6323218 739 SYKFGLLTIGS-RGDVQPYIALGKGLIKEGHQVVIITHSEFRDFVESHGiQFEEIAGNpVELMSLMVENESMNVKMLReA 817 baker's yeast 20089343 1 -MKIMIFICGEgLGHTSRCLALGKELLNAGHEIKFGAYGYSKELVEKTG--YTAQEIPsEIKLVGKAGSLDLTGSIEAtL 77 Methanosarcina ac... 20089344 37 NMKILLFICGEgLGHTSRCLALGKEFLAAGHEVSFGAYGYSRELVRKTG--YSAWEIQpEIRLIGETGIFDIGKSIKEtL 114 Methanosarcina ac... 15669441 4 NMKILISVCGEgFGHTTRCVAIG-EALKNDYEISYIAYGKSKNFIEKYG--FKVFETFpEIKLKGKDGKFDITSSILN-K 79 Methanocaldococcu... 20094413 1 -------------------MGLGRELRRIGLEPVFSSFGEGREMLMREFpDAPVYGLP-KIELFSEDGSFDLLLLLR--R 58 Methanopyrus kand... 15842509 30 RQRILFVGEAAtLAHVVRPFVLARSLDPSRYEVHFACDPRFNKLLGPLP--FPHHPIH-TVPSEEVLLKIAQGRLFYN-T 105 Mycobacterium tub... 15842513 42 RRRILFVAEAVtLAHVVRPFALAQSLDPSRYEVHFACDPRYNQLLGPLP--FRHHAIH-TIPSERFFGNLTQGR-FYA-M 116 Mycobacterium tub... 15678904 236 krRVLYSVCGEgMGHAIRSGVILDKLTEDHEVLIFASDRAYKYLSSKFD---NVHEIY-GFNTVYEDNSVNDVKTFLR-A 310 Methanothermobact... 15610095 30 RQRILFVGEAAtLAHVVRPFVLARSLDPSRYEVHFACDPRFNKLLGPLP--FPHHPIH-TVPSEEVLLKIAQGRLFYN-T 105 Mycobacterium tub... 15610099 42 RRRILFVAEAVtLAHVVRPFALAQSLDPSRYEVHFACDPRYNQLLGPLP--FRHHAIH-TIPSERFFGNLTQGR-FYA-M 116 Mycobacterium tub... 20089343 1 -MKIMIFICGEgLGHTSRCLALGKELLNAGHEIKFGAYGYSKELVEKTG--YTAQEIPsEIKLVGKAGSLDLTGSIEAtL 77 Methanosarcina ac... 20089344 37 NMKILLFICGEgLGHTSRCLALGKEFLAAGHEVSFGAYGYSRELVRKTG--YSAWEIQpEIRLIGETGIFDIGKSIKEtL 114 Methanosarcina ac... 15669441 4 NMKILISVCGEgFGHTTRCVAIG-EALKNDYEISYIAYGKSKNFIEKYG--FKVFETFpEIKLKGKDGKFDITSSILN-K 79 Methanocaldococcu... 20094413 1 -------------------MGLGRELRRIGLEPVFSSFGEGREMLMREFpDAPVYGLP-KIELFSEDGSFDLLLLLR--R 58 Methanopyrus kand... 15842509 30 RQRILFVGEAAtLAHVVRPFVLARSLDPSRYEVHFACDPRFNKLLGPLP--FPHHPIH-TVPSEEVLLKIAQGRLFYN-T 105 Mycobacterium tub... 15842513 42 RRRILFVAEAVtLAHVVRPFALAQSLDPSRYEVHFACDPRYNQLLGPLP--FRHHAIH-TIPSERFFGNLTQGR-FYA-M 116 Mycobacterium tub... 15678904 236 krRVLYSVCGEgMGHAIRSGVILDKLTEDHEVLIFASDRAYKYLSSKFD---NVHEIY-GFNTVYEDNSVNDVKTFLR-A 310 Methanothermobact... 15610095 30 RQRILFVGEAAtLAHVVRPFVLARSLDPSRYEVHFACDPRFNKLLGPLP--FPHHPIH-TVPSEEVLLKIAQGRLFYN-T 105 Mycobacterium tub... 15610099 42 RRRILFVAEAVtLAHVVRPFALAQSLDPSRYEVHFACDPRYNQLLGPLP--FRHHAIH-TIPSERFFGNLTQGR-FYA-M 116 Mycobacterium tub...
