416911 8 STTQSDVAFQKVETHEIDRSSYLGPCYNSDELMQlIsayYNVEPLVGYLEQHPEYQnVTLQFPDDLIKDSSLIVRLLQSK 87 baker's yeast 7299937 3 SSETSASAFSSSDTAALERQAEVEQPVTLEQIWN-E---NHRRSSVDWIRKSGYKR-VCLQFPDDYLPHSNAISVGLKEL 77 fruit fly 15231723 1 --------------------------MELEFESK-----YEINRTAEFIISKSFTR-IALQFPDELLKDSTKVVSALKSK 48 thale cress 10176920 29 pkqppkRFIKNQIPDSILGDASLNAAISILPSIY-H---FEVHKCVWRIKTSNAKR-IALQLPEGLLMYALTLSDIFTSF 103 thale cress 6226755 4 SAPSAFFTTSTPADHVHEEESSNTGYFENLPENDiHs-fFEIDATSEWIKQGNHQR-IALQFPDSLLPYSEKVTKLIESR 81 Caenorhabditis elegans 8247965 1 --matrATQISTLVEEIANNPNLKEDLKILPSNY-T---FEVPKTIWKIRSTESKY-VALQFPEGLIMYACVIADILEKY 73 Caenorhabditis elegans 30584261 1 ----MESMFSSPAEAALQRETGVPGLLTPLPDLDgV---YELERVAGFVRDLGCER-VALQFPDQLLGDAVAVAARLEET 72 synthetic construct 4503361 1 -------------------------------------------------------------MPEGLLLFACTIVDILERF 19 human 1723275 1 MSFELSAPVPLSDNSEAILEKEIGETVKIEGDLVeV---YEINRTVDFIKSGNYNS-VALQFPDEHLADSGKVASILTNL 76 fission yeast 19113201 40 NSKRSAGRVATQIPEDILNDKAINEAIKLLPQNY-N---FEIHKTIWHIRLRKAKR-VALQLPEGLLMFGCILSDIFEQF 114 fission yeast 7299937 3 SSETSASAFSSSDTAALERQAEVEQPVTLEQIWN-E---NHRRSSVDWIRKSGYKR-VCLQFPDDYLPHSNAISVGLKEL 77 fruit fly 15231723 1 --------------------------MELEFESK-----YEINRTAEFIISKSFTR-IALQFPDELLKDSTKVVSALKSK 48 thale cress 10176920 29 pkqppkRFIKNQIPDSILGDASLNAAISILPSIY-H---FEVHKCVWRIKTSNAKR-IALQLPEGLLMYALTLSDIFTSF 103 thale cress 6226755 4 SAPSAFFTTSTPADHVHEEESSNTGYFENLPENDiHs-fFEIDATSEWIKQGNHQR-IALQFPDSLLPYSEKVTKLIESR 81 Caenorhabditis elegans 8247965 1 --matrATQISTLVEEIANNPNLKEDLKILPSNY-T---FEVPKTIWKIRSTESKY-VALQFPEGLIMYACVIADILEKY 73 Caenorhabditis elegans 30584261 1 ----MESMFSSPAEAALQRETGVPGLLTPLPDLDgV---YELERVAGFVRDLGCER-VALQFPDQLLGDAVAVAARLEET 72 synthetic construct 4503361 1 -------------------------------------------------------------MPEGLLLFACTIVDILERF 19 human 1723275 1 MSFELSAPVPLSDNSEAILEKEIGETVKIEGDLVeV---YEINRTVDFIKSGNYNS-VALQFPDEHLADSGKVASILTNL 76 fission yeast 19113201 40 NSKRSAGRVATQIPEDILNDKAINEAIKLLPQNY-N---FEIHKTIWHIRLRKAKR-VALQLPEGLLMFGCILSDIFEQF 114 fission yeast
416911 88 FPHgk---iKFWVLADTAYSACCVDEVAAEHVHAEVVVHFGDACLNAIQNLPV----VYSFGTPFLDLALVVENFQRAFP 160 baker's yeast 7299937 78 LAPed---vKVFILADTTYGSCCVDEIAAAHVDADSVIHFGNACRSRAARLPV----LYLYPELPLDVNVLLSKLQGLRA 150 fruit fly 15231723 49 TRLltdrevRFFVMADTTYGSCCIDEVGALHIDSECVVHYGQTCLSPTSVLPA----FFVFGKASINVSSCVKHLIDYAS 124 thale cress 10176920 104 AGAs-----HCFVLGDVTYGACCVDDFSACALGADLLIHYGHSCLVPIDSTKIp--cLYVFVEIQIDVKCLLNTIHLNLA 