2500057 1 MNVEE----------IEKYLEENFD----KLPEGCKQCVKGGKL-VLFITGICN-NNCYYCPLSEKRKNKDVIYANERLI 64 Methanocaldococcus ... 11498816 7 KGCSM----------RRIEAGSRYT----YLPEGCRLCRKGAKL-VLFVTGICN-NSCFYCPVSKEKIGRDVVFANERPV 70 Archaeoglobus fulgidus 14600862 10 MGTVAgvrlrrgrllGDPLKALLAGsrgvWMARGCDLCFPGRKA-VVFVTGLCD-DSCFYCPVSRAKLGRDVFYVNEVPV 87 Aeropyrum pernix 15896576 43 IDNRNnklmseikslKTLDNRTFFVgnesKFPKGCRSCLLGTGLsAIRKTNKCN-LECKFCYNYGELDDIAPIGEDMWEI 121 Clostridium acetobu... 20092510 1 -MEKF----------TEDQTGSFCS----YLSEGCRFCQQGAKM-VLFVTGLCP-KSCFYCPLSDERRGKDLVFANERPV 63 Methanosarcina acet... 20094423 1 ---------------------MVRG----AFPKGCRLCVCGAKL-VVFVTGVCN-RGCWYCPVSPRKKGSDVSFANERPI 53 Methanopyrus kandle... 14521276 10 IIMVQ----------KTPYYSYVVG----ELPKGCQYCVRGEKL-VLFVTGVCP-RNCFYCPLSPWRR-KDVVYANERPV 72 Pyrococcus abyssi 18313215 1 ------------------------------MARGCELCLLGSKS-VIFITGLCP-LSCPYCPVGADRFGKDVIYVNDVPV 48 Pyrobaculum aerophilum 14590991 10 EIMR-----------KTPYYSYVVG----ELPKGCQYCVRGEKL-VLFVTGVCP-RNCFYCPLSSWRR-KDVAYANERPI 71 Pyrococcus horikoshii 15897049 1 -MTII----------GNPEIGLYTG----KLPKGCELCRLGGKL-VLFITGECD-DNCYYCPVSDDRFGKNKIFANETEV 63 Sulfolobus solfatar... 15790988 1 ---------------------MRHQ----MISKGCEQCAEGGKM-VLFVYGYCDqRDCFYCPLGENRKNVQQVYANERPV 54 Halobacterium sp. N... 11498816 7 KGCSM----------RRIEAGSRYT----YLPEGCRLCRKGAKL-VLFVTGICN-NSCFYCPVSKEKIGRDVVFANERPV 70 Archaeoglobus fulgidus 14600862 10 MGTVAgvrlrrgrllGDPLKALLAGsrgvWMARGCDLCFPGRKA-VVFVTGLCD-DSCFYCPVSRAKLGRDVFYVNEVPV 87 Aeropyrum pernix 15896576 43 IDNRNnklmseikslKTLDNRTFFVgnesKFPKGCRSCLLGTGLsAIRKTNKCN-LECKFCYNYGELDDIAPIGEDMWEI 121 Clostridium acetobu... 20092510 1 -MEKF----------TEDQTGSFCS----YLSEGCRFCQQGAKM-VLFVTGLCP-KSCFYCPLSDERRGKDLVFANERPV 63 Methanosarcina acet... 20094423 1 ---------------------MVRG----AFPKGCRLCVCGAKL-VVFVTGVCN-RGCWYCPVSPRKKGSDVSFANERPI 53 Methanopyrus kandle... 14521276 10 IIMVQ----------KTPYYSYVVG----ELPKGCQYCVRGEKL-VLFVTGVCP-RNCFYCPLSPWRR-KDVVYANERPV 72 Pyrococcus abyssi 18313215 1 ------------------------------MARGCELCLLGSKS-VIFITGLCP-LSCPYCPVGADRFGKDVIYVNDVPV 48 Pyrobaculum aerophilum 14590991 10 EIMR-----------KTPYYSYVVG----ELPKGCQYCVRGEKL-VLFVTGVCP-RNCFYCPLSSWRR-KDVAYANERPI 71 Pyrococcus horikoshii 15897049 1 -MTII----------GNPEIGLYTG----KLPKGCELCRLGGKL-VLFITGECD-DNCYYCPVSDDRFGKNKIFANETEV 63 Sulfolobus solfatar... 15790988 1 ---------------------MRHQ----MISKGCEQCAEGGKM-VLFVYGYCDqRDCFYCPLGENRKNVQQVYANERPV 54 Halobacterium sp. N...