6323218 818 SSKFRGWIDALLQTSWEVCNRRKFDILIESPSamvgiHITEALQIPYFRAFTMPWTRTRAYPHAFIVPDQKrGGNYNYLT 897 baker's yeast 20089343 78 KSAQLLGGPKLLKLLREFKPDVVVSDSYYLGT-----LAAMVLKLPVYLIINQ-SNMEEFFKNRGVPVRII-GKLTKKFY 150 Methanosarcina ac... 20089344 115 RNLSPVGFRKLLKLIEVLEPDVVLSDGYYSGI-----LAARSRKVPVYFIGHQ-FNMEEFFQKKGPLLAVA-GKLVRRFY 187 Methanosarcina ac... 15669441 80 EYSPKKAIRREINIIREYNPDLIISDCKYSTV-----VAAKLLKKPVICISNQNYTRYKLKT-DLIVYP------TMKAL 147 Methanocaldococcu... 20094413 59 HPDLPLRFYAGVEADRR---------------------VIRRHGCKVVVSDCQFHALVAAQIIGVPAIVIS-NMLRVPGE 116 Methanopyrus kand... 15842509 106 RTLRKYIA-ADRKILNEIAPDVVVGDNRLSLS-----VSARLAGIPYIAIANAYWSPQARRRFPLPDVPWT-RFFGVRPV 178 Mycobacterium tub... 15842513 117 RTLRKYVE-ADLRVLDEIAPDLVVGDLRISLS-----VSARLAGIPYIAIANAYWSPYAQRRFPLPDVIWT-RLFGVRLV 189 Mycobacterium tub... 15678904 311 MKTFPRDLKENLRLLYR---------------------IARDFKPDVVVSDFEFYASVVSNMLRIPLISID-----NMHV 364 Methanothermobact... 15610095 106 RTLRKYIA-ADRKILNEIAPDVVVGDNRLSLS-----VSARLAGIPYIAIANAYWSPQARRRFPLPDVPWT-RFFGVRPV 178 Mycobacterium tub... 15610099 117 RTLRKYVE-ADLRVLDEIAPDLVVGDLRISLS-----VSARLAGIPYIAIANAYWSPYAQRRFPLPDVIWT-RLFGVRLV 189 Mycobacterium tub... 20089343 78 KSAQLLGGPKLLKLLREFKPDVVVSDSYYLGT-----LAAMVLKLPVYLIINQ-SNMEEFFKNRGVPVRII-GKLTKKFY 150 Methanosarcina ac... 20089344 115 RNLSPVGFRKLLKLIEVLEPDVVLSDGYYSGI-----LAARSRKVPVYFIGHQ-FNMEEFFQKKGPLLAVA-GKLVRRFY 187 Methanosarcina ac... 15669441 80 EYSPKKAIRREINIIREYNPDLIISDCKYSTV-----VAAKLLKKPVICISNQNYTRYKLKT-DLIVYP------TMKAL 147 Methanocaldococcu... 20094413 59 HPDLPLRFYAGVEADRR---------------------VIRRHGCKVVVSDCQFHALVAAQIIGVPAIVIS-NMLRVPGE 116 Methanopyrus kand... 15842509 106 RTLRKYIA-ADRKILNEIAPDVVVGDNRLSLS-----VSARLAGIPYIAIANAYWSPQARRRFPLPDVPWT-RFFGVRPV 178 Mycobacterium tub... 15842513 117 RTLRKYVE-ADLRVLDEIAPDLVVGDLRISLS-----VSARLAGIPYIAIANAYWSPYAQRRFPLPDVIWT-RLFGVRLV 189 Mycobacterium tub... 15678904 311 MKTFPRDLKENLRLLYR---------------------IARDFKPDVVVSDFEFYASVVSNMLRIPLISID-----NMHV 364 Methanothermobact... 15610095 106 RTLRKYIA-ADRKILNEIAPDVVVGDNRLSLS-----VSARLAGIPYIAIANAYWSPQARRRFPLPDVPWT-RFFGVRPV 178 Mycobacterium tub... 15610099 117 RTLRKYVE-ADLRVLDEIAPDLVVGDLRISLS-----VSARLAGIPYIAIANAYWSPYAQRRFPLPDVIWT-RLFGVRLV 189 Mycobacterium tub...
