Conserved Protein Domain Family
Lhr

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COG1201: Lhr 
Lhr-like helicase [Replication, recombination and repair]
Statistics
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PSSM-Id: 224122
View PSSM: COG1201
Aligned: 37 rows
Threshold Bit Score: 480.99
Threshold Setting Gi: 14590941
Created: 7-Oct-2002
Updated: 23-Jan-2015
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831616    8 SSPLPDVFSPATRDWFLRA--FKQPTAVQSQTWHVAA-RGEHALVIAPTGSGKTLAAFLYALDRLFREGgedtrEAHKRK 84
gi 20089647    4 nND-FNSFHPKIQEALRTLg-FTRPTEPQERAFPHIL-DGKHTLLIAPTGSGKTESAVLPVFNAILKK------KPEKRS 74
gi 15678340    1 --MSAESLNPRLRHFLANRlgWRSLRDVQKSALEAIG-RGEDTLIVAPTASGKTEAALIPVFNSILSEG------LPP-- 69
gi 14521025    1 -------MHILLKKAIKEK--FRELNRLQIEAFKRIS-EGKSVLIIAPTGSGKTEAAILPVMNSILKD------GLPP-- 62
gi 14591140    1 -------MHIVLKKAIKEK--FGKLNKLQIQAFKAIYgEGESVLIIAPTGSGKTEAAIIPVINSILKD------NLRP-- 63
gi 15897328    1 ---MINVTNEFLVRLKKLG--YEDLTPIQKIAIPKVL-SGKNVLIIAPTGYGKTEAAILPIFYTIFKD-------KPEK- 66
gi 13541648    1 MENAFDLLDKRIISVLQTHg-ITDPTDPQERIIPEIL-DGKNVLLLSPTGSGKTEAAVMPIFDMILKR------HPDK-- 70
gi 16081894    1 MSNSFSYLDERIIAMLRDRg-ITDPTDPQEQIIPLVL-EGKNVLLLSPTGSGKTEAAVLPVFQRILRE------KPKK-- 70
gi 15790306    8 RMDAFTHLGSEVRNALSERg-FTTPTEPQRRAVPALA-DGRNGLVVAPTGTGKTETAMLPVFDALVSD------GGPP-D 78
gi 17230823    1 MTNAFNRLAPFIQEYIYHHq-WTELRPVQTAACEVVFdSDAHLLIAAATAAGKTEAAFLPVLTLLHDN---------PAS 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831616   85 TSRILYISPIKALGTDVQRNLQIPLKgiaderrRRGETEvnlrvGIRTGDTPAQERSKLTRNPPDILITTPESLYLMLTS 164
gi 20089647   75 GISALYITPLRALNRDMLSRIEVMGK-------LLDIKV-----QVRHGDTPQSERQRQSRNPPDLLITTPETLQAMFSG 142
gi 15678340   70 -VSMLYVSPLKALINDMHSRLELWGN-------HFNLEV-----MKWHGDVPANRKRRFIKNPSDILLITPESLEVMMIN 136
gi 14521025   63 -ISCLYIAPLKALNRDLLERLKWWEA-------KTGIRI-----DVRHGDTTQYRRAKQVRNPPHVLITTPETLPALLTV 129
gi 14591140   64 -ISCLYIAPLKALNRDLLERLKWWGE-------KTGIKV-----EVRHGDTPQSMRAKQVKNPPHILITTPESLPAILTT 130
gi 15897328   67 -ISTLYITPLRALNRDLELRLRRLGE-------AFNISV-----NVRHGDSSQKERKEILDNPPDVLLVTPETLLYLVLN 133
gi 13541648   71 -IFAIYITPLRALNRDIVYRLVEYGK-------DLGIKV-----QVRHSDMTDSDRKRMTADPPDIVVTTPESLQILLNG 137
