1ECQ,1JPM,1JCT,1JPD


Conserved Protein Domain Family
RspA

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COG4948: RspA 
L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily [Cell wall/membrane/envelope biogenesis, General function prediction only]
linked to 3D-structure
Statistics
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PSSM-Id: 227284
View PSSM: COG4948
Aligned: 116 rows
Threshold Bit Score: 52.0075
Threshold Setting Gi: 15803310
Created: 7-Oct-2002
Updated: 23-Jan-2015
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1ECQ_A     8 PVVTEMQVIPVAGHDSMLMNLSG--AHAPFFTRNIVIIKDN-SGHTGVGEIPGGEKIRKTLEDAI-P------LVVGKTL 77  Escherichia coli
19553600  15 LSDLTIQKVESRILDVPLIRPHGfaTTTSTEQHILLVSVHLeNGVIGYGEGVVPGGPWWGGESVEtMkalvdgYLAPVLI 94  Corynebacterium glu...
17368727   1 ----MIPTLTELLDRLHVVALP---MRVRFRGITTREVALI-DGPAGWGEFGAF-LEYQPLEASA-W------LVAGIEA 64  Mycobacterium leprae
17367875   1 -MIPVLPPLEALLDRLYVVALP---MRVRFRGITTREVALI-EGPAGWGEFGAF-VEYQSAQACA-W------LASAIET 67  Mycobacterium tuber...
17367875   1 -MIPVLPPLEALLDRLYVVALP---MRVRFRGITTREVALI-EGPAGWGEFGAF-VEYQSAQACA-W------LASAIET 67  Mycobacterium tuber...
15597705   4 AVIQSLESIIVDLPTIRPHKLAM--HTMNRQTLVILRLRCS-DGIEGLGEATTIGGLAYGSESPEsIksnldaHFAPLLL 80  Pseudomonas aerugin...
15599236   1 MRIQEVRERSIPLSRYAGVAAATg-GLSTSLVAVLTDIVRDgRRVVGYGHASVGRYAQGGLIRERfAprl-lgAPADSLA 78  Pseudomonas aerugin...
17227530   2 FPNYEFSFRPIARKFVRSLVTSH--GIWEVREAIILRLTDT-TGKVGWGEIAPISWFGSETLAQ-----------ALDFC 67  Nostoc sp. PCC 7120
13476122   1 MQIKSIKAYHVVQPFVDGPYRMSkgRQADAFDAVIVAITAD-SGLTGWGEMAPLGNFYSAAFPAGaRag--vpEIAPHLI 77  Mesorhizobium loti
20138596   2 DKPYHVKFYSYNFPLPKPVVTAH--GHWQRRRGLIVELTDQ-RGNRGRGEIAPLPWFGTEDLAS-----------ATDFC 67  Synechocystis sp. P...
1ECQ_A    78 GEYKNVLTLvrntfADRDAGGRGLQTfDLRTTIHVVTGIEAAMLDLLGQHLGVNVASLLGDGQQrSEVEMLGYLFFVgnr 157 Escherichia coli
19553600  95 GRAVSELAG------IMADLERVVAR-----ARYAKAAVDVAMHDAWARSLNVPVRDLLGGTVRdKVDVTWALGVLP--- 160 Corynebacterium glu...
17368727  65 AYGEPPEGRr------------------------DRIPINATVPAVSATQVPEVLARFPG-------VRTAKVKVAE--- 110 Mycobacterium leprae
17367875  68 AYCAPPPVRr------------------------DRVPINATVPAVAAAQVGEVLARFPG-------ARTAKVKVAE--- 113 Mycobacterium tuber...
17367875  68 AYCAPPPVRr------------------------DRVPINATVPAVAAAQVGEVLARFPG-------ARTAKVKVAE--- 113 Mycobacterium tuber...
15597705  81 GQPADNVNA-----AMQRLDRHIRGN------TFARSAVETALLDAHGKRLGLAVSELLGGRLHdSLEVAWTLASG---- 145 Pseudomonas aerugin...
15599236  79 SDDGSGIDPl---rAWDLMMRDEKPG-GHGERCVAVGALDMALWDAAAKAAGLPLHRFLARRLGlAEDYPQRVPVYAggg 154 Pseudomonas aerugin...
