Conserved Protein Domain Family
COG5329

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COG5329: COG5329 
Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
Statistics
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PSSM-Id: 227637
Aligned: 11 rows
Threshold Bit Score: 494.216
Created: 7-Oct-2002
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1176581    31 GKYTLYETKdRMYIVGSNKRETMFRILeidlTVPRGELTVLEDNVFFTRNEIMNVLASLEEAtedglHKKITGYGLLgf- 109  baker's yeast
19173074    1 -------------MDTGTNLKVTVSPE---------EIVFESINGNGTFAMKGQHIDSRKSA-----YHSYGVYGMI--- 50   Encephalitozoon c...
19173467    1 --------------MASLAYSASSRRIs-------WETESGIAMLSYVGTVNKKPDSKQIEF-----QTILGILRVEk-- 52   Encephalitozoon c...
19114514      --------------------------------------------------------------------------------      fission yeast
19113333    1 -----------MVQFEANEKQFKLRRE--------DCCLTIDRESGAVSFEPDELKPVARSK-----ENSVTLFGSI--- 53   fission yeast
19113223    1 MQCLLREKP-RSLALVNKDHALMFHSV----PQNKNSLSVCVAEFTALSEKPLEGFRKISS------HRIYGTLGLI--- 66   fission yeast
19112103    1 MQCYLKRKE-RSVAFITEKYAAIIQKP----SVKDSDCIITFTCISLEEFEKIKEYELLFGG-----EKILGTLGLFnyv 70   fission yeast
731772      1 MRLFIGRRS-RSIVISSNNYCLSFQRLrsipGASSQQRQLSKTPSVTIKSYPDTDLSSDSNY-----LEVKSCIFNGllg 74   baker's yeast
417726      1 --------MtGPIVYVQNADGIFFKLAe--gKGTNDAVIHLANQDQGVRVLGAEEFPVQGEV-----VKIASLMGFI--- 62   baker's yeast
1730760     1 MKILLSKQQtRKIAIVSETHGLVFRPI----NSKNSRRSTCAVELVPKAELNGNGFRRLSN------HEIYGFIGLI--- 67   baker's yeast
6324683     1 MIIFVSEEPeRRLAIVSNLYALVLKPV----GKKPSDKPLCAIELLQKNDLKKYGFKRLTS------HEIFGVIGLI--- 67   baker's yeast
1176581   110 -iKFTCWYYLIMVTKYSQV----------AVIGGHGIYHIDGIDIIPITNNYKKPEKSS------------------DEA 160  baker's yeast
19173074   51 --TISKSSYLILVVDAVIR----------GMMYEHAVYEIRDVEIIQLTREKAKNFTN---------------------- 96   Encephalitozoon c...
19173467   53 --NDAYEEFLAFVTKSTLA----------GMYEGIEIYKIDKIKFLNINEPDKPDEVMS--------------------- 99   Encephalitozoon c...
19114514      --------------------------------------------------------------------------------      fission yeast
19113333   54 --KLKKDKYLILATEKSSA----------AQILGHKIYRVHKFEVIPYRNLLADDQDE---------------------L 100  fission yeast
19113223   67 --ELEGSNFLCVISGASEVa---------RVRDKERVFRIMEVCFYSVNRSNWDHIRQenys-----------pdipDGY 124  fission yeast
19112103   71 ceDMKEGVFLCVARKAKLVl---------RIGNRDPISKLENVSFISLDQELWDEELFEpmprnssps-stfststsDLN 140  fission yeast
731772     75 lvCLNGDIYVAVISGVQNVgfprwklidhQVRPSESIYKVLDVDFYSLENDVFDYLLCEr-----------------SEQ 137  baker's yeast
417726     63 --KLKLNRYAIIANTVEET----------GRFNGHVFYRVLQHSIVSTKFNSRIDSEE---------------------A 109  baker's yeast
1730760    68 --EIEGLMFIATITGKSKVa---------QPIPNKTVNKIYAVDFFCLNNSKWDFMDIDssgypivtndgdfaisspPSI 136  baker's yeast
6324683    68 --EVNGLLFVGAITGKSKVa---------QPCPGETVNKIFAVDFFCLNDNSWDFIEIDssgy----------pvlpETA 126  baker's yeast
1176581   161 RLLN-------------------------IFKDLDLTKTFYFSYTYDITNTLQTNiLREKLKAVDRCDITIPCGITDYNE 215  baker's yeast
19173074   97 EMKN-------------------------VKKFLEKTGIYFSTYPLYKTMSIKKD------------EDKDFLFNSLPLE 139  Encephalitozoon c...