2500057 65 TTV----EEAIEEAKLCSS-KGVGITGGNPLLKINRTVKFLKALKKEF-DEFHAHLYTTPETVNEENLKLLKEADLDEIR 138 Methanocaldococcus ... 11498816 71 KSV----EDVFEEIEMMDA-EGIAITGGEPLLKIEKVREYLKLAKKLD---LHVHLYT--SLPAGEKLKKLE--GLDEIR 138 Archaeoglobus fulgidus 14600862 88 ASV----EEAVAEVLRTGA-SGASLTGGDPLVALHRTLDVARALKSELgRGFHIHLYTSGRRMTPEVARALWEAGVDEVR 162 Aeropyrum pernix 15896576 122 GGTrfyeKDIDLLLSIHKKpTGISYVYLEPFMEIEKYYSIVKKFSDAK---VYQHLYTNGTLATEETLKALGEAGLDEIR 198 Clostridium acetobu... 20092510 64 KSD----EDLLKEAGLMDA-LGTGITGGEPLIKVERVLYYIRLLKSSFgKEHHIHLYT-SLAPDREILEKLAEAGLDEIR 137 Methanosarcina acet... 20094423 54 RSE----RDLVKEAELMDA-EGASLTGGDPLTRLERAVNIIRTLKDEFgDDFHIHLYAPAESVREGAIEELDGVGLDELR 128 Methanopyrus kandle... 14521276 73 RSE----KDIIEEAKIQDA-RGAGITGGDPLARLSRTVEYIRLLKEEFgKKFHIHLYTTGILASEEALEKLYDAGLDEIR 147 Pyrococcus abyssi 18313215 49 KRL----EDIPKIVAEYGS-DGAAVTGGDPSVVAERVKAVADLLKREFgEEFHIHMYTHILNLDSKRVGILAASKVDEVR 123 Pyrobaculum aerophilum 14590991 72 TKI----EDIIEEAKIQEA-KGAGVTGGDPLARLTRTVDYIRALKEEFgSKFHIHLYTTGILADKKALSMLYDAGLDEIR 146 Pyrococcus horikoshii 15897049 64 NNS----MDVIYEAYRMKA-LGAGITGGDPILEIGRVIEIIEELKNEFgYDFHIHLYTTGRYVNDDIMRELVNAGLDEMR 138 Sulfolobus solfatar... 15790988 55 EDD----EDIISEAKLMDA-LGTSITGGEPQEVLDRTCRYLRLLKDEFgEDHHTHLYT-GITGGRENMRRLSEAGLDEIR 128 Halobacterium sp. N... 11498816 71 KSV----EDVFEEIEMMDA-EGIAITGGEPLLKIEKVREYLKLAKKLD---LHVHLYT--SLPAGEKLKKLE--GLDEIR 138 Archaeoglobus fulgidus 14600862 88 ASV----EEAVAEVLRTGA-SGASLTGGDPLVALHRTLDVARALKSELgRGFHIHLYTSGRRMTPEVARALWEAGVDEVR 162 Aeropyrum pernix 15896576 122 GGTrfyeKDIDLLLSIHKKpTGISYVYLEPFMEIEKYYSIVKKFSDAK---VYQHLYTNGTLATEETLKALGEAGLDEIR 198 Clostridium acetobu... 20092510 64 KSD----EDLLKEAGLMDA-LGTGITGGEPLIKVERVLYYIRLLKSSFgKEHHIHLYT-SLAPDREILEKLAEAGLDEIR 137 Methanosarcina acet... 20094423 54 RSE----RDLVKEAELMDA-EGASLTGGDPLTRLERAVNIIRTLKDEFgDDFHIHLYAPAESVREGAIEELDGVGLDELR 128 Methanopyrus kandle... 14521276 73 RSE----KDIIEEAKIQDA-RGAGITGGDPLARLSRTVEYIRLLKEEFgKKFHIHLYTTGILASEEALEKLYDAGLDEIR 147 Pyrococcus abyssi 18313215 49 KRL----EDIPKIVAEYGS-DGAAVTGGDPSVVAERVKAVADLLKREFgEEFHIHMYTHILNLDSKRVGILAASKVDEVR 123 Pyrobaculum aerophilum 14590991 72 TKI----EDIIEEAKIQEA-KGAGVTGGDPLARLTRTVDYIRALKEEFgSKFHIHLYTTGILADKKALSMLYDAGLDEIR 146 Pyrococcus horikoshii 15897049 64 NNS----MDVIYEAYRMKA-LGAGITGGDPILEIGRVIEIIEELKNEFgYDFHIHLYTTGRYVNDDIMRELVNAGLDEMR 138 Sulfolobus solfatar... 15790988 55 EDD----EDIISEAKLMDA-LGTSITGGEPQEVLDRTCRYLRLLKDEFgEDHHTHLYT-GITGGRENMRRLSEAGLDEIR 128 Halobacterium sp. N...
