1BI8_A     8 RADQQ-------------------------YECVAE-IGEGAYGKVFKARDLKNGg----RFVALKRVRVQTGE---EG- 53  human
7302908   14 QAKKFgdgd------------------pfnYQELNI-IGEGAYGTVYRARDVITG-----NIVALKKVRISLNE---NG- 65  fruit fly
18409136  95 ALTALsylwatpgv-------apgffdmfvLAFVER-LFRPTFRKDDFVVGKKLGe---gSFGVVYKVSLSKKRsneEGe 163 thale cress
30696335  61 NVEEIddnpsvsledesahvmqfkwsdfriLDRVSIgHGGRADELVFEAIVQVPDsplfnQGVVLRKLNTTRAQr--RGr 138 thale cress
17551220  19 KMMNNmtcgqma-----------kpltmkdFQIHQA-LGKGAYGNVYRVRSLHDG-----KDYALKQIMISSKN---EG- 77  Caenorhabditis elegans
15718266  79 KFGNNgtiavvfsi-------fptgatpslTFLFQA-LGKGAYGNVYRVRSLHDG-----KDYALKQIMISSKN---EG- 141 Caenorhabditis elegans
16936533   1 MATSR-------------------------YEPVAE-IGVGAYGTVYKARDPHSG-----HFVALKSVRVPNGGgggGG- 48  human
1168867    1 MATSR-------------------------YEPVAE-IGVGAYGTVYKARDPHSG-----HFVALKSVRVPNGGgggGG- 48  human
544107     1 --------------------mksvghfvpwLTDIRH-LTDGTISEVFVGERKNSK-----KLYVIKVQGLVFK-----R- 48  fission yeast
1170645    1 ----------------------------mkLDSIDI-THCQLVKSTRTARIYRSD------TYAIKCLALDFDI------ 39  baker's yeast

1BI8_A    54 -----MPLSTIREVAVLRHLETFEHp-nVVRLFDVCTVSRt----------DRETKLT-LVFEHVDQDLTTYLDKVPEP- 115 human
7302908   66 -----VPMSTLREISLLKQLNASNHa-nIVKLYEVCQFLEr----------DGQLLIL-LVFEHVEQDLSDLIDRLPKS- 127 fruit fly
18409136 164 yvlkkATEYGAVEIWMNERVRRACGnscADFVYGFLDKSSkkgpeywllwkYEGESTLaGLMQSKEFPYNVETIILGKVq 243 thale cress
30696335 139 ra-ieVFKKLVRRRLLYHSYSMQVHgyiTNNLSDDQYSFTlv---------hgCHGSFsIRHWLQQSDWIPTLEATLALd 208 thale cress
17551220  78 -----IPQSVLREITVMKHLARKAHp-nIISLKSVFHQLDp----------VRAILKInMIMERCDWDLHTFLRNIPR-- 139 Caenorhabditis elegans
15718266 142 -----IPQSVLREITVMKHLARKAHp-nIISLKSVFHQLDp----------VRAILKInMIMERCDWDLHTFLRNIPR-- 203 Caenorhabditis elegans
16936533  49 -----LPISTVREVALLRRLEAFEHp-nVVRLMDVCATSRt----------DREIKR---CFVESLSSVETLKPTSWAK- 108 human
1168867   49 -----LPISTVREVALLRRLEAFEHp-nVVRLMDVCATSRt----------DREIKVT-LVFEHVDQDLRTYLDKAPPP- 110 human
544107    49 -----PPHDAMRGKLILESIGHPH----IERIVDSFIDNEa--------------gSVyLITSFKSFVLSDVMDEIS--- 102 fission yeast
1170645   40 -----PPHNAKFEVSILNKLGNKCKh--ILPLLESKATDNndllllfpfeeMNLYEFMqMHYKRDRRKKNPYYDLLNPSi 112 baker's yeast