19173467  100 QVRG----------------------------FVQSHDFYYFSTPLFIEDEFIWN--------RHMRANLLKYFGPTSYP 143  Encephalitozoon c...
19114514      --------------------------------------------------------------------------------      fission yeast
19113333  101 DLYNl-----------------------lQN--HLKTGPFYFSYTWDLTNSLQRScTDEGKASPILRSDKRFFWNEFASK 155  fission yeast
19113223  125 DTDTqgydsyk-----------yaaepfsSLRKLLTNGSFYFSLDFDITTRLQLRtSQTMTEPQYDSMHTQFMWNEFMLR 193  fission yeast
19112103  141 NIEKdnlvnseysskyssttriypyhslsQLTDLLTDGSFYVSTNISCFSRFQSE------QPYGP--KDIYCWNRFLIT 212  fission yeast
731772    138 NYDKlihe-----------------hpcgPLKKLFSDGTFYYSRDFDISNIVKNHgLSHNLEYTVDNQDLSFIWNANLAS 200  baker's yeast
417726    110 EYIKl-----------------------lEL--HLKNSTFYFSYTYDLTNSLQRN-EKVGPAASWKTADERFFWNHYLTE 163  baker's yeast
1730760   137 STHSsrsslrssssrslnaqeqapkhpchELRKLLSNGSFYYSTDFDLTCTLQKR-GFTEHSLSFDDFDREFMWNSFLMD 215  baker's yeast
6324683   127 STEYqdalp---------------khpcyELKKLLSNGSFYYSSDFDLTSTLQHR-GYGQHSLSTDTYEEEYMWNSFLMQ 190  baker's yeast
1176581   216 MFVWNNNLLSPIFACiDTVfdWFQCIIHGFIDQVNVSVLGKSIYITLIARRSHHFAGARFLKRGVNNKGHVANEVETEQI 295  baker's yeast
19173074  140 KFLGHAGDKGSLFS---------VWCIQGFFGSVDIGT----VCLRLISRRSWRRAGARYFSRGSDASGYVSNYVETEQI 206  Encephalitozoon c...
19173467  144 WVLSHRPKSPSLSLN-------ISTLFCGFFVAKAFKTSEDFYHMKLLSLVSSNRVGTRYLCRGIDEEGNASLFVKTHFQ 216  Encephalitozoon c...
