729924 6 YALTDLIESDPRFESLKTRLAGYtkgsdeyieelysQLPLTS--------------YPRYKTFLKKQAVAISNPDNEAGf 71 baker's yeast 7298130 1 --------------------------------------------------------MSTIDALYNRPGPNRLRQADAYR- 23 fruit fly 7298132 1 --------------------------------------------------------------------MNDLKPATSYR- 11 fruit fly 17564090 1 ----------------------------------------------------------MVQKKMLTHPELFSRLVDGPE- 21 Caenorhabditis elegans 19074698 1 ----------------------------------------------------------------------MDMASRIRVt 10 Encephalitozoon cun... 19074700 13 GILMGRVRFMVIAPFFITTMVLCaapfneklksnteHGSASIkngdakaseksavaNHGKAEGNKVLNCHEDMTSRIRVt 92 Encephalitozoon cun... 14424532 1 MPRNSGAGYGCPHGDPSMLDSREtpqesrqdmivrtTQEKLKtssltdrqplskesLNHALELSVPEKVNNAQWDAPEEa 80 human 21359960 1 -----------------------------------------------------mtgTPKTQEGAKDLEVDMNKTEVTPRl 27 human 27477105 1 ---------------------mprnsgagygcphgdpsmldsretpqesrqdmivrttqeklktssltdrqplskeslnh 59 human 12053213 1 -----------------------------------------------------mtgTPKTQEGAKDLEVDMNKTEVTPRl 27 human
729924 72 --SSIYRSSLSS----ENLVSCVDKNLRTAYDHFMFSARRWPQRDCLGSRPIDKatgtWEETFRFESYSTVSKRCHNIGS 145 baker's yeast 7298130 24 --TTNRQDAVKIrmakDG--IG-AEEPISVPGLLKRTVNNYGDYPALRTKN-------GKNGYHTVTYKQYEQKVHQVAK 91 fruit fly 7298132 12 --STSLHDAVKLrldePSSFSQ-TVPPQTIPEFFKESCEKYSDLPALVWETPGS----GNDGWTTLTFGEYQERVEQAAL 84 fruit fly 17564090 22 ---RIRESVQVP----KPITGCPDGITKTVWDVLTRSAQLNPNAPLFGESVN--------GRHVYTTYREAVEEATIIGS 86 Caenorhabditis elegans 19074698 11 -dDGSVQHVNY-----QKGIVCAPDGSKTILELLGARCASMGSDPFLGTIVG--------SEVKYRSAEDIWREAEGLAA 76 Encephalitozoon cun... 19074700 93 -dDGSVQHVNY-----QKGIVCAPDGSKTILELLGARCASMGSDPFLGTIVG--------SEVKYRSAEDIWREAEGLAA 158 Encephalitozoon cun... 14424532 81 lwTTRADGRVRLridpSCP-----QLPYTVHRMFYEALDKYGDLIALGFKR--------QDKWEHISYSQYYLLARRAAK 147 human 21359960 28 -wTTCRDGEVLLrlskHGP---GHETPMTIPEFFRESVNRFGTYPALASKN--------GKKWEILNFNQYYEACRKAAK 95 human 27477105 60 alelsvpekvnnaqwdapeealwttradgrvrlridpscpqlpytvhrmfyealdkygdlialgfkrqdkwehisysqyy 139 human 12053213 28 -wTTCRDGEVLLrlskHGP---GHETPMTIPEFFRESVNRFGTYPALASKN--------GKKWEILNFNQYYEACRKAAK 95 human