1BI8_A   116 ------------GVPT-----ETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTS------SGQI-KLADFGLAR--- 168 human
7302908  128 ------------GMSP-----PTIQRLSRELLTGVDFLHSHRIIHRDLKPQNLLVSS------QGHL-KIADFGLAK--- 180 fruit fly
18409136 244 dl--------pkGLERe---nKIIQTIMRQLLFALDGLHSTGIIHRDVKPQNIIFSEg-----SRSF-KIIDLGAAAdlr 306 thale cress
30696335 209 eesfrrvgddttGGPAvsrqlRLIRTLMRDILIGVNYLHSHGLAHTELRLENVHISPvdrhikVGILgNAADFNGDVpst 288 thale cress
17551220 140 ------------GVPE-----QQAKHVTAQIVRALDFLHTHSIIHRDLKPQNILLNR------DQTV-KLADFGLSK--- 192 Caenorhabditis elegans
15718266 204 ------------GVPE-----QQAKHVTAQIVRALDFLHTHSIIHRDLKPQNILLNR------DQTV-KLADFGLSK--- 256 Caenorhabditis elegans
16936533 109 ------------SLT----------------------------------------------------------------- 111 human
1168867  111 ------------GLPA-----ETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTS------GGTV-KLADFGLAR--- 163 human
544107   103 -------------IDT-------KCKIVLQISSALEYLEKHGILHRDIHPNNILLDSm-----NGPA-YLSDFSIAW--- 153 fission yeast
1170645  113 piva---dppvqKYTNqldvnRYSLSFFRQMVEGIAFLHENKIIHRDIKPQNIMLTNnts-tvSPKL-YIIDFGISYdma 187 baker's yeast

1BI8_A   169 ------------IYS-FQMA--------------------------------------------------------LTSV 179 human
7302908  181 ------------TYG-SEMK--------------------------------------------------------LTSV 191 fruit fly
18409136 307 ----------vgINYiPKEFlld--------------------------------------------------pryAAPE 326 thale cress
30696335 289 snaystmdrrqmMIAfDMRCvgfmmakmvlqelmdplifaklksflakgndpsslreffvttlntnsesgntgvqiLDRN 368 thale cress
17551220 193 ------------EYS-NTTA--------------------------------------------------------FTTL 203 Caenorhabditis elegans
15718266 257 ------------EYS-NTTA--------------------------------------------------------FTTL 267 Caenorhabditis elegans
16936533     --------------------------------------------------------------------------------     human
1168867  164 ------------IYS-YQMA--------------------------------------------------------LTPV 174 human
544107   154 ------------SKQhPGEEvq-----------------------------------------------------eLIPQ 168 fission yeast
1170645  188 n--------nsqTSAePMDS--------------------------------------------------------KVTD 203 baker's yeast

1BI8_A   180 VVTLW--Y------RAPEV-----------LLQS-S-YATPVDL--WSVGCIFAEMFR------------RKPLFRGSSD 224 human
7302908  192 VVTLW--Y------RAPEV-----------LLAQ-P-YNSTVDI--WSAACIIFEMFN------------RRALFPGTSE 236 fruit fly
18409136 327 QYIMS--T------QTPSApsapvaaalspVLWQmN-LPDRFDI--YSIGLIFLQMAFpslrsdsnliqfNRQLKRCDYD 395 thale cress
30696335 369 WGAGWhlLslliatRPSERiscldalkhpfLCGPrWrVAPSMDIirWGLGSTAVKISEeyiyr--mpqrqRLAHFIGLME 446 thale cress
17551220 204 VVTLW--Y------RSPEV-----------LLQS-Y-YNSTVDM--WALGCIVSEIYC------------RQPLFVGQNE 248 Caenorhabditis elegans
15718266 268 VVTLW--Y------RSPEV-----------LLQS-Y-YNSTVDM--WALGCIVSEIYC------------RQPLFVGQNE 312 Caenorhabditis elegans
16936533     --------------------------------------------------------------------------------     human
1168867  175 VVTLW--Y------RAPEV-----------LLQS-T-YATPVDM--WSVGCIFAEMFR------------RKPLFCGNSE 219 human
544107   169 IGTGH--Y------RAIET-----------LFGChS-YGHEVDR--WTFGILIAELFS------------NQALFDDGSS 214 fission yeast
1170645  204 ISTGI--Y------KAPEV-----------LFGVkC-YDGGVDV--WSLLIIISQWFQre--------tsRMGHVPAMID 253 baker's yeast

