416911 37 DELMQLIsAYYNVEPLVGYLEQHPe-YQNVTLQFPDDLIKDSSLIVRLLQSKFph--gKIKFWVLADTAYSACCVDEVAA 113 baker's yeast 14600719 1 ---------MVDIDSAVEAARRRG--ARRIVLQLPEGMLQYGLYIAKCFEEMLg---gAAQVYLHADPTFGACDLHYGEL 66 Aeropyrum pernix 19074520 80 LRYLPRN-YNFETGKVLRTIRRLG--AKRVTLQFPDGLLRYSFVIMDVIEKYT-----GAECILLNDVVYGGCCIDDESI 151 Encephalitozoon cun... 2496001 11 LQKKVTTlFNLETERVIREIENLNknNPKVIFQAPEGLKLKVEKEIEKIKQYFkqkniNIEIYLWGNTCFGACDLIDNHV 90 Methanocaldococcus ... 18313748 1 ----------MDNVEIHPLAWTAD---SETLIEAPPGFKWLAIEIASKTGAA-----------VSGRPVWGSCDVRLDKR 56 Pyrobaculum aerophilum 1723275 27 VKIEGDLvEVYEINRTVDFIKSGN--YNSVALQFPDEHLADSGKVASILTNLV-----EANVQILADTNYGSCCVDEVAA 99 fission yeast 19113201 66 IKLLPQN-YNFEIHKTIWHIRLRK--AKRVALQLPEGLLMFGCILSDIFEQFC-----QVETIVMGDVTYGACCIDDFTA 137 fission yeast 15897238 1 ------MsYNFEEERVIKEIREKN--AKRVLLQFPEGLKYFSIDIVKKLREKLp----NVNFIISGEPSWGACDIAEDEA 68 Sulfolobus solfatar... 13542170 1 MNLD----IYKDIEEIRAALEHLG--AKKILLQLPDGLKPEVYHYFNYLSAN-------YNVVISSSPVYGACDIGPSSI 67 Thermoplasma volcanium 16081398 11 MNLEVKDfVHRDVEEADRRLREIG--ARKILLQLPDGLKPYAFDYFTYLSQR-------YDVILSSSPVYGACDIGPSYL 81 Thermoplasma acidop... 14600719 1 ---------MVDIDSAVEAARRRG--ARRIVLQLPEGMLQYGLYIAKCFEEMLg---gAAQVYLHADPTFGACDLHYGEL 66 Aeropyrum pernix 19074520 80 LRYLPRN-YNFETGKVLRTIRRLG--AKRVTLQFPDGLLRYSFVIMDVIEKYT-----GAECILLNDVVYGGCCIDDESI 151 Encephalitozoon cun... 2496001 11 LQKKVTTlFNLETERVIREIENLNknNPKVIFQAPEGLKLKVEKEIEKIKQYFkqkniNIEIYLWGNTCFGACDLIDNHV 90 Methanocaldococcus ... 18313748 1 ----------MDNVEIHPLAWTAD---SETLIEAPPGFKWLAIEIASKTGAA-----------VSGRPVWGSCDVRLDKR 56 Pyrobaculum aerophilum 1723275 27 VKIEGDLvEVYEINRTVDFIKSGN--YNSVALQFPDEHLADSGKVASILTNLV-----EANVQILADTNYGSCCVDEVAA 99 fission yeast 19113201 66 IKLLPQN-YNFEIHKTIWHIRLRK--AKRVALQLPEGLLMFGCILSDIFEQFC-----QVETIVMGDVTYGACCIDDFTA 137 fission yeast 15897238 1 ------MsYNFEEERVIKEIREKN--AKRVLLQFPEGLKYFSIDIVKKLREKLp----NVNFIISGEPSWGACDIAEDEA 68 Sulfolobus solfatar... 13542170 1 MNLD----IYKDIEEIRAALEHLG--AKKILLQLPDGLKPEVYHYFNYLSAN-------YNVVISSSPVYGACDIGPSSI 67 Thermoplasma volcanium 16081398 11 MNLEVKDfVHRDVEEADRRLREIG--ARKILLQLPDGLKPYAFDYFTYLSQR-------YDVILSSSPVYGACDIGPSYL 81 Thermoplasma acidop...