729924 146 GILsLVNTKrkrpleaNDFVVAILSHNNPEWILTDLACQAYSLTNTALYETLGPNTSEYILNLTEAPILIFAKSNMYHvl 225 baker's yeast 7298130 92 AFI-KLGLE-------EHHSVGVLAFNCAEWFYSAMGAIHARGIIAGIYTTNSADAVQHVLESSHAQIVVVDDAKQMD-- 161 fruit fly 7298132 85 MLL-SVGVE-------ERSSVGILAFNCPEWFFAEFGALRAGAVVAGVYPSNSAEAVHHVLATGESSVCVVDDAQQMA-- 154 fruit fly 17564090 87 GIVaIMQKNq-----sTNKLIGIAGIHSRKYMHTMHGISGFDLTTVPLYHQSKLETLCDIIDNCKLEIIFCENAKRAE-- 159 Caenorhabditis elegans 19074698 77 LFA-RLLAQ--------EDKVGIYSVNRYEWVVSEMASYMSGCINVPLYSTFSPADVRQILAETEMKVCVAS-ADKAQ-- 144 Encephalitozoon cun... 19074700 159 LFA-RLLAQ--------EDKVGIYSVNRYEWVVSEMASYMSGCINVPLYSTFSPADVRQILAETEMKVCVAS-ADKAQ-- 226 Encephalitozoon cun... 14424532 148 GFL-KLGLK-------QAHSVAILGFNSPEWFFSAVGTVFAGGIVTGIYTTSSPEACQYIAYDCCANVIMVDTQKQLE-- 217 human 21359960 96 SLI-KLGLE-------RFHGVGILGFNSAEWFITAVGAILAGGLCVGIYATNSAEACQYVITHAKVNILLVENDQQLQ-- 165 human 27477105 140 llarraakgflklglkqahsvailgfnspewffsavgtvfaggivtgiyttsspeacqyiaydccanviMVDTQKQLE-- 217 human 12053213 96 SLI-KLGLE-------RFHGVGILGFNSAEWFITAVGAILAGGLCVGIYATNSAEACQYVITHAKVNILLVENDQQLQ-- 165 human
729924 226 kmvpdmKFVNTLVCMDELTHDELRMLNESLLPVKCNSLNEKITFFSLEQVEQVG------CFNKIPaIPPTPDSLYTISF 299 baker's yeast 7298130 162 ------KIHAIRD--KLPKLKAAIQIQEPYSPYLKKEDG----YYRWSEIESMNvsd-veDQYMTRlENVAINECCCLVY 228 fruit fly 7298132 155 ------KLRAIKE--RLPRLKAVIQLHGPFEAFVDHEPG----YFSWQKLQEQTfsselkEELLAReSRIRANECAMLIF 222 fruit fly 17564090 160 ------GFLSSKLGDRLRSLKTLIILDKTTTLQKHDD----VEVMSLDEFKEIGk----rNKRNP--VKPKPETTYVICH 223 Caenorhabditis elegans 19074698 145 ------LLLETVLED-SKAGLSCIVLMDRDAGVAERLRNAGVLVYYFGDVVSSGd----kAGRKR---YPKGDDLATICY 210 Encephalitozoon cun... 19074700 227 ------LLLETVLED-SKAGLSCIVLMDRDAGVAERLRNAGVLVYYFGDVVSSGd----kAGRKR---YPKGDDLATICY 292 Encephalitozoon cun... 14424532 218 ------KILKIWK--QLPHLKAVVIYKEPP---PNKMAN----VYTMEEFMELGnev-peEALDAIiDTQQPNQCCVLVY 281 human 21359960 166 ------KILSIPQS-SLEPLKAIIQYRLP----MKKNNN----LYSWDDFMELGrsi-pdTQLEQViESQKANQCAVLIY 229 human 27477105 218 ------KILKIWK--QLPHLKAVVIYKEPP---PNKMAN----VYTMEEFMELGnev-peEALDAIiDTQQPNQCCVLVY 281 human 12053213 166 ------KILSIPQS-SLEPLKAIIQYRLP----MKKNNN----LYSWDDFMELGrsi-pdTQLEQViESQKANQCAVLIY 229 human