2500057 139 LHPt-kIFNEGYDEEYIKFLCNKLnlcnKYIEDVGVEIPAIPNMENEILKLAEAIDGIA-KFMNINELEFSEENYHELEK 216 Methanocaldococcus ... 11498816 139 FHP----PELKSPEKYEESIRLAK----KLGMDAGFEIPAIRFEE----KIVEIVNRND-AFLNVNQLEVSESNWERIAE 205 Archaeoglobus fulgidus 14600862 163 IHP-----TERSLLSRVGMVK--R----YTGMSVGVEMPIAPGLEELAIEAVKTVEAVGgDFVNLNEMEIVEPNARALLA 231 Aeropyrum pernix 15896576 199 FNLg----ASKCSDKVIKNIGIAK----KYIKNVGIETPMTPELFEAFFEKKQAILDTKlDFINCAELHLNENNIGNYYG 270 Clostridium acetobu... 20092510 138 FHPpqvVWGELRHSPYADSLKNAK----ALGMETGIEIPSLEGAE----IVAAFAEEMG-IFLNLNELEFSDNNSDALLE 208 Methanosarcina acet... 20094423 129 VHP---SPDSTVNRRAAEVLE-------DSGMDLGFEMPAIPGEENWILEVAKLADEYGfDFLNVNELEFTESNAEELRR 198 Methanopyrus kandle... 14521276 148 FHPdlfQPNSKFFEREIENMKKAF----DFGWDVGGEVPAVPGFEDRIKWFASLLDKLGaKFLNINELEFSETNLRALLD 223 Pyrococcus abyssi 18313215 124 IHVi-sREQAVGREKYLKALV-------AAGKVVGVEVPALPGYERQIAEAINYLSPYI-SFVNINELDVSETNLERLRA 194 Pyrobaculum aerophilum 14590991 147 FHPdlfEPSSKFLNREIENLKNAF----DFNWDVGGEVPAVPGFEDRIKWFAGILDKWGgKFLNINELEYSETNLRNLLN 222 Pyrococcus horikoshii 15897049 139 FHP--------VKELYLNAVKVAL----KYDIDIGLELPAIPNEKDKIVRLIKWAEENNvKFVNLNELELNSRNYLNLNS 206 Sulfolobus solfatar... 15790988 129 FHPpyeLWGDMHGTEWEEILYIAR----EEGLTPAFEIPGIRAED----EFLEFLDEGAaDFCNINEFEMSDGNYERMQE 200 Halobacterium sp. N... 11498816 139 FHP----PELKSPEKYEESIRLAK----KLGMDAGFEIPAIRFEE----KIVEIVNRND-AFLNVNQLEVSESNWERIAE 205 Archaeoglobus fulgidus 14600862 163 IHP-----TERSLLSRVGMVK--R----YTGMSVGVEMPIAPGLEELAIEAVKTVEAVGgDFVNLNEMEIVEPNARALLA 231 Aeropyrum pernix 15896576 199 FNLg----ASKCSDKVIKNIGIAK----KYIKNVGIETPMTPELFEAFFEKKQAILDTKlDFINCAELHLNENNIGNYYG 270 Clostridium acetobu... 20092510 138 FHPpqvVWGELRHSPYADSLKNAK----ALGMETGIEIPSLEGAE----IVAAFAEEMG-IFLNLNELEFSDNNSDALLE 208 Methanosarcina acet... 20094423 129 VHP---SPDSTVNRRAAEVLE-------DSGMDLGFEMPAIPGEENWILEVAKLADEYGfDFLNVNELEFTESNAEELRR 198 Methanopyrus kandle... 