Conserved Protein Domain Family
PRK05582

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PRK05582: PRK05582 (this model, PSSM-Id:235516 is obsolete)
type I DNA topoisomerase
Statistics
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PSSM-Id: 235516
Aligned: 247 rows
Threshold Bit Score: 747.795
Created: 9-Dec-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
13508000    1 MSKNLVVIESPNKVKTLQKYLPNDFEIVSTIGHIREMVHK---NFGFNEADYSPVWedwtkskkkfsslsfkGNLKGKKL 77 
291320199   1 MSYKLVIVESPNKVETIKKYLGENYNVMASVGHIARLSKKgsmGLGIDMSKWEPEF----------------EIDPAKKE 64 
269114937   1 MENKIMIVESPNKVNTIQKIVGDNIKVLSSIGHILKMSTSgigGLGIDFENWEPKM----------------VIDPSKRK 64 
71893631    4 IVEKLIIVESPNKINTISSYLDSSYKVTACVGHITNLAKTgqfGLGIDINTWTPSY----------------VLDKTKKK 67 
72080622    4 IVEKLIIVESPNKINTISSYLDSSYKVTACVGHITNLAKTgqfGLGIDINTWTPSY----------------VLDKTKKK 67 
54020038    1 -MEKLIIVESPNKINTISSYLDSSYKVTACVGHITNLAKTgqfGLGIDINTWTPSY----------------VLDKTKKK 63 
15828942    6 NMNKLVIVESPNKIKAISKYLGKDYVVKASVGHIAYLPASgayGLGIDLENWQPLM----------------KMDPEKRA 69 
148377541   1 MSYKLVIVESPNKVETIKKYLGENYNVMASVGHIARLSKKgsmGLGIDMSKWEPEF----------------EIDPAKKE 64 
193216652   1 MDQKVLIVESPNKVKTIQQYVGSDYNVVSSVGHILKLSTSgvdGLGIDFTNWEPMM----------------IQDRTKAK 64 
47458917    1 MAEKVVIVESPNKVKTISKYLGKDYEVLASVGHIVKLPASgkfQLGIDLENWEPQY----------------VLDPTKKK 64 
13508000   78 lskydIIKSIKEKASKATNIYLATDPDREGEAISWHVYDVLDEKDKSKcQRITFNEITKNAVLDALKNPREIDQSWVQSQ 157
291320199  65 -----IVKQLKTAVKDADFVYIATDPDREGEAIGDHLVKYLKCKEGKF-ARIKYNEITKDAILYSVENPTQLDQNLIDAQ 138
269114937  65 -----IVSELKEAAKNASEVLIATDPDREGEAIANNLVNTLKVQDKYK--RVKYNEITPDAINYAIENPLTIDENLVNAQ 137
71893631   68 -----TIDEIKKLAKQAKTVIIATDADREGEAIGASLVEHLAITDKYQ--RIKYNEITKTAILEALENPGELNQNLINSQ 140
72080622   68 -----TIDEIKKLAKQAKTVIIATDADREGEAIGASLVEHLAITDKYQ--RIKYNEITKTAILEALENPGELNQNLINSQ 140
54020038   64 -----TIDEIKKLAKQAKTVIIATDADREGEAIGASLVEHLAITDKYQ--RIKYNEITKTAILEALENPGELNQNLINSQ 136
15828942   70 -----ICKELKEAADKSELVYIATDPDREGESIGQNLVDILKLKNY---KRIVYNEITEQAIKNAINNPKMLDENLITAQ 141
148377541  65 -----IVKQLKTAVKDADFVYIATDPDREGEAIGDHLVKYLKCKEGKF-ARIKYNEITKDAILYSVENPTQLDQNLIDAQ 138
193216652  65 -----VIKALKDATKNAKEVLIATDPDREGEAIAQNLVDTLKLSKIYR--RIKYNEITAEAIKEALENPQMIDDNLVKAQ 137
47458917   65 -----VVSELKKAVKNAKEVFIATDLDREGEAIGENLVHFLNLEDKY--SRIRYGEITKNAILTAMENPTKLDLNLVNAQ 137
13508000  158 FARQILDRMIGFRLSRLLNNYLS----AKSAGRVQSVALRFLEEREQEIRSFVPRFWWTLDVLL--NPKAEgvReacanr 231