729924 300 TSGTTGLPKGVEMSHRNIASGIAFAFSTFRIPPDKRNQ-QLYDMCFLPLAHIFERMVIAYDL-AIGFGIGFLHkPDPTVL 377 baker's yeast 7298130 229 TSGTVGMPKGVMLSHDNITFDVR----GIVKAMDRVVVgAESIVSYLPLSHVAAQTVDIYTCaFVAGCIWFAD-KDALKG 303 fruit fly 7298132 223 TSGTVGMPKAVMLSHDNLVFDTK----SAAAHMQDIQVgKESFVSYLPLSHVAAQIFDVFLGlSHAGCVTFAD-KDALKG 297 fruit fly 17564090 224 TSGTTGRPKGVEMSHGSLVTSVSGIFTSWTIAYKWKFGlEDTYFSFLSLAHIYEHLIQTLTI-YFGGKIGIYD-GNTATL 301 Caenorhabditis elegans 19074698 211 TSGTSGSPKGVMLTHRNFVSCVAGISRGSRAGEMVEIGrDDVYLSYLPLAHVMERVCMNISM-ASGCRIVFFR-GNLKEI 288 Encephalitozoon cun... 19074700 293 TSGTSGSPKGVMLTHRNFVSCVAGISRGSRAGEMVEIGrDDVYLSYLPLAHVMERVCMNISM-ASGCRIVFFR-GNLKEI 370 Encephalitozoon cun... 14424532 282 TSGTTGNPKGVMLSQDNITWTARY--GSQAGDIRPAEVqQEVVVSYLPLSHIAAQIYDLWTGiQWGAQVCFAE-PDALKG 358 human 21359960 230 TSGTTGIPKGVMLSHDNITWIA----GAVTKDFK-LTDkHETVVSYLPLSHIAAQMMDIWVPiKIGALTYFAQ-ADALKG 303 human 27477105 282 TSGTTGNPKGVMLSQDNITWTARY--GSQAGDIRPAEVqQEVVVSYLPLSHIAAQIYDLWTGiQWGAQVCFAE-PDALKG 358 human 12053213 230 TSGTTGIPKGVMLSHDNITWIA----GAVTKDFK-LTDkHETVVSYLPLSHIAAQMMDIWVPiKIGALTYFAQ-ADALKG 303 human
729924 378 VED--LKILKPYAVALVPRILTRFEAGIKNALDKST-VQRNVANTILDSKS-ARftARGGPDKSi---mNFLVYHRVLID 450 baker's yeast 7298130 304 TLVksLQDARPTRFMGVPRVYEKFQERMVAVASSSGsLKKMLASWAKGITLkHYm-VSQGKSSgg---fRYKIAKSLIMS 379 fruit fly 7298132 298 TLIktFRKARPTKMFGVPRVFEKLQERLVAAEAKARpYSRLLLARARAAVAeHQttLMAGKSPSiygnaKYWLACRVVKP 377 fruit fly 17564090 302 IPQ--IQKLEPTIVSLVPRLLNKLYEAVHDGVAKKGfIARKLFDYAKKTKArQ---LQRGVLR------YDTFFDKIVFK 370 Caenorhabditis elegans 19074698 289 KED--YLVVRPTFIIAVPRVLNLFKEKIEEKVQQKNfAARCAFRGALWYKM-WR--VSKGELR-------SRFVDWLVFD 356 Encephalitozoon cun... 19074700 371 KED--YLVVRPTFIIAVPRVLNLFKEKIEEKVQQKNfAARCAFRGALWYKM-WR--VSKGELR-------SRFVDWLVFD 438 Encephalitozoon cun... 14424532 359 SLVntLREVEPTSHMGVPRVWEKIMERIQEVAAQSGfIRRKMLLWAMSVTLeQNl-TCPGSDLKp---fTTRLADYLVLA 434 human 21359960 304 TLVstLKEVKPTVFIGVPQIWEKIHEMVKKNSAKSMgLKKKAFVWARNIGFkVNskKMLGKYNTp---vSYRMAKTLVFS 380 human 27477105 359 SLVntLREVEPTSHMGVPRVWEKIMERIQEVAAQSGfIRRKMLLWAMSVTLeQNl-TCPGSDLKp---fTTRLADYLVLA 434 human 12053213 304 TLVstLKEVKPTVFIGVPQIWEKIHEMVKKNSAKSMgLKKKAFVWARNIGFkVNskKMLGKYNTp---vSYRMAKTLVFS 380 human