14521276 148 FHPdlfQPNSKFFEREIENMKKAF----DFGWDVGGEVPAVPGFEDRIKWFASLLDKLGaKFLNINELEFSETNLRALLD 223 Pyrococcus abyssi 18313215 124 IHVi-sREQAVGREKYLKALV-------AAGKVVGVEVPALPGYERQIAEAINYLSPYI-SFVNINELDVSETNLERLRA 194 Pyrobaculum aerophilum 14590991 147 FHPdlfEPSSKFLNREIENLKNAF----DFNWDVGGEVPAVPGFEDRIKWFAGILDKWGgKFLNINELEYSETNLRNLLN 222 Pyrococcus horikoshii 15897049 139 FHP--------VKELYLNAVKVAL----KYDIDIGLELPAIPNEKDKIVRLIKWAEENNvKFVNLNELELNSRNYLNLNS 206 Sulfolobus solfatar... 15790988 129 FHPpyeLWGDMHGTEWEEILYIAR----EEGLTPAFEIPGIRAED----EFLEFLDEGAaDFCNINEFEMSDGNYERMQE 200 Halobacterium sp. N...
2500057 217 RGFMPKDDV-SNAIAGSEETALKVIKEFKG---DLFINYCPSVLKDAIQMRNRLINRAKNVAKPYEVITEDGLLLRGIMI 292 Methanocaldococcus ... 11498816 206 S-YSITDYY---VSDEETERIVKEYERAEK------FHYCSARFKDIAQFRRRLIRMAMNHP-EFYAVTRDGTLVCTRVE 274 Archaeoglobus fulgidus 14600862 232 RGYTESGER-PFTVRGALEAVLRVLEWAAEn-sSVPVHFCPASFKDSIQTGNRLRSSAARDAYWYEEPTPHGTLTWGEVR 309 Aeropyrum pernix 15896576 271 ESMYISRQG-YISPIWSRELTLKLMKIADEenwDLAVHDCSNHTKFARDLNLSSKEGKWFGASSYSCEFDRLPYQVFLPI 349 Clostridium acetobu... 20092510 209 NGFSLESDT-SCAAAGSHTHSEKAFQVCKR------VHFCSSTYKDAVQLRKRFQRIAKNTAREFDEITEDGTLIYGVIN 281 Methanosarcina acet... 20094423 199 RRFERVDDDlSDAVAGSERTALTALSEVANd-vGITLHYCPSEVKDAVQFRKRIKRMAKNVARDHEEIDEEGLIVKGIFE 277 Methanopyrus kandle... 14521276 224 RGYKPVSDE-SSAIKGSLEMGLKVLEWGEKn-tSLNYHLCTAKLKDAVQLRNRLKRMAKNVARPYMEITEDGTLRFGIAE 301 Pyrococcus abyssi 18313215 195 IGYKAEGLN----VAGSLEAARKIAQMVSVp-----VHICTGKTKDRVQIGSRLFKYAMRTSKPHEFVLDDGSVMYDEEG 265 Pyrobaculum aerophilum 14590991 223 RGYKPVSNE-SSAIKGSLELGLRILEWGERn-tSLNYHLCTAKLKDAVQLRNRLRRMAKNVAKPYMEITEDGTLRFGIAE 300 Pyrococcus horikoshii 15897049 207 KGFHAKHGI--TGVEGSFETALDVLKKFEDn-kKITVHYCSSIYKDLVETRTRFFRIIKYSSKPYEEYTNEATVVRAIVK 283 Sulfolobus solfatar... 15790988 201 AGYELQEGH-MSAVDGSKDAILSEMADHEQ------VYFCTSVFKDAAQHRSRLKRMARNVRREFDEITDDGTLVYGKTT 273 Halobacterium sp. N... 11498816 206 S-YSITDYY---VSDEETERIVKEYERAEK------FHYCSARFKDIAQFRRRLIRMAMNHP-EFYAVTRDGTLVCTRVE 274 Archaeoglobus fulgidus 14600862 232 RGYTESGER-PFTVRGALEAVLRVLEWAAEn-sSVPVHFCPASFKDSIQTGNRLRSSAARDAYWYEEPTPHGTLTWGEVR 309 Aeropyrum pernix 15896576 271 ESMYISRQG-YISPIWSRELTLKLMKIADEenwDLAVHDCSNHTKFARDLNLSSKEGKWFGASSYSCEFDRLPYQVFLPI 349 Clostridium acetobu... 