19114514      --------------------------------------------------------------------------------      fission yeast
19113333  156 DFIDLIGAHSEVSL----F---ITPMIYGFITSASTIVKGRTITLALISRRSKQRAGTRYFTRGLDENGNPANFNETEQI 228  fission yeast
19113223  194 QLIKFRSHLNGDEKSaLDGcrFFTCAIRGFASTEQFKLGIQTIRLSLISRLSSLRAGTRFLSRGVDDDGNVANFVETETI 273  fission yeast
19112103  213 ELDNHFSEAHILEK--FPN--LLLHCFRGYVERMFIDS---MS-MSIISKVSSYGSRQTYPPSGIDDSSYCSMFVETEFI 284  fission yeast
731772    201 EVINWRSKISNEEKQlFANagFLTFVIRGYCKTALIEDGPNTASITIISRISTESKQDTLELEGISEDGRVSLFVETEIV 280  baker's yeast
417726    164 DLRNFAHQDPRIDS-------FIQPVIYGYAKTVDAVLNATPIVLGLITRRSIFRAGTRYFRRGVDKDGNVGNFNETEQI 236  baker's yeast
1730760   216 EIITYRDRLDVTAKElLDQrgFLTTVIRGFAETIFSYINRLKVGLTIISRQSWKRAGTRFNARGIDDDGHVANFVETEMI 295  baker's yeast
6324683   191 EMITYRDHLDTNLKQiLDDegFLTTVIRGFAETFVSYVKKLKVALTIISKQSWKRAGTRFNARGVDDEANVANFVETEFI 270  baker's yeast
1176581   296 VTDMiltpfhqpgngffdsDRYTSFVQHRGSIPLYWTQdaSNLTTKPPIRINVVDP-FFSPAALHFDNLFQRYGGgtIQI 374  baker's yeast
19173074  207 IYDG---------------EKTVSHLQVRGSIPLIWEHv-LGREYNPKIVVSD-----RKILHIADKVLRDKYGD--VFY 263  Encephalitozoon c...
19173467  217 TKRNn--------------STIFDFTIIRGSVPIFWSQ--RGHGIPAKVNIYGEDGaVKKAFAKHFKKLRREYGK--IYV 278  Encephalitozoon c...
19114514    1 ------------------------------------------------------------VFGKHFQELANDYGDn-LVV 19   fission yeast
19113333  229 TIVSde-----------ksEVTYSHVQTRGSVPAFWAE--VNNLRYKPLMVANSASmAAAAAKKHFDEQISIYGD--QVV 293  fission yeast
19113223  274 LDSS---------------KYCVSYCQVRGSIPIFWEQe-GVQMFGQKIDITRSLEaTRAAFEKHFTSLIEEYGP--VHI 335  fission yeast
19112103  285 VEIA---------------QTVFSFVQVRGTVPCFWEEq-FSSWYGPSISFLRSSQaSQSLFNFHFSKLYKAYGD--IYV 346  fission yeast
731772    281 VTTE---------------KFIFSYTQVNGSIPLFWESveSQLLYGKKIKVTKDSIeAQGAFDRHFDNLTSKYGV--VSI 343  baker's yeast
417726    237 LLAEnpe---------sekIHVFSFLQTRGSVPIYWAE--INNLKYKPNLVLG--EnSLDATKKHFDQQKELYGD--NYL 301  baker's yeast
1730760   296 MYSS---------------QYCYAFTQIRGSLPIFWEQ--DTSLISPKIQITRSVEaTQPTFDEHFIRLFKKYGP--VHI 356  baker's yeast
6324683   271 MYSS---------------QYCYAFTQIRGSIPVFWEQ--GTSLINPRVQITRSFEaTQPVFDKHIMKSVEKYGP--VHV 331  baker's yeast
1176581   375 LNLIKTKEktpRETKLLWEFEQCIDyLNEFLPTlkklDYTSWDMSRASKQDGQGVIEFLEKYAVNTvTTTGIFHN----- 449  baker's yeast
19173074  264 LNLIRNSG---YEGMLHCAYEKELL-GNNKEGV-------HFNFFKEGGILEGDTRKKFLGLVEQA-LLSFGYHG----- 326  Encephalitozoon c...
19173467  279 INLLGEKK---YEKQLTSHFSRLLD-LENIPYT-------TFDLNAHASN--YDDLKFLLYFKLQG-------------- 331  Encephalitozoon c...
