1KKH


Conserved Protein Domain Family
ERG12

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COG1577: ERG12 
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Mevalonate kinase [Lipid transport and metabolism]
linked to 3D-structure
Statistics
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PSSM-Id: 224493
View PSSM: COG1577
Aligned: 25 rows
Threshold Bit Score: 228.733
Threshold Setting Gi: 19173299
Created: 7-Oct-2002
Updated: 23-Jan-2015
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1KKH_A     6 MIIETPSKVILFGEHAVVY-GYRAISMAIDLTSTIEIKETQEDEIILNLNDLNKSlg-------lnLNEIKNINpnnf-- 75  Methanocaldococcus ...
15595033   2 LRIRKPAKILFLGEHSAVY-GFPVIGATVPIYMDLIYSVSKNWKYLGKPSTRLNS------------------------- 55  Lyme disease spiroc...
19173299   3 YLARSPLKVILFGEHGVLS-GGRCLAVAIDVYGYLAMKSSSINKAIIIDTNGNCV------------------------- 56  Encephalitozoon cun...
15672388   8 MSIKVPGKLFFAGEYSVTKeGNLALITTIETNFEVRISATTGKSIFKTNVGLSDFef-------slSKIEFTKEnpwn-- 78  Lactococcus lactis ...
15926268   1 --------------MAVPF-NAGKIKVLIEALESGNYSSIKS--DVYDGMLYDAP------------------------- 38  Staphylococcus aure...
15926270   2 IQVKAPGKLYIAGEYAVTEpGYKSVLIALDRFVTATIEEADQYKGTIHSKALHHNp---------vTFSRDEDSivisdp 72  Staphylococcus aure...
15900306   2 IAVKTCGKLYWAGEYAILEpGQLALIKDIPIYMRAEIAFSDSYRIYSDMFDFAVD------------LRPNPDY------ 63  Streptococcus pneum...
1170661    5 LIVSSPGKTILFGEHAVVY-GATALAAAVSLRSYCKLQTTNNNEIVIVMSDIGTErr-------wnLQSLPWQHvtvenv 76  fission yeast
125407     5 FLTSAPGKVIIFGEHSAVY-NKPAVAASVSALRTYLLISESSAPDTIELDFPDISfnhkwsindfnAITEDQVNsqklak 83  baker's yeast
16799089   2 ATGIGTAKMILCGEHAVVY-GEPAISVPFTQAIVTTNVETST-KTKFSSAFFTGD------------LENMPDFl----- 62  Listeria innocua
1KKH_A    76 ---gdfKYCLCAIKNTLDYLNi---------------------EPKTGFKINISSKIPI----SCGLGSSASITIGTIKA 127 Methanocaldococcus ...
15595033  56 -------LISFIVSNYSKVNP---------------------------IEFDIISEIPI----GVGLGSSASLSLCFAEY 97  Lyme disease spiroc...
19173299  57 ---------D-LIEKYKYAIP--------------------------GFDAILFLETPL----GCGLGTSAAISLLMSYG 96  Encephalitozoon cun...
15672388  79 ---falTALKNTLSAADSFEKksvs---------------kilSSSPEISLEIVSDLGFge-nKKGYGSSASVVCGLVNA 139 Lactococcus lactis ...
15926268  39 ------DHLKSLVNRFVELNN-----------------------ITEPLAVTIQTNLPP----SRGLGSSAAVAVAFVRA 85  Staphylococcus aure...
15926270  73 haakqlNYVVTAIEIFEQYAKsc-------------------dIAMKHFHLTIDSNLDDsnghKYGLGSSAAVLVSVIKV 133 Staphylococcus aure...
15900306  64 ------SLIQETIALMGDFLAvr-------------------gQNLRPFSLEICGKMEReg-kKFGLGSSGSVVVLVVKA 117 Streptococcus pneum...
