417572 21 FQSTSSGS----SNGNFFLRHWKLLSVIGSFTAGVAIYDMSDVrSFIHGRIEMPLFHAFTTPEFSHRVAILAASWGITPK 96 fission yeast 7299059 8 NAKNATR-----RVGRLRS---LGIVTVGGAALVAGITAYKNQdQLFRT--FVMPAVRLLPAEASHQLAVLACKYRLCPV 77 fruit fly 10177819 37 GASSAPKVphfsKRGRILTGATIGLAIAGGAYVSTADEATFCG-WLFNATKVVNPFFALLDAEFAHKLAVSAAARGWVPR 115 thale cress 17509475 1 MSQNAEQKyiysKLPPGAISKSTVIVLATGIASYTALELLYGS-ETFYKKAVMPMVHKFVDGEDSHRWAVRAASWGLLPR 79 Caenorhabditis elegans 131723 -------------------------------------------------------------------------------- baker's yeast 2507279 2 LPWRHLQKr----------AQDAVIILGGGGLLFASYLMATGD-ERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPR 70 human 7299059 8 NAKNATR-----RVGRLRS---LGIVTVGGAALVAGITAYKNQdQLFRT--FVMPAVRLLPAEASHQLAVLACKYRLCPV 77 fruit fly 10177819 37 GASSAPKVphfsKRGRILTGATIGLAIAGGAYVSTADEATFCG-WLFNATKVVNPFFALLDAEFAHKLAVSAAARGWVPR 115 thale cress 17509475 1 MSQNAEQKyiysKLPPGAISKSTVIVLATGIASYTALELLYGS-ETFYKKAVMPMVHKFVDGEDSHRWAVRAASWGLLPR 79 Caenorhabditis elegans 131723 -------------------------------------------------------------------------------- baker's yeast 2507279 2 LPWRHLQKr----------AQDAVIILGGGGLLFASYLMATGD-ERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPR 70 human
417572 97 DRVADDPSLAVE--VWGKKFCNPIGLAAGFD-KQADAISGLLN-FGFSYLEIGSVTPKPQPGNPKPRYFRLKPDLSVINR 172 fission yeast 7299059 78 SQYHDDQNLHTS--FFGRMLSNPIGIAAGFD-KNAEAVDGLQD-LGFGFIEVGTVTPAAQEGNPKPRVFRLTEDKAIINR 153 fruit fly 10177819 116 EKRPDPAILGLE--VWGRKFSNPIGLAAGFD-KNAEATEGLLG-MGFGFVEVGSVTPVPQEGNPKPRIFRLSQEGAIINR 191 thale cress 17509475 80 FGWNRKEYPELKceLFGREFKNPIGLAAGFD-KDGQAITQLAKnSGFGLIEIGSVTPIPQPGNNRPRVFRLLEDEGVINR 158 Caenorhabditis elegans 131723 1 ----MTASLTTK--FLNNTYENPFMNASGVHcMTTQELDELAN-SKAGAFITKSATTLEREGNPEPRYISVP--LGSINS 71 baker's yeast 2507279 71 ARFQDSDMLEVR--VLGHKFRNPVGIAAGFD-KHGEAVDGLYK-MGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINR 146 human 7299059 78 SQYHDDQNLHTS--FFGRMLSNPIGIAAGFD-KNAEAVDGLQD-LGFGFIEVGTVTPAAQEGNPKPRVFRLTEDKAIINR 153 fruit fly 10177819 116 EKRPDPAILGLE--VWGRKFSNPIGLAAGFD-KNAEATEGLLG-MGFGFVEVGSVTPVPQEGNPKPRIFRLSQEGAIINR 191 thale cress 17509475 80 FGWNRKEYPELKceLFGREFKNPIGLAAGFD-KDGQAITQLAKnSGFGLIEIGSVTPIPQPGNNRPRVFRLLEDEGVINR 158 Caenorhabditis elegans 131723 1 ----MTASLTTK--FLNNTYENPFMNASGVHcMTTQELDELAN-SKAGAFITKSATTLEREGNPEPRYISVP--LGSINS 71 baker's yeast 2507279 71 ARFQDSDMLEVR--VLGHKFRNPVGIAAGFD-KHGEAVDGLYK-MGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINR 146 human
