Conserved Protein Domain Family
IspE

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COG1947: IspE 
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]
Statistics
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PSSM-Id: 224858
View PSSM: COG1947
Aligned: 40 rows
Threshold Bit Score: 256.033
Threshold Setting Gi: 12230307
Created: 7-Oct-2002
Updated: 23-Jan-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
20138622   1 MRSYKLIAPAKINLYLEIIGDRPD-GYHELVMILQSID-LADEIEIHSLSSETIHVHC-N-HPQVPTDKs--NLVYRAAE 74  Nostoc sp. PCC 7120
20138682   1 ---MNVKAYAKVNISLDVIGKRED-GYHLLKMIMQSIN-LYDVLDIRIID-EGIKITS-N-RRNIPTNDk--NIAYRAAK 70  Clostridium acetobu...
6919913    1 ---MHFLSPAKLNLFLQILGRRED-DFHEIVTRYQAIA-FGDQLSLSISSRDSLQVIN---ACHLETPS---NSIWKSVA 69  Chlamydia trachomatis
12230307   1 -----MKAYAKANIFLKLTGFDSR-KYHLLESRFILLKdVFDELELVDKESDSKKEF--EiISNFKCEN---NIIQKAYL 69  Campylobacter jejuni
22095772   5 LNKYKIFSNAKINIGLNVFQKESD-GYHNIDSIMAPID-LSDEMDVTFYSDLGDLKIE-CsDKSIPTDEr--NILYKTYK 79  Fusobacterium nucle...
6919910    1 -MTHVFEVYPKVNIFLKILHKEG--AYHKLISRMCLVK-DKLKDIISVKSALSFSLKG-DfDCPLEENSlfkALQILKNF 75  Helicobacter pylori
6919916    7 SGSAELVSYAKLNLYLDVLGKRSD-GYHEIVGLFQTIS-LHDTLTVEICD-RGFYLES-S--VALPSD----NTIKRAWE 76  Thermotoga maritima
6919912    1 MQSLSLRAHAKVNMHLWVGARRAD-GLHSIESVMQRIT-LADSLSLSRLDIPGRCEVC-SpYMALPRE----NTLTRAYA 73  Treponema pallidum
13358165   1 ---MKVKSFAKIDLGYSVYKKQKNfTKHDFESIFILVEnIYDDIEITKIEKNIDDVHYyNeTNEIYVYS---RLVHKTLE 74  Ureaplasma urealyticum
6919918    1 -MTHVFEVYPKVNVFLKILHKEG--AYHKIISRMCLVK-NKLKDIISVKNALSFSLKG-DfDCPLEENSlfkALQVLKKF 75  Helicobacter pylori...
20138622  75 LMVTRFPea-ftKHGGVDITVHKHIPVAAGLAGGSTNAAAVLVGIDLLWNLGLTQTELEELGSTLGSDVPFCVA-GGTVI 152 Nostoc sp. PCC 7120
20138682  71 LFMDTYK-----IDKGISIHINKRIPVAAGLAGGSADGAAVLKAMRDIFKKDVSDEELINLGVKIGADIPFCIV-GGTAF 144 Clostridium acetobu...
6919913   70 LFRRYTG-----ITTPVSWRVVKQIPVGAGLAGGSSNAATALFALNQIFKTGLSDEEMRSLAEQLGVDTPFFFS-TGAAL 143 Chlamydia trachomatis
12230307  70 LLSRRYNnelkeLFSKKSLKLTKNIPVCAGLGGGSSDCASFLLLINETLNLKLNLQELINLSIQLGSDIAFFLSgFHSAN 149 Campylobacter jejuni
22095772  80 IFFEESKk----EKEKIDIILKKNIPSEAGLGGGSSNAGFFLKLLNKHYGNVYNEKELEKLAMRVGSDVPFFIK-NKTAR 154 Fusobacterium nucle...
6919910   76 LKSKNFShsvikSLDTLAIEVEKNIPTQAGLGGGSTDAGGLLYHLNQIFDWRLSLEELYSMGSLVGADTNFFISqYKSTN 155 Helicobacter pylori
6919916   77 MFRKNTG-----KEFGLKVTLKKEIPVGSGLGGGSSNAAAVLRYLGEVFKIPLEDL--LNIAAQVGSDVPFFLY-GGTAL 148 Thermotoga maritima
6919912   74 RFCQVTG-----VHDGVRVRVVKRIPAGSGLGGGSADAAALLCGLDTLFGTTLSARVLREVAYSVGSDVPFFLA-SQAAC 147 Treponema pallidum
13358165  75 WIRHTYH-----IKNHYRINIKKRIPIGAGLGGGSSNAAAIMKYILEFEGIKEINY--KDVVNKLGADIPFFLSgYKTAY 147 Ureaplasma urealyticum
6919918   76 LVQKNFShsvikSLDTLAIEVEKNIPTQAGLGGGSADAGGLLYHLNQMFDWRLSLKELYTMGSLVGADTNFFISqYKSAN 155 Helicobacter pylori...