1170661   77 -qhpasSPNLDLLQGLGELLKneenglihsamlctlylftslsSPSQGCTLTISSQVPL----GAGLGSSATISVVVATS 151 fission yeast
125407    84 aqqatdGLSQELVSLLDPLLAqlsesfhyhaafcflymfvclcPHAKNIKFSLKSTLPI----GAGLGSSASISVSLALA 159 baker's yeast
16799089  63 -----aGIKALVVDVLNEIGN------------------------GENVSIHVTSGVPI----GRGLGSSAAVATSIARG 109 Listeria innocua
1KKH_A   128 VSGFYNKELKDDEIAKLGYMVEKEIQ-----------GKASITDTSTITYKGILEIKNNk------------------FR 178 Methanocaldococcus ...
15595033  98 ITSHF--EYKDCNKILLANQIENIFH-----------GKSSGMDIRLIDLNGTFYLEKKe------------------NV 146 Lyme disease spiroc...
19173299  97 KARGP-------NMLREAYAMENTFH-----------GKSSGVDVSTCYSGGLISFKEG--------------------V 138 Encephalitozoon cun...
15672388 140 VNQFFDFQLSLEKRFEIAAKTHFEVQ-----------GSGSMGDIAAIMYGGSVFYQNH-------------------KR 189 Lactococcus lactis ...
15926268  86 SYDFLGKSLTKEELIEKANWAEQIAH-----------GKPSGIDTQTIVSGKPVWFQKG-------------------HA 135 Staphylococcus aure...
15926270 134 LNEFYDMKLSNLYIYKLAVIANMKLQ-----------SLSSCGDIAVSVYSGWLAYSTFdhewvkhqiedttveevliKN 202 Staphylococcus aure...
15900306 118 LLALYDVSVDQELLFKLTSAVLLKRG-----------DNGSMGDLACIVAEDLVLYQS--------------------FD 166 Streptococcus pneum...
1170661  152 LLLAFGNIEPPSSNSLQNNKALALIEawsflgeccihGTPSGIDNAVATNGGLIAFRKA-------------------TA 212 fission yeast
125407   160 MAYLGGLIGSNDLEKLSENDKHIVNQwafig-ekcihGTPSGIDNAVATYGNALLFEKDsh----------------nGT 222 baker's yeast
16799089 110 LYKYFNQELDSKKLLAIINAAEKIAH-----------GNASGVDAITVVSEKPVWYERD-------------------RK 159 Listeria innocua
1KKH_A   179 KIKGEFEEFLkn-ckFLIVYAEKRKKKTA-------------ELVNEVAK-----IENKDEIFKEID-KVIDEALKIKNK 238 Methanocaldococcus ...
15595033 147 LHSKKIKDSGf----YFLIGAIKRDLTTK-------------EIVVNLKKdl-lsNAYLFVFIEKLG-LAVSNSYASFQN 207 Lyme disease spiroc...
19173299 139 VEKLSVDHLS-----QFKILIFNSQISKN----------------TEAAVrl---gELNRELYDEIG-KVSEEAYWLLQR 193 Encephalitozoon cun...
15672388 190 VIPLEIPWAT-------YVVQTGKAAKTS---------------EKIKIKl-------sDEFYQASN-ELVIELATAIDI 239 Lactococcus lactis ...
15926268 136 ETLKTLSLDG-----YMVVIDTGVKGSTR-------------QAVEDVHKlc--eDPQYMSHVKHIG-KLVLRASDVIEH 194 Staphylococcus aure...
15926270 203 WPGLHIEPLQapenmEVLIGWTGSPASSP-------------HFVSEVKRlk-sdPSFYGDFLEDSH-RCVEKLIHAFKT 267 Staphylococcus aure...
15900306 167 RQKVAAWLEEen-laTVLERDWGFSISQVkptlecdflvgwtKEVAVSSHmvqqiKQNINQNFLTSSkETVTSLVEALEQ 245 Streptococcus pneum...