176 thale cress 6226755 82 FRSes--akKTFVLADTSYRSCCVDEVAAAHADCTALVHFGEACHSAPTDKIDv---KYVLGSMPIFIDQFRMEFQNVAD 156 Caenorhabditis elegans 8247965 74 TGC------DTVIMGDVTYGACCVDDYTAKSMGCDLLVHYGHSCLVPIQNTDGia-mLYVFVNIHINLSHLIDCVKENFQ 146 Caenorhabditis elegans 30584261 73 TGS------KMFILGDTAYGSCCVDVLGAEQAGAQALIHFGPACLSPPARPLPv---AFVLRQRSVALELCVKAFEAQNP 143 synthetic construct 4503361 20 TEA------EVMVMGDVTYGACCVDDFTARALGADFLVHYGHSCLIPMDTSAQdfrvLYVFVDIRIDTTHLLDSLRLTFP 93 human 1723275 77 VEA------NVQILADTNYGSCCVDEVAAEHMSADAIVHYGRACLSPTSRLPV----LYVFGRLPINLHKLEKCLTIPLD 146 fission yeast 19113201 115 CQV------ETIVMGDVTYGACCIDDFTARALDCDFLVHYGHSCLIPVDQTPIk--vLYVFVDIKIDLQHVVSSLKHNLP 186 fission yeast 7299937 78 LAPed---vKVFILADTTYGSCCVDEIAAAHVDADSVIHFGNACRSRAARLPV----LYLYPELPLDVNVLLSKLQGLRA 150 fruit fly 15231723 49 TRLltdrevRFFVMADTTYGSCCIDEVGALHIDSECVVHYGQTCLSPTSVLPA----FFVFGKASINVSSCVKHLIDYAS 124 thale cress 10176920 104 AGAs-----HCFVLGDVTYGACCVDDFSACALGADLLIHYGHSCLVPIDSTKIp--cLYVFVEIQIDVKCLLNTIHLNLA 176 thale cress 6226755 82 FRSes--akKTFVLADTSYRSCCVDEVAAAHADCTALVHFGEACHSAPTDKIDv---KYVLGSMPIFIDQFRMEFQNVAD 156 Caenorhabditis elegans 8247965 74 TGC------DTVIMGDVTYGACCVDDYTAKSMGCDLLVHYGHSCLVPIQNTDGia-mLYVFVNIHINLSHLIDCVKENFQ 146 Caenorhabditis elegans 30584261 73 TGS------KMFILGDTAYGSCCVDVLGAEQAGAQALIHFGPACLSPPARPLPv---AFVLRQRSVALELCVKAFEAQNP 143 synthetic construct 4503361 20 TEA------EVMVMGDVTYGACCVDDFTARALGADFLVHYGHSCLIPMDTSAQdfrvLYVFVDIRIDTTHLLDSLRLTFP 93 human 1723275 77 VEA------NVQILADTNYGSCCVDEVAAEHMSADAIVHYGRACLSPTSRLPV----LYVFGRLPINLHKLEKCLTIPLD 146 fission yeast 19113201 115 CQV------ETIVMGDVTYGACCIDDFTARALDCDFLVHYGHSCLIPVDQTPIk--vLYVFVDIKIDLQHVVSSLKHNLP 186 fission yeast
416911 161 DLSS-KICLMANAPFSKHLSQLYNILKGDLHY---------TNIIYSQVNt-------sAVEek---------fVTILDT 214 baker's yeast 7299937 151 ESIDrQVCVYLDIGYQHVYGEKLKKQLSEILEp--------KELLLELFP------------------------PIEAES 198 fruit fly 15231723 125 KSDK-PIMILYGLEYAHVIPQIREELGLSKTDsqlsvanvlCSFISPSKDpresmehprPYSesdssdslsssrSYRLGG 203 thale cress 10176920 177 SDVK-NIILAGTIQFTSAIRAVKPELEKQG-----------FNVLIPQSK---------PLS------------AGEVLG 223 thale cress 6226755 157 QLTAeHIVLLMDSCFSHEQEKVAAVIKEVLPGnr-----hvECSLLPSEDvl------kQNR------------QNIYLG 213 Caenorhabditis elegans 8247965 147 GKR---LVVVSTVQFIPSLQTLRTTFNKDDSs---------IRIDIPQCK---------PLS------------PGEVLG 193 Caenorhabditis elegans 30584261 144 DPKA-PVVLLSEPACAHALEALATLLRPRYLD---------LLVSSPAFPq--------PVGslsp-----epmPLERFG 