17227530  68 RQLPEEITQ-------EIIFSIPDDLp------ACQFGFESALEAMGSGEDVTITNAQFS---------ALLP------- 118 Nostoc sp. PCC 7120
13476122  78 GHDPRGLAS------IGRLMDTVFKG-----HPYIKSALDMACWDLAARAAGVPLVTMLGGRES-DMAETYRVVTHG--- 142 Mesorhizobium loti
20138596  68 RSLKGRITP------AQIEKIGDRLP-------CCGFAFGSAEWELESGSVIENSPNSLS------YCQLLPTG------ 122 Synechocystis sp. P...
1ECQ_A   158 katplpyqsqpddscdwyrlrheeaMTPDAVVRLAEAAYEK--YGFNDFKLKGGVLAGEEEAESIVALAQRFP-QARITL 234 Escherichia coli
19553600 161 ---------------------------LDVAVAEIEERIEE--FGNRSFKLKMGAGDPaEDTRRVAELAREVGdRVSLRI 211 Corynebacterium glu...
17368727 111 ---------------------------PGQNL-------------A-------------DDVDRVNAVRELVE---TVRV 134 Mycobacterium leprae
17367875 114 ---------------------------PGQSL-------------A-------------DDIERVNAVRELVP---MVRV 137 Mycobacterium tuber...
17367875 114 ---------------------------PGQSL-------------A-------------DDIERVNAVRELVP---MVRV 137 Mycobacterium tuber...
15597705 146 --------------------------DTGRDIEEAGRMLDL--RRHRHFKLKIGAGEVDADVAHAIAIKRALGeRASVRV 197 Pseudomonas aerugin...
15599236 155 -----------------------ypYPHDDLGRLEEELRRFvdLGYTHAKIKIGAAGLDQDRRRIDRALRVLGdASRLAV 211 Pseudomonas aerugin...
17227530 119 ---------------------------AGEAALHQWQSLWD--EGYRTFKWKIAVGEVAQELRIFDSLTQILPaSAKLRL 169 Nostoc sp. PCC 7120
13476122 143 ---------------------------TLDQMAALAKRIIA--EGCRRLQVKVGGNv-hDDIERVTTVASAVPkGTVIFC 192 Mesorhizobium loti
20138596 123 ----------------------------EAALDYLASNPQ---LGASTFKWKIGVGDFAVERDLYGQLWRRLPeGCQIRL 171 Synechocystis sp. P...
1ECQ_A   235 DPNGAWSL------NEAIKIGKYLKGs-LAYAEDPCGAEQGFSGREVMAEFRrATGLPTATNMIATDWRQMGHTLS---- 303 Escherichia coli
19553600 212 DINARWDRr----tALHYLPILAEAG--VELFEQPTPADDLETLREITRRTN-VSVMADESVWTPAEALAVVKAQA---- 280 Corynebacterium glu...
17368727 135 DANGGWSVe----aAAQAAVALTADGp-LEYLEQPCATVAELAALRRRVD---IPIAADESIRKADDPLAVVRSHA---- 202 Mycobacterium leprae
17367875 138 DANGGWGVa----eAVAAAAALTADGp-LEYLEQPCATVAELAELRRRVD---VPIAADESIRKAEDPLAVVRAQA---- 205 Mycobacterium tuber...
17367875 138 DANGGWGVa----eAVAAAAALTADGp-LEYLEQPCATVAELAELRRRVD---VPIAADESIRKAEDPLAVVRAQA---- 205 Mycobacterium tuber...
15597705 198 DVNQAWDEg----vAQRACATLGDNG--IALIEQPIARHNRVGLARLSSRGG-APIMADEAIESVEDAFHLAREGA---- 266 Pseudomonas aerugin...
15599236 212 DAMNRYDAe----gAVDAAKALAPLG--LWWFEDICDPHDFPTQAEVADIYP-GPIGAGEALFSLAEARLLDLYGGvrre 284 Pseudomonas aerugin...