gi 16081894   71 -VFALYITPLRALNRDILSRLVDYGR-------ELGIDV-----QVRHSDMSDADKRRMAESPPDILVTTPESLQILLNG 137
gi 15790306   79 GFGALYVTPLRALNRDMRERLDWWGE-------TLGLEV-----DVRHGDTTDYQRRQQATDPPDVLVTTPETLQAMLTG 146
gi 17230823   71 TIGALYIGPIKALINDQFARLNDLLR-------LADIPV-----YHWHGDVAQSRKNKLLKNPQGILQITPESLESLLVN 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831616  165 ----RARETLRGVETVIIDEVHAVAGSKRGAHLALSLERLDALLHt-SAQRIGLSATVRSASDVAAFLGGDR-PVTVVNP 238
gi 20089647  143 s---RLRKNMETVTHVVVDEIHELASSKRGAQLAIGLERLVEISG--EFQRIGLSATVGNPWEIAKFLAGANrDFTVIEV 217
gi 15678340  137 rsraEKERILGNLRYIIVDEIHQFIEADRGVQLNSLLARLERYTGv-RPQRIGLSATVGNPEEVLNWMSPSG---AVVRD 212
gi 14521025  130 k---SLRPYLKNVRFVVVDEVTELIDNKRGAQLILNLKRLSLIA---DFIRIGLSATVGNEEEVKEWLGVD----EIVKP 199
gi 14591140  131 k---SLRKYLENVKFVIVDEITELVDNKRGIQLILNLKRLSLIA---DFIRIGLSATVGNEEEIREWFEAK----RIIKP 200
gi 15897328  134 d---TFRKYFTNLKWIIIDELQEMLDEKRGIELSVLIQRIKKIATrnKIQLIGISATIGDVEIAKRYLDREG-EVEIANI 209
gi 13541648  138 r---NLSKLISNVKIVVVDELHDAAENERGSQLSVALERLRDLAG--NFQRIGLSATVGNPKDLAKFLVPEg-ECEIVAT 211
gi 16081894  138 k---NLRRFIANVRVVIVDELHDAAENERGSQLSLALERLRDLAG--NFQRIGLSATVGNPGDLARFLVPNg-TCEIIST 211
gi 15790306  147 s---TLRDGLADVEHVVVDEVHELAGAKRGAQLAIGLERLVEVAG--RVQRIGLSATVGDPHEIGAFLTGGr-GCEIIEV 220
gi 17230823  139 kh-kEILRLFGDLRFVVIDEIHAFMGSERGCQIICQLQRLTNLTKt-QPRRIGLSATLGDYSMAEEWLRLGTnRQVITPK 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831616  239 PAMRHPQIRIVVPVANMDDVssvasgtgedshagreGSIWPYIETGILDEVLRHRSTIVFTNSRGLAEKLTARLNELYAa 318
gi 20089647  218 ALLKLLEFDVISPQVSGEAEdrevmei---artvgcEPEFASHLSLIRKIVEESQSTLIFVNTRQSAEALAAGFRKLG-- 292
gi 15678340  213 TAERKLQYRIFELNHH------------------------K-LIEVLRRFTGKKV--LIFVPSRRDAEKYYNIIRKCLD- 264
gi 14521025  200 PLKKRYKFKVLFPRPRPEDKelael--------lrvdvEVAARLRTLWEIVEKHKRVLVFVNTRQFAEVLAHRLKTWG-- 269
gi 14591140  201 HLKKRYKFKVLYPQPKPEDQelaek--------lkvpgDVATRLRTLWEIVEKYKKALIFVNTRQFAEILGHRLKTWG-- 270
gi 15897328  210 NAIKDIKVDLILPKVEKKDAdlav--------klglRPDTIARLEKLNEIIKNNKPIIIFTNTRETSEFIANQLMSNYS- 280
gi 13541648  212 GLRKNMDIEVMVPQEA--SEgdaei--------mgcdrQYAGAVLKVWELINRHAGSLVFVNRRFVAEDLAFRLRLKFGd 281
gi 16081894  212 TLKKNMSIDVMVPDES--SEedaev--------mgcdrQYAGAILKVWDLINRHAGSLVFVNRRFVAEDLAFRLKLKFGe 281