291320199 139 KTRRMLDRIIGFRLSQLMQKKLSnspaTPSAGRVQSIALKLVVDREKEIENFVPRGYYSIEALI----SNS--------- 205
269114937 138 KARRILDRIIGFKLSQLIQRKVKntptNPSAGRVQSIALKLVVDKEEEIAKFIPTLYSKIEAHT----ADE--------- 204
71893631  141 QTRRMLDRIIGFRLTALLKNKIKnppkNPAAGRVQSFALSLIFDREKEIREFIPEKYFNLEVKIndENGNF--------- 211
72080622  141 QTRRMLDRIIGFRLTALLKNKIKnppkNPAAGRVQSFALSLIFDREKEIREFIPEKYFNLEVKIndENGNF--------- 211
54020038  137 QTRRMLDRIIGFRLTALLKNKIKnppkNPAAGRVQSFALSLIFDREKEIREFIPEKYFNLEVKIndENGNF--------- 207
15828942  142 KTRRMLDRIIGFRLSKLMKHKFSnipsAPSAGRVQSIALKLVIEREKLVENFVAQKYFNIIANL----DQD--------- 208
148377541 139 KTRRMLDRIIGFRLSQLMQKKLSnspaTPSAGRVQSIALKLVVDREKEIENFVPRGYYSIEALI--SDSLTaeI------ 210
193216652 138 KTRRMLDRIIGFRLSQLMKRKVKnapsLPSAGRVQSIALKLVCDKEKEIKAFIPIKYNKIQAKI----SED--------- 204
47458917  138 KARRMLDRIIGFRLSKLMASKLSnyptKPTAGRVQSIGLKLIIDRENEIKAFEPEKYHTLEAKI----SED--------- 204
13508000  232 sipivlreinPALRagLKFEEEKsv-sGIDFLDE-ASAKKFGEQLK----GVFEVYNIDEtKHYSSSPNSAYTTASLQKD 305
291320199 206 ----------LTAE--IYMPKHIaaekNWVFPEElESVKKSIDILPs---NILIVKDIKE-SKKTLPALTPFKQAAL--- 266
269114937 205 ----------QIAN--FVYRDNLdfvgENEWIKR-EKVDDILAQLNq--nKSLKVIDFKK-SIRSEAMVVPFKQSILYKE 268
71893631  212 ----------FDTI--YCNQQNEa--kKVNWINSeEELSEIIAEIKe---NPYLIFKKYSkATRKDPKVIPLKQATIFKK 274
72080622  212 ----------FDTI--YCNQQNEak-kVNWINSE-EELSEIIAEIKe---NPYLIFKKYSkATRKDPKVIPLKQATIFKK 274
54020038  208 ----------FDTI--YCNQKNEa--kKVNWINSeEELSEIIAEIKe---NPYLIFKKYSkATRKDPKVIPLKQATIFKK 270
15828942  209 ----------YQAL--LYLEENQg---DKNWINE-DQVDKIYNSLS----GKLTIKKIKH-STRKDSKATPFKQAVL--- 264
148377541 211 ----------YMPK--HIAAEKTwv--------fpDELESVKKSIDilpsNILVVKDIKE-SKKTLPALTPFKQAAL--- 266
193216652 205 ----------VIAD--FYYPTNSdfknDNTWILP-EKIDSIVAELNk--nKSLLVKDFKV-SQRKESQITPFKQSVLYKE 268
47458917  205 ----------VVAEyfNSNHDGD----HRSWIYP-KDIEKIKKEIK----GPLEVKSIKT-GQRTEAQITPLKQSVV--- 261
13508000  306 AINKLGWSSKKVTLIAQHLYEGVSIngeqTALISYPRTDSTRLSAQFQQSCKEYILNHYGEKyLSNRIVSAKGKKgekII 385
291320199 267 -YKKSPFSSSITQASLQRLYEGFg----dGGLISYPRTDSTRLSHTFVNATKNYISIKYGDEyVLDKVKGFK------GD 335
269114937 269 S----QYSSATVQIAAQKLFE--------MGLISYPRTDSTRLSSIFIEKSQKFIAQKYGKEyIATEIKGFS------GD 330
71893631  275 MSQ---YSSASVSNALQKLYEGYg----dYGLISYPRTDSTRLSQTFIEKGKEFIIKNFGPKyFTKSIKGFA------GD 341
72080622  275 MSQ---YSSASVSNALQKLYEGYg----dYGLISYPRTDSTRLSQTFIEKGKEFIIKNFGPKyFTKS---IKGFA---GD 341
54020038  271 MSQ---YSSASVSNALQKLYEGYg----dYGLISYPRTDSTRLSQTFIEKGKEFIIKNFGPKyFTKSIKGFA------GD 337