417572 173 YGFNSIGHDAILAKIQKrvrKYIAKTSPQLLKqfdanpasctdpavlgvprslipnkfLGINLGKNK-NGNEIEDYVEGV 251 fission yeast 7299059 154 YGFNSDGHQAVLQRL------RLLRKKENFNg-------------------------vVGVNLGRNKtTMSPIADYVQGV 202 fruit fly 10177819 192 CGFNSEGIVVVAKRLGAqhgKRMLAETSATSSspsddvkp----------ggksgpgiLGVNLGKNKtSEDAAADYVQGV 261 thale cress 17509475 159 YGFNSDGVGRVHQRVRS---ARDSWVPESYAY--------------------------FGVNLGKNKlTEDAKLDYEIGV 209 Caenorhabditis elegans 131723 72 MGLPNEGIDYYLSYVLN----RQKNYPDAPA-----------------------------IFFSVAGmSIDENLNLLRKI 118 baker's yeast 2507279 147 YGFNSHGLSVVEHRLRAr-qQKQAKLTEDGLP--------------------------LGVNLGKNKtSVDAAEDYAEGV 199 human 7299059 154 YGFNSDGHQAVLQRL------RLLRKKENFNg-------------------------vVGVNLGRNKtTMSPIADYVQGV 202 fruit fly 10177819 192 CGFNSEGIVVVAKRLGAqhgKRMLAETSATSSspsddvkp----------ggksgpgiLGVNLGKNKtSEDAAADYVQGV 261 thale cress 17509475 159 YGFNSDGVGRVHQRVRS---ARDSWVPESYAY--------------------------FGVNLGKNKlTEDAKLDYEIGV 209 Caenorhabditis elegans 131723 72 MGLPNEGIDYYLSYVLN----RQKNYPDAPA-----------------------------IFFSVAGmSIDENLNLLRKI 118 baker's yeast 2507279 147 YGFNSHGLSVVEHRLRAr-qQKQAKLTEDGLP--------------------------LGVNLGKNKtSVDAAEDYAEGV 199 human
417572 252 RTFGNFADILVINVSSPNTPGLRNLQKKSALSTLLTAVVSERNKLNSPHP---PVLVKIAPDLNEEELTDIADVL--KKC 326 fission yeast 7299059 203 RVFGPVADYLVINVSSPNTKGLRDMQSKEKLRELLEQVNDTKSSLDKNKNv--PILLKLSPDLSLDDMKDIVWVIkrKKS 280 fruit fly 10177819 262 HNLSQYADYLVINVSSPNTAGLRMLQGRKQLKDLVKKVQAARDEMQWGDEgppPLLVKIAPDLSRGELEDIAAVA--LAL 339 thale cress 17509475 210 NYFAPHCDYLVLNVSSPNTPGLRSMQKKSDLEKLLAYVHQALEMHKLEKQp--QVFLKIAPDLIESELKDIAQVVtnKKF 287 Caenorhabditis elegans 131723 119 QDS-EFNGITELNLSCPNVPGKPQVAYDFDLTKETLEKVFAFFKKPLGVKl-pPYFDFAHFDIMAKILNEFPLAY----V 192 baker's yeast 2507279 200 RVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRp--AVLVKIAPDLTSQDKEDIASVV--KEL 275 human 7299059 203 RVFGPVADYLVINVSSPNTKGLRDMQSKEKLRELLEQVNDTKSSLDKNKNv--PILLKLSPDLSLDDMKDIVWVIkrKKS 280 fruit fly 10177819 262 HNLSQYADYLVINVSSPNTAGLRMLQGRKQLKDLVKKVQAARDEMQWGDEgppPLLVKIAPDLSRGELEDIAAVA--LAL 339 thale cress 17509475 210 NYFAPHCDYLVLNVSSPNTPGLRSMQKKSDLEKLLAYVHQALEMHKLEKQp--QVFLKIAPDLIESELKDIAQVVtnKKF 287 Caenorhabditis elegans 131723 119 QDS-EFNGITELNLSCPNVPGKPQVAYDFDLTKETLEKVFAFFKKPLGVKl-pPYFDFAHFDIMAKILNEFPLAY----V 192 baker's yeast 2507279 200 RVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRp--AVLVKIAPDLTSQDKEDIASVV--KEL 275 human
