Conserved Protein Domain Family
MutS2

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COG1193: MutS2 
dsDNA-specific endonuclease/ATPase MutS2 [Replication, recombination and repair]
Statistics
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PSSM-Id: 224114
Aligned: 26 rows
Threshold Bit Score: 326.6
Created: 7-Oct-2002
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3914083   11 EETLALLEWPRLCQHLSTFTQTPLGAIAARYLLPPSQWEESRELLAQTQAVESIENSpESNWHFKGIADITEPLARVE-R 89  Synechocystis sp. P...
3914072    6 DKYLKNIDFYEILSLVSKYVSNPDTVNLLSNQKILKTKESLEKIFSFVSLIRMLFEScKG-YPNSFINSLKYPISLLLkE 84  Lyme disease spiroc...
15792379   1 ----MMNDT---KEELISKLDLNSYLEEFKALFARDKE-IFLQGDSNLHFKRIHELCeVEFPTMPELSNLDKALVHLS-K 71  Campylobacter jejuni
19705169   1 -------------------------------MKFIDENSLNRLNFKELLSRIDMYSG----YGKNKLNNLSNFLVGEE-- 43  Fusobacterium nucle...
3914057   10 NPTLMMNNNNTPPKPLEESLDLKEFIALFKTFFAKERDTIALENDLKQTFTYLNEVDaIGLPTPKSVKESDLIIIKLT-K 88  Helicobacter pylori
20088979   1 ----------------MMSGQSISGLQELNGIGERVACRLVEHFGSEEAALQAILEG--DIASLSEVNGVSHTFALSLaR 62  Methanosarcina acet...
15679750   1 ------------------------------------------------------------------MMNSRDSVGPILtE 14  Methanothermobacter...
14521789     --------------------------------------------------------------------------------     Pyrococcus abyssi
15791082   1 -----------------------------------MDLQAIPGVGAKTADALGSLDDpEGALERGDVAAVAGAPGVSEgR 45  Halobacterium sp. N...
7387931   10 NPTLMMNNNNTLPKPLEESLDLKEFIALFKTFFAKERGSIALENDLKQAFTYLNEVDaIGLPAPKSVKESDLIVVKLT-K 88  Helicobacter pylori...
3914083   90 GGLVTGLELLAIAGTLAGVRRLRRVIEERDDLEi-----lQTLVAEVRTLPELEQAIHHCLGEDGKVAERASPKLGEIRQ 164 Synechocystis sp. P...
3914072   85 NSRVSIENLRDIIVFLDEVLRINLFLHKNSDIKhlnvqilSDLLFLNPELKNLLNELKEHIDVDALELKSGVVKEYDSIE 164 Lyme disease spiroc...
15792379  72 QGILHLDEIFEFVKIFRYFEKLK-KIKLGTNLG---------SWLQKIEFVSGALELCLNFDEKGELKESLDERLVNLNA 141 Campylobacter jejuni
19705169  44 --NKLEEEFERMEKIYNLISDDKREMLKLEMIL----------YKFDNIRKTIENAINDIVLDTVDLFELKVQLMAMIEL 111 Fusobacterium nucle...
3914057   89 LGTLHLDEIFEIVKRLHYIVVLQNAFKTFTHLKf-------HERLNAIVLPPFFNDLIALFDDEGKIKQGANATLDALNE 161 Helicobacter pylori
20088979  63 DFRARVEG-CAISDFLKTKEALDLYSRLLELIK--------TFAHTAHARDKLDLFYPFPASRMDLIQERRAFVGEYLEL 133 Methanosarcina acet...
15679750  15 VGGIGERLARKIIDEFGGEDELLRAVKNLEIDR----------LVAIEGIS---QRRAIEIANKLLGNPLPSFLKTEKAF 81  Methanothermobacter...
14521789   1 -------------------------------------------------------------------------MKLKLRG 7   Pyrococcus abyssi
15791082  46 AARIVRNAIRVRHDDPGGFLATDRAAEIHERVLg------LLQERAVTEYARQRLRTFYPSAADSRIAEVNAFVADAMQR 119 Halobacterium sp. N...
7387931   89 LGTLHLDEIYEIVKRLRYIVVLQNAFKPFTHLKf-------HERLNAIILPPFFNDLILLLDDEGQIKQGANATLDALNE 161 Helicobacter pylori...
3914083  165 KL-KAVREQIQQKLQKIIQRQ----SNALQEAVITQRGDRFVLPIKAGYKEQMPGIVHDSSASGNTLYVEPQAIV--ELG 237 Synechocystis sp. P...