1170661  213 HQSAMKEFLKpkdtlSVMITDTKQPKSTK-------------KLVQGVFElkerlPTVIDSIIDAIDgISKSAVLALTSE 279 fission yeast
125407   223 INTNNFKFLDdfpaiPMILTYTRIPRSTKd------------LVARVRVLvtekfPEVMKPILDAMGeCALQGLEIMTKL 290 baker's yeast
16799089 160 LEIMHFPKKIt-----FVVADTGVPSETR-------------DAVKDVQIlykenQAEIGKIIHQLG-DISREIKLHLEG 220 Listeria innocua
1KKH_A   239 ED------------------FGKLMTKNHELLKKLN---ISTPKLDRIVDIGNRFGFG-AKLTGAGGGGCVIILVN---- 292 Methanocaldococcus ...
15595033 208 KDvy---------------sLANEMNIAQCCLKRLG---LSNDTLDWLISEGIKLGALsGKLSGAGKGGAFIFLFEslik 269 Lyme disease spiroc...
19173299 194 EFtl--------------peLYKLIRKSQDLLDRLG---VCPDEMRKVVSKMRKLGIE-AKITGAGCGGHLVTVVKk--g 253 Encephalitozoon cun...
15672388 240 QDfa---------------lFKEKLSENQLLLLENIpegYMTKELAIALNLLNSYPEFaAKISGAGFGENIILFAQn--- 301 Lactococcus lactis ...
15926268 195 HNfe---------------aLADIFNECHADLKALT---VSHDKIEQLMKIGKENGAIaGKLTGAGRGGSMLLLAKd--- 253 Staphylococcus aure...
15926270 268 NNikgv-----------qkmVRQNRTIIQRMDKEATv-dIETEKLKYLCDIAEKYHGA-SKTSGAGGGDCGITIIN---- 330 Staphylococcus aure...
15900306 246 GKse---------------kIIDQVEVASKLLEGLSt-dIYTPLLRQLKEASQDLQTV-AKSSGAGGGDCGIALSFd--- 305 Streptococcus pneum...
1170661  280 SDknss-----------akkLGEFIVLNQKLLECLG---VSHYSIDRVLQATKSIGWT--KLTGAGGGGCTITLLTpeck 343 fission yeast
125407   291 SKckgtddeavetnnelyeqLLELIRINHGLLVSIG---VSHPGLELIKNLSDDLRIGsTKLTGAGGGGCSLTLLRrdit 367 baker's yeast
16799089 221 DAdt--------------vkIGAAMNKAQSYLETLT---VSDSSLEKLIKVARSNGADgAKLTGGGRGGCIIAVAKn--- 280 Listeria innocua
1KKH_A   293 EE--K------------EKELLKELNKEDVRIFN----CRMMN 317 Methanocaldococcus jannaschii
15595033 270 ANivQ------------KELNNMLKDSKIDLLLK----LKVIE 296 Lyme disease spirochete
19173299 254 QQipGw-----------RSVSIDHQGFHVFGTEL--------- 276 Encephalitozoon cuniculi
15672388 302 TQaiA-------------EVQNKLSEYGINLEKF----KVAQK 327 Lactococcus lactis subsp. lactis
15926268 254 LPt-A------------KNIVKAVEKAGAAHTWI----ENLGG 279 Staphylococcus aureus subsp. aureus N315
15926270 331 KDvdK------------EKIYDEWTKHGIKPLKF-----NIYH 356 Staphylococcus aureus subsp. aureus N315
15900306 306 AQs-T------------KTLKNRWADLGIELLYQ----ERIGH 331 Streptococcus pneumoniae TIGR4
1170661  344 EEe-F------------KLCKESLLAHKNSIYDVqlggPGVSV 373 fission yeast
125407   368 QEqiDsfkkklqddfsyETFETDLGGTGCCLLSAknlnKDLKI 410 baker's yeast
16799089 281 QEi-A------------KQITKALHNAGAAQEWIftigEGSYE 310 Listeria innocua
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