416911 114 EHVh-AEVVVHFGDACLN-------AIQNLPVVYSFGTPFLDLALVVENFQR-AFPD--LSSKICLMANAPFSKHLSQLY 182 baker's yeast 14600719 67 DTTvrPDLIVHVGHSPYPaelahegLEPRGRVVYVRALSKSQLPLDALREAAgLLASryGVRRVGIATTAQHTHLAEKAA 146 Aeropyrum pernix 19074520 152 ASD----LLVHYGHSCLVp-----vGEMSTKVLYIFVDIRIDIDHAAEMIRR-NFQ----GK-IGVIGTIQFNSSINRLK 216 Encephalitozoon cun... 2496001 91 KNLn-VDLIIHYGHEKLSy------ANPEIKTLFIPAYHIFNKDE--------EEK-----------ILNDIKNFIEKHK 144 Methanocaldococcus ... 18313748 57 YKR-----IFHLGHGVPPn------VAYLLEKNLGGKVERLDTDLYVLKAGGiEVYF--I--PVYYIPPPRLPLPQKGGK 121 Pyrobaculum aerophilum 1723275 100 EHMs-ADAIVHYGRACLSp-------TSRLPVLYVFGRLPINLHKLEKCLTIpLDQN------ILLVSDTRWYYAQDSIL 165 fission yeast 19113201 138 RALd-CDFLVHYGHSCLIp-----vDQTPIKVLYVFVDIKIDLQHVVSSLKH-NLPS--NSR-LALVGTIQFVGSLNSIK 207 fission yeast 15897238 69 QQVn-ADLIIHFGHTPYTw------YYPKFPTIFINAESNLDISENALHSLEnDISKy-NGRKISLTATLQHVRLLSKIK 140 Sulfolobus solfatar... 13542170 68 YDK--VDAIVQIGHSPMPn------VKYPKPTIFVEHHYNARISN---IDTS-LLEG--KYDRIGLLFSVQYKEVADEVR 133 Thermoplasma volcanium 16081398 82 YDR--VDAIVQVGHSIMRn------VKYPRPVIFIEHYRTVDVED---INTE-ALK---NYRRIGLIYSIQYRPVADRVK 146 Thermoplasma acidop... 14600719 67 DTTvrPDLIVHVGHSPYPaelahegLEPRGRVVYVRALSKSQLPLDALREAAgLLASryGVRRVGIATTAQHTHLAEKAA 146 Aeropyrum pernix 19074520 152 ASD----LLVHYGHSCLVp-----vGEMSTKVLYIFVDIRIDIDHAAEMIRR-NFQ----GK-IGVIGTIQFNSSINRLK 216 Encephalitozoon cun... 2496001 91 KNLn-VDLIIHYGHEKLSy------ANPEIKTLFIPAYHIFNKDE--------EEK-----------ILNDIKNFIEKHK 144 Methanocaldococcus ... 18313748 57 YKR-----IFHLGHGVPPn------VAYLLEKNLGGKVERLDTDLYVLKAGGiEVYF--I--PVYYIPPPRLPLPQKGGK 121 Pyrobaculum aerophilum 1723275 100 EHMs-ADAIVHYGRACLSp-------TSRLPVLYVFGRLPINLHKLEKCLTIpLDQN------ILLVSDTRWYYAQDSIL 165 fission yeast 19113201 138 RALd-CDFLVHYGHSCLIp-----vDQTPIKVLYVFVDIKIDLQHVVSSLKH-NLPS--NSR-LALVGTIQFVGSLNSIK 207 fission yeast 15897238 69 QQVn-ADLIIHFGHTPYTw------YYPKFPTIFINAESNLDISENALHSLEnDISKy-NGRKISLTATLQHVRLLSKIK 140 Sulfolobus solfatar... 13542170 68 YDK--VDAIVQIGHSPMPn------VKYPKPTIFVEHHYNARISN---IDTS-LLEG--KYDRIGLLFSVQYKEVADEVR 133 Thermoplasma volcanium 16081398 82 YDR--VDAIVQVGHSIMRn------VKYPRPVIFIEHYRTVDVED---INTE-ALK---NYRRIGLIYSIQYRPVADRVK 146 Thermoplasma acidop...