200 synthetic construct 4503361 94 PAT--ALALVSTIQFVSTLQAAAQELKAE------------YRVSVPQCK---------PLS------------PGEILG 138 human 1723275 147 QNIL-LVSDTRWYYAQDSILKSLKTLGYQNVYes-----hlKERIEPNLEe--------AST------------SYTIPG 200 fission yeast 19113201 187 SNS--RLALVGTIQFVGSLNSIKDALQIQDEDgk-----ggFYVVIPQAK---------PLS------------PGEALG 238 fission yeast 7299937 151 ESIDrQVCVYLDIGYQHVYGEKLKKQLSEILEp--------KELLLELFP------------------------PIEAES 198 fruit fly 15231723 125 KSDK-PIMILYGLEYAHVIPQIREELGLSKTDsqlsvanvlCSFISPSKDpresmehprPYSesdssdslsssrSYRLGG 203 thale cress 10176920 177 SDVK-NIILAGTIQFTSAIRAVKPELEKQG-----------FNVLIPQSK---------PLS------------AGEVLG 223 thale cress 6226755 157 QLTAeHIVLLMDSCFSHEQEKVAAVIKEVLPGnr-----hvECSLLPSEDvl------kQNR------------QNIYLG 213 Caenorhabditis elegans 8247965 147 GKR---LVVVSTVQFIPSLQTLRTTFNKDDSs---------IRIDIPQCK---------PLS------------PGEVLG 193 Caenorhabditis elegans 30584261 144 DPKA-PVVLLSEPACAHALEALATLLRPRYLD---------LLVSSPAFPq--------PVGslsp-----epmPLERFG 200 synthetic construct 4503361 94 PAT--ALALVSTIQFVSTLQAAAQELKAE------------YRVSVPQCK---------PLS------------PGEILG 138 human 1723275 147 QNIL-LVSDTRWYYAQDSILKSLKTLGYQNVYes-----hlKERIEPNLEe--------AST------------SYTIPG 200 fission yeast 19113201 187 SNS--RLALVGTIQFVGSLNSIKDALQIQDEDgk-----ggFYVVIPQAK---------PLS------------PGEALG 238 fission yeast
416911 215 FHVPEDVDQvgVFEKNSVLFGqhdkaDNISPEDYHLFHLttpQDPRLLYLSTVFQSVHIFDPALPGMVTgpfpslmRRYK 294 baker's yeast 7299937 199 TTTRETTN----LERICIFIGa----DNQRFANLSLTAP---AAVQWHIYDGSSDSLSSKNPLTAQFIR-------RRYF 260 fruit fly 15231723 204 LTWDLPEGSk-IEDYLLFWIGs----DSSAFANVVLTFN----GCDIVRYDAEEDSLVTEFYQQRRILK-------RRYY 267 thale cress 10176920 224 CTAPKVKTVedCKDQVLVFVA-----DGRFHLEAFMIAN---PKIKAFRYDPYLGKLFLEEYDHKGMRE-------TRMR 288 thale cress 6226755 214 REIPSCLRN--NQPTDLIFCG-----FPNSPLLPIWLLSy-pSCSTVSHFNPINKTIQHESTRSSRLLR-------KRLF 278 Caenorhabditis elegans 8247965 194 CTSPRLDA---SKYDAIVYLG-----DGRFHLESIMIHN---PEIEAFQYDPYSRKLTREFYDHDLMRK-------NRIG 255 Caenorhabditis elegans 30584261 201 RRFPLAPGRrlEEYGAFYVGGskaspDPDLDPDLSRLLLgwaPGQPFSSCCPDTGKTQDEGARAGRLRA-------RRRY 273 synthetic construct 4503361 139 CTSPRLS----KEVEAVVYLG-----DGRFHLESVMIAN---PNVPAYRYDPYSKVLSREHYDHQRMQA-------ARQE 199 human 1723275 201 RTYSLPKSLs-LQDMTLLYIG------PDSPTLSSILMShysLVNQFLSFDPLSNKIVEESSFTGAKLR-------RRYA 266 fission yeast 19113201 239 CTSPYIEK---GSVDALIYIG-----DGRFHLESVMIAN---PDLPAYRYDPYSHKLSIESYAHEEMKS-------IRYS 