVDsdrlveRNRVSKPVEAYTQYT-QNV 628
gi 169237239 557 EARQRSTPGFIEDVQRDCLEILGQTQSPD-------VVINRLERAISELHAGDVDsdrlveRNRVSKPVEAYTQYT-QNV 628
gi 292653630 559 EARQRSTPPFIEDVQRDCLNRLDATQSPD-------AVLGRLERAIKELHSGAVGveqlveRNRVSKPLEGYTQNT-QNV 630
gi 13541876  466 ELRRADAPEICKRFQVEALEVLRECRTVEDVMSSKAKIEALEHRYIKNIRR--FPlnyftiSKKITRHSSEYSVNT--VT 541
gi 222476155 558 EARQRSTPAFVEEIQRECLDRLDETRSPE-------AVLGYLERAIAELHAGDVAvdqlveRNRVSKPLEGYTQNT-LNV 629
gi 300712715 552 ECRQRSTPDWITNAQQELIVTLDQSRSPE-------VVCARLQRQLAELHAGRVDpevltiDNRPSKHVEEYTRTT-RTV 623
                        810       820       830       840       850       860
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 218884625 777 KAAQQLIDYGISVQEGDIITYVKVKSRD-DYKAIQl--tRLHEVDPEKYIELLKSGLEQLLSALS 838
gi 55376565  630 AALKRARDQDLAVHPGQDIEYVVVDDEKsSRERVVlaheEVETYDPSYYETQLVRAVESVLSPLG 694
gi 16120259  630 AALKRAREQDLAVHPGQDIEYVVVDDEKsSRDRVAlaheAIETYDTSYYETQLVRAVESVLSPLG 694
gi 169237626 630 AALKRAREQDLAVHPGQDIEYVVVDDEKsSRDRVAlaheAIETYDTSYYETQLVRAVESVLSPLG 694
gi 169237743 629 AALERARDQDLAVHPGQDVEYVVVDDEKaSRERVAlaheETDQYDPSYYETQLVRAVESIISPLG 693
gi 169237239 629 AALERARDQDLAVHPGQDVEYVVVDDEKaSRERVAlaheETDQYDPSYYETQLVRAVESIISPLG 693
gi 292653630 631 AALKRARDQDLAVHPGQDIEYVVDDDEKiSRDRVAlsheEIETYDASYYETELVQAVESVLSPLG 695
gi 13541876  542 RSALKAAETFGKVSLGQIIKYTVSDESR---KIVNl--dDDGTIDYRYYERCLRRAFQPFDFIFS 601
gi 222476155 630 AALKRACDQNLAVHQGQDIEYVVVDDEKsSRDRVSlvheDGETYDPSYYETQLVRAVESVLSPLG 694
gi 300712715 624 AALQRAQDEGLDPQPGQDVSYVVVDDSKrSRDRVQltheLSQQYDAEFYADLLLRAAESVCSPLG 688
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