416911 183 NILKGDLHy-----tNIIYSQVNTSaVEEKFVTILDTFHVPEDvdQVgvfeKNSVLFGQHDKadnispedYHLFHLTTP- 256 baker's yeast 14600719 147 EVLRGEGL-------EVAVPPGLRP-YFGAAQVLGCDYRLARG--VR----ADGFVYVGGGV--------FHPLGLYLA- 203 Aeropyrum pernix 19074520 217 RVLDEERG-------GVECTLPQIR-PLSSGEVLGCTAPKIEG--------VSAVISIGDGR--------FHLEGAMIRn 272 Encephalitozoon cun... 2496001 145 SGGKKVAI-------ATTIQYKKLLkDFNPSIILGCRGEVKEG---------DVILFVGTGR--------FHPLMIAYK- 199 Methanocaldococcus ... 18313748 122 IYFPVPYRr------IAEAVHRQTGfPMAREPITGCWVGEPPG---------NVAYVVATGL--------FYPLTLKLFy 178 Pyrobaculum aerophilum 1723275 166 KSLKTLGYqnvyeshLKERIEPNLEeASTSYTIPGRTYSLPKSlsLQ----DMTLLYIGPDSp------tLSSILMSHYs 235 fission yeast 19113201 208 DALQIQDEdg---kgGFYVVIPQAK-PLSPGEALGCTSPYIEK--GS----VDALIYIGDGR--------FHLESVMIAn 269 fission yeast 15897238 141 SFLEDKGY-------DIVIGKPSNR-FMFDGQVLGCDYKAAE---VE----ADIYVIVSGGL--------FHALGLGLA- 196 Sulfolobus solfatar... 13542170 134 KIFENKGF-------TVIIGKKDGR-MAYDGQVLGCNFSSVHSisYD----VDAYVLVSTGQ--------FHGIGAQLS- 192 Thermoplasma volcanium 16081398 147 RILESKGF-------EVIIGRSDRR-MTYDGQVLGCNFSSVHSveAE----VEAFVIVSTGS--------FHALGSQIS- 205 Thermoplasma acidop... 14600719 147 EVLRGEGL-------EVAVPPGLRP-YFGAAQVLGCDYRLARG--VR----ADGFVYVGGGV--------FHPLGLYLA- 203 Aeropyrum pernix 19074520 217 RVLDEERG-------GVECTLPQIR-PLSSGEVLGCTAPKIEG--------VSAVISIGDGR--------FHLEGAMIRn 272 Encephalitozoon cun... 2496001 145 SGGKKVAI-------ATTIQYKKLLkDFNPSIILGCRGEVKEG---------DVILFVGTGR--------FHPLMIAYK- 199 Methanocaldococcus ... 18313748 122 IYFPVPYRr------IAEAVHRQTGfPMAREPITGCWVGEPPG---------NVAYVVATGL--------FYPLTLKLFy 178 Pyrobaculum aerophilum 1723275 166 KSLKTLGYqnvyeshLKERIEPNLEeASTSYTIPGRTYSLPKSlsLQ----DMTLLYIGPDSp------tLSSILMSHYs 235 fission yeast 19113201 208 DALQIQDEdg---kgGFYVVIPQAK-PLSPGEALGCTSPYIEK--GS----VDALIYIGDGR--------FHLESVMIAn 269 fission yeast 15897238 141 SFLEDKGY-------DIVIGKPSNR-FMFDGQVLGCDYKAAE---VE----ADIYVIVSGGL--------FHALGLGLA- 196 Sulfolobus solfatar... 13542170 134 KIFENKGF-------TVIIGKKDGR-MAYDGQVLGCNFSSVHSisYD----VDAYVLVSTGQ--------FHGIGAQLS- 192 Thermoplasma volcanium 16081398 147 RILESKGF-------EVIIGRSDRR-MTYDGQVLGCNFSSVHSveAE----VEAFVIVSTGS--------FHALGSQIS- 205 Thermoplasma acidop...