20092510 209 NGFSLESDT-SCAAAGSHTHSEKAFQVCKR------VHFCSSTYKDAVQLRKRFQRIAKNTAREFDEITEDGTLIYGVIN 281 Methanosarcina acet... 20094423 199 RRFERVDDDlSDAVAGSERTALTALSEVANd-vGITLHYCPSEVKDAVQFRKRIKRMAKNVARDHEEIDEEGLIVKGIFE 277 Methanopyrus kandle... 14521276 224 RGYKPVSDE-SSAIKGSLEMGLKVLEWGEKn-tSLNYHLCTAKLKDAVQLRNRLKRMAKNVARPYMEITEDGTLRFGIAE 301 Pyrococcus abyssi 18313215 195 IGYKAEGLN----VAGSLEAARKIAQMVSVp-----VHICTGKTKDRVQIGSRLFKYAMRTSKPHEFVLDDGSVMYDEEG 265 Pyrobaculum aerophilum 14590991 223 RGYKPVSNE-SSAIKGSLELGLRILEWGERn-tSLNYHLCTAKLKDAVQLRNRLRRMAKNVAKPYMEITEDGTLRFGIAE 300 Pyrococcus horikoshii 15897049 207 KGFHAKHGI--TGVEGSFETALDVLKKFEDn-kKITVHYCSSIYKDLVETRTRFFRIIKYSSKPYEEYTNEATVVRAIVK 283 Sulfolobus solfatar... 15790988 201 AGYELQEGH-MSAVDGSKDAILSEMADHEQ------VYFCTSVFKDAAQHRSRLKRMARNVRREFDEITDDGTLVYGKTT 273 Halobacterium sp. N...
2500057 293 FDNeddlkEMAEILEENEI--EFEIIDKN---ICLNPFILEDIIEEMKRqrf--piTFSAYISELYPTADALEV--ERIP 363 Methanocaldococcus ... 11498816 275 GDAer-lsIAEEILRKAGQ--EFVRFEDC---IETTPELEKKIREALKSe------GLRLRIVERYPTYNRLVL--EVMD 340 Archaeoglobus fulgidus 14600862 310 GGS-----PPPGLGEERGG---RIMLPPR-------ADLLETVVRMYGG---------EAYIVEAHPTPSRTPIvsERRI 365 Aeropyrum pernix 15896576 350 LR--------DENFKFLSE--EELPDGYK------PGEMLF--------------------------------------- 374 Clostridium acetobu... 20092510 282 GGNq---aLAEEILREIEIpdELFEVKEGk--IEIAWWVLEDLKDGLKEele--plGTRIFIVERHPFEDGLLV--ELIP 352 Methanosarcina acet... 20094423 278 VISgdpedLADVLINILEVpeEWVYVDGSr--VETKPFVVDELADVLSDleeasrcEIRAWIIREYPTWDRTVV--ERWP 353 Methanopyrus kandle... 14521276 302 YDdl--eeLYEFLVEEAEVprEWLYINWEkkrIEMPVEVAEELADAIEG-------DVKFYIVEEYPTWDRIEV--ERIP 370 Pyrococcus abyssi 18313215 266 YHP------KSVRAKKIRV---KITLGGK------EIEV----------------------------------------- 289 Pyrobaculum aerophilum 14590991 301 YEdl--eeLYKFLIEEAEVprEWLYINWEkkrIEMPIEVAEELAEVVEG-------DVKFYIVEEYPTWDRIEV--ERIP 369 Pyrococcus horikoshii 15897049 284 TKG-------EIPILENFG--ESTGSDEY----SISPSIVGDLLNDYTNl------INEIYIVEEHPDSRRLRVg-EKLI 343 Sulfolobus solfatar... 