417572 327 KIDGVIVGNTTVQRPKTLKSTSHVEETGGLSGPPLKPIALNTLRTLRKHLSSDIPIIGCGGISSGKDAIEYARAGATMVQ 406 fission yeast 7299059 281 RVDGLIVSNTTVSR-ENIEKNKLAEETGGLSGPPLKARSTEMIAQMYQLTDGKIPIIGVGGVASGYDAYEKIEAGASYVQ 359 fruit fly 10177819 340 HLDGLIISNTTVSRPDAVSNNPVATETGGLSGKPLFALSTNMLRDMYTLTRGKIPLIGCGGVSSGEDAYKKIRAGATLVQ 419 thale cress 17509475 288 AIDGIIVSNTTIAR-PDYLRSENKTETGGLSGAPVREISTECVRKIYKLTNGQIPIIGCGGVFSGADAYEKIRAGASLVQ 366 Caenorhabditis elegans 131723 193 NSINSIGNGLFIDVEKESVVVKPKNGFGGIGGEYVKPTALANVRAFYTRLRPEIKVIGTGGIKSGKDAFEHLLCGASMLQ 272 baker's yeast 2507279 276 GIDGLIVTNTTVSR-PAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQ 354 human 7299059 281 RVDGLIVSNTTVSR-ENIEKNKLAEETGGLSGPPLKARSTEMIAQMYQLTDGKIPIIGVGGVASGYDAYEKIEAGASYVQ 359 fruit fly 10177819 340 HLDGLIISNTTVSRPDAVSNNPVATETGGLSGKPLFALSTNMLRDMYTLTRGKIPLIGCGGVSSGEDAYKKIRAGATLVQ 419 thale cress 17509475 288 AIDGIIVSNTTIAR-PDYLRSENKTETGGLSGAPVREISTECVRKIYKLTNGQIPIIGCGGVFSGADAYEKIRAGASLVQ 366 Caenorhabditis elegans 131723 193 NSINSIGNGLFIDVEKESVVVKPKNGFGGIGGEYVKPTALANVRAFYTRLRPEIKVIGTGGIKSGKDAFEHLLCGASMLQ 272 baker's yeast 2507279 276 GIDGLIVTNTTVSR-PAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQ 354 human
417572 407 VYTALGYDGPVIAHKIKQEILAELKGK---RWVDIIGKEE 443 fission yeast 7299059 360 IYTALVYEGPALVEDIKAELSALITRLghtNVADVVGTNS 399 fruit fly 10177819 420 LYTGFAYGGPALIPQIKVSPSP------------------ 441 thale cress 17509475 367 LYSAFVYEGFPVIGKIKRELVELLRKDgfsHVSEAIGADH 406 Caenorhabditis elegans 131723 273 IGTELQKEGVKIFERIEKELKDIMEAKgytSIDQFRGKLN 312 baker's yeast 2507279 355 LYTALTFWGPPVVGKVKRELEALLKEQgfgGVTDAIGADH 394 human 7299059 360 IYTALVYEGPALVEDIKAELSALITRLghtNVADVVGTNS 399 fruit fly 10177819 420 LYTGFAYGGPALIPQIKVSPSP------------------ 441 thale cress 17509475 367 LYSAFVYEGFPVIGKIKRELVELLRKDgfsHVSEAIGADH 406 Caenorhabditis elegans 131723 273 IGTELQKEGVKIFERIEKELKDIMEAKgytSIDQFRGKLN 312 baker's yeast 2507279 355 LYTALTFWGPPVVGKVKRELEALLKEQgfgGVTDAIGADH 394 human
Lu S et al.(2020). "CDD/SPARCLE: the conserved domain database in 2020.",