17227530 170 DANGGLSYp----eAHLWLQACDNLPveVEFIEQPLPVEQFSQMLELSEAYP-TAIALDESVANLKQLAACYAQGWr--- 241 Nostoc sp. PCC 7120
13476122 193 DANAGWTPy----qARQFADATRGID---YTFEQPCTT--IEENMSVRRMLD-KPMVLDESVTSLEEMLEIHRLGA---- 258 Mesorhizobium loti
20138596 172 DANGGLSVdiaqqwLTLLDRQRENSGpkIQYLEQPLPPGEIDEMFRLQEDFA-TSIALDEAVCSLAQLAQLYDKG----- 245 Synechocystis sp. P...
1ECQ_A   304 LQSVDIPLADphFWTMQGSVRVAQMCHe-fGLTWGSHSNNHFDISLAMFTHVAAAAp--------GKITAIDTHWIWQEG 374 Escherichia coli
19553600 281 ADVIALKTTK--HGGLLESKKIAAIAEa-gGLACHGATSLEGPIGTAASLQFAAST----------KAISYGTELFGPQL 347 Corynebacterium glu...
17368727 203 ADVAVLKVAP--LGGIASFLAIAAQIdipvVVSSALDSVVGITAGLIAAAALPELDyacglgtgrLFVADVAEPMLPVDG 280 Mycobacterium leprae
17367875 206 ADIAVLKVAP--LGGISALLDIAARIavpvVVSSALDSAVGIAAGLTAAAALPELDhacglgtggLFEEDVAEPAAPVDG 283 Mycobacterium tuber...
17367875 206 ADIAVLKVAP--LGGISALLDIAARIavpvVVSSALDSAVGIAAGLTAAAALPELDhacglgtggLFEEDVAEPAAPVDG 283 Mycobacterium tuber...
15597705 267 APVFALKIAK--NGGPRAVLRSAAIAEa-aGIGLYGGTMLEGGIGTLAAAHAFVTL----------DRLAWHSELFGPLL 333 Pseudomonas aerugin...
15599236 285 RDVLVFDPVH--CYGLPGYLAILDHLC---ARGWPRAAFRP-HAGYLFSLHLVAALr--------LGWAEATPSAFRPFD 350 Pseudomonas aerugin...
17227530 242 -DVFVIKPAI--AGSPSRLRQFCQQHE----IDAVFSSVFETAIARKASLQLAAELs--------RDNRAVGFGVNHLFH 306 Nostoc sp. PCC 7120
13476122 259 ADGLTLKISR--LGGVTRTRQIRDVAVd-lGFMITVEDTGGAEIDTAAMAHLSLST---------PQERRLHAIAFHEWV 326 Mesorhizobium loti
20138596 246 -----W--SG--LYILKAAIMGNPR-----VLNHWLKTH-PIPAIFSSVFETAIAR---------GQVLALAQKWNLPDH 301 Synechocystis sp. P...
1ECQ_A   375 N--QRLTKEPfEIKGG-LVQVPEKPGLGVEIDMDQVMKAHELYQK 416 Escherichia coli
19553600 348 LkdTYIVQEF--EYKDgQVAIPQGPGLGVDVDMDKVNFYTRK--- 387 Corynebacterium glutamicum ATCC 13032
17368727 281 FlpVGPVTPDpARLQA-LGTPPARRQWWIDRVKTCYSLLVPCAGD 324 Mycobacterium leprae
17367875 284 FlaVARTTPDpARLQA-LGAPPQRRQWWIDRVKACYSLLVPSFG- 326 Mycobacterium tuberculosis
17367875 284 FlaVARTTPDpARLQA-LGAPPQRRQWWIDRVKACYSLLVPSFG- 326 Mycobacterium tuberculosis
15597705 334 LteDILLESP--RYQDfHLHVPRAPGLGLALDEERLARFRRR--- 373 Pseudomonas aeruginosa PA01
15599236 351 D-----FAGA-LPFSSgLAGLPQSPGIGFERQATLAGLFRKLLEA 389 Pseudomonas aeruginosa PA01
17227530 307 --------Q---EAENwLQSLWNNP-------------------- 320 Nostoc sp. PCC 7120
13476122 327 TvrTAFNAPP--VTGS-HMGIPDGPGLGIDVDPSLLGKPFFEIG- 367 Mesorhizobium loti
20138596 302 A----VGFAP--LREPiTEATPDSV-------------------- 320 Synechocystis sp. PCC 6803
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