15790988 274 VG--------AGRIRELGVpeEYYTVKSDh--VEVAWWLLEEMID--DGdi---ddGE---IVEQYPTYDGQVV--ERTP 333 Halobacterium sp. N... 11498816 275 GDAer-lsIAEEILRKAGQ--EFVRFEDC---IETTPELEKKIREALKSe------GLRLRIVERYPTYNRLVL--EVMD 340 Archaeoglobus fulgidus 14600862 310 GGS-----PPPGLGEERGG---RIMLPPR-------ADLLETVVRMYGG---------EAYIVEAHPTPSRTPIvsERRI 365 Aeropyrum pernix 15896576 350 LR--------DENFKFLSE--EELPDGYK------PGEMLF--------------------------------------- 374 Clostridium acetobu... 20092510 282 GGNq---aLAEEILREIEIpdELFEVKEGk--IEIAWWVLEDLKDGLKEele--plGTRIFIVERHPFEDGLLV--ELIP 352 Methanosarcina acet... 20094423 278 VISgdpedLADVLINILEVpeEWVYVDGSr--VETKPFVVDELADVLSDleeasrcEIRAWIIREYPTWDRTVV--ERWP 353 Methanopyrus kandle... 14521276 302 YDdl--eeLYEFLVEEAEVprEWLYINWEkkrIEMPVEVAEELADAIEG-------DVKFYIVEEYPTWDRIEV--ERIP 370 Pyrococcus abyssi 18313215 266 YHP------KSVRAKKIRV---KITLGGK------EIEV----------------------------------------- 289 Pyrobaculum aerophilum 14590991 301 YEdl--eeLYKFLIEEAEVprEWLYINWEkkrIEMPIEVAEELAEVVEG-------DVKFYIVEEYPTWDRIEV--ERIP 369 Pyrococcus horikoshii 15897049 284 TKG-------EIPILENFG--ESTGSDEY----SISPSIVGDLLNDYTNl------INEIYIVEEHPDSRRLRVg-EKLI 343 Sulfolobus solfatar... 15790988 274 VG--------AGRIRELGVpeEYYTVKSDh--VEVAWWLLEEMID--DGdi---ddGE---IVEQYPTYDGQVV--ERTP 333 Halobacterium sp. N...
2500057 364 L 364 Methanocaldococcus jannaschii 11498816 341 I 341 Archaeoglobus fulgidus 14600862 366 A 366 Aeropyrum pernix 15896576 - Clostridium acetobutylicum 20092510 353 L 353 Methanosarcina acetivorans C2A 20094423 354 V 354 Methanopyrus kandleri AV19 14521276 371 L 371 Pyrococcus abyssi 18313215 - Pyrobaculum aerophilum 14590991 370 L 370 Pyrococcus horikoshii 15897049 344 Y 344 Sulfolobus solfataricus 15790988 334 L 334 Halobacterium sp. NRC-1 11498816 341 I 341 Archaeoglobus fulgidus 14600862 366 A 366 Aeropyrum pernix 15896576 - Clostridium acetobutylicum 20092510 353 L 353 Methanosarcina acetivorans C2A 20094423 354 V 354 Methanopyrus kandleri AV19 14521276 371 L 371 Pyrococcus abyssi 18313215 - Pyrobaculum aerophilum 14590991 370 L 370 Pyrococcus horikoshii 15897049 344 Y 344 Sulfolobus solfataricus 15790988 334 L 334 Halobacterium sp. NRC-1
Lu S et al.(2020). "CDD/SPARCLE: the conserved domain database in 2020.",