15828942  265 -YKRSSLTSTQVQSASQKLFEGFg----dDGLITYPRTDSTRLSQYFIENAHKYIEKTYGLEyVSKEIKGFA------GD 333
148377541 267 -YKKSPFSSSITQASLQRLYEGFg----dGSLISYPRTDSTRLSHTFVNATKNYISIKYGDEyVLDKVKGFK------GD 335
193216652 269 A----KYSATTVQISAQKLFE--------MGLISYPRTDSTRMSDTFIAKAREYIKEKFGENyVASDIKSFS------GA 330
47458917  262 -FRKVQGSSNVIQSAMQRLYEGYDEg----GLISYPRTDSTRLSQTFINESKKYIEKKFGKQyFSESIK---GVA---GD 330
13508000  386 QDAHEAIHPTDINITPEMVKN--AIKKDEFLLYRLIWIRTVASLMADCKKSHTHIRFIN--DGNKFYASSKSLVFDGYRK 461
291320199 336 QDAHEAIRPTDITLLPDEAKNkyDLNNYDYQIYKLIYEHTLMCLITPPLRANKTYKFAK--DKLEFRLNVSWVLFDGYYI 413
269114937 331 QDAHEAIRPTDISLLATEAQQkfNLSNEETNVYKLIYEKTLMALMATPKREIYQYELKN--GQYNFKMSYSKIIFDGYYK 408
71893631  342 QDAHEAIRPTNLELSPELAREkyHLGQIEFQIYQLIYQTTIQALMRSPERKITNLTFKTpiKDHIFSYSYSEFTFDGYYK 421
72080622  342 QDAHEAIRPTNLELSPELAREkyHLSQIEFQIYQLIYQTTIQALMRSPERKITNLTFKTpiKDHIFSYSYSEFTFDGYYK 421
54020038  338 QDAHEAIRPTNLELSPELAREkyHLGQIEFQIYQLIYQTTIQALMRSPERKITNLTFKTpiKDHIFSYSYSEFTFDGYYK 417
15828942  334 QDAHEAIRPTNLELTPEKARSkyNLKREEYETYKLIYNNTLQAIMSVPIREITSYTLED--NGNIFKFYESKILFDGYFK 411
148377541 336 QDAHEAIRPTDITLLPDEAKNkyDLNNYDYQIYKLIYEHTLMCLITPPLRANKTYKFAK--DKLEFRLNVSWVLFDGYYI 413
193216652 331 QDAHEAIRPTDIYLIPQVAKTkyDLGEVESYIYTIIYNKTMSSLMTPPVREIYRYELVN--GLYYFKMSYSKVIFDGYYR 408
47458917  331 QDAHEAIRPTDVSLTPEMAVAkyGIEGAELRVYTFIYNTTLQALMKSPIRSTLRYELEN--NSHKFKLSSSKVIFDGYYV 408
13508000  462 IYEhfENKE-SNdlyIDLDKIRVGDRFMAKDIKITARQ----------THPAARYTQASLIEALEKSNIGRPSTYNTMAS 530
291320199 414 V----KGEM-NE---SVDPDYKIGQLVNVKEFVIEGKE----------TKPPARYSEGSLIEKLDDIKVGRPSTFATTVK 475
269114937 409 IFD--KKQE------SIIPNYKVGDIIKVLEFVKLDKE----------TKAPARYNDGSLIKMLDDIKVGRPSTFATTVK 470
71893631  422 AT--------EKpslKFKPEFSDIESLISKKFQVDKNFdnsiksslhqTKPPAHFRDGTLIEKLDDEKVGRPSTFAISVK 493
72080622  422 A----TEKP-SL---KFKPEFSDIESLISKKFQVDKNFdnsiksslhqTKPPAHFRDGTLIEKLDDEKVGRPSTFAISVK 493
54020038  418 AT--------EKpslKFKPEFSDIESLISKKFQVDKNFdnsiksslhqTKPPAHFRDGTLIEKLDDEKVGRPSTFAISVK 489
15828942  412 AI---GFPE-IKapySQNKKLQEDDIIEVQEYIKQEKT----------TKPPARYNDGSLIEALDNIKVGRPSTFATTVN 477
148377541 414 V----KGEM-NE---SVDPDYKIGQLVSVREFVIEGKE----------TNPPARYSEGSLIEKLDDIKVGRPSTFATTVK 475
193216652 409 VL---NFEEpKP-----LPKYEIGEAIPVLEFTRFDKE----------TQPPARYNEGSLIKMLDDIKVGRPSTFASTIN 470
47458917  409 I----DGYD-RD---KELPIYTEGQKIEVKQYVYSDHE----------TKPPARYNDGTLIQMLDDLKIGRPSTFAATVS 470