gi 15790306  221 DVTSNVSFEVREPAVT-DADerlas-------ellttPAMASHVRAIREIVDRHDSVLIFVNTRQTAEALGSRFKELD-- 290
gi 17230823  217 VEAGKRQIKLALEHFYIAKDv---------------dESEATAYEQYIFNLSQSRKCLIFANNRTQTESIIASLRQIASq 281
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831616  319 rlqrspsiaadaahfestsgatsnrvqssdvFIARSHHGSVSKEQRAITEQALKSGE-LRCVVATSSLELGIDMGAVELV 397
gi 20089647  293 -------------------------------ASIGVHHGSLSFEARVEAEEAFKAGA-LRGLICTSSMELGIDIGNVDRV 340
gi 15678340  265 -------------------------------VDVFIHHSSINRDSREEAEERFRSVS-AAFMVNTSTLELGIDVGDIDVV 312
gi 14521025  270 -------------------------------KPVEVHHGSLSKEARIEAERKLKEGK-VKALICTSSMELGIDIGEVDAV 317
gi 14591140  271 -------------------------------KPVEVHHGSLSKEARIEAERKLKEGK-IKALICTSSMELGIDIGDVDVV 318
gi 15897328  281 -------------------------------LKIASHHGSLSREIRIKTENDFKNGN-IDAIVATSSLELGIDIGRINLV 328
gi 13541648  282 -------------------------------IPVLVHHGSLSRETRENAENSFKEGK-VRALICTSSLELGIDIGTASAV 329
gi 16081894  282 -------------------------------IPVLVHHGSLSKETREFAERSFKNGE-VKALICTSSLELGIDVGTANAV 329
gi 15790306  291 -------------------------------ANIGVHHGSLSKDARIDVEDRFKSGD-LDGLLCTSSMELGIDVGGIDHV 338
gi 17230823  282 qa---------------------------hpDIYHVHHGSISASLRQVAENAMREPHnPAVTAATLTLELGIDIGHLERV 334
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831616  398 IQVATPLSVASGLQRIGRAGHQIGGISKGLFFPRT-R-----------RDLVDSAVIVECMFAGRLE-NLTPPHNPLDVL 464
gi 20089647  341 VQYGSPRQVSRLLQRVGRAGHRLHEVSRGTVLSME-A-----------DDTAESMAITKAALEGRVE-DISPHVNSLDVV 407
gi 15678340  313 IHIRSPTSVNRFLQRTGRSGRRRGL-QRTIIFQEK--------------EALTALSVASLALSGRLE-DLRIPVRPLDIY 376
gi 14521025  318 IQYMSPRQVNRLIQRAGRSKHRLLEVSEAYIIATG-V-----------EDYLQSLIIAKRAIEGKLE-RIKPYENALDVL 384
gi 14591140  319 IQYMSPRQVNRLIQRAGRSRHRLWEVSEAYIITTG-V-----------EDYLQGLVIAKRALEGKLE-GVKPYENALDVL 385
gi 15897328  329 VQYMSPRQVIRLIQRVGRSGHKIGRTSIGYVIPSEdL-----------FDILECRAIIEALYSGYLE-KPLFEENPLDVA 396
gi 13541648  330 IQFNSPRQINKMIQRIGRSEHWIGRTSKGYVVCTD-V-----------IEMEEAIAIVDSIKEGKIE-PVQIMRNSLSTL 396
gi 16081894  330 IQFNSPRQINKMIQRIGRSEHWIGKTSKGYVVCTD-V-----------IEMEEAIAIVDSIAEGKIE-NVQIMKNSLSTL 396
gi 15790306  339 VQYNSPREVKRLLQRVGRAGHSRDAVSEGTVITGS-T-----------DDTLEALAVADRANEGAVE-DTQVHHGSLDTV 405