416911 257 QDPRLLYLSTVFQSVHIFDPAlpgmvtgPFPSLMRRYKYMHVARTAG--CIGILVNTLSLRNTRETINELVKLIKTREKK 334 baker's yeast 14600719 204 TLKPVVQVDPYRGVSEDLTRE-------GEKLYRSRLYRVSQSIGAR--RWGIIVGLKSGQYRPWLVEKLARAIESAGGE 274 Aeropyrum pernix 19074520 273 PHLRFYKYCPFSRRMTQESYD-------HSTMLSDRKSEIRKAFSGR--SFGVILGSLGRQGNRSILRSVVDRLKEY--D 341 Encephalitozoon cun... 2496001 200 YQKEVFIYNPLSKCFDKISEEe------INKFIKKRILAISKLLLNKpkKVGVVLSTKKGQCRKRVFDEIIKLLEENDVN 273 Methanocaldococcus ... 18313748 179 PESRVFQIDPFRGEVRDVEG---------DFARILKLKARAHVTEAK--RVAVLLTTKPGQRQDEKARELAARGHTV--- 244 Pyrobaculum aerophilum 1723275 236 LVNQFLSFDPLSNKIVEESSf-------TGAKLRRRYALVQRCRDAG--VIGIVIGTLGVHRYLHVLNQLRKMILNAGKK 306 fission yeast 19113201 270 PDLPAYRYDPYSHKLSIESYA-------HEEMKSIRYSAVEKARTAK--KFGLIQGTLGRQGSPKVLENLKNTLRKNNKD 340 fission yeast 15897238 197 TNKPTIKLDPYLQKSEDITND-------VRKILKVRYGKILQALDKR--SWVIIQGVKVGQNRPNMIKYFYDKLTEKGYD 267 Sulfolobus solfatar... 13542170 193 TEREVFVLDLNDYKLHSMKDE-------ADKFIRKRYAQIFRAKEAR--KICIISDTRIGQRRERLARIILRQVQQMGLE 263 Thermoplasma volcanium 16081398 206 TERPVFLLDLNEMSLRSMEKE-------ADTFIRKRYAQIYRAMDAK--RICFLVDTRIGQRREKLARMLMDRARDLGKE 276 Thermoplasma acidop... 14600719 204 TLKPVVQVDPYRGVSEDLTRE-------GEKLYRSRLYRVSQSIGAR--RWGIIVGLKSGQYRPWLVEKLARAIESAGGE 274 Aeropyrum pernix 19074520 273 PHLRFYKYCPFSRRMTQESYD-------HSTMLSDRKSEIRKAFSGR--SFGVILGSLGRQGNRSILRSVVDRLKEY--D 341 Encephalitozoon cun... 2496001 200 YQKEVFIYNPLSKCFDKISEEe------INKFIKKRILAISKLLLNKpkKVGVVLSTKKGQCRKRVFDEIIKLLEENDVN 273 Methanocaldococcus ... 18313748 179 PESRVFQIDPFRGEVRDVEG---------DFARILKLKARAHVTEAK--RVAVLLTTKPGQRQDEKARELAARGHTV--- 244 Pyrobaculum aerophilum 1723275 236 LVNQFLSFDPLSNKIVEESSf-------TGAKLRRRYALVQRCRDAG--VIGIVIGTLGVHRYLHVLNQLRKMILNAGKK 306 fission yeast 19113201 270 PDLPAYRYDPYSHKLSIESYA-------HEEMKSIRYSAVEKARTAK--KFGLIQGTLGRQGSPKVLENLKNTLRKNNKD 340 fission yeast 15897238 197 TNKPTIKLDPYLQKSEDITND-------VRKILKVRYGKILQALDKR--SWVIIQGVKVGQNRPNMIKYFYDKLTEKGYD 267 Sulfolobus solfatar... 13542170 193 TEREVFVLDLNDYKLHSMKDE-------ADKFIRKRYAQIFRAKEAR--KICIISDTRIGQRRERLARIILRQVQQMGLE 263 Thermoplasma volcanium 16081398 206 TERPVFLLDLNEMSLRSMEKE-------ADTFIRKRYAQIYRAMDAK--RICFLVDTRIGQRREKLARMLMDRARDLGKE 276 Thermoplasma acidop...