729924 451 KIRDSLGlSNNSFIITGSAPISKDTLLFLRSALDIGIRQGYGLTETFAGVCLSEPFEK-DVGSCGAIGISAECRL-KSVP 528 baker's yeast 7298130 380 KVKQALGfDRVLTLASAAAPMSPETKKYFLSLD-LKIVDAFGMSETA-GCHTICLPDSvGLNTIGKTLPGCESKF----- 452 fruit fly 7298132 378 -IREMIGvDNCRVFFTGGAPTSEELKQFFLGLD-IALGECYGMSETS-GAITLNV-DIsNLYSAGQACEGVTLKI----- 448 fruit fly 17564090 371 KLKLMLG-GKLKVLTSGGAPITKEVKTFTRYAYGCPLVEGYGQTECSAAGTLTLPWDT-TYGNVGGPAPWAQVKL-VDVP 447 Caenorhabditis elegans 19074698 357 RIAKEFG-GRINRILCGSAPLRREVLVYMQAVLSCRIFQGYGQTENVGAGIVQPLDSR-VYDNVGIPFPANEVNLgEIPE 434 Encephalitozoon cun... 19074700 439 RIAKEFG-GRINRILCGSAPLRREVLVYMQAVLSCRIFQGYGQTENVGAGIVQPLDSR-VYDNVGIPFPANEVNLgEIPE 516 Encephalitozoon cun... 14424532 435 KVRQALGfAKCQKNFYGAAPMMAETQHFFLGLN-IRLYAGYGLSETS-GPHFMSSPYNyRLYSSGKLVPGCRVKL----- 507 human 21359960 381 KVKTSLGlDHCHSFISGTAPLNQETAEFFLSLD-IPIGELYGLSESS-GPHTISNQNNyRLLSCGKILTGCKNML----- 453 human 27477105 435 KVRQALGfAKCQKNFYGAAPMMAETQHFFLGLN-IRLYAGYGLSETS-GPHFMSSPYNyRLYSSGKLVPGCRVKL----- 507 human 12053213 381 KVKTSLGlDHCHSFISGTAPLNQETAEFFLSLD-IPIGELYGLSESS-GPHTISNQNNyRLLSCGKILTGCKNML----- 453 human
729924 529 EMGYHADKDl----KGELQIRGPQVFERYFKNPNETSKAVDQDGWFSTGDVAFIDG-KGRISVIDRVKNFFKLAHGEYIA 603 baker's yeast 7298130 453 -INKDANGH------GELCIRGRHVFMGYIDNKEKTEESLDDDCWLHSGDLGFVDD-KGYVSLTGRSKEIIITAGGENIP 524 fruit fly 7298132 449 -HEPDCNGQ------GEILMRGRLVFMGYLGLPDKTEETVKEDGWLHSGDLGYIDP-KGNLIISGRLKELIITAGGENIP 520 fruit fly 17564090 448 EKNYFSMND-----EGEVCFRGNAMMTGYFQDPELTAKTIDSEGWLHTGDIGKWLP-TGGLQIIDRKNEMFKLSQGDFVS 521 Caenorhabditis elegans 19074698 435 ELGSEYMRRypgcrVGEILLRGDNVTQGYYKRPKETGQLFTKDGWLRTGDIGMFDSsAGVFSVIGRVKDGFKTSQGEYID 514 Encephalitozoon cun... 19074700 517 ELGSEYMRRypgcrVGEILLRGDNVTQGYYKRPKETGQLFTKDGWLRTGDIGMFDSsAGVFSVIGRVKDGFKTSQGEYID 596 Encephalitozoon cun... 14424532 508 -VNQDAEGI------GEICLWGRTIFMGYLNMEDKTCEAIDEEGWLHTGDAGRLDA-DGFLYITGRLKELIITAGGENVP 579 human 21359960 454 -FQQNKDGI------GEICLWGRHIFMGYLESETETTEAIDDEGWLHSGDLGQLDG-LGFLYVTGHIKEILITAGGENVP 525 human 27477105 508 -VNQDAEGI------GEICLWGRTIFMGYLNMEDKTCEAIDEEGWLHTGDAGRLDA-DGFLYITGRLKELIITAGGENVP 579 human 12053213 454 -FQQNKDGI------GEICLWGRHIFMGYLESETETTEAIDDEGWLHSGDLGQLDG-LGFLYVTGHIKEILITAGGENVP 525 human
729924 604 PEKIENIYLSsCPYITQIFVFGDPLKTFLVGIVGVDVDAAQPILAaKHpEVKtWTKEVLVENLNRNKKLRKEFLNKIn-- 681 baker's yeast 7298130 525 PVHIENTIKK-ELDAISNAFLVGEQRKYLTVLITLKTEVDKDSGEpLD-ELS-HESSVWVKSLGVEHKTVSDILAAGpcp 601 fruit fly 7298132 521 PVHIEELIKK-ELPCVSNVLLIGDHRKYLTVLLSLKTKCDAKTGIpLD-ALR-EETIEWLRDLDIHETRLSELLNIPadl 597 fruit fly 17564090 522 