gi 17230823  335 IQLEAPLSVASFLQRLGRAGRRGEAADMRFICAEDeIsaeaplpeqipWQLLQCIAIIQLYLEERWIePIEPIKYPLSLL 414
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831616  465 AQHTVAAAAMD-ALQVDEWYSRVRRAAPWKDLPRRVFDATLDMLSGrypsgdfsAFRPKLVWNREtGILTA-RPGAQLLA 542
gi 20089647  408 ANQIAGMVMDFgEVGIEKIFRILRRAYPFRDLRPEELQRVVDQIGD--------YRLVWHEKGSQ--IVKK-RRKSWQYY 476
gi 15678340  377 FHQILSSVFELeKPTPGDIYRGLGRAHVFSDLDADDFRHLVEFMVE--------NDFLRVHGPYIhHGFNFeKTFGKMNF 448
gi 14521025  385 AHFIVGLLIEYqKLNVHEPYRMAKETYPYRNLKWEHYLEVINVLED--------AGIIRREEGI----LKL-GRRAFKYY 451
gi 14591140  386 AHFIVGLLIEYrDLKINEPYRLAKDTYPYRKLRWEDYLRVLEILEE--------AGIIKRHEDR----LRL-GRKSFKYY 452
gi 15897328  397 AHEIAGMVLEG-YKNPKEMMEILRNSFYFENFTDEMFENVIELLES--------AKIVKRREDGS---LFP-SRRIWKYY 463
gi 13541648  397 ANQILSEVNSKkRVNVDAFFATVKRAYAFADLTYDEYMEVIHFLAD--------TKKIWLEDKF----IGK-RRNTLRYY 463
gi 16081894  397 ANQILSEINAQgKVNVKNFFETVKRSYAYADLPWDEYYSVVSFLAS--------TRKLWLEDEL----MGR-RRNTLKYY 463
gi 15790306  406 ANQIVGVVMDVgETEAWHAYNIITRAYPFKQLTEETFRAVAMELHR--------NRVVYVDEDDD--TIST-SGGTWQYY 474
gi 17230823  415 YHQTMSILVAVgEISPAALAKQVLSLPPFAAISQEDFKLLLRYLID----------IGHIQHTEQnKLILGlAGERIVSK 484
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831616  543 VTSGGTIPDR-GMYSVLLPEgeeqagsRRVGELDEEMVYESR-VNDIITLGATSWRIQQITRDQ-------VIVTPAPGR 613
gi 20089647  477 YDNLSMIPDE-KKYEIYDIVg-----gRSIGVLDEAFVVNFAePGAVFITKGDMWRVIEMPDRErepsrdrIKVEPVEG- 549
gi 15678340  449 LEFYTVFPPN-YEFTVKHRT-------KVIGSLDSFFVVTYLkVGRGFILGGEKWVVKDIDHERf-----iVRVKPCTR- 514
gi 14521025  452 FDNLSTIPDE-VSYKVVDIGs-----gKVIGRLDENFVMDLEe-GMEFIMHGRSWLVLEIDGENl-----iIKVRESENI 519
gi 14591140  453 FENLSTIPDE-VSYKVIDVVs-----gKLIGRLDENFVINLEe-GIEFIMHGKSWLVLEIKDDv-------IKVRESENI 518
gi 15897328  464 YT-TNMIPDSiRSYIVIDHAt-----nMKIGTLDEDFVVTLD-EDSVFILGSRLWKVVSIENDR-------IFVERAELK 529
gi 13541648  464 IENISMIPSE-KNYKVIDIt------gKFIGTLDERYVASDIdAGSYFVMRGNTWRVIRLE-KDr------ILVESFFT- 528
gi 16081894  464 IENISMIPSE-KNYKVIDTg------gKFIGTLDERYVASEIdAGSYFVMRGNTWRVVRID-HDr------ILVESFFT- 528
gi 15790306  475 YANLSMIPDE-ETYEVYDMAg-----gRQVGTLDERFVVNFAePGATFVQRGEMWRITNIDEDDq-----qVEVSPIEDP 543