300 fission yeast 7299937 199 TTTRETTN----LERICIFIGa----DNQRFANLSLTAP---AAVQWHIYDGSSDSLSSKNPLTAQFIR-------RRYF 260 fruit fly 15231723 204 LTWDLPEGSk-IEDYLLFWIGs----DSSAFANVVLTFN----GCDIVRYDAEEDSLVTEFYQQRRILK-------RRYY 267 thale cress 10176920 224 CTAPKVKTVedCKDQVLVFVA-----DGRFHLEAFMIAN---PKIKAFRYDPYLGKLFLEEYDHKGMRE-------TRMR 288 thale cress 6226755 214 REIPSCLRN--NQPTDLIFCG-----FPNSPLLPIWLLSy-pSCSTVSHFNPINKTIQHESTRSSRLLR-------KRLF 278 Caenorhabditis elegans 8247965 194 CTSPRLDA---SKYDAIVYLG-----DGRFHLESIMIHN---PEIEAFQYDPYSRKLTREFYDHDLMRK-------NRIG 255 Caenorhabditis elegans 30584261 201 RRFPLAPGRrlEEYGAFYVGGskaspDPDLDPDLSRLLLgwaPGQPFSSCCPDTGKTQDEGARAGRLRA-------RRRY 273 synthetic construct 4503361 139 CTSPRLS----KEVEAVVYLG-----DGRFHLESVMIAN---PNVPAYRYDPYSKVLSREHYDHQRMQA-------ARQE 199 human 1723275 201 RTYSLPKSLs-LQDMTLLYIG------PDSPTLSSILMShysLVNQFLSFDPLSNKIVEESSFTGAKLR-------RRYA 266 fission yeast 19113201 239 CTSPYIEK---GSVDALIYIG-----DGRFHLESVMIAN---PDLPAYRYDPYSHKLSIESYAHEEMKS-------IRYS 300 fission yeast
416911 295 YMHVARTAGCIGILVNTLSLRNTRETINELVKLIKTREKKHYLFVVGKPNVAKLANFED-IDIWCILGCSQsgIIVDQFN 373 baker's yeast 7299937 261 HIEKCKDAQTLGLIVATLSAEGYLDVVTRLQTMAKGRGIKTQLISVGRINPAKLANFLE-IDCFVLIGCPF--NNMYDSK 337 fruit fly 15231723 268 LVEKAKDANIIGILVGTLGVAGYLHMIHHMQALISAAGKKSYILAMGRPNPAKLANFPE-CDVFIYISCAQ--TALLDSK 344 thale cress 10176920 289 AIARAREAKTWGIVLGTLGRQGNPKILERLEKKMMEKGIDSTVVLMSELSPTRVALFEDsVDAWVQIACPR--LSIDWGE 366 thale cress 6226755 279 LVEKLKDADTVGLVVGSVGVDKHREAVKRMREMCKKAGKKIYVISVGKINVPKLSNFSTdIDVFVLLSCPFg--VVLDSS 356 Caenorhabditis elegans 8247965 256 SIEIARKCTTFGLIQGTLGRQGNLKVVEELEAQLERKGKKFLRVLLSEIFPEKLAMFPE-VDCWVQVACPR--LSIDWGT 332 Caenorhabditis elegans 30584261 274 LVERARDARVVGLLAGTLGVAQHREALAHLRNLTQAAGKRSYVLALGRPTPAKLANFPE-VDVFVLLACPLgaLAPQLSG 352 synthetic construct 4503361 200 AIATARSAKSWGLILGTLGRQGSPKILEHLESRLRALGLSFVRLLLSEIFPSKLSLLPE-VDVWVQVACPR--LSIDWGT 276 human 1723275 267 LVQRCRDAGVIGIVIGTLGVHRYLHVLNQLRKMILNAGKKPYMLAVGKLNPAKLANFQE-IECFVLIACGE--NSLIDSK 343 fission yeast 19113201 301 AVEKARTAKKFGLIQGTLGRQGSPKVLENLKNTLRKNNKDFVCVLMSEIFPSRLGQFSD-IDAWIQVACPR--LSIDWGY 377 fission yeast 7299937 261 HIEKCKDAQTLGLIVATLSAEGYLDVVTRLQTMAKGRGIKTQLISVGRINPAKLANFLE-IDCFVLIGCPF--NNMYDSK 337 fruit fly 15231723 268 LVEKAKDANIIGILVGTLGVAGYLHMIHHMQALISAAGKKSYILAMGRPNPAKLANFPE-CDVFIYISCAQ--TALLDSK 344 thale cress 10176920 289 AIARAREAKTWGIVLGTLGRQGNPKILERLEKKMMEKGIDSTVVLMSELSPTRVALFEDsVDAWVQIACPR--LSIDWGE 