PIQIEAIYAN-SPLITQIYVTGKTERSFLVGIVVLDLPRFKQLPLvKA-LDGkESIEMIMENKEVKNAVIAELNKYA--- 596 Caenorhabditis elegans 19074698 515 PEKLEVLYAD-GDVVQDVCIPRRSDSDRIVAIVVC-PETKKSDAEiLA-HVR-ETGEKLFKQRRITRLEIPWRVVVL--- 587 Encephalitozoon cun... 19074700 597 PEKLEVLYAD-GDVVQDVCIPRRSDSDRIVAIVVC-PETKKSDAEiLA-HVR-ETGEKLFKQRRITRLEIPWRVVVL--- 669 Encephalitozoon cun... 14424532 580 PVPIEEAVKM-ELPIISNAMLIGDQRKFLSMLLTLKCTLDPDTSDqTD-NLT-EQAVEFCQRVGSRATTVSEIIEKKdea 656 human 21359960 526 PIPVETLVKK-KIPIISNAMLVGDKLKFLSMLLTLKCEMNQMSGEpLD-KLN-FEAINFCRDLDSQASTVTEIVKQQdpl 602 human 27477105 580 PVPIEEAVKM-ELPIISNAMLIGDQRKFLSMLLTLKCTLDPDTSDqTD-NLT-EQAMEFCQRVGSRATTVSEIIEKKdea 656 human 12053213 526 PIPVETLVKK-KIPIISNAMLVGDKLKFLSMLLTLKCEMNQMSGEpLD-KLN-FEAINFCRGLGSQASTVTEMVKQQdpl 602 human
729924 682 -------------------------------kCTDGLQGFEKLHNIKVGLEPLTLEDDVVTPTFKIKRAKASKFFKDTLD 730 baker's yeast 7298130 602 kvwks-------------------iedaikraNKQSISNAQKVQKFTILPHDFSIPTGELGPTLKVKRNVVSKMYADEIE 662 fruit fly 7298132 598 qlpndtaalaatleitakpklleaieegikraNKYAISNAQKVQKFALIAHEFSVATGELGPTLKIRRNIVHAKYAKVIE 677 fruit fly 17564090 597 --------------------------------KQNGLQTIELIRNVHLTLQEFTEENGLITSTLKNRRKILEDYFAPQIA 644 Caenorhabditis elegans 19074698 588 --------------------------------R----RGFESFEGADL------LTP-----TAKKRRPLIERYFSQEID 620 Encephalitozoon cun... 19074700 670 --------------------------------R----RGFESFEGADL------LTP-----TAKKRRPLIERYFSQEID 702 Encephalitozoon cun... 14424532 657 vyqai--------------------eegirrvNMNAAARPYHIQKWAILERDFSISGGELGPTMKLKRLTVLEKYKGIID 716 human 21359960 603 vykai--------------------qqginavNQEAMNNAQKIQKWVILEKDFSIYGGELGPMMKLKRHFVAQKYKKQID 662 human 27477105 657 vyqai--------------------eegirrvNMNAAARPYHIQKWAILERDFSISGGELGPTMKLKRLTVLEKYKGIID 716 human 12053213 603 vykai--------------------qqginavNQEAMNNAQRIEKWVILEKDFSIYGGELGPMMKLKRHFVAQKYKKQID 662 human
729924 731 QLYAEGSL 738 baker's yeast 7298130 663 KLYA---- 666 fruit fly 7298132 678 RLYK---- 681 fruit fly 17564090 645 KMYKEVEA 652 Caenorhabditis elegans 19074698 621 SLLGIK-- 626 Encephalitozoon cuniculi 19074700 703 SLLGIK-- 708 Encephalitozoon cuniculi 14424532 717 SFYQEQKM 724 human 21359960 663 HMYH---- 666 human 27477105 717 SFYQEQKM 724 human 12053213 663 HMYH---- 666 human
Jiyao W et al.(2023). "The conserved domain database in 2023.",