Conserved Protein Domain Family
DnaQ

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COG0847: DnaQ 
DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]
Statistics
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PSSM-Id: 223916
View PSSM: COG0847
Aligned: 95 rows
Threshold Bit Score: 42.1393
Threshold Setting Gi: 586926
Created: 7-Oct-2002
Updated: 23-Jan-2015
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115539   76 ENYPRLQTTENNlqkplkisdlqelvfwcladgqaPSWVLVRNKQMIHRAvillvpglepsqfgfqpvrgnkhsflLPNL 155
gi 19074460    6 ELKRLTVYDIQRilcwafnlskrpsflplratdrpDTINMVKLEETSENIsrl--------------------lgkLKAR 65
gi 586926        --------------------------------------------------------------------------------
gi 19115627   59 LPYKYDNCKLSIcvpivttcipyhsvenlnfnirqNISTTLNLEKTNDSIketknenfrmdvletykckqlnhqttHLPT 138
gi 1175466   736 lpkklhlrrvndtmqcvsqkisnldkdqqslsvyvLRGIIYEIRQNGEEP--------------------------HFVS 789
gi 19113423    1 MS-SSNWEKLKKkl-------------------dsAKSGRVEKKHSNEKK---------------------------YLK 33
gi 1709565   745 efsnirssknwltsefygsiiknkavlrstaselkgTSHIFKYELNGYVAk-------------------------ITDN 799
gi 1723780   101 VLFIPGLQPDDFengkntfneisddnfkyipgeiaSTFHTFPVMAPGSKMtlfspynsfinvglskmekinklkelQKKK 180
gi 6323136     3 SLLRPVDLVNQPlgfqerykilqklfkqlqkayahTKGTNIDLERLATRLevhvakn------------slsgqsyKFNM 70
gi 6324493     1 MALSSNWQALLAse-------------------snPTSNGKNKQSNRKIR---------------------------NVK 34
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115539  156 LNENGPIQLPDFCEVFDRawptrspgdrfrvfspvnaflqsplsneqkkkrdketramasfskpsdylmsyesfiedeyp 235
gi 19074460   66 HTALVNEQLSLDDIVECIlrd---------------------------------------------------------gg 88
gi 586926        --------------------------------------------------------------------------------
gi 19115627  139 NTVLKKRSLFNDAISIVPnkkkqlvsaistnsdsqgassniiptpkydsnspaghelrkrmthllyesykdlgysnaess 218
gi 1175466   790 TIRVSDNTSSDNPDDNRWyifndflv-----------------------------------------------kevteee 822
gi 19113423   34 SVKGKNNENENSYIVDKKr------------------------------------------------------------- 52
gi 1709565   800 NNETRLVTYVKKYNPKENcfkwlmfndy-------------------------------------------lvveiteee 836
gi 1723780   181 KITINDLVLSEQQLVANDypldsgdtnfdtdwvqtvdfthggshif------aldcemclseqglvltrislvnfdnevi 254
gi 6323136    71 SILLRDVLKYKGDLSKIKin----------------------------------------------------------gr 92
gi 6324493    35 KVSKTVNVSSTTQYAPRKrkng-------------------------------------------------------ski 59
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115539  236 LHPTVMKgEEVtqpsgwvasagdfhSPPINPKILAIDCEMVRTEngleiarvtIVDMKSEVIYDEFVKPEspvTDYVTQY 315
gi 19074460   89 YDGIIPSlEYVr--------------MDNLPLIPMVRFEDVYRSg--------IFVDSKSPQPEIDVSKYrraHVSALHD 146
gi 586926      1 --MKPAPgAEP--------------VRMYKSPYGGKYGVWRLADc-------vPMRAKRPQTEKQRLASTr-lGLQARMK 56
gi 19115627  219 MLALLDEkNICetan-------skmIYSSSCKSKILSLKKAPKKneiqgstpdEKLESLVHSEEELILWGyniGDVAPVN 291
gi 1175466   823 ALTVHGPwKIPiivy-------yekLDTKIPQWDEVSDYTLLYQpysl--nknPPINKIQPLTTDEMLYP---KMLVGID 890
gi 19113423   53 ----MNElKKF--------------AK-ENDIPESQVLDAYG--------------VDASKLTRKTNLETl--GKYIAMD 97
gi 1709565   837 ALKMTYPwKTPeii---------iyCDAEELRKPFFSVDTYSINy-------dILFRDYFANGIRDTARRe--YKLLTHD 898
gi 1723780   255 YEELVKP-DVP--------------IVDYLTRYSGITEEKLTVGa-------kKTLREVQKDLLKIISRS---DILIGHS 309
gi 6323136    93 PLKGAKPhLSSign--------ansITTKSKAMEALKALILDSKv-------lEKNGYIVKEMQNKTNDDnstQLYAPCL 157
gi 6324493    60 MDMVYNMnKEI--------------SKHEKDKLEGKVFEFNPNKantsttikePVKVGISEDTRINSNKSkeiGKYIAMD 125