366 thale cress 6226755 279 LVEKLKDADTVGLVVGSVGVDKHREAVKRMREMCKKAGKKIYVISVGKINVPKLSNFSTdIDVFVLLSCPFg--VVLDSS 356 Caenorhabditis elegans 8247965 256 SIEIARKCTTFGLIQGTLGRQGNLKVVEELEAQLERKGKKFLRVLLSEIFPEKLAMFPE-VDCWVQVACPR--LSIDWGT 332 Caenorhabditis elegans 30584261 274 LVERARDARVVGLLAGTLGVAQHREALAHLRNLTQAAGKRSYVLALGRPTPAKLANFPE-VDVFVLLACPLgaLAPQLSG 352 synthetic construct 4503361 200 AIATARSAKSWGLILGTLGRQGSPKILEHLESRLRALGLSFVRLLLSEIFPSKLSLLPE-VDVWVQVACPR--LSIDWGT 276 human 1723275 267 LVQRCRDAGVIGIVIGTLGVHRYLHVLNQLRKMILNAGKKPYMLAVGKLNPAKLANFQE-IECFVLIACGE--NSLIDSK 343 fission yeast 19113201 301 AVEKARTAKKFGLIQGTLGRQGSPKVLENLKNTLRKNNKDFVCVLMSEIFPSRLGQFSD-IDAWIQVACPR--LSIDWGY 377 fission yeast
416911 374 EFYKPIITPYELNLALSEEvTWTGKWVVDFRDAIDEIEqNLGGQDTisastts----depefdVVRGRYTSTSRPLRALT 449 baker's yeast 7299937 338 EYYKPIVSVFEAEMALNP--AWHMRYPEAYVTDFKQLLpEGRSFLP-----------------FDAADIPENDVSLVSGR 398 fruit fly 15231723 345 EFMSPVITPFEANLAFSRGsEWTGAYLMHFQDVINSVK-SESEAHIgseeprfsffqggyvedHKTNDQAKNGEEDTGET 423 thale cress 10176920 367 AFLKPLLTTFEAEIALGFIrGWWENDSSSRVNSSSGCC-KEDKETScacknenvkddkkdndgALDGDYPMDYYAQEGGE 445 thale cress 6226755 357 DYFRPVVSYFEAEIALNPAkTWAADFGWSAEFAAFLEDkIETEVPD---------------------DKAAGDFSLISGK 415 Caenorhabditis elegans 8247965 333 QFPKPLLYPFELAVALDNI-SVPS----DH--------------------------------------WPMDYYSNDSLG 369 Caenorhabditis elegans 30584261 353 SFFQPILAPCELEAACNP--AWPPPGLAPHLTHYADLL-PGSPFHValp-----------ppeSELWETPDVSLITGDLR 418 synthetic construct 4503361 277 ASPKPLLTPYEAAVALRDI-SWQQ----P---------------------------------------YPMDFYAGSSLG 312 human 1723275 344 EFYRPIVTPFELVKALSSDmSWNNDFILSFDEVLKLSEgKQSKEPSevlteesaephfslitgKFVNSTPMRHLDVTLET 423 fission yeast 19113201 378 AFPAPLLTPYEASAAFN---VVPWKEV-----------------------------------------YPMDFYATNSLG 413 fission yeast 7299937 338 EYYKPIVSVFEAEMALNP--AWHMRYPEAYVTDFKQLLpEGRSFLP-----------------FDAADIPENDVSLVSGR 398 fruit fly 15231723 345 EFMSPVITPFEANLAFSRGsEWTGAYLMHFQDVINSVK-SESEAHIgseeprfsffqggyvedHKTNDQAKNGEEDTGET 423 thale cress 10176920 367 AFLKPLLTTFEAEIALGFIrGWWENDSSSRVNSSSGCC-KEDKETScacknenvkddkkdndgALDGDYPMDYYAQEGGE 445 thale cress 6226755 357 DYFRPVVSYFEAEIALNPAkTWAADFGWSAEFAAFLEDkIETEVPD---------------------DKAAGDFSLISGK 415 Caenorhabditis elegans 8247965 333 QFPKPLLYPFELAVALDNI-SVPS----DH--------------------------------------WPMDYYSNDSLG 369 Caenorhabditis elegans 30584261 353 SFFQPILAPCELEAACNP--AWPPPGLAPHLTHYADLL-PGSPFHValp-----------ppeSELWETPDVSLITGDLR 418 synthetic construct 4503361 277 ASPKPLLTPYEAAVALRDI-SWQQ----P---------------------------------------YPMDFYAGSSLG 312 human 1723275 344 EFYRPIVTPFELVKALSSDmSWNNDFILSFDEVLKLSEgKQSKEPSevlteesaephfslitgKFVNSTPMRHLDVTLET 423 fission yeast 19113201 378 AFPAPLLTPYEASAAFN---VVPWKEV-----------------------------------------YPMDFYATNSLG 413 fission yeast
