Conserved Protein Domain Family
PksG

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COG3425: PksG 
3-hydroxy-3-methylglutaryl CoA synthase [Lipid transport and metabolism]
Statistics
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PSSM-Id: 225959
View PSSM: COG3425
Aligned: 27 rows
Threshold Bit Score: 103.151
Threshold Setting Gi: 15925742
Created: 7-Oct-2002
Updated: 23-Jan-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1708241   47 QNVGIKGIQIYIPTQCVNQSELEKFDGV--------SQGKYTIGLGQTNMSFVNDREDIYSMSLTVLSKLIKSYNIDTNK 118 baker's yeast
15595028   1 MRIGISDIRIFLPLNYLDFSVLLENPLYfsnevffkKINRAIDATLQKGFRFTSPNEDSVTMASSAVKLIFDNNNLDLSK 80  Lyme disease spiroc...
730331       -------------------------------------------------------------------------------- Bacillus subtilis
19074660   5 NMFGIIGVEYQLPSLYISQEEVANNIDF--------EVDKIKIGLGLEQMGVPSRREDAISLALNAVSRLMKRYNVDPMA 76  Encephalitozoon cun...
15673554   1 MKVGIDKLGFFVPNTFVDMRDLANARNV--------DPAKFQIGIGQDEMAVNPATQDIITFAANAAASILT--EEDKKA 70  Lactococcus lactis ...
15925742     -------------------------------------------------------------------------------- Staphylococcus aure...
15928125   1 MTIGIDKINFYVPKYYVDMAKLAEARQV--------DPNKFLIGIGQTEMAVSPVNQDIVSMGANAAKDIIT--DEDKKK 70  Staphylococcus aure...
15901560   9 MTIGIDKIGFATSQYVLKLQDLAEARGI--------DPEKLSKGLLLKELSIAPLTEDIVTLAASASDSILT--EQERQE 78  Streptococcus pneum...
15674906   1 MTIGIDKIGFATSQYVLKLEDLALARQV--------DPAKFSQGLLIESFSVAPITEDIITLAASAADQILT--DEDRAK 70  Streptococcus pyoge...
16121732   2 NSIGIEKISIYPSSLALKLSELAQARGG--------DNKYIQESLMVIKRSLVPQWEDAVTLAVNSAKDMLN--DQDRSD 71  Yersinia pestis
1708241  119 IGRLEVGTETLIDKSKSVKSVLM-----QLFGENTDVEGIDTLNACYGGTNALFNSLNWIESNAWDgrDAIVVCGDIAIY 193 baker's yeast
15595028  81 IRILLGGTETGVDHSKAISSYVFgalkqSGICLGNNFLTFQVQHACAGAAMSLHTVASVLSHSNNSe-YGIVFSSDIAHY 159 Lyme disease spiroc...
730331     1 --MLITCSESGIDFGKSLSTYIH-----EYLGLNRNCRLFEVKQACYSGTAGFQMAVNFILSQTSPgaKALVIASDISRF 73  Bacillus subtilis
19074660  77 IGRLEVGTESNPDGSKSIKSYLT-----DLFPGNTSICGCDNVHACYSGTNALLSAIAWMESSFWDgrLAIVVASDVAMY 151 Encephalitozoon cun...
15673554  71 IDMIIVGTESSLDESKASAVVVH-----DLLGIQPFARSIEMKEACYATTAGLTLARDHVLLNPDT--KVLVIASDIAKY 143 Lactococcus lactis ...
15925742     -------------------------------------------------------------------------------- Staphylococcus aure...
15928125  71 IGMVIVATESAVDAAKAAAVQIH-----NLLGIQPFARCFEMKEACYAATPAIQLAKDYLATRPNE--KVLVIATDTARY 143 Staphylococcus aure...
15901560  79 VDMVIVATESGIDQSKAAAVFVH-----GLLGIQPFARSFEIKEACYGATAALHYAKLHVENSPES--KVLVIASDIAKY 151 Streptococcus pneum...
15674906  71 IDMVILATESSTDQSKASAIYVH-----HLVGIQPFARSFEVKQACYSATAALDYAKLHVASKPDS--RVLVIASDIARY 143 Streptococcus pyoge...