6323218 898 HVLFENVFWKGISGQVnkwrVETLGLGKTNLFLLQQNNVPFLYNVSPTIFPPSIDFSEWVrvTGYWFLDDKSTFKPPAEL 977 baker's yeast 20089343 151 KEVFEKTDKIIIPDYP----LPYTVCRKNLNFAPKLR--GKLFYSGPLVREKYEDIDSIP--LEKPHVVSLIGGFGYREP 222 Methanosarcina ac... 20089344 188 NYIFSSVDGIMVPDYP----LPYSVNRRNFTIPRALN--PNIFFSGPLIRSRYREVEAKA--FRHPNVLSTIGAFGYRAA 259 Methanosarcina ac... 15669441 148 NIINERCERFIVPDFP----LPYTICEYNLK--I----IKNMEFIGPLIRYDVDDVDN----YGEDYILSVIGGFEYRYK 213 Methanocaldococcu... 20094413 117 GSLVRLINGMLRRMFE----LADIVLIPDT---------YDDTYDVPEIDTEVVWVG--------PILKRRPDELPPRDA 175 Methanopyrus kand... 15842509 179 SILYRLYRPLIFALYC----LPLNWLRRKHGLSSLGWDLCRIFTDGDYTLYADVPELVPT--YNLPANHRYLGPVLWSPD 252 Mycobacterium tub... 15842513 190 KLLYRLERPLLFALQC----MPLNWVRRRHGLSSLGWNLCRIFTDGDHTLYADVPELMPT--YDLPANHEYLGPVLWSPA 263 Mycobacterium tub... 15678904 365 ITQCRIEYPERFRRDK----LKAEAVVRSFIVR------PRRYLITSYFFPEVKN----------PDKVSMYPPVLREKI 424 Methanothermobact... 15610095 179 SILYRLYRPLIFALYC----LPLNWLRRKHGLSSLGWDLCRIFTDGDYTLYADVPELVPT--YNLPANHRYLGPVLWSPD 252 Mycobacterium tub... 15610099 190 KLLYRLERPLLFALQC----MPLNWVRRRHGLSSLGWNLCRIFTDGDHTLYADVPELMPT--YDLPANHEYLGPVLWSPA 263 Mycobacterium tub... 20089343 151 KEVFEKTDKIIIPDYP----LPYTVCRKNLNFAPKLR--GKLFYSGPLVREKYEDIDSIP--LEKPHVVSLIGGFGYREP 222 Methanosarcina ac... 20089344 188 NYIFSSVDGIMVPDYP----LPYSVNRRNFTIPRALN--PNIFFSGPLIRSRYREVEAKA--FRHPNVLSTIGAFGYRAA 259 Methanosarcina ac... 15669441 148 NIINERCERFIVPDFP----LPYTICEYNLK--I----IKNMEFIGPLIRYDVDDVDN----YGEDYILSVIGGFEYRYK 213 Methanocaldococcu... 20094413 117 GSLVRLINGMLRRMFE----LADIVLIPDT---------YDDTYDVPEIDTEVVWVG--------PILKRRPDELPPRDA 175 Methanopyrus kand... 15842509 179 SILYRLYRPLIFALYC----LPLNWLRRKHGLSSLGWDLCRIFTDGDYTLYADVPELVPT--YNLPANHRYLGPVLWSPD 252 Mycobacterium tub... 15842513 190 KLLYRLERPLLFALQC----MPLNWVRRRHGLSSLGWNLCRIFTDGDHTLYADVPELMPT--YDLPANHEYLGPVLWSPA 263 Mycobacterium tub... 15678904 365 ITQCRIEYPERFRRDK----LKAEAVVRSFIVR------PRRYLITSYFFPEVKN----------PDKVSMYPPVLREKI 424 Methanothermobact... 15610095 179 SILYRLYRPLIFALYC----LPLNWLRRKHGLSSLGWDLCRIFTDGDYTLYADVPELVPT--YNLPANHRYLGPVLWSPD 252 Mycobacterium tub... 15610099 190 KLLYRLERPLLFALQC----MPLNWVRRRHGLSSLGWNLCRIFTDGDHTLYADVPELMPT--YDLPANHEYLGPVLWSPA 263 Mycobacterium tub...