1BI8_A   225 ----------------------VDQLGKILDVIGLPGE------------------------------------EDWPRD 246 human
7302908  237 ----------------------KNQLDRIFELTGRPTE------------------------------------QQWPQT 258 fruit fly
18409136 396 ltawrk----------lvepraSADLRRGFELVDLDGG------------------------------------IGWELL 429 thale cress
30696335 447 mlnpypkpncwlellpgrwrllYSTGKHIGLTLRQPSTralignvhltitrasesinntslsftsdirftaitsKDWPHN 526 thale cress
17551220 249 ----------------------AEQLTDIFKKMGTPVG------------------------------------KDWPSE 270 Caenorhabditis elegans
15718266 313 ----------------------AEQLTDIFKKMGTPVG------------------------------------KDWPSE 334 Caenorhabditis elegans
16936533     --------------------------------------------------------------------------------     human
1168867  220 ----------------------ADQLGKIFDLIGLPPE------------------------------------DDWPRD 241 human
544107   215 egw----------------pseLRLTSSIIQTLGTPNP------------------------------------SMWPEL 242 fission yeast
1170645  254 dgsddm----------nsdgsdFRLICSIFEKLGIPSI------------------------------------QKWEEV 287 baker's yeast

1BI8_A   247 VALPRQAF------------HSKSAQPIEKFVTDIDE----------LGKDLLLKCLTFNP----------------AKR 288 human
7302908  259 ISVALEHF------------PQRHPKRPKDFCPHLCK----------YADDLLNKMLSYDL----------------HLR 300 fruit fly
18409136 430 TSMVRYKArqrisakaalahPYFDRQGLLALSVMQNLrmqyfratqqDYSEAANWVIQLMA----------------KNG 493 thale cress
30696335 527 KIGAAGKLqt--------lsQFRLIAGKRLYLKEEKKnigkfsmgepDAEEGLAEKLETEKwkkvvpfkefpsslpvAKL 598 thale cress
17551220 271 SVIARDSF------------PQYRPTNLKDLSPQMSK----------QAIEFVQQCLRYDH----------------SKR 312 Caenorhabditis elegans
15718266 335 SVIARDSF------------PQYRPTNLKDLSPQMSK----------QAIEFVQQCLRYDH----------------SKR 376 Caenorhabditis elegans
16936533     --------------------------------------------------------------------------------     human
1168867  242 VSLPRGAF------------PPRGPRPVQSVVPEMEE----------SGAQLLLEMLTFNP----------------HKR 283 human
544107   243 STFPDWNKf-----------IFHEYP-PKPWSEILPSvd-------tSIQYIVSHLVTYS------------------NR 285 fission yeast
1170645  288 AQHGSVDAfv---------gMFGADGDGKYVLDQEKDvq-------iSIVERNMPRLDEIAdv-------------kVKQ 338 baker's yeast

1BI8_A   289 ISAYSALSHPYFQDLERCKENLDSHLPPSQ 318 human
7302908  301 PSALACLEHDYFQQEPL------------- 317 fruit fly
18409136 494 TEKDGGFTETQLQELREKEPRKKANAQRNA 523 thale cress
30696335 599 VSGEIEVTMNMNDHIDSPGSVIGEVRKQIP 628 thale cress
17551220 313 LSARGALSHPFLKPAVATKSRVLKQINFNK 342 Caenorhabditis elegans
15718266 377 LSARGALSHPFLKPAVATKSRVLKQINFNK 406 Caenorhabditis elegans
16936533     ------------------------------     human
1168867  284 ISAFRALQHSYLHKDEGNPE---------- 303 human
544107   286 ASPSFVIES--FPKVSARLSQYA------- 306 fission yeast
1170645  339 KFINCILGMVSFSPNERWSCQRILQELEKP 368 baker's yeast