13508000  531 VNLDRGYASLNKHAFHVTQLGEQVNEELSKHFGKIINKEFTKNMEKSLDEIAENKKNYQEFLRDFWSNFKEEVKLAEGSI 610
291320199 476 IVLSREYVRSENSALVPTDFGKLILEKLIQGFPDIINEGYTAEVENQLDLIATNKISVAPVMEDFYSKFKNNYESASQNL 555
269114937 471 IIKDRLFVETKNNSLYPTDYGKLVLEKLIQGFPTTINEEYTASVENQLDLISEGLSDYKVLLKDFWNNFNLQLQNVNETM 550
71893631  494 KLKDHLYVDSESKSLVLSDFGKIVYENLKIISPEIIDAKFTAQVEEELDLIAQGKQDYKKYLDSMWSKIENTIEKA-VEV 572
72080622  494 KLKDHLYVDSESKSLVLSDFGKIVYENLKIISPEIIKAKFTAQVEEELDLIAQGKQDYKKYLDSMWSKIENTIEKA-VEV 572
54020038  490 KLKDHLYVDSESKSLVLSDFGKIVYENLKIISPEIINAKFTAQVEEELDLIAQGKQDYKKYLDSMWSKIENTIEKA-VEV 568
15828942  478 ILKKRGYVDQIERELIPTNFGKEVNEKLITGFPTIINEDYTASVEKNLDEIAEGKSDHKILMSEFWNLFEKNIDDAYKTM 557
148377541 476 IILNREYVRSENAALVPTDFGKLILEKLIQDFPDIINEGYTAEVENQLDLIATNKISVAPVMEDFYSKFKNNYESASQNL 555
193216652 471 IIKKRLFVETINGALHPTVFGEVVLKKLIEGFPNTITEEYTAQVEEELDEVSEGKADYKILLEDFWNRFQRSYDDASKTI 550
47458917  471 KLKERLYVKAEATNLEPSDFGFQVLEKLLISFPGTINEEYTAKVEADLDLIAENKIDYKKVLQDFWDLFSETLDTAYLTL 550
13508000  611 QRVKKEKEFVGRDCPSCASPLLYRYTKRGneKFVGCSNFPNCKYNEfsqnkpnLTLekLeELCPEC--NSQLVKRRT-KF 687
291320199 556 DHTS-------------------------------------------------MSLqkIdESCPND--NGNLVIRRN-KR 583
269114937 551 ETDFLPQEILQEKCPLCGHDLLYRYTKSKhqKFIGCSNFSSCRYIRn-------------IDNEKP-------------- 603
71893631  573 EKVIMEARTTGEKCTECDADLVYRYNRKTnqRFIGCSSFPNCRFIK-------------------VdeNAKKVYRFRkRN 633
72080622  573 EKVIMEARTTGEKCTECDADLVYRYNRKTnqRFIGCSSFPNCRFIK--------------------------VDENAkK- 625
54020038  569 EKVIMEARTTGEKCTECDADLVYRYNRKTnqRFIGCSSFPNCRFIK-------------------VdeNAKKVYRFRkRN 629
15828942  558 EKTILIPSFVGENCPLDNQPLVYRKNNYGkgRYIACSAYPKCSFTR---------------------------------- 603
148377541 556 DHTS-------------------------------------------------MSLqkIdESCPNd--NGNLVIRRN-KR 583
193216652 551 EISIMPQEFLERSCPRCGSTLLYRNNSKKhtKFIGCSNFPACRYSE--------------------------------NA 598
47458917  551 ERTILIPEQVGEECPDDGGVLIYKNSRRGd-RFIACANWPECTFTR------------------------SIAKKKWfNK 605
13508000  688 NPnkTFVGCSNFPRCRYIKKDNAS 711
291320199 584 GD--KFIACDNFPKCNFTKSYDDG 605
269114937 604 ----KFFkrrynk----------- 612
71893631  634 TKiltnk----------------- 640
72080622  626 --------VYRFrkrntkiltnk- 640
54020038  630 TKiltnk----------------- 636
15828942  604 ------------SEQKFNFFKKTF 615
148377541 584 GD--KFIACDNFPKCNFTKSYDDG 605
193216652 599 DG--TPTGQKTY---------KPR 611
47458917  606 KKsteein---------------- 613
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