16121732  72 IGLFIIATESGLDQEKAISTWAH-----RYLGLPATCRVFELKSACHAGAAALKMAESWISSGLNRgkKVLLINVDISNN 146 Yersinia pestis
1708241  194 DKG-----------AARPTGGAGTVAMWIGPD-APIVFDS-VRASYMEHAYDFYKPDFTsEYPYVDGHFSLTCYVKALDQ 260 baker's yeast
15595028 160 SNLt----------TAEITQGAGATAILIEKNpKLLSINLsEFGVYTDDVDDFFRPFGS-VEAKVRGQYSVECYNNANEN 228 Lyme disease spiroc...
730331    74 LIAeggdalsedwsYAEPSAGAGAVAVLVGENpEVFQIDPgANGYYGYEVMDTCRPIPD--SEAGDSDLSLMSYLDCCEQ 151 Bacillus subtilis
19074660 152 KDK-----------SCQPTGGAGAVAILLGPN-CIYRVVPsSVIHYFTNQFDFMKPRELhPFPVVKGKESIENYRTAFEI 219 Encephalitozoon cun...
15673554 144 GLNt----------GGEPTQGAGSVAMLITAD-PKILALNnDNVALTQDIYDFWRPFGQ-AYPSVDGKFSNETYIDAFAK 211 Lactococcus lactis ...
15925742     -------------------------------------------------------------------------------- Staphylococcus aure...
15928125 144 GLNs----------GGEPTQGAGAVAMVIAHN-PSILALNeDAVAYTEDVYDFWRPTGH-KYPLVDGALSKDAYIRSFQQ 211 Staphylococcus aure...
15901560 152 GIEt----------PGEPTQGAGSVAMLITQN-PRMMAFNnDNVAQTRDIMDFWRPNYS-TTPYVNGVYSTQQYLDSLKT 219 Streptococcus pneum...
15674906 144 GVGs----------PGESTQGSGSIALLVTAN-PRILALNeDNVAQTRDIMDFWRPNYS-FTPYVDGIYSTKQYLNCLET 211 Streptococcus pyoge...
16121732 147 MICh---------gKMEYSLGAGAIALLISDNpVFAVIETgKSGIHTHEVTDVIRPLPW-KEVAFDVEASLFSYMDGLEN 216 Yersinia pestis
1708241  261 VYKSYSKKAISKglvsdpagsdalnvLKYFDYNVFHVPTCKLVTKSYGRLLYNdfranpqlfpevdaelatrdydesltd 340 baker's yeast
15595028 229 ALRDFAFKKQLSmk-----------dLFSNYRFVLHVPFAKMPIDSMHYILKKyysddesv------------------- 278 Lyme disease spiroc...
730331   152 TFLEYQKRVPGAn------------yQDTFQYLAYHTPFGGMVKGAHRTMMRKv-------------------------- 193 Bacillus subtilis
19074660 220 CYGRFREKMAEE---------------SSFDYIVLHSPYTRLPEKICIANHIDr-------------------------- 258 Encephalitozoon cun...
15673554 212 IWKEYSHRTNLK--------------FEDFAAIAFHTPYTKMGKKALLPMLEsekpan---------------------- 255 Lactococcus lactis ...
15925742     -------------------------------------------------------------------------------- Staphylococcus aure...
15928125 212 SWNEYAKRQGKS--------------LADFASLCFHVPFTKMGKKALESIIDnadett---------------------- 255 Staphylococcus aure...
15901560 220 TWLEYQKRYQLT--------------LDDFAAVCFHLPYPKLALKGLKKIMDKslpqek--------------------- 264 Streptococcus pneum...
15674906 212 TWQAYQKRENLQ--------------LSDLAAVCFHIPFPKLALKGLNNIMDNtvppeh--------------------- 256 Streptococcus pyoge...