416911 450 HLELEAADDDDSkqlttrhtasgAVIKGTVSTSasaLQNRSWKGLgsdfDSTEVDNTGADIEEGISGVARGYGFD 524 baker's yeast 7299937 399 LRGAVNDSLETGgdpaslalatqAKMALMTTDTglsFEDRTWQGL----DPALGQTEPAKLQQGLSGIPINYSHQ 469 fruit fly 15231723 424 MTLVQAAEKALQlrgndhnsltkQTAAKSGPEY---FLNRVYRGL----EINSENTLPEPYIVGRSGKASGYKHE 491 thale cress 10176920 446 ----WNSS----------------------------YLKKSSRP-----IRRNPLPSSVV--------------- 468 thale cress 6226755 416 VRVQKTEEEKNG-----------DGPSSVAIYNpgyCNDRTWKGLn---DGVSTAEDSTKMGEGRSGIAQGYSGK 476 Caenorhabditis elegans 8247965 370 -P--WTNN--------------------NE-------ANRPKRE------KRKPHIVVRTEAS------------ 396 Caenorhabditis elegans 30584261 419 PPPAWKSSNDHGslaltprpqleLAESSPAASF---LSSRSWQGL----EPRLGQTPVTEAVSGRRGIAIAYEDE 486 synthetic construct 4503361 313 -P--WTVNHGQ-------------DRRPHAPGR---PARGKVQEG----SARPPSAVACEDCSCRDEKVAPLAP- 363 human 1723275 424 ADAKNNDSSSASiekrgmrslavNGVYSPAAAF---LQSKSWSGL----DSVDEGEGPSKLYEGQSGIAKGYVGE 491 fission yeast 19113201 414 -N--WTPN------------------------------NPENRPL----PNRKKTGPVSS--------------- 436 fission yeast 7299937 399 LRGAVNDSLETGgdpaslalatqAKMALMTTDTglsFEDRTWQGL----DPALGQTEPAKLQQGLSGIPINYSHQ 469 fruit fly 15231723 424 MTLVQAAEKALQlrgndhnsltkQTAAKSGPEY---FLNRVYRGL----EINSENTLPEPYIVGRSGKASGYKHE 491 thale cress 10176920 446 ----WNSS----------------------------YLKKSSRP-----IRRNPLPSSVV--------------- 468 thale cress 6226755 416 VRVQKTEEEKNG-----------DGPSSVAIYNpgyCNDRTWKGLn---DGVSTAEDSTKMGEGRSGIAQGYSGK 476 Caenorhabditis elegans 8247965 370 -P--WTNN--------------------NE-------ANRPKRE------KRKPHIVVRTEAS------------ 396 Caenorhabditis elegans 30584261 419 PPPAWKSSNDHGslaltprpqleLAESSPAASF---LSSRSWQGL----EPRLGQTPVTEAVSGRRGIAIAYEDE 486 synthetic construct 4503361 313 -P--WTVNHGQ-------------DRRPHAPGR---PARGKVQEG----SARPPSAVACEDCSCRDEKVAPLAP- 363 human 1723275 424 ADAKNNDSSSASiekrgmrslavNGVYSPAAAF---LQSKSWSGL----DSVDEGEGPSKLYEGQSGIAKGYVGE 491 fission yeast 19113201 414 -N--WTPN------------------------------NPENRPL----PNRKKTGPVSS--------------- 436 fission yeast
Lu S et al.(2020). "CDD/SPARCLE: the conserved domain database in 2020.",