Conserved Protein Domain Family
HutI

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COG1228: HutI 
Imidazolonepropionase or related amidohydrolase [Secondary metabolites biosynthesis, transport and catabolism]
Statistics
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PSSM-Id: 224149
View PSSM: COG1228
Aligned: 45 rows
Threshold Bit Score: 162.539
Threshold Setting Gi: 11498526
Created: 7-Oct-2002
Updated: 23-Jan-2015
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16126215  34 EKAEIKPLPKGLDGQASTGFPStykplparatafvgatvltaTGQQIDnGVVFVSEGKITAVGGPD---TPIPAG---IV 107
gi 15615497   1 ---------MKYCIHNTRLIIGi-------------------ADRVIEnGSILFDQDKILKVSAHS----ITDAD----V 44
gi 16124555  15 SALAGAANAQATFVQAGRLLADp------------------aTGKVEIaKTLVLENGKVTRILDG----YVAEPG---GK 69
gi 16126907  19 TLGGAASAAEIKAVSAARLLDVa-------------------SGKYVDnPLVIVTDGRITSIG-KKg--dAVPAG---AT 73
gi 16127355  13 TLLPAVAAAQVSYVRAGKLVDPq-------------------AGKVLTdQILRIEGERIVSVGPWKgapKDGPKD---AK 70
gi 15679530  12 DHKGIFRGFYMRFAVKGEFLDIy-------------------SGEHER-RYVLVDKGRITAIESS-------VTG---VE 61
gi 16263373  28 EALFLLARPVFTLLRSGREMLAaalvlglcatasaddvlfenVRIFDGkGAVLSAPSNVLVKGNVIaaiSTSPIEgegAE 107
gi 15898831   1 -----------MELAIRNGIVFn-------------------GKEIIGkTNIYVREGKIVEVS------REDHSA---KM 41
gi 15899262   1 -----------MDLGIKNGNVFn-------------------GKGVVGkVNIYVKDGKIVEIS------KENKQA---KI 41
gi 731968       --------------------------------------------------------------------------------
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16126215 108 VIDAKGKWITPGIVDAHSHLGVYPSPGVSARSDgnEATDPNTAQVWAEHSVWPQDPGFNRARAGG-----VTTLLVLPGS 182
gi 15615497  45 FIDGTTFSVLPGLIDVHVHLGMDCSVDPFDTME--NTEDAFTSFIAYKQGLQFLRAGITTVRNLGtk-nnVDIIYKKAVE 121
gi 16124555  70 VVDLKDSFVLPGLIDSHVHLTGQQNPNGRLQAV--TQSPSDSAMVGAGFARKTLMAGFTTVANLGan-sqAIFALREGVK 146
gi 16126907  74 AVDLPGVTLLPGLIDMHVHLDSLAEVGGYNSl---EYSDRFWSVVQTANAKKTLEAGFTTVRNVGaa-dyDDVGLREAID 149
gi 16127355  71 VTDWSGLTVLPGLIDMHTHLVDDEQSENIALPl--LRSAAQQAYIGAGHARTTLMAGFTSVRDVGtwralGDAALRDAIT 148
gi 15679530  62 VIDASDKFILPGFIDLHTHLMEDGFRTESKL----EDPLSLYFYGALDNMRATLQAGVTTVRDAGl----ADLGVKMASD 133
gi 16263373 108 RIAGDGRTLMPGLIDAHWHAMLAASSPAEAMG-----DVSFASILAGEEATDTLMRGFTTVRDLGg----PAFGLKRAID 178
gi 15898831  42 EIDAKDMFVMPGLIDAHIHLSG-IKGGSLLKIm--FEKPEYRVLRAAKWLEKLLLAGFTTVRDCGe---tVSLALKRALN 115