6323218 978 QEFISEa--RSKGKKLVYIGFGSIVVSnaKEMTEALVEAVMEADVYCILNKgwserlGDkAAKkTEVDLPRNILNIGNVP 1055 baker's yeast 20089343 223 IFR-KVlttAMLDPGINYTLISGPS---------LDPSKLGGVP----------------------KNVRILNFVEDTYP 270 Methanosarcina ac... 20089344 260 IFR-KVleaAKLDPDIHYTFIAGPG---------IVPEQFPEIP----------------------ENVEFTGFTDNPFP 307 Methanosarcina ac... 15669441 214 ILEELG---KIALKNNLNVKLVCGS-------YEVAKKLMRDLN----LNS------YK------NENVEIIPITTNMKE 267 Methanocaldococcu... 20094413 176 VRRKYG---IPDDATVVLVTAGGSKYG--RRIVRIAVEGLKLLSKSIDVFP------VIiSEE--RVGDGLGLQLRYVDN 242 Methanopyrus kand... 15842509 253 VKPPTWwhsLPTDRPIIYATLGSSGGK---NLLQVVLNALADLPVTVIAAT------AG--RN-HLKNVPANAFVADYLP 320 Mycobacterium tub... 15842513 264 GKPPTWwdsLPTDRPIVYATLGTSGGR---NLLQLVLNALAELPVTVIAAT------AG--RS-DLKTVPANAFVADYLP 331 Mycobacterium tub... 15678904 425 MNLKP----YYGDHVMVYQTSQSNR---------KLLELLRSIDRKFVVYG------FD--RE--GVDGNLTFRRFNEDQ 481 Methanothermobact... 15610095 253 VKPPTWwhsLPTDRPIIYATLGSSGGK---NLLQVVLNALADLPVTVIAAT------AG--RN-HLKNVPANAFVADYLP 320 Mycobacterium tub... 15610099 264 GKPPTWwdsLPTDRPIVYATLGTSGGR---NLLQLVLNALAELPVTVIAAT------AG--RS-DLKTVPANAFVADYLP 331 Mycobacterium tub... 20089343 223 IFR-KVlttAMLDPGINYTLISGPS---------LDPSKLGGVP----------------------KNVRILNFVEDTYP 270 Methanosarcina ac... 20089344 260 IFR-KVleaAKLDPDIHYTFIAGPG---------IVPEQFPEIP----------------------ENVEFTGFTDNPFP 307 Methanosarcina ac... 15669441 214 ILEELG---KIALKNNLNVKLVCGS-------YEVAKKLMRDLN----LNS------YK------NENVEIIPITTNMKE 267 Methanocaldococcu... 20094413 176 VRRKYG---IPDDATVVLVTAGGSKYG--RRIVRIAVEGLKLLSKSIDVFP------VIiSEE--RVGDGLGLQLRYVDN 242 Methanopyrus kand... 15842509 253 VKPPTWwhsLPTDRPIIYATLGSSGGK---NLLQVVLNALADLPVTVIAAT------AG--RN-HLKNVPANAFVADYLP 320 Mycobacterium tub... 15842513 264 GKPPTWwdsLPTDRPIVYATLGTSGGR---NLLQLVLNALAELPVTVIAAT------AG--RS-DLKTVPANAFVADYLP 331 Mycobacterium tub... 15678904 425 MNLKP----YYGDHVMVYQTSQSNR---------KLLELLRSIDRKFVVYG------FD--RE--GVDGNLTFRRFNEDQ 481 Methanothermobact... 15610095 253 VKPPTWwhsLPTDRPIIYATLGSSGGK---NLLQVVLNALADLPVTVIAAT------AG--RN-HLKNVPANAFVADYLP 320 Mycobacterium tub... 15610099 264 GKPPTWwdsLPTDRPIVYATLGTSGGR---NLLQLVLNALAELPVTVIAAT------AG--RS-DLKTVPANAFVADYLP 331 Mycobacterium tub...