gi 17230823  485 FQFYAVFADN-KEYTVKQGT-------KEIGSIATPPVVGKQ-----FALAGVTWEVTEIDFKKr-----vVIVKQVEG- 545
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831616  614 SARLPFWRGEGNGRPAELGEMIGDFLH----LLADG----AFFSGTIPPWLAE-ENTIANIQGLIDEQRNATGIVPGSRH 684
gi 20089647  550 MGEVPSWTGEEIPVPFEVAQDVGKLRAeiaaLLRDGledeAVAEKLRLKYPVS-RSAVLELIRLIRDQVEGDFPLPDAET 628
gi 15678340  515 DAEIPDWSSGGAPTTFEVARHVYDILLg---DFDRG---------LLRWLDPG----SQARVQSCMEMASAEG---LDHG 575
gi 14521025  520 EGAIPSWEGELIPVPYEVAREVGRLRr----TLLYDpr---kAPDLIKGVEFN-----GEELELALNSLKQNTLIPSDRD 587
gi 14591140  519 EGAIPSWEGELIPVPYEVAIEVGRLRr----ELVQDke---rAIRLIKGVEFE-----EKELDIARERLKENDLIPSDRD 586
gi 15897328  530 NGILPSWFGESIPVEKEIARKVYEYIY-----AVE-----------KEKRETE----DNSLAEVVREYMKRGYPELRPDL 589
gi 13541648  529 PAVAPRWTGEDIPVLYDVVDKVSKNRla--kRIPECtd-eFSAEKLRQWYCND---------------------VATSDE 584
gi 16081894  529 PAIAPRWTGEDIPVLYDVVQRVSANRks--rSILNYid-dASARKLEEWYQND---------------------IATVDR 584
gi 15790306  544 AGEVPSWTGQEIPVPYAVAQAVGGMRAtggrQLGTGtpkdAVARDVAARYPTThRTAGSALDRMARHVTEQDAPVPSAER 623
gi 17230823  546 -KATSYWRGGSGTIHTKVLQRMRRVLL-----------------EDAEYSYL-----QKKALQRLRKVRELVKEVGLDKQ 602
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831616  685 LVLERCRdeigdWRIILHSPYGRRVHEPWALAIAGRIHALWGADASVVASDDGIVARIPDTD----GKLPDAAIFLF--E 758
gi 20089647  629 IVIEDEG-----DAVTLNACFGHNTNGTLARVLTSLLSARFGSSVAQEVDPYRIRLTLPRRVg---PIQIRDMLLSL--R 698
gi 15678340  576 MIPVRIG-----ERIEINTFAGERVN-ALISDVFRLEHGVHGISNSAFTSSFSARLDYHD---------IESTLRDIpaI 640
gi 14521025  588 IIITVLP-----DTVIIHSDLGNKVNEGISRYILGFLYSKYGRVFTAKSQAHSIIIHAPFKMn---PNEVKEILL----K 655
gi 14591140  587 ILISVFP-----NLVIVHSDFGNKTNEGLARYILAFLSLKYGKIFSARTQSNGIIITTPFKMn---PDEIKDILR----I 654
gi 15897328  590 ILVEIVKn----NLIIVHSPFGSRGNNTLGAIISVMLDVEKQTKTTYRADPYHIAISSVLPItkndMEKIVSTLNST--P 663
gi 13541648  585 VIVESYN-----DEIVIQILLGTKGNFAVAEVLSNLLSSITGESVESDYSPYHIYLRTSRKIy---ADDAKKLILDV--F 654
gi 16081894  585 VIIESFN-----DEIIIQILLGTRGNFALAEILSNVLTSITGESVEMDFSPYHIYLRTSRKIy---AEDVMRMIKSI--N 654
gi 15790306  624 IVVEQAG-----STVVVNACFGHEVNETLGRLVSALLGQQTGSSVGLDAGPYRIELEVPSRVs---ATDVVAVLRDT--D 693
gi 17230823  603 YILQLEK-----GRCCIFPWMGTVAYRTLERLLNNFCRESLEISSIGGVNPYYLTIKLGKGKf---KYIQQEIVSLCeqR 674