19114514   20 VNLLDQKG---REAPLRSGFEKLCK-RNKNPPL----SYVYYDYHKQGS----RNLPLFLAEIQSL-LIEGKYYA----- 81   fission yeast
19113333  294 VNLVNCKG---HELPIKQLYENVIR-RLDNPHI----HYHYFDFHKECSHMRWDRVSLLLNEIQPE-LEEQGYTTl---- 360  fission yeast
19113223  336 INLLGTGS---GERSLSERLRQHIQ-LSPEKDLi---HLTEFDYHSQIR--SFEDANKIRPMIYSD-AETFGFYf----- 400  fission yeast
19112103  347 IDLLQTKG---FEASLYEAYKHHLM-LLPFPAV-------VKKFHFTPDPARPDIDPRLETDLADD-LKEMGYTQk---- 410  fission yeast
731772    344 VNIIKPKS---ESQEKLALTYKDCA-ESKGIKI----TNIEYSSSVLTK-----SPHKLLYLLKQD-IYEFGAFAy---- 405  baker's yeast
417726    302 VNLVNQKG---HELPVKEGYESVVH-ALNDPKI----HYVYFDFHHECRKMQWHRVKLLIDHLEKLgLSNEDFFHkvids 373  baker's yeast
1730760   357 INLLSTKS---SEIQLSRRYKEQLK-NSEKMKIgrdvFLTSFDFHRETSQDGFAAASRIIPKIRNT-ILDAGYFSy---- 427  baker's yeast
6324683   332 VNLLSTKS---SEIELSKRYKEHLT-HSKKLNFnkdiFLTEFDFHKETSQEGFSGVRKLIPLILDS-LLSSGYYSy---- 402  baker's yeast
1176581   450 -GPDFASTKIQEGICRSNCIDCLDRTNAAQFVIGk---RALGCQLKSLGIIDNSYLey-dsDIVNILTELFHDLGDTIAL 524  baker's yeast
19173074  327 ------PGSLQSGVIRTNCIDCLDRTNISQFIMG----EIILEKQLSHFDIEDKKH------FCEQAKCLWYDNGNSLSM 390  Encephalitozoon c...
19173467  332 -------IGQQDIVFRVNCLDCLDRTNVAQSLIC---------MFYFEKVVCDGNA-------LKRMQECWADNGNSLSN 388  Encephalitozoon c...
19114514   82 -EHGSKTTAMQTNFVRTNCMDCLDRTNVIQTSIAq---FILNMQLHDIGVLSSSESleeydSFLQDFRLIWANTGDYISD 157  fission yeast
19113333  361 dTQKYRVLSRQNGVVRSNCMDCLDRTNVVQSCIGr---WVLTNQLRKCGIIGATHPlrsviPLDNIFCNIWSDNADYISL 437  fission yeast
19113223  401 eNNEGQSIVVQDGVFRTNCLDCLDRTNVIQNLVS----RVFLEQVMIYTRQNAGYD------FWQVHSTIWANNGDALAR 470  fission yeast
19112103  411 sIENDMLESFQKGVFRINDLDCLGRTNVIQYQIS----RLVLKDIFFNLQIGVTFN------ILEYLRHLWSNNGDAIAK 480  fission yeast
731772    406 dISRGIYFAKQTGVLRISAFDSIEKPNTVERLVS----KEVLELTTNEIDVFELTS-----PFLDAHDKLWSENYYWLDR 476  baker's yeast
417726    374 nGNTVEIVNEQHSVVRTNCMDCLDRTNVVQSVLAq---WVLQKEFESADVVATGSTwednaPLLTSYQNLWADNADAVSV 450  baker's yeast
1730760   428 dVKEGRLISEQDGVFRTNCLDCLDRTNLIQQTISlavfKLFLEDFRLVKPSSFIDDn----EFVQKVNALWADNGDQISQ 503  baker's yeast
6324683   403 dVREKKNISEQHGIFRTNCLDCLDRTNLAQQIISlaafRTFLEDFRLISSNSFIDDd----DFVSKHNTLWADHGDQISQ 478  baker's yeast
1176581   525 QYGGSHLVNTMETYRKINQWSSHSRDMIESIKRFYSNSFVDAQRQDAINLFLGHYSWREGFPSLwemntdfYLHNAYSLN 604  baker's yeast
19173074  391 QYSGSFALKSHFLSRKRQGVVDRLRDGIIGFQRYFINRLCHGSLQTTYEILTTDLDGKTIISYRdr---vgTIRKTFLLL 467  Encephalitozoon c...