16121732 217 AFEEYCHQTPEAr------------eSTYFNYNLYHVPFPGISKEAHKVLLELqglfgke-------------------- 264 Yersinia pestis
1708241  341 kniEktfvnvakpfhkERVAQSLIVPTNTGNMYTASVYAAFASLLNYVGsd-dLQGKRVGLFSYGSGLAASLYSCKIVGD 419 baker's yeast
15595028 279 ---------rnaylesIDFYDGVEAAMEVGNLYTGSIFLSLAFYLKRVFskkdITGEKILFCSYGSGNIMIIYELTIEKS 349 Lyme disease spiroc...
730331   194 ---AkvktsgietdflTRVKPGLNYCQRVGNIMGAALFLALASTIDQGRf---DTPKRIGCFSYGSGCCSEFYSGITTPQ 267 Bacillus subtilis
19074660 259 ----------------KKLLRSLEASRRNGNAYSASLYLSLISLLECHDg---EVGEKILMFSYGSGASSSMFC---LER 316 Encephalitozoon cun...
15673554 256 -----------aeelmEQFEHGIVYNRRVGNLYTGSLYLSLISLLENSDk--lSAGQRIGLFSYGSGTVAEFFSGELVEG 322 Lactococcus lactis ...
15925742   1 -------------------------------MYTGSLYLSLISLLQNHTf---QPEEKVCLFSYGSGAVGEIFSGSIVKG 46  Staphylococcus aure...
15928125 256 -----------qerlrSGYEDAVDYNRYVGNIYTGSLYLSLISLLENRDl---QAGETIGLFSYGSGSVGEFYSATLVEG 321 Staphylococcus aure...
15901560 265 -----------kdllqKHFDQSILYSQKVGNIYTGSLFLGLLSLLENTDs--lKAGDKIALYSYGSGAVAEFFSGELVEG 331 Streptococcus pneum...
15674906 257 -----------rekliEAFQASISYSKQIGNIYTGSLYLGLLSLLENSKv--lQSGDKIGFFSYGSGAVSEFYSGQLVAG 323 Streptococcus pyoge...
16121732 265 ---------alatsfkQKVMPSLYYAQKIGATYCGSIFLSLFSLMVKAPe--iKSGDRIGVYSYGSGSCAEYFSMQVGDQ 333 Yersinia pestis
1708241  420 VQHIIKEL--DITNKLAKRITETPKDYEAAIELRENAHLKKNFKPqgs-------iehLQSGVYYLTNIDDKFRRSYDV 489 baker's yeast
15595028 350 AFDVIKLW--DLEGLIKNRNNANFEEYKDFFQNKIIPG--------------------ESRGFYLKELRNDGYRVYGYR 406 Lyme disease spirochete
730331   268 GQERQRTF--GIEKHLDRRYQLSMEEYELLFKGSGMVRFGTRNVKldfemipgimqstQEKPRLFLEEISEFHRKYRWI 344 Bacillus subtilis
19074660 317 ISKGCMVT--GFRERLLERKEISYQEFTKILEEPVPQDNYEAQER-------------IYSPGYYLKRISSFARYYEYL 380 Encephalitozoon cuni...
15673554 323 YENHLLKI--EHQSMLDARTRLSIPEYENMFNQYLDLN-HNISFN--------------DETDYSVSEVVDNHRKYKKR 384 Lactococcus lactis s...
15925742  47 YDKALDKE--KHLNMLESREQLSVEEYETFFNRFDNQEFDFERELt-----------qDPYSKVYLYSIEDHIRTYKIE 112 Staphylococcus aureu...
15928125 322 YKDHLDQA--AHKALLNNRTEVSVDAYETFFKRFDDVEFDEEQDAv-----------hEDRHIFYLSNIENNVREYHRP 387 Staphylococcus aureu...
15901560 332 YEAYLDKD--R-LNKLNQRTALSVADYEKVFFEEVNLDETNSAQFa-----------gYENQDFALVEILDHQRRYSKV 396 Streptococcus pneumo...
15674906 324 YDKMLMTN--R-QALLDQRTRLSVSKYEDLFYEQVQLDDNGNANFd-----------iYLTGKFALTAIKEHRRIYHTN 388 Streptococcus pyogen...
16121732 334 AVEIAQQQgaALDILLTQRKILDVAAYEQLENARSAQMQGKDYRLdgdnlqdwythhySGSGLLILERIDNHLRRYRYA 412 Yersinia pestis
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