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115539  316 sgi--teeKLRNVTTVLSDVQSYLKKTVdnnt----vllGHSLNSDLNCLKFTHPHiidtani---ynhtrgpPSKPSLK 386
gi 19074460  147 i-------VALDVEKVRTKMGKEPGRVTmvd------cnGEVIYDKIIKPKEPVVDyltk---------ysglTKEVVDR 204
gi 586926     57 ser--grfAMLAHTWLALGPVFLDTETTg----------LDAGAQALEIGLVNARG------------------ERIFET 106
gi 19115627  292 pp-----dELRECDRCGTRFADPRGPCTyhwgklfrekqGGEKIRTYTCCGVKEGDssgcii------ednhvFKYRHLP 360
gi 1175466   891 se-----fVALQQEETEVRSDGTKSTIKp----------SKLSLARVSVLRGEGPNkglpfi------ddyvaTDDKVTD 949
gi 19113423   98 c-------EMVGVADD--MSVLARVSIVny--------hGHVVYDTYVRPKEKVTDw---------------rTWVSGVK 145
gi 1709565   899 eapksgtlVAIDAEFVSLQSELCEIDHQgirsiirpkrtALARISIIRGEEGELYGvpfv---------ddyvVNTNHIE 969
gi 1723780   310 --------LQNDLKVMKLKHPLVVDTAIiyh-----hkaGDPFKPSLKYLSETFLNksiqngehdsvedaracLELTKLK 376
gi 6323136   158 rcs--snfKKTDIMEKTLCRYHPLKRIYnrdtknhqypcCGETTDSVSFLRLGCKTffhhvfrgesydelckiSKFSSTD 235
gi 6324493   126 c-------EFVGVGPEGKESALARISIVny--------fGHVVLDEFVKPREKVVEw---------------rTWVSGIK 175
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115539  387 WLATkwlRREIQKA-GALG------HDSAEDALACVDLLKLKVKNgpafglfnqdfesifhRLSRQQPTpligAIADYGn 459
gi 19074460  205 GIDIeivRNEVLNFiGTNTvi--igHGIENDLSSLRLYHDKIIDTahlflsplgrkislaqLARTYLAKdihvETHDSRv 282
gi 586926    107 RLKP---TVGIDPAaAAVQ--------IVTEPYRFPVLSVRLA------------------------------------- 138
gi 19115627  361 YLASvhpFSYLPDStNSKQl----sHCALDCELCYTTNGMELARLtvvakesiimdvfikpKGKILSLNtrfsGIHDAKe 436
gi 1175466   950 YLTE---YSGIHPGdLDPDrs---pYNVVPLKVAYKKLRLLVNAGcif-----------vgHGLQKDFRiinlLVPPEQv 1012
gi 19113423  146 SFHM---RDAPSFEkVQAE------VAKILDNRVLVGHAVHNDLKv---------------LLLSHPRR----MIRDTSr 197
gi 1709565   970 DYLTr--YSGILPGdLDPEks---tKRLVRRNVVYRKVWLLMQLGcvf-----------vgHGLNNDFKhiniNVPRNQi 1033
gi 1723780   377 ILNGl--AFGIGIN-TENLft--klHRFEVKTVLLNDMIIKNHTEddskg-------qlirCVEDDETWthihENLNKDv 444
gi 6323136   236 DIDGvenVLSLDCEmAFTSlgyemiRLTIVDFFTGKTLFDHVIQPigdivd----lnsdfsGVHEIDRTncptYKEALDv 311
gi 6324493   176 PEHM---KNAITFKeAQKK------TADILEGRILVGHALKHDLEa---------------LMLSHPKS----LLRDTSr 227
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115539  460 pescigkaahksvscanddevVSAVVSLSDMHNFVWGRFRELEHAAMWNANRNTKQENNSDtdtendsveedqvTSYSSA 539
gi 19074460  283 davtclel-----lsvkiqymLRVTDPGCPKLKIQAIIEKKCASDLLKHDRGHLNIAACSYrdlakhlksyrkrRECLWM 357
gi 586926        --------------------------------------------------------------------------------
gi 19115627  437 lesg------------itmdqMYIKIKELGMNKNTILIGHGLENDLNAMRLIHKRVIDTALlfthargppfrysLKYLTK 504
gi 1175466  1013 vdt--------------vdlfFLSSRQRKLSLKFLAWYLLDEEIQLTEHDSIEDALTALKLydcydklksqgklEETLDN 1078
gi 19113423  198 fs----------------gyrKL-AKGRTPGLKKLAEVILGRDIQSGQHSSVQDAQATMEL-------------YKKVKK 247
gi 1709565  1034 rd----------------taiYFLQGKRYLSLRYLAYVLLGMNIQEGNHDSIEDAHTALILykkylhlkekaifEKVLNS 1097
gi 1723780   445 klivg----------riknleRSRNYNKKPRKETPSFDASMVLHDIGQHLTQLYENATPGTmilimsgtgdtrpWNNLST 514
gi 6323136   312 flsenlinknsilighglendLNVMRLFHNKVIDTAILYSRTKFKVSLKNLAFEVLSRKIQngehdssqdaiatMDVVKV 391
gi 6324493   228 hl----------------pfrKLYAKGKTPSLKKLTREVLKISIQEGEHSSVEDARATMLL-------------YKKEKT 278

                 ..
gi 19115539  540 LE 541
gi 19074460  358 LI 359
gi 586926        --
gi 19115627  505 KY 506
gi 1175466  1079 IY 1080
gi 19113423  248 EM 249
gi 1709565  1098 VY 1099
gi 1723780   515 EL 516
gi 6323136   392 KI 393
gi 6324493   279 EF 280
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