416911 335 HYLFVVGKPNVAKLANFE--DIDIWCILGCSQsgIIVDQFNEFYKPIITPYELNLALSeevtWTgkwvVDFRDAIDEIEQ 412 baker's yeast 14600719 275 YLLVASEVTTLSQLVAIDnpWFEAFTVTSCPR--LPTDDFWSYEKPVLTPGEAMMALEg----R-----LEPYRFPW--- 340 Aeropyrum pernix 19074520 342 VYLIMLDEISPKKLERYN--FIDSFVQISCPR--LSIDWGKLFKKPLLTPFEVFYSGG-----E--------YLMDYYSR 404 Encephalitozoon cun... 2496001 274 YLPILVDNISPDILFYD----VDCYIIVACPR--IVLDDYILYKKPIYTPEEFKLFLKn----------SFKYKFDEIKE 337 Methanocaldococcus ... 18313748 245 ---VVLDEASPDYIDDL---QFDLVINTACPR--IGIDDLDRIKTPIINYYEYIHNRLd-----------PRLAATLL-- 303 Pyrobaculum aerophilum 1723275 307 PYMLAVGKLNPAKLANFQ--EIECFVLIACGE--NSLIDSKEFYRPIVTPFELVKALSsdmsWN----NDFILSFDEVLK 378 fission yeast 19113201 341 FVCVLMSEIFPSRLGQFS--DIDAWIQVACPR--LSIDWGYAFPAPLLTPYEASAAFNv---VP----WKEVYPMDFYAT 409 fission yeast 15897238 268 VFTVTNKVLTLDILRNLDrnYIDVFLVTSCPR--LPIDDLYNYEKPVLTPGEAKMIIN-----N----SLEPYIFPW--- 333 Sulfolobus solfatar... 13542170 264 GILAVTDNISNQDLENM---RCDAVVYTGCPR--VPIDDQQKFTMPLLTPAEFEMGFV----KN----S-NRYVLDEIVS 329 Thermoplasma volcanium 16081398 277 AVLAYTDNISDQDIQNM---GCDLAVYTGCPR--VPIDDQDRFTVPVLTPAEFSMAFF----KS----S-KRYVLDEIVS 342 Thermoplasma acidop... 14600719 275 YLLVASEVTTLSQLVAIDnpWFEAFTVTSCPR--LPTDDFWSYEKPVLTPGEAMMALEg----R-----LEPYRFPW--- 340 Aeropyrum pernix 19074520 342 VYLIMLDEISPKKLERYN--FIDSFVQISCPR--LSIDWGKLFKKPLLTPFEVFYSGG-----E--------YLMDYYSR 404 Encephalitozoon cun... 2496001 274 YLPILVDNISPDILFYD----VDCYIIVACPR--IVLDDYILYKKPIYTPEEFKLFLKn----------SFKYKFDEIKE 337 Methanocaldococcus ... 18313748 245 ---VVLDEASPDYIDDL---QFDLVINTACPR--IGIDDLDRIKTPIINYYEYIHNRLd-----------PRLAATLL-- 303 Pyrobaculum aerophilum 1723275 307 PYMLAVGKLNPAKLANFQ--EIECFVLIACGE--NSLIDSKEFYRPIVTPFELVKALSsdmsWN----NDFILSFDEVLK 378 fission yeast 19113201 341 FVCVLMSEIFPSRLGQFS--DIDAWIQVACPR--LSIDWGYAFPAPLLTPYEASAAFNv---VP----WKEVYPMDFYAT 409 fission yeast 15897238 268 VFTVTNKVLTLDILRNLDrnYIDVFLVTSCPR--LPIDDLYNYEKPVLTPGEAKMIIN-----N----SLEPYIFPW--- 333 Sulfolobus solfatar... 13542170 264 GILAVTDNISNQDLENM---RCDAVVYTGCPR--VPIDDQQKFTMPLLTPAEFEMGFV----KN----S-NRYVLDEIVS 329 Thermoplasma volcanium 16081398 277 AVLAYTDNISDQDIQNM---GCDLAVYTGCPR--VPIDDQDRFTVPVLTPAEFSMAFF----KS----S-KRYVLDEIVS 342 Thermoplasma acidop...
416911 413 NLGGQDTISA 422 baker's yeast 14600719 ---------- Aeropyrum pernix 19074520 405 EGSGEWKNYR 414 Encephalitozoon cuniculi 2496001 338 DDF------- 340 Methanocaldococcus jannaschii 18313748 ---------- Pyrobaculum aerophilum 1723275 379 LSEGKQSKEP 388 fission yeast 19113201 410 NSLG-NWTPN 418 fission yeast 15897238 ---------- Sulfolobus solfataricus 13542170 330 VDDPADK--- 336 Thermoplasma volcanium 16081398 343 VDEFTDQ--- 349 Thermoplasma acidophilum 14600719 ---------- Aeropyrum pernix 19074520 405 EGSGEWKNYR 414 Encephalitozoon cuniculi 2496001 338 DDF------- 340 Methanocaldococcus jannaschii 18313748 ---------- Pyrobaculum aerophilum 1723275 379 LSEGKQSKEP 388 fission yeast 19113201 410 NSLG-NWTPN 418 fission yeast 15897238 ---------- Sulfolobus solfataricus 13542170 330 VDDPADK--- 336 Thermoplasma volcanium 16081398 343 VDEFTDQ--- 349 Thermoplasma acidophilum
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