20138622 153 ATGRGEQLSPLPS-LDHIYIVLGKYrSLEVSTAWAYKnyrqeygstyLRDTNdla--srAAAVHSGSIVKAIVEKDAVAI 229 Nostoc sp. PCC 7120
20138682 145 CEGIGEKITKLRS-MNGKIIVLVKP-DFGVSTKMVYTe--------yDKCLD-------VKHPDSEGLVKAVNNGHFKFV 207 Clostridium acetobu...
6919913  144 GVARGEKIIALEEsVSDRYVLYFSS--EGVLTSRAFA----------AVQPS---------DCSSR-----KNLEYT--- 194 Chlamydia trachomatis
12230307 150 VSSCGEIIEEFED--DIPNLKWTFP-QISCQTKAVYDe--------fDRGIFd-----fQKNNNQAQIYKKLSTKELLQN 213 Campylobacter jejuni
22095772 155 VGGKGNRVDLVEN-NLKDSIILIKPlDFGVSTKEAYEs---------FDNLK-------EVKYADFDKIIKNLKEGNRIA 217 Fusobacterium nucle...
6919910  156 ATSYGEVIENFEEePLENRLEIYAPnHVFCSTKAVYQa---------YKPET-------CFSQAKEWLK-KPSLECLKTY 218 Helicobacter pylori
6919916  149 VRGRGEIVEKLED-IEGYSVDLFFP-GIHSSTKEMYLs--------lTPEMYr------KGPGRVEELHRAYLERNYEKI 212 Thermotoga maritima
6919912  148 VLGGGEQLVPLVP-KTGYLGLLVWP-GLHSGSAQAYEd---------LDRLRacgvhaaDGEQYSLRGATALSAHYAQDC 216 Treponema pallidum
13358165 148 ISDYGSVLEDLTGqFKLNYEVYLMN--VNVNTKIVFEk---------FDDNS-------WHVIKNN---FKTIIKNLKEN 206 Ureaplasma urealyticum
6919918  156 ATSYGEVIENFEEeSLEDRLEIYAPnHVFCSTKAVYQa---------YKPET-------CFFQAKEWLK-KTSLECLKTY 218 Helicobacter pylori...
20138622 230 AQRLH-NDLEKVVLPSYPQVLHl-RELLASQP-GVIGTMMSGSGPSVFALCETQAQAEQVQQQVR--QTIPde---dLEL 301 Nostoc sp. PCC 7120
20138682 208 VNNMV-NVLENVTAVKYKEINE--IKEKALEY-NSIGTMMSGSGPTVFSFFDNTKEAEKYFYEMKk-EYN--------KV 274 Clostridium acetobu...
6919913  195 Q--N---DLEKPVFRLRLDLKEkkHWLENLWAeLPVHIGLTGSGATLFVRYPEILEEDLSYAAQIqrAVTLsgglltSPI 269 Chlamydia trachomatis
12230307 214 FKNKElNDLFTPCATLYPKMKS----YLQE-D-----FFLSGSGSSVFKVDR---------------------------- 255 Campylobacter jejuni
22095772 218 LESNIeNSLEQGILETDTNIKM--LKMTLNSVvSGKKFFMSGSGSTYYTFVTELEKSQIETRLKT-------------FV 282 Fusobacterium nucle...
6919910  219 DRNGL-NDLLKPALLTNQALKD--IESELGKE-W----FFSGSGSAFFRLKPMQKGGE---------------------- 268 Helicobacter pylori
6919916  213 KELSY-NVFEKVFLEKHPEVMD--GLRNFGD--GSIVKMMTGSGSVFFALYPLDKGNYSFVGGV---------------- 271 Thermotoga maritima
6919912  217 ARWRFfNSLDAPVQRRYPVVAL--ARWDLARA-GACFTAMSGSGSXVFGLYRDEEELRRAHKLLAk-RWC--------WC 284 Treponema pallidum
13358165 207 IVVNIhNDLQEYCFELYPNIKY--KYNELLSD-G-FYTILSGAGSSFIRIKLKNKEDLIINEN----------------- 265 Ureaplasma urealyticum
6919918  219 DRNEL-NDLLKPALRTNPALKD--IESQLSKE-W----FFSGSGSAFFRLKNTQKGANETHCQQ---------------- 274 Helicobacter pylori...
20138622 302 FVTRTITHGIQ 312 Nostoc sp. PCC 7120
20138682 275 FITRTV----- 280 Clostridium acetobutylicum
6919913  270 RRDPTAWYSIY 280 Chlamydia trachomatis
12230307     ----------- Campylobacter jejuni
22095772 283 DNVKIIICKTI 293 Fusobacterium nucleatum subsp. nucleatum
6919910      ----------- Helicobacter pylori
6919916      ----------- Thermotoga maritima
6919912  285 VRVRLCG---- 291 Treponema pallidum
13358165     ----------- Ureaplasma urealyticum
6919918      ----------- Helicobacter pylori J99
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