19173467  389 LYTGSDAMKRELALKGRRSFVGYMDDFVISATRLINGRFTDRQKHSIINVLLEKKEDAEDTGDSc--------------- 453  Encephalitozoon c...
19114514  158 LYTGTPALKGDVTRHGTRTIFGAFKDLLNCFRRYILNNFFDGMLQDSYDLGLGVFRPYDSLSIP-------DLPLRFHWT 230  fission yeast
19113333  438 SYSGTGALKTDFTRTGIRTRKGAFNDFVNSAKRYILNNFYDGARQDAYDLVLGQFRPDVNFRYRld---lrPLTIRCVPY 514  fission yeast
19113223  471 IYTGTGALKSSFTRKGKLSIAGALNDLSKSVGRMYINNFQDKGRQETIDLLLGrlidqhpvilydpiheyvnhelrkren 550  fission yeast
19112103  481 LITGVGSIGSSATRRGRKSIAGSLSDISKSFGRMYVGRYPDVESQNAILLLLGCFpnqspvlisesvssyiqgvlrqrrs 560  fission yeast
731772    477 TYTKHTKNSGKYTKVYSKLFGsrvrlydplhiyisqylkqlrskytfekdisifagtfnisgkipkddikdwifpksmsk 556  baker's yeast
417726    451 AYSGTGALKTDFTRTGKRTRLGAFNDFLNSASRYYQNNWTDGPRQDSYDLFLGGFRPHTASIKSpfp-drrPVYIQLIPM 529  baker's yeast
1730760   504 IYTGTNALKSSYSRKGKMSFSGALSDATKSVSRMYINNFVDKGKQQNIDTLLGKLPHQQVVElydpiceyvnerllesee 583  baker's yeast
6324683   479 IYTGTNALKSSFSRKGKMSLAGALSDATKSVSRIYINNFMDKEKQQNIDTLLGRLPYQKAVQLYdp---vnEYVSTKLQS 555  baker's yeast
1176581   605 MPKRSYIHWWNDYNIKSVKELINEELIATGnDVTREKIIKNVRGYPGAF 653  baker's yeast
19173074  468 LITVCTASWVSTGIFIISLLCSTLAITLVTiAVVLIFLDSLIQKPRPRA 516  Encephalitozoon cuniculi
19173467      -------------------------------------------------      Encephalitozoon cuniculi
19114514  231 RFVAPGIFLFTTIILTIQELFGNPSLFCRLlYSIPMVNAGIYLYFHRRQ 279  fission yeast
19113333  515 ILLACLILFFMTLFSRSSSTILPPSILLIL-TFLGIVASLYYCFAHGLQ 562  fission yeast
19113223  551 efsehknvkifvasynlngcsattklenwlfpentpladiyvvgfqeiv 599  fission yeast
19112103  561 eyrverdfsifsstfnangkvpstdefkrlllpfgertsaydlyvvavq 609  fission yeast
731772    557 edemadlyvigleevveltpghmlatdpyvrqfwekkiltllngpgrkk 605  baker's yeast
417726    530 IICAALTVLGATIFFPKDRFTSSKNLLYFAgASIVLALSTKFMFKNGIQ 578  baker's yeast
1730760   584 kftthsninlfvgtfnvngnsrradlskwlfpigdkfkpdvvvlglqev 632  baker's yeast
6324683   556 MSDKFTSTSNINLLIGSFNVNGATKKVDLS-KWLFPIGEKFKPDIVVLG 603  baker's yeast
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