gi 15899262  42 EIDAKDMFVMPGLIDAHIHLTG-IKGGSLLKTm--FEKPEYRVLRASKWLEKLLLAGFTTVRDCGe---tISLALKRGVS 115
gi 731968     1 ----------------------------------mLMPKSVALLRIRYTLEAALARGFTTVRDCGg----AEGFLKAEIR 42
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16126215 183 ANLFGGRSVTLKNVPSLTMQGMKFPGAPYG--LKMACGENPK-------RVYGGRGRSPSTAMANVFGFRKawIDAADYA 253
gi 15615497 122 SGLVIGPRVYAAGQPLIMTGGHGQPMGTEV---------------------DGKDEVIKATRQRIKEGADL--IKIMATG 178
gi 16124555 147 RGDVAGPRILASGSSISVHGGHGDINGYSEdvMHALRPES---------VCSGADDCRRAVREQIWLGADL--IKITATG 215
gi 16126907 150 AGYVPGPRIVTAAISFGATGGHCDSTFFPP----SMDQKNPF-------NSDSPDEARKAVRTLKKYGAQV--IKICATG 216
gi 16127355 149 EGLVPGPRMSVAGAYVTAPGGGGEITGVAPdvTIPADMRRGV-------VEDAADVHRK-VRALLVGGADF--IKLIATG 218
gi 15679530 134 RHIIQAPRMQISVTPLSITGGHFDFHTRSGlnIERRYRGLPSg------ICDGIPSVRKRTREVLRAGADV--VKVMATG 205
gi 16263373 179 QGIIPGPRIYASGAMITVTSGHGDFRQLTDlpRRTGGLLTPMetvggamVVDSPDEVRLRVREQFMQGAVL--IKLTAGG 256
gi 15898831 116 DGIIGGPKVIAAGKPITQTFGHGELSHDVPl-EFSKTMSFSE-------FCDGMESCIHAARKVLRDGADF--IKIFATG 185
gi 15899262 116 EGIINGPRIIAAGKPISQTFGHGELSHDVPl-EFSMALSFSE-------FCDGVESCIRASRKVLRDGADF--IKIFATG 185
gi 731968    43 QGSLNGPRLITCGHAISQTGGHGDLRSGALpaSAFDSCSCHFgqv--gvVADGVPECYKAAREEFRRGADF--IKIMGGG 118
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16126215 254 RKWDDYRAKVAKGEKADAPKrdlqMETLAGVLKGEILVQNHCYRADEMAVMIDIAREFGYKITMFHHAIESYKLAPv--- 330
gi 15615497 179 GVLTKGN-HPGAVHFNVDEL----KCICQEAAKASLTTAAHAIGLNGVKNAIKAGVNTIEHGYYLDKETVDTMRDLgiyl 253
gi 16124555 216 GVLSNTAAG-LAKQFSDAEL----AAIVESAHSMGRKVTAHAHGGDGINAFLKAGGDSIEHGTYLDNEGIALMKKSgayl 290
gi 16126907 217 GVFSRGN-EPGQQQLTYEEM----KAVVDEAHMAGIKVAAHAHGASGIREAVRAGVDTIEHASLVDDEGIKLAVQKgayf 291
gi 16127355 219 AVLTEGT-EPGQLELSEEEI----RAAVEEAAKRGTYVTAHAHGAEGIKIAVRAGVRSIEHGSLIDDEGIALMKAKgafl 293
gi 15679530 206 GVMSSTD-RPSDTQFTPSEL----AAIVEEASFRGKNVMVHAHGLQGIKNSIKAGVHSVEHGTYLDKRTARLMAERgvyl 280
gi 16263373 257 GVSSPFS-PLDVTTFTEPEL----RAAVEIAENWGTYVAAHAFTSDAIRKAIAAGVKCIEHGFLMDEATARLIAENdiwl 331
gi 15898831 186 GVLSQRD-RPEHPQLSYEEI----RAIVNEAEKVNTYVAAHAHGDRGARIAIEAGVKTLEHGTLLKDETLKLMKEKnvtl 260
gi 15899262 186 GVLSQRD-RPEHPQLSYEEI----SAIVNEAEKINTYVAAHAHGDKGARIAVEAGIKTLEHGTLLRDETLKLMRERnvtl 260
gi 731968   119 GVASPTD-KISNKQFCDDEI----KALVDVANSYHTYVTAHAYTAEAIQNCIKLGVKGIEHGNLLDERTAELMAELgcyl 193
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16126215 331 --------------LAKEeiCsATWASWTGFKMESLDGIDa-nAAILAKNGACVVIHSDDPIMTQr---lNQEAAIAMTA 392