3914072  165 FEiKNLNRRVENQIKKIISLN----AEYLTSNFVCYKSNKYTLALKSNFKGKIKGNIISISSSGETFYIEPNDIV--NAN 238 Lyme disease spiroc...
15792379 142 AL-RLKNESIIAEFKKFCYTKa--lMPYLIDTQIHLINNLEALLVRGGFNHAIKAKIIGRSSGG-GFYIVPLSVE--NLQ 215 Campylobacter jejuni
19705169 112 NL---LLNENRDVFSDFILED----MGELFGALDPNNEKIATFYIYESYSVILKEIRRQKKEVENKLFNETDYETiqKLK 184 Fusobacterium nucle...
3914057  162 SLnRLKKES-VKIIHHYARSKe--lAPYLVDTQSHLKHGYECLLLKSGFSGAIKGVVLERSANG-YFYLLPESAQ--KIA 235 Helicobacter pylori
20088979 134 GDvLSADKEFLDLLSSVKKLRpvpgSLRVRDRVILSGDRKTLDEAKERFQAFLPVQAVESFSEFVDLARGYSNVI--IFD 211 Methanosarcina acet...
15679750  82 QIyRDILELMMSYAHTDYARN----RIMLLHPTTDTASMREHIRMVMEAKKMVEELPVEKLRGLLSNIDRPRDPP--INF 155 Methanothermobacter...
14521789   8 DA-REIYRAIRRKIESEIRVSe---AKRFLDNFEPVSDVGEILKRQNYLKRAMESVSEEVEGLL--LKVKPIKFR--KEF 79  Pyrococcus abyssi
15791082 120 TP-RDDVLEALAGVEPLSAPS----GVSVRERCVATTDAETYSDAAAAFPELSVEIVEDARDLA-ELARGYTTVV--ALD 191 Halobacterium sp. N...
7387931  162 SLnRLKKES-TKIIHHYAHSKe--lAPYLVDTQSHLKHGYECLLLKSGFSSAIKGVVLERSANG-YFYLLPESAQ--KIA 235 Helicobacter pylori...
3914083  238 NKLRQARRQEQTEEERILRQLSDQVLEVLLDLEHLLAIATRLDLATARVRYSFW--LGAHPPQWLtpgDEKPITLRQLRH 315 Synechocystis sp. P...
3914072  239 NRLNYLSLEKERIILKILRNLSAKVHSNIVLLDNLYNNFLYYDSLKARAIYGIK--TKGVFPEIS---N--VLNIFDAHH 311 Lyme disease spiroc...
15792379 216 NDIEKIKNQKEEIYYEYAKNFSAFLAKNLPFLKFINTAFDLFDHYSARVLLAKKrdFEFVLCDQS-----TDLVLKNFAH 290 Campylobacter jejuni
19705169 185 NERLSILVDEEREEFKIRRNLTALVKKFSSIFLNNTEKIGNLDFVLGKVRFAKE--YNGIRPVVS---KKKEIVLEDAIN 259 Fusobacterium nucle...
3914057  236 QKIAQIGNEIDCCIVEMCQTLSHSLQKHLLFLKFLFKEFDFLDSLQARLNFAKAynLEFVMPSFTq----KKMILENFSH 311 Helicobacter pylori
20088979 212 DTYLAFDLPEGLEPEFFQDPSKAEFWQILPEVE-LAFFARNLDCILACLDITST--LRVLGFDFFeelSDEELETLKTAL 288 Methanosarcina acet...
15679750 156 NPSKAILVETREDYDLLIDMGLNRYHPVI-----LNPDPGELDEYELIIYVYSEg-MLELEDTFS----TIMVTADSDKH 225 Methanothermobacter...
14521789  80 LGDRLLVVSEDEVEEAEKLGLCMVSTEPIEGYDIVLSTIGYGIDVELKPYEIAP--ELYIKPLWE---SRDVLEALARIF 154 Pyrococcus abyssi
15791082 192 EAFVGVEVEGDVRVEPDAMERPAEVVPER----VLSFFAANRDRIRAAVSVHEA---AGIDTDVD-------LDALDGAL 257 Halobacterium sp. N...
7387931  236 QKIAQIGNEIDCCIVEMCQTLSRSLQKHLLFLKFLFKEFDFLDSLQARLNFAKAynLEFVMPSFTq----KKMILENFSH 311 Helicobacter pylori...
3914083  316 PLLHWQaekeggpavVPITLTIDSQIRVIAITGPNTGGKTVTLKTLGLVALMAKVGLYIPAKET-VEMPWFAQILADIGD 394 Synechocystis sp. P...