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831616  759 PEKLLQIVREAVGSSALFAARFRECAARALLMPGRtpghrtpLWQQRLRASQLLEIAQGYPdfPAILETLRECLQDVYDL 838
gi 20089647  699 PEHVEPIIEMTLKNTTLMKWKMVHVARKFGALSRD-------VDYDRISMKKLLEIYEGSS---MYDEVVREIFHDMLDV 768
gi 15678340  641 ISEEDFLLRLEDNLDRFVKNKFIEHLPGDVAAHMR-------YS-LLYRPDELLRLLRDNG--PVEVHDFKL-------- 702
gi 14521025  656 DYDTKTIISKTIRDSTVYRWKMINVAKRMGALSK------------RARIRNVQKLFEGTI---IEVETLNEVFHDKVDV 720
gi 14591140  655 KGNVREIISRALKDSPIYRWKMLNVAKRMGALRK------------DARIKKVERLFEDTI---IEVETFNEIFHDKVDV 719
gi 15897328  664 IDRIIEILKKGIKESPQFKWKLLVEIKRFGMIDPE---------KEITLTSSIIKAYGDTI---IGEEAVKELLVKNYDV 731
gi 13541648  655 GSDFEQYLAASAPRSRFFKSVFLYEARKFGVISAE-------ADLDRIRIDKIMDAYMDTV---LYRDSVRKLINDYMDV 724
gi 16081894  655 LENLNSYIRSSASRSRFFKSVFLYEARKFGIISED-------ADLERIRVDKIMDAYSESV---VFEDSIRKLINDYMDI 724
gi 15790306  694 PDHVAGLLELSLKQSETLKFTLAQVAAKFGALKRW-------KGRDGVGLSRLLGALEGTP---VYEEAIREVFHTTLDV 763
gi 17230823  675 IRSEDLISSAEAPEMQKYDEFIPHPLLRKAFADDY---------LDMDEIRRVIGNW----------------------- 722
                        890       900       910       920       930       940       950
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15831616  839 PALERLMRRLNGGeiQISDVTTTTPSPFATSLLFGYVAEFMYQSDA-PLAERRASVLSLDSELLRNLLGQvDPGEL 913
gi 20089647  769 PRAKEVLTKLTAG--EIAVEVSGP-TPIGSAGFAMKKDLVAPEKADr-SIVLALKERIMNDNIILFCTTC-KKWTS 839
gi 15678340      ----------------------------------------------------------------------------
gi 14521025  721 QKVEEVLKLIAKGeiRITGRILNEPEEIDKEHGTISMEFMVSLHHTdEEIVELFKQRIMDSSIVMVCTNCgFSWET 796
gi 14591140  720 ERVNTVLKKIKDGeiRVKGRILEEPTSLELEYMRLRGEFLMTSPLDeKEIELLFKEKLLESSITLVCTNCgFSWET 795
gi 15897328  732 EIIKELKNYNWK------IVEVYEASPLAKQFLDKILNYTSFDKEEkPLMIEIFKKRLENKELKLICLSCgWEGKY 801
gi 13541648  725 DALRSFKAKLPT----INFILRDSISKSSDIFISHYSERITPLRPTk-AILESVKNRIMNERVSLYCLSC-GSVRS 794
gi 16081894  725 DAITSFIGSLDT----VQFVLKDKISKASDIFISHYSERVAPLRPTk-VILESVRNRILNERVTLYCVSC-GNVRT 794
gi 15790306  764 ARASDVLARVQSG--ELGVEIVGERTAVGAGGRSAGTELLTPEHADa-SVVQTIKDRIQDDRVKLFCVHC-ADWSH 835
gi 17230823      ----------------------------------------------------------------------------
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