gi 15615497 254 tptl---laptllqKNSE--HiPQHMIDKIEEIEKEHRKS---FRLALERGVKIIAGTDAGTPFNn----PGQLVEELKI 321
gi 16124555 291 vptlmagdfvyriaSGPNnyF-TPAQTAKALEAGPKMLDM---VRRAHADGVKVAFGTDSGVSA------HGDNAGEFAL 360
gi 16126907 292 smdi--yntdytqaEGKKngV-LEDNLRKDRDIGELQREN---FRKALKAGVKMVYGTDAGIYP------HGDNAKQFAV 359
gi 16127355 294 vadi--yngdfidtYGREhgW-PAGMIRKNRETTDAQREG---FRKAVKAGVKIAYGTDAGVYP------HGWNARQMPY 361
gi 15679530 281 vptf---lvtrlnnDKALrgElAEYSRRDAIEVAEVHREN---MEMAYNEGVRMVMGTDSGVVE------HGMNLLELSY 348
gi 16263373 332 slq----plpelmrTGLRd---GSVERAKADEVWPGIGRT---YELAKRYKIKTAWGTDVLFSR------ALAKQQGAIL 395
gi 15898831 261 tptl--tiqelifkYGKQigV-DEWGLQKITSVRENIANV---VRKAKEYGVTIISGTDLGFETGleeidMGKNWMETVL 334
gi 15899262 261 tptl--tiqeliykYGKQigV-DEWGLQKINEVRESVVNV---VKKAEEYGVMIITGTDLGFETGleeidIGKNWMESVL 334
gi 731968   194 tpt-----lvtykvMGSDq-FsAFLGPENSRKNTEVLYKGidaMKIAQKKKVKICFGSDLLGPL------YGYQTQEFRI 261
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16126215 393 GAKLGinIPRAEAIKWITANPAKAMGIG-------DKTGSIEPGKAADLVVWSRDPFSVYaQAEQVYIDGALTYDRKNPR 465
gi 15615497 322 MLEEG--MTTAQAIESATYLGAKCLKVD-------SLIGSLEEQKLADLIVVKGNPLED----ISNLKNIQHVFKGGVRL 388
gi 16124555 361 LVKAG--MTPLEAIQTATVNAADHFSLS-------NEIGSLTPGKAADLIAVKGDPLKD----VTELQRVTSVIKGGVVY 427
gi 16126907 360 MVRYG--ATPLQAIQSATLTAAEALGRS-------KDVGQVAVGRYGDMIAVAGDPLAD----VTTLEKPVFVMKGGAVV 426
gi 16127355 362 MVRYG--MTPMQAIQSATTVAAELMGKT-------GQVGCHAPGCYADLIAVAGDPLAD----VSVLTKVAKVMKGGTVV 428
gi 15679530 349 LTETG--MEPLEAIRAGTIHAAECMGWE-------DRIGSIEKGKIADIVVTEVNPVEEI-DELSRPGNVLLVVRDGIIY 418
gi 16263373 396 ASLVRw-YTPAEALVMATATNAELLALSgqrnpypGKLGVIEEDALADLLLVEGNPLENIdLVADPANSFKIIMKDGVIY 474
gi 15898831 335 LVERGg-LSPIEALRASTYNAAMAIG---------INAGVIEIGKDADIIIINGDPTLN----VREISKITHVVKNGKLT 400
gi 15899262 335 LVERGg-LSTISSLRASTYNSAFAIG---------INAGAIEVGKDADIIVIDGDPTEN----IRDLSKVRRVVKNGKLT 400
gi 731968   262 RGKVQ---TTQEILLSATVTPAEMNGLG-------DKLGQIKPGFIADLLMMKSNPLDDItILDEPESNILFVMKEGRIY 331

                ....*.
gi 16126215 466 FQPKSD 471
gi 15615497 389 YPDQIH 394
gi 16124555 428 K----- 428
gi 16126907 427 KAP--- 429
gi 16127355 429 KDD--- 431
gi 15679530 419 RDELVY 424
gi 16263373 475 KNTLTP 480
gi 15898831 401 VENKSI 406
gi 15899262 401 VEDGKF 406
gi 731968       ------
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