3914072  312 PLLKD----------SKAITFTPAENRVVIITGPNAGGKTVTLKTIGLLSAMFQFGIPIVVGES-STFKIFDNIFIDIGD 380 Lyme disease spiroc...
15792379 291 PALKN----------P-KSVSLEFKKQVLIITGVNAGGKSMLLKSMLSAAFLAKHLLPMHIKASeSKIGTFKEFDAIIED 359 Campylobacter jejuni
19705169 260 LEVKEVlea---knkKYTPISIKLNVGTTMITGANMGGKSVALKTIAENVLLFQMGFFVFAKYA--SIPLLDFIFFVSDD 334 Fusobacterium nucle...
3914057  312 PILKE----------P-KPLNLKFEKSMLAVTGVNAGGKTMLLKSLLSAAFLSKHLIPMKINAHhSIIPYFKEIHAIIND 380 Helicobacter pylori
20088979 289 LKVGDD---------GKPVEGFDPELDRLEAALQNLDPVLTSVLNEANQRMNRTLEASSLTLSG-QELIKLVSGGMEIKD 358 Methanosarcina acet...
15679750 226 EIVPEC---------VLNYFRKNLELFRNALEIKRILGMETCLHEVVEIMDELQAAGGEEVDID--EVVNSVKAWADMKL 294 Methanothermobacter...
14521789 155 PGGAAAk--------ILRELEGIEDVMRRNERLENIEEIIRRYESELNKRIEEKLERFKLTLSG-KELVEFLRSLR-YGD 224 Pyrococcus abyssi
15791082 258 AHLEGD-----------GSVAGDDELDRLTRAVNDLDAAVSDAESVANDRLREAIGEQDVTIEG---ADLLSLVERGAGV 323 Halobacterium sp. N...
7387931  312 PILKE----------P-KPLNLKFEKSMLAVTGVNAGGKTMLLKSLLSAAFLSKHLIPMKINAHhSTIPYFREIHAIIND 380 Helicobacter pylori...
3914083  395 EQSLQQNLSTFSGHICRIIRILqalpsGVQDvldpeidspnhpifpSLVLLDEVGAGTDPTEGSALAIALLRHLADQPCL 474 Synechocystis sp. P...
3914072  381 EQSISNSLSTFSSHMSNISYILk---hTTKD---------------SLVIFDEFCSGTDIDQGQALAISILEYLININSY 442 Lyme disease spiroc...
15792379 360 PQNVKNDISTFAGRMLHFSRLF-----SKKN---------------LLLGIDEIELGTDFEEAACLYSVLISKLIANNLK 419 Campylobacter jejuni
19705169 335 MQDISKGLSTFGAEIIKLKEINs----YVKNg-------------tGLIVFDEFARGTNPKEGQKFVRALAKYLNEKSSI 397 Fusobacterium nucle...
3914057  381 PQNSANNISTFAGRMKQFSALL-----SKEN---------------MLLGVDEIELGTDADEASSLYKTLLEKLLKQNNQ 440 Helicobacter pylori
20088979 359 -LLAKELHRVYTGEIEAVKEELa----EKLD----------------FQKQEKLLLDSLFSDEIAYPLRAEQAQLQLLRQ 417 Methanosarcina acet...
15679750 295 RDLIKDIDLSGDEVLTLLNQGM------TAK---------------LERIFDDVLSEARSMIKKRSGVEFDPFIKSYPLK 353 Methanothermobacter...
14521789 225 ---VEAILSKFSSLNDDIIEEI------RKA---------------EEKLSQELGVAIEVFP-RDYPVEVPPDVVERLKR 279 Pyrococcus abyssi
15791082 324 DSLLGRELADEYDDAVGAARDA--------------------------LEEQLG-LRGEAAK---LARRVFGDEPTFPVA 373 Halobacterium sp. N...
7387931  381 PQNSANNISTFAGRMKQFSALL-----SKEN---------------MLLGVDEIELGTDADEASSLYKTLLEKLLKQNNQ 440 Helicobacter pylori...
3914083  475 TVATTHYGELKALKYQDARFENASVEFDDQSLSPTYRLLWGIPGRSNALAIAQRLGLPLAIVEQAKDKLGGFSEDINQVI 554 Synechocystis sp. P...
3914072  443 VLISTHYNALKYFAYTHEGVVNASMRMDLETMQPNYNLIFSIPGESYAFNVASKALIDRSIVIRANEIYSSQKTEINEIL 522 Lyme disease spiroc...
15792379 420 IIITTHHKRLAMLLAKNEQVELIAALYDEELSRPKYEFLKGTIGKSYAFETALRYQIPPNLVSEAKKLYGEDKENLEELV 499 Campylobacter jejuni
19705169 398 SIITTHFDSVVEKNMKHYQVVGLKN-LDFESLKNRLKANNSLELIQD-------N-MDFTLEESIETEVPKDALNIAKLI 468 Fusobacterium nucle...
3914057  441 IIITTHHKRLSVLMAENKEVELLAALYDEEKERPTYTFLKGVIGKSYAFETALRYGVPHFLIEKAKTFYGEDKEKLNVLI 520 Helicobacter pylori
20088979 418 KLNMSFEKVRLARKRELAKVLSSFRRPVERLVREVLDFDLGFSIAC--FASRFRLKMPEPISEAGIGFEEGENLFLKARY 495 Methanosarcina acet...
15679750 354 IDQREVERVKRLEAASRNLREFEVKVDAATRLGELRGAVEGEIRDIMEFDYRLALGLFAHEYELTEPEFGDEISLRGALH 433 Methanothermobacter...
14521789 280 SVERELKIELYMRAREIVPRIIPYIQGLKEEIERAYELEFILALKR------FSRGFTFPKIEEGGIGFIKGRNLFIENP 353 Pyrococcus abyssi
15791082 374 RDDDAMARVRESLTAARDRRAAGRKRELAATLADLRAPTEALVHDALEVDVALAVARFAADFDCVLAERGGRGFRIEGGR 453 Halobacterium sp. N...
7387931  441 IVITTHHKRLSVLMAENKEVELLAALYDEEKERPTYTFLKGVIGKSYAFETALRYGVPPFLIEKAKAFYGEDKEKLNVLI 520 Helicobacter pylori...
3914083  555 AGLESQRREQEQKAANAQKLLQETEIFYQQVSQKAASLQARERELKSYQDQEVQQAIAAAKEEIAKVIRQLQrgkpsAQK 634 Synechocystis sp. P...
3914072  523 EKLIEKEKDLLLIKESMDKKLIQIELQEKELENFYQDLLLREKNIETKLLNEQNEFLKNSRKVLENLVREIKe----GNI 598 Lyme disease spiroc...
15792379 500 GKNINLELELKAKLENVEKKEQKVDEILLSLKEQKEKNEQEFRTSLRNLEFKFHKAIEEAKKTIQLKDIKDK------QR 573 Campylobacter jejuni
19705169 469 GLDDEISEMIYKEYEWEEQ------------------------------------------------------------- 487 Fusobacterium nucle...
3914057  521 ENSSALERELKQKNEHLENALKEQEYLKNAWLLEMEKQKEIFHNKKLELEKSYQQALNILKSEVASKDTSSM------HK 594 Helicobacter pylori
20088979 496 GKIDPVSYSVGKTRFSPEGFENRVVLLSGVNSGGKTSLLELLAQCVVLGYMGFPVPAKELELGSVEEFYYFG-----KSK 570 Methanosarcina acet...
15679750 434 LNLVGSRKPQRVDYRIGDP--DNVVLLTGANSGGKTTLLETLAQVTIMAQMGLPVCALEACVRVVDEVYFIS------KK 505 Methanothermobacter...
14521789 354 QPVSYFVGSAKGQFKGIQE--SSVVILTGANSGGKTSLLELMLQIVILAHMGLPVPASEAWVEPLDEVFFFK-----RKR 426 Pyrococcus abyssi
15791082 454 NPLLDVAFAETEP---VEYGVDGVALLSGVNSGGKTSTLDLVAVVVVLAHMGLPVPAEAARVPAIAELHYYAk-----SQ 525 Halobacterium sp. N...
7387931  521 ENSSTLERELKQKNEHLENALKEQEDLKNAWLLEMEKQKEIFHHKKLELEKSYQQALNILKSEVASKDTSSM------HK 594 Helicobacter pylori...
3914083  635 AQQATEILGQIQAE----QKAKVAPKPi----gYQPTVGERIRIPSfGQTAEVTQVNATAQTVNVTLG-LMKMTVPMADI 705 Synechocystis sp. P...
3914072  599 NVAKNKAFISDLEKnvdlKTNKVNSLNnkrnvvADFKIGDKVRIVNsNAKGKIVGIS--KKKITVNVG-AFNVSVSSSEI 675 Lyme disease spiroc...
15792379 574 SLNKTNEL----------KKEIILPSMeq---neELRVGDFVKYE--KIKGKIISIS-KNDAMVESD--GIKLRVPLKLL 635 Campylobacter jejuni
19705169     --------------------------------------------------------------------------------     Fusobacterium nucle...
3914057  595 EIHKASEILSKH------KTNQEIPQIit-----nFQANEKARYK--NESVLIVQILDKGYYWIETEL-GMRLKAHGSLL 660 Helicobacter pylori
20088979 571 GTLDAGAFETTLK------QFSVLSEAsg-----kLVLADELESIT--EPGASARIIAGILEYLTRSEeSLGVFVSHLSE 637 Methanosarcina acet...
15679750 506 RSLDAGAFESFIRT-----FTPVTTSEns-----kLILLDELEAIT--ELEAAVKIIATFIEFIGESS-SLAVIVTHMAR 572 Methanothermobacter...
14521789 427 INYGAGAFESSLKS-----IVKALKGKgr-----kLILIDEFEAIT--EPGAAAKILAELLKIGVEKG-FYIVIVSHLGE 493 Pyrococcus abyssi
15791082 526 GTLDAGAFEATLRDfaslTERVADDEGgeesaaSRLVLVDELESIT--EPGASAKIIAGILEALHEAG-ASGVFVSHLAG 602 Halobacterium sp. N...
7387931  595 EIHKASEILNKH------KTDQEIPQIit-----sFQINEKARYK--NESVLVIQILDKGYYLVETEL-GMRLKAHGSWL 660 Helicobacter pylori...
3914083  706 ESLNgkkVEPPPKSEPvpkkVKAEPPAteaksppvlvrteKNTLDCRGDRLERAESRLEKALNQALDA--GVLWIIHGKG 783 Synechocystis sp. P...
3914072  676 SLENf--KEKKENGKNfnfsIDYNKENl-----------lSFTIDIRGMRSVDALDFLNKKIDNIILNgiNKFEIIHGKG 742 Lyme disease spiroc...
15792379 636 KKST---PTPKISPKTsi-sVAKPTNL-------------SVSLDLHGLRSDEAISRLDKFISDALLAgfDEVLVYHGIG 698 Campylobacter jejuni
19705169     --------------------------------------------------------------------------------     Fusobacterium nucle...
3914057  661 KKIQ---KPPKNKFKPpkttIPKPKEA-------------SLRLDLRGQRSEEALDLLDAFLNDALLGgfEEVLICHGKG 724 Helicobacter pylori
20088979 638 LILEn--TGTDIRVDG----IEAEGLD--------------SRLELIVNRN-PIYNRVARSTPELIVEr------LLRKT 690 Methanosarcina acet...
15679750 573 EIMK----YVDVRVDG----IEARGLD--------------DDYNLIVDRTPRINYLARSTPELIIRMiyEKSSDDERIV 630 Methanothermobacter...
14521789 494 DLKK---ELPYARVDG----IEASGLD-------------EELNLIVDRQ--PKFGVIGKSTPELILEr------LARKG 545 Pyrococcus abyssi
15791082 603 EIRDq--CGFGVTVDG----IHAAGLE---------------DGELVVERS-PVKDHLARSTPELIVEk-------LAEA 653 Halobacterium sp. N...
7387931  661 KQIQ---KPPKNKFKPpktiVPKPKEA-------------SLRLDLRGQRSEEALDLLDAFLNDALLGgfEEVLICHGKG 724 Helicobacter pylori...
3914083  784 TGKLRQGVQEYLSHHPLVKSYALAPQNDGGAGVTIAYL 821 Synechocystis sp. PCC 6803
3914072  743 EGHLMREVHNLLKELKFIRKYYFAHPSDGGSGKTIVEI 780 Lyme disease spirochete
15792379 699 TGKLAFAVREFLKTHKSVKGFNDAPINQGGFGAKVVRL 736 Campylobacter jejuni
19705169     --------------------------------------     Fusobacterium nucleatum subsp. nucleatum ATCC 25586
3914057  725 SGILEKFVKEFLKNHPKVVSFSDAPINLGGSGVKIVKL 762 Helicobacter pylori
20088979 691 TGKEQE-FYAHLKNKFKN-------------------- 707 Methanosarcina acetivorans C2A
15679750 631 YGRILEKFQKTDKAEEQ--------------------- 647 Methanothermobacter thermautotrophicus str. Delta H
14521789 546 RGEEREILMKVLAKLNNTYVPTQNI------------- 570 Pyrococcus abyssi
15791082 654 DGAVGEGFYERLLEKF---------------------- 669 Halobacterium sp. NRC-1
7387931  725 SGILEKFVKEFLKNHPKVVSFSDAPINLGGSGVKIVKL 762 Helicobacter pylori J99
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