6323218 1056 HDWLFPQVDAAVHHGGSGTTGASLRAGLPTVIKPFF--GDQFFYAGRVEDIGVGIALK--KLNAQTLADALKVATTNKIM 1131 baker's yeast 20089343 271 ---YIKSSDAVIAPGGHSTIMEALSFGVPILSFPDEghSEQESNAAVVEEEGYGRMLSy-STPPEVILECIREVIEDEAY 346 Methanosarcina ac... 20089344 308 ---YYRGSDLVITAGGHGTIMESLAFGLPVLSFPDEkhTEQENNATVLEDAGYGKRMSy-LTRPEVILACIREVLEDENY 383 Methanosarcina ac... 15669441 268 ---LIKNAELIVSHGGHSTIMEALSFGKPLIVIPDLdhPEQGNNAKKVHDLGCGIALS--YKELYRLEEAILDIRNMKMY 342 Methanocaldococcu... 20094413 243 LLELIKVSNVVITHGGHTTLSECACLRTPVVSVPLPnhPEQHMNAERVLQRGLGVAVPpeELSPKRIAEAIEQAID---W 319 Methanopyrus kand... 15842509 321 GEAAAARSAVVLCNGGSPTTQQALAAGVPVIGLPSN--MDQHLNMEALERAGAGVLLRteRLNTEGVAAAVKQVLSGAEF 398 Mycobacterium tub... 15842513 332 GEAAAARSAVVVCNGGSLTTQQALVAGVPVIGVAGN--LDQHLNMEAVERAGAGVLLRteRLKSQRVAGAVMQVISRSEY 409 Mycobacterium tub... 15678904 482 FFRDFESAAAVITNGGFTLISEALYLRKPVYSVPVRgqFEQILNAVYLEKLGYG------EFHEKTERESLERFLDRLDI 555 Methanothermobact... 15610095 321 GEAAAARSAVVLCNGGSPTTQQALAAGVPVIGLPSN--MDQHLNMEALERAGAGVLLRteRLNTEGVAAAVKQVLSGAEF 398 Mycobacterium tub... 15610099 332 GEAAAARSAVVVCNGGSLTTQQALVAGVPVIGVAGN--LDQHLNMEAVERAGAGVLLRteRLKSQRVAGAVMQVISRSEY 409 Mycobacterium tub... 20089343 271 ---YIKSSDAVIAPGGHSTIMEALSFGVPILSFPDEghSEQESNAAVVEEEGYGRMLSy-STPPEVILECIREVIEDEAY 346 Methanosarcina ac... 20089344 308 ---YYRGSDLVITAGGHGTIMESLAFGLPVLSFPDEkhTEQENNATVLEDAGYGKRMSy-LTRPEVILACIREVLEDENY 383 Methanosarcina ac... 15669441 268 ---LIKNAELIVSHGGHSTIMEALSFGKPLIVIPDLdhPEQGNNAKKVHDLGCGIALS--YKELYRLEEAILDIRNMKMY 342 Methanocaldococcu... 20094413 243 LLELIKVSNVVITHGGHTTLSECACLRTPVVSVPLPnhPEQHMNAERVLQRGLGVAVPpeELSPKRIAEAIEQAID---W 319 Methanopyrus kand... 15842509 321 GEAAAARSAVVLCNGGSPTTQQALAAGVPVIGLPSN--MDQHLNMEALERAGAGVLLRteRLNTEGVAAAVKQVLSGAEF 398 Mycobacterium tub... 15842513 332 GEAAAARSAVVVCNGGSLTTQQALVAGVPVIGVAGN--LDQHLNMEAVERAGAGVLLRteRLKSQRVAGAVMQVISRSEY 409 Mycobacterium tub... 15678904 482 FFRDFESAAAVITNGGFTLISEALYLRKPVYSVPVRgqFEQILNAVYLEKLGYG------EFHEKTERESLERFLDRLDI 555 Methanothermobact... 15610095 321 GEAAAARSAVVLCNGGSPTTQQALAAGVPVIGLPSN--MDQHLNMEALERAGAGVLLRteRLNTEGVAAAVKQVLSGAEF 398 Mycobacterium tub... 15610099 332 GEAAAARSAVVVCNGGSLTTQQALVAGVPVIGVAGN--LDQHLNMEAVERAGAGVLLRteRLKSQRVAGAVMQVISRSEY 409 Mycobacterium tub...
6323218 1132 KDRAGLIKKKISKEDGikTAISAIYNELEYARSVTLS 1168 baker's yeast 20089343 347 RNKVERLQRLSGELDG--PKTIRKLLEKEIGKKAS-- 379 Methanosarcina acetivorans C2A 20089344 384 RRKTRRLMELAEVLDG--PAAVRKLLEEKFGERSAGK 418 Methanosarcina acetivorans C2A 15669441 343 KRNASKMKELAKKYDG--KKNIKKIIDEFFETRKNIR 377 Methanocaldococcus jannaschii 20094413 320 KVPKIRMMDGRGAERA--ARIVAGTLD---------- 344 Methanopyrus kandleri AV19 15842509 399 RQAARRLAEAFGPDFAgfPQHIESALRLVC------- 428 Mycobacterium tuberculosis CDC1551 15842513 410 RQAAARLADAFGRDRVgfPQHVENALRLMPENRPRTW 446 Mycobacterium tuberculosis CDC1551 15678904 556 YRRNLEDYDGGNNEII--EA-LKRTIDECSRGC---- 585 Methanothermobacter thermautotrophicus str. Delta H 15610095 399 RQAARRLAEAFGPDFAgfPQHIESALRLVC------- 428 Mycobacterium tuberculosis H37Rv 15610099 410 RQAAARLADAFGRDRVgfPQHVENALRLMPENRPRTW 446 Mycobacterium tuberculosis H37Rv 20089343 347 RNKVERLQRLSGELDG--PKTIRKLLEKEIGKKAS-- 379 Methanosarcina acetivorans C2A 20089344 384 RRKTRRLMELAEVLDG--PAAVRKLLEEKFGERSAGK 418 Methanosarcina acetivorans C2A 15669441 343 KRNASKMKELAKKYDG--KKNIKKIIDEFFETRKNIR 377 Methanocaldococcus jannaschii 20094413 320 KVPKIRMMDGRGAERA--ARIVAGTLD---------- 344 Methanopyrus kandleri AV19 15842509 399 RQAARRLAEAFGPDFAgfPQHIESALRLVC------- 428 Mycobacterium tuberculosis CDC1551 15842513 410 RQAAARLADAFGRDRVgfPQHVENALRLMPENRPRTW 446 Mycobacterium tuberculosis CDC1551 15678904 556 YRRNLEDYDGGNNEII--EA-LKRTIDECSRGC---- 585 Methanothermobacter thermautotrophicus str. Delta H 15610095 399 RQAARRLAEAFGPDFAgfPQHIESALRLVC------- 428 Mycobacterium tuberculosis H37Rv 15610099 410 RQAAARLADAFGRDRVgfPQHVENALRLMPENRPRTW 446 Mycobacterium tuberculosis H37Rv
Lu S et al.(2020). "CDD/